Abstract:
OBJECTIVE:Systemic and/or local interleukin-6 (IL-6) reportedly plays an active role in the progression and prognosis of thoracic esophageal squamous cell carcinoma (TESCC). We assessed the associations between IL-6 and IL-6 receptor (IL-6R) genetic polymorphisms, tumoral IL-6 expression and survival rates following surgery. METHODS:The study participants were 63 Japanese patients treated between 2003 and 2008 for T2-T4 advanced TESCC using curative esophagectomy without neoadjuvant treatment. We investigated IL-6 -634G>C (rs1800796) and IL-6R 48892A>C (rs8192284, Asp358Ala) genetic polymorphisms using DNA from peripheral blood samples. In addition, tumoral IL-6 expression was investigated immunohistochemically in resected specimens, and serum IL-6 was measured using a human IL-6 immunoassay. RESULTS:There was a significant difference in survival between patients with the IL-6 -634G/G+G/C genotype and those with the C/C genotype, such that their 5-year overall survival rates were 42 and 72%, respectively. By contrast, the IL-6R 48892A /C genotype and tumoral IL-6 expression had no significant effect on survival among patients. Univariate and multivariate analyses revealed that IL-6 -634G>C polymorphism was an independent prognostic factor with a hazard ratio of 3. CONCLUSIONS:IL-6 -634G>C genetic polymorphism may be a predictive prognostic factor in patients receiving esophagectomy for TESCC.
journal_name
Dig Surgjournal_title
Digestive surgeryauthors
Motoyama S,Nakatsu T,Miura M,Hinai Y,Minamiya Y,Ogawa Jdoi
10.1159/000336952subject
Has Abstractpub_date
2012-01-01 00:00:00pages
194-201issue
3eissn
0253-4886issn
1421-9883pii
000336952journal_volume
29pub_type
杂志文章abstract:BACKGROUND:Pancreatic serous cystic tumors are considered to have a benign biological and clinical course with only few malignant cases. METHODS:We retrospectively analyzed data from 26 patients affected by serous cystic tumors consecutively observed in our Pancreas Unit. We explored the different clinical pictures in...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000142947
更新日期:2008-01-01 00:00:00
abstract::A 64-year-old man with Muir-Torre syndrome (MTS), a condition characterized by the association of multiple sebaceous tumours and kerato-acanthomas with internal malignancies, developed a carcinoma of the ampulla of Vater. This is the 2nd reported ampullary carcinoma in 205 reported cases of MTS, suggesting a higher pr...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000052010
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIM:Laparoscopy-assisted surgery has proved useful in the treatment of early gastric cancer, but its use in advanced cancer has rarely been studied. To investigate the efficacy and advantages of laparoscopy-assisted distal gastrectomy (LADG) with D2 dissection of lymph nodes versus conventional open D2 dista...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000281818
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The reduction in plasma cholesterol with increase in large and lower dense LDL (pattern A) obtained by statins is usually associated with a prompt reduction in cardiovascular risk, but after bariatric surgery for morbid obesity a delay of some years is observed. No data regarding LDL pattern are available in...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000068861
更新日期:2003-01-01 00:00:00
abstract:AIMS:To assess the safety and feasibility of minimally invasive esophagectomy and selected three-field lymphadenectomy with the right bronchial occlusion in left semi-prone position under artificial pneumothorax. METHODS:Thoracoscopic-laparoscopic subtotal esophagectomy and selected three-field lymphadenectomy were pe...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000371747
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:To elucidate the clinical presentation, diagnosis and management of primary hepatic carcinoid tumours, a literature search was conducted and summarized. MATERIALS AND METHODS:Published primary hepatic carcinoid tumour case reports and series were searched and selected in the Medline, EMBASE and Cochrane L...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000167021
更新日期:2008-01-01 00:00:00
abstract::Ileal J-pouch-anal anastomosis is a commonly accepted surgical treatment for patients with ulcerative colitis. However, making a J-pouch anal anastomosis can be difficult due to anatomical variations of patients. We experienced an informative case of ulcerative colitis in which the ileal pouch was damaged when it was ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000105526
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Diverticulitis can lead to localized or generalized peritonitis and consequently induce abdominal adhesion formation. If adhesions would lead to abdominal complaints, it might be expected that these would be more prominent after operation for perforated diverticulitis with peritonitis than after elective sig...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000486868
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Hilar resection in combination with extended liver resections has resulted in a higher rate of R0 resections and increased survival in patients with hilar cholangiocarcinoma (HCCA). This aggressive surgical approach is, however, associated with high rates of operative morbidity and mortality, largely due to ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000323825
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:It is unclear whether total gastrectomy (TG) is always necessary for gastric cancer of the cardia. We therefore investigated whether cardiac cancers treated by TG would have been cured by proximal gastrectomy (PG). METHODS:Photocopies of the resected stomachs of 55 patients who had received TG for cardiac c...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000052000
更新日期:2002-01-01 00:00:00
abstract::Resection of liver metastases for locally resectable pancreatic cancer has rarely been performed. Recently, promising results regarding morbidity and mortality as well as long-term survival have been shown. Thus, we conducted a systematic review of the literature on pancreatic cancer resection with associated liver me...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000184739
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Recent trials have shown promising results for the efficacy of gum chewing for the amelioration of postoperative ileus. This finding could have a major clinical impact since gum chewing is relatively harmless and cheap while postoperative ileus has a significant impact on healthcare. METHODS:Systematic revi...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000117822
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To assess our current concept and results of transperitoneal laparoscopic adrenalectomy (TPLA) and retroperitoneal endoscopic adrenalectomy (ERA) for a variety of benign disorders of the adrenal glands. BACKGROUND DATA:According to the literature, minimal invasive adrenalectomy has shown to be a safe and eff...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000075823
更新日期:2004-01-01 00:00:00
abstract::One of the main reasons for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is its late diagnosis. At the time of presentation, only approximately 15-20% of all patients with PDAC are considered resectable and around 30% are considered borderline resectable. A surgical approach, which is the only curat...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000493466
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:The aim of this review is to summarize the available evidence for changes in bile composition following liver surgery and assess their use in predicting post-operative complications. MATERIALS AND METHODS:A literature search was undertaken for all studies focusing on bile composition, bile volume and anal...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000320459
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Laparoscopic distal pancreatectomy (LDP) has been adopted relatively slowly despite the benefits of minimally invasive approach. The robotic approach can overcome the limitations of LDP, thus increasing the acceptance of minimally invasive distal pancreatectomy. METHODS:We performed a 1:1 retrospective case...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000501428
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Morbidity following pancreaticoduodenectomy (PD) has been reported to remain high. This study sought to measure the peak Hounsfield units (HUs) of visceral attenuation in patients undergoing PD and to assess the quality of adipocytes by comparing these measurements with perioperative factors. METHODS:Patien...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000505060
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Approximately 20% of patients undergoing surgery for ulcerative colitis will retain their rectum. A single-stage proctocolectomy could be an appropriate procedure in patients who are definitely not candidates for a later restorative procedure, but it is generally not advised in acutely ill patients. The...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000381033
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Mechanical stapling devices are widely used in all fields of surgery as they can cut and sew tissue in a quick and easy manner. However, complications like bleeding or leakage at the staple line are frequently encountered and can have devastating consequences. Recent developments have led to the introduction...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000096648
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:Intra-abdominal adhesions typically occur after surgically damaged tissues are situated in apposition, leading to fibrotic connections. The goal of this study was to demonstrate the in vivo efficacy of a cross-linked and insoluble hyaluronic acid (HA) film to reduce postsurgical adhesion in a rat model....
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000253872
更新日期:2009-02-01 00:00:00
abstract::Partial liver resections are the treatment of choice for patients with a malignant liver or bile duct tumor. The most frequent indications for partial liver resections are colorectal metastasis, hepatocellular carcinoma (HCC) and cholangiocarcinoma. Liver resection is the only therapy with a chance for cure in these p...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000103656
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Ehlers-Danlos syndrome (EDS) is a rare inherited group of connective tissue diseases characterized by joint hypermobility, skin hyperextensibility and bruising tendency. Common features of patients with EDS include vascular and gastrointestinal perforations. The purpose of this systematic review is to addr...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000343738
更新日期:2012-01-01 00:00:00
abstract::Surgery is the definitive tool in the management of patients with rectal carcinoma. Early failure of treatment remains problematic and is manifest in local recurrence. Development of surgical techniques and inclusion of other treatment modalities aim to reduce the incidence of local recurrence and improve survival. Th...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000085355
更新日期:2005-01-01 00:00:00
abstract::This report presents a case of a patient with a huge hepatocellular carcinoma in the right lobe of the liver with an extensive portal venous tumor thrombus extending into the main portal trunk and left portal branch. The patient underwent extended right hemihepatectomy with tumor thrombectomy with direct extraction fr...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000324596
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:In the treatment of gastroesophageal reflux disease (GERD), anterior fundoplications are emphasized for their lower risk of complications compared to the posterior approach. AIM:The aim of this study was to evaluate the long-term results of laparoscopic anterior 180 degrees fundoplication in consideration o...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000235959
更新日期:2009-01-01 00:00:00
abstract::Accurate preoperative staging of gastrointestinal malignancies is of major importance in the decision for adequate stage-related therapy. There is evidence that laparoscopy in combination with laparoscopic ultrasound is more accurate in the detection of intra-abdominal metastases than conventional preoperative imaging...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000067600
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Different results and opinions exist concerning the use of a standard or an extended lymphadenectomy, and about the indications for portal vein resection in the surgical treatment of pancreatic cancer. The site of recurrence of pancreatic cancer may help to define the usefulness of different treatments in av...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000018735
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:Because the TNM system disregards the number of lymph nodes dissected and inter-individual differences exist in the number of regional lymph nodes, the lymph node ratio (LNR), which is estimated by dividing the number of metastatic lymph nodes by the number of dissected lymph nodes, has been proposed as...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000355444
更新日期:2013-01-01 00:00:00
abstract:AIMS:To describe the extremely rare case of an adenomyoma of the papilla of Vater. CASE REPORT:A 42-year-old woman was hospitalized for epigastralgia and high fever. The clinical presentation and endoscopic, biochemical, and radiologic findings led to the diagnostic impression of a dysfunction of the papilla of Vater....
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000050115
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Living-donor liver transplantation using a right-lobe graft has increased the frequency of hilar anatomical variations despite its advantage of a larger graft volume. METHODS:Sixty-seven living-donor liver transplantations using right-lobe grafts are reviewed, regarding the surgical anatomy of hilar vascula...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000121907
更新日期:2008-01-01 00:00:00