Abstract:
BACKGROUND/AIMS:Intra-abdominal adhesions typically occur after surgically damaged tissues are situated in apposition, leading to fibrotic connections. The goal of this study was to demonstrate the in vivo efficacy of a cross-linked and insoluble hyaluronic acid (HA) film to reduce postsurgical adhesion in a rat model. METHODS:To measure in vitro adhesion resistance, porcine monocytes were deposited on the surface of films and their attachment was monitored by scanning electron microscopy. A rat cecum abrasion and abdominal insult model was utilized to demonstrate in vivo efficacy. Briefly, an HA film was deployed as a barrier between the damaged cecal and abdominal tissue surfaces for 21 days; control animals did not receive treatment. At the study conclusion, the rats were sacrificed and the degree of adhesion was determined using a scale from 0 to 3, where 0 = no adhesion and 3 = severe fibrosis. RESULTS:HA films resisted monocyte adhesion in vitro. The in vivo study results demonstrated a significantly lower mean adhesion score (0.625 +/- 0.517) with HA film treatment compared to the controls (2.09 +/- 1.22). CONCLUSION:Placement of HA films between injured tissues significantly decreases the severity of abdominal adhesions. Furthermore, the HA film's resistance to monocyte adhesion could be contributory to lowering in vivo adhesion scores.
journal_name
Dig Surgjournal_title
Digestive surgeryauthors
Falabella CA,Chen Wdoi
10.1159/000253872subject
Has Abstractpub_date
2009-02-01 00:00:00pages
476-81issue
6eissn
0253-4886issn
1421-9883pii
000253872journal_volume
26pub_type
杂志文章abstract:BACKGROUND/AIM:Pancreatitis is the most common and feared complication of endoscopic retrograde cholangiopancreatography (ERCP). We previously examined patency of the accessory pancreatic duct (APD) by dye injection endoscopic retrograde pancreatography (ERP). APD patency was found in 43% of 291 control cases who had n...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000286962
更新日期:2010-01-01 00:00:00
abstract:AIM:To prove further the safety of primary closure of the common bile duct. METHOD:Twenty patients among 99 common bile duct explorations underwent primary closure. Pre- and postoperative liver function test, ultrasound and intraoperative cholangiography data, operation time, postoperative complications and the length...
journal_title:Digestive surgery
pub_type: 临床试验,杂志文章
doi:10.1159/000018706
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:The management of patients with silent or asymptomatic gallstones remains controversial. The objective of this study is to determine the complications of laparoscopic cholecystectomy performed to treat patients under 50 years of age with asymptomatic gallstones. METHOD:207 patients, 13-49 years of age ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018876
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The prevalence and significance of joint symptoms appearing in patients with ulcerative colitis (UC) following a colectomy are unclear. AIM:We investigated the relationship between joint symptoms during steroid tapering following an ileal pouch-anal anastomosis (IPAA) and the cumulative risk for developing ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000093495
更新日期:2006-01-01 00:00:00
abstract::Resection of liver metastases for locally resectable pancreatic cancer has rarely been performed. Recently, promising results regarding morbidity and mortality as well as long-term survival have been shown. Thus, we conducted a systematic review of the literature on pancreatic cancer resection with associated liver me...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000184739
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The prognosis of patients with pancreatic cancer is poor. This is mainly caused by the late diagnosis, the aggressive biology and the lack of effective treatment modalities. Adenoviral gene therapy has the potential to selectively treat both primary tumor and (micro)metastatic tissue. METHODS:This review pr...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000145981
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Proinflammatory cytokines like TNF-alpha and IL-8 have been thought to play a pivotal role in the propagation of severe acute pancreatitis (AP) and the development of its systemic complications, particularly acute lung injury. OBJECTIVE:To investigate the effects of pretreatment with hydrocortisone on the p...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018730
更新日期:1999-01-01 00:00:00
abstract::The conventional methods of making an ileal J pouch require an enterotomy to introduce a linear stapler. We devised a new surgical technique that removes any need for this enterotomy by using both circular and linear staplers. We applied this method to two patients who underwent a total colectomy for ulcerative coliti...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000092843
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Public hospitals' long waiting lists make outpatient surgery in private facilities very attractive provided a standardized protocol is applied. The aim of this study was to assess this kind of innovative collaboration in abdominal surgery from a clinical and economical perspective. METHODS:All consecutive p...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000330788
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:Oesophageal intubation remains one of the principal methods of palliation for an obstructing oesophageal carcinoma. We present a case which illustrates a rare but fatal complication of this procedure. METHODS:A 60-year-old female with oesophageal cancer presented with total dysphagia 9 months following...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018886
更新日期:2000-01-01 00:00:00
abstract:AIMS:To describe the extremely rare case of an adenomyoma of the papilla of Vater. CASE REPORT:A 42-year-old woman was hospitalized for epigastralgia and high fever. The clinical presentation and endoscopic, biochemical, and radiologic findings led to the diagnostic impression of a dysfunction of the papilla of Vater....
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000050115
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the early postoperative hematological changes after spleen-preserving distal pancreatectomy (SpDP) with preservation of the splenic artery and vein (PSAV). METHODS:We reviewed 53 patients who underwent SpDP with PSAV (n = 21) or distal pancreatectomy with splenectomy (...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000337312
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Laparoscopic distal pancreatectomy (LDP) for large pancreatic tumors may require prolonged dissection, and this could be associated with increased operative time and intraoperative complications. METHODS:From a total cohort of 190 consecutive patients undergoing LDP, 18 patients were found to have pancreati...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000445008
更新日期:2016-01-01 00:00:00
abstract:AIM:We investigated the clinical significance of metastasis to the lymph node (LN) along the superior mesenteric vein (14v) in gastric cancer. METHODS:A retrospective study of 2,513 gastrectomy patients with a 14v dissection was done using the Ganken Igan Database. RESULTS:The incidence of 14v metastasis correlated w...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000165382
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Crohn's disease is a chronic relapsing inflammatory bowel disease requiring surgery in a large number of patients. This review describes new developments in surgical techniques for treating Crohn's disease. RESULTS:Single-incision laparoscopic surgery decreases abdominal wall trauma by reducing the num...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000341567
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Different results and opinions exist concerning the use of a standard or an extended lymphadenectomy, and about the indications for portal vein resection in the surgical treatment of pancreatic cancer. The site of recurrence of pancreatic cancer may help to define the usefulness of different treatments in av...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000018735
更新日期:1999-01-01 00:00:00
abstract:AIMS:To assess the safety and feasibility of minimally invasive esophagectomy and selected three-field lymphadenectomy with the right bronchial occlusion in left semi-prone position under artificial pneumothorax. METHODS:Thoracoscopic-laparoscopic subtotal esophagectomy and selected three-field lymphadenectomy were pe...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000371747
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIM:We report an unusual case of metastatic testicular germ cell tumor with its unusual presentation. METHOD:A patient presented to the San Joaquin General Hospital with gastrointestinal bleeding and obstruction and a testicular mass is described. The patient's clinical course is followed and the literature...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018764
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:Graft failure is a critical complication associated with vascular occlusion in esophageal reconstruction with a free jejunal graft following pharyngolaryngoesophagectomy. In this study, we evaluated the usefulness of intramucosal pH (pHi) measurement using a tonometer to assess the graft viability. MET...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000102902
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To assess our current concept and results of transperitoneal laparoscopic adrenalectomy (TPLA) and retroperitoneal endoscopic adrenalectomy (ERA) for a variety of benign disorders of the adrenal glands. BACKGROUND DATA:According to the literature, minimal invasive adrenalectomy has shown to be a safe and eff...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000075823
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Laparoscopic sigmoidectomy for diverticulitis has initially been confined to the elective setting. However, open acute sigmoidectomy for perforated diverticulitis is associated with high morbidity rates that might be reduced after laparoscopic surgery. The aim of this systematic review was to assess the feas...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000441150
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:The aim of this review is to summarize the available evidence for changes in bile composition following liver surgery and assess their use in predicting post-operative complications. MATERIALS AND METHODS:A literature search was undertaken for all studies focusing on bile composition, bile volume and anal...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000320459
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Cholecystolithiasis is a common disease. Cholecystectomy is the main treatment method but is associated with various complications in some patients. This study explores a novel, minimally invasive surgery for the removal of calculi and the preservation of the gallbladder using a laparoscope combined with the...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000357823
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Recent trials have shown promising results for the efficacy of gum chewing for the amelioration of postoperative ileus. This finding could have a major clinical impact since gum chewing is relatively harmless and cheap while postoperative ileus has a significant impact on healthcare. METHODS:Systematic revi...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000117822
更新日期:2008-01-01 00:00:00
abstract::Tumour recurrence that obstructs the afferent limb, blocking outflow of bile and pancreatic juice, constitutes a major clinical problem after a Whipple procedure. The endoscopic route is often not a possible alternative. Surgery may be difficult and perhaps dangerous to the often very sick patient and decompression wi...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000071760
更新日期:2003-01-01 00:00:00
abstract::Behçet's disease (BD) is a multisystem disorder characterized by vasculitis. The aim of this report is to present a patient with BD and diverticular disease of the colon and discuss the possible association between BD and diverticulosis. To our knowledge, diverticular disease of the colon has not been previously repor...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000050185
更新日期:2001-01-01 00:00:00
abstract:AIMS:To evaluate the role of the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM), the Portsmouth variant (p-POSSUM) and the Glasgow Prognostic Score (GPS) in predicting outcome after pancreatic surgery with reference to the International Study Group of Pancreatic Surge...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000313693
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Primary distal bile duct adenocarcinomas (DBDAs) are unusual neoplasms, necessitating pancreaticoduodenectomy for cure. The aims of this study were to evaluate the prognostic importance of lymphatic and perineural invasion, long-term outcome of patients after resection, and differences in outcome with h...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018798
更新日期:2000-01-01 00:00:00
abstract::The monocyte/macrophage plays a key role in the network of immune reactions. Dependent on activation, it is able to produce various cytokines which act on other cells of the immune system in the sense of upregulation or downregulation. In addition, it presents antigens by the HLA-DR molecule as an initial trigger of a...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018601
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Long-term functional results of ileal pouch-anal anastomosis (IPAA) with mucosal proctectomy (MP) for ulcerative colitis (UC) are satisfactory but may be compromised by perianal fistulae. METHODS:We analyzed the effect of the level of MP (above or below the dentate line) on the risk of perianal fistulae in ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000351443
更新日期:2013-01-01 00:00:00