Abstract:
BACKGROUND:Therapeutic strategies to prevent port site recurrences in laparoscopy surgery of malignancies have not been investigated until now. METHODS:The effects of taurolidine, heparin, and povidone iodine on the growth of rat and human colon adenocarcinoma as well as gallbladder carcinoma were investigated in vitro. Furthermore, cytokine release of growth-stimulating IL-1beta by peritoneal macrophages was measured after incubation with carbon dioxide and additional incubation with the different agents. In the third experiment, prevention of intra- and extraperitoneal metastases by intraperitoneal instillation of the different agents during laparoscopy was investigated in a colon carcinoma model in the rat. Tumor cells were administered intraperitoneally in 100 rats, and pneumoperitoneum (8 mm Hg) was established over 30 min with carbon dioxide. Rats received either tumor cells, cells + heparin, cells + povidone iodine, cells + taurolidine, or cells + taurolidine + heparin. RESULTS:In vitro, tumor cell growth decreased after incubation with taurolidine, taurolidine/heparin, and povidone iodine. Cytokine release was stimulated by incubation with carbon dioxide and could only be suppressed by incubation with taurolidine in vitro. In vivo, intraperitoneal tumor weight was lower in rats receiving heparin (251 +/- 153 mg) and povidone iodine (134 +/- 117 mg) compared to the control group (541 +/- 291 mg), but even less when taurolidine (79 +/- 82 mg) or taurolidine/heparin (18.3 +/- 30 mg) were instilled. CONCLUSION:Heparin slightly inhibits intraperitoneal tumor growth in vivo, while povidone iodine and taurolidine cause a significant decrease in tumor cell growth in vitro as well as intraperitoneal tumor growth in vivo. Cytokine release of peritoneal macrophages is only suppressed by taurolidine. Total tumor take and trocar metastases are only suppressed by taurolidine and taurolidine/heparin.
journal_name
Dig Surgjournal_title
Digestive surgeryauthors
Jacobi CA,Peter FJ,Wenger FA,Ordemann J,Müller JMdoi
10.1159/000018754subject
Has Abstractpub_date
1999-01-01 00:00:00pages
393-9issue
5eissn
0253-4886issn
1421-9883pii
dsu16393journal_volume
16pub_type
杂志文章abstract:BACKGROUND/AIMS:To evaluate the short-term surgical outcomes of laparoscopic intersphincteric resection (ISR) for lower rectal cancer, and to compare them with a case-control series of open ISR. METHODS:Between July 2002 and March 2011, 29 patients with lower rectal cancer underwent laparoscopic ISR, and 22 of 29 pati...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000332007
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Tata Memorial Centre (TMC) is a high-volume centre for pancreatic tumour resections. We found a continually increasing referral of pancreatic tumours for re-evaluation for surgery, after an initial unsuccessful attempt at resection. AIM:To evaluate reasons of initial in-operability, the feasibility of re-op...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000489275
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Since carcinoma of the esophagus is usually diagnosed at an advanced stage, many cases of esophageal cancer are beyond possible radical resection and only palliative treatment can be performed in such cases. Therefore, a great deal of discussion has taken place concerning indications for treatment modality, ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018619
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The reduction in plasma cholesterol with increase in large and lower dense LDL (pattern A) obtained by statins is usually associated with a prompt reduction in cardiovascular risk, but after bariatric surgery for morbid obesity a delay of some years is observed. No data regarding LDL pattern are available in...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000068861
更新日期:2003-01-01 00:00:00
abstract:BACKGROUNDS:Endoscopic submucosal dissection (ESD) has been widely performed in the treatment of early esophageal squamous cell carcinoma (ESCC). Few studies have compared the long-term outcomes of esophageal ESD based on absolute indications and relative indications. The aim of the current study was to investigate the...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000507437
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Chyle leaks are a rare complication following abdominal surgery. The aim of this study is to describe the management of chyle leaks following surgery for pancreatico-duodenal malignancy. METHODS:Data were collated from a consecutive series of 105 patients who had undergone a pancreatico-duodenectomy for mal...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000108324
更新日期:2007-01-01 00:00:00
abstract::Ileal J-pouch-anal anastomosis is a commonly accepted surgical treatment for patients with ulcerative colitis. However, making a J-pouch anal anastomosis can be difficult due to anatomical variations of patients. We experienced an informative case of ulcerative colitis in which the ileal pouch was damaged when it was ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000105526
更新日期:2007-01-01 00:00:00
abstract::A 26-year-old male was admitted to our hospital with a complaint of mild dysphagia. Preoperative examinations revealed a cystic lesion at the lower esophagus, thought to be a bronchogenic cyst. The patient underwent successful thoracoscopic tumor extirpation, assisted by endoscopy, without undergoing major thoracotomy...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000094751
更新日期:2006-01-01 00:00:00
abstract::Local invasion of adjacent viscera by colorectal liver metastases (CRLM) is no longer considered an absolute contraindication to curative hepatic resection. A growing number of observational analyses have illustrated the feasibility of such resections; however, the evidence base is at best heterogeneous with a lack of...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000485198
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To assess our current concept and results of transperitoneal laparoscopic adrenalectomy (TPLA) and retroperitoneal endoscopic adrenalectomy (ERA) for a variety of benign disorders of the adrenal glands. BACKGROUND DATA:According to the literature, minimal invasive adrenalectomy has shown to be a safe and eff...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000075823
更新日期:2004-01-01 00:00:00
abstract::The abdominal cocoon is a rare disease that is characterized by a total or partial encasement of the small bowel by a thick and fibrotic membrane. Thirty-five cases were reported since it was first described. It occurs primarily in females. Preoperative diagnosis is a matter of challenge and usually made at laparotomy...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000065827
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:In bioartificial liver preparation, serum-contained medium is ordinarily replaced by serum-free medium and hepatocytes are generally cultured at high density. This study was to undertaken to evaluated the dynamic changes in morphology, viability and functions of porcine hepatocytes in serum-free medium at hi...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000064211
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:Postoperative urinary retention (POUR) is one of the most frequent complications of epidural anesthesia. This study aims to clarify risk factors of POUR and to estimate the appropriate timing of urethral catheter removal. METHODS:Between September and December 2014, a retrospective cohort study was con...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000490199
更新日期:2019-01-01 00:00:00
abstract:AIMS:To describe the extremely rare case of an adenomyoma of the papilla of Vater. CASE REPORT:A 42-year-old woman was hospitalized for epigastralgia and high fever. The clinical presentation and endoscopic, biochemical, and radiologic findings led to the diagnostic impression of a dysfunction of the papilla of Vater....
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000050115
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:It has recently been reported that rebamipide (OPC-12759) inhibits inflammatory cytokines and activation of neutrophils. The aim of the present study was to investigate the effects of preoperative administration of rebamipide on parameters of systemic inflammatory response syndrome (SIRS) and serum leve...
journal_title:Digestive surgery
pub_type: 临床试验,杂志文章
doi:10.1159/000073645
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Different results and opinions exist concerning the use of a standard or an extended lymphadenectomy, and about the indications for portal vein resection in the surgical treatment of pancreatic cancer. The site of recurrence of pancreatic cancer may help to define the usefulness of different treatments in av...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000018735
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:The aim of this review is to summarize the available evidence for changes in bile composition following liver surgery and assess their use in predicting post-operative complications. MATERIALS AND METHODS:A literature search was undertaken for all studies focusing on bile composition, bile volume and anal...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000320459
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Laparoscopic distal pancreatectomy (LDP) has been adopted relatively slowly despite the benefits of minimally invasive approach. The robotic approach can overcome the limitations of LDP, thus increasing the acceptance of minimally invasive distal pancreatectomy. METHODS:We performed a 1:1 retrospective case...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000501428
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Little data is available on the prognosis of esophageal cancer (EC) in Iran. We studied the short- and long-term survival of EC patients treated at the Cancer Institute of Iran. METHODS:619 patients were followed who had been operated in the years 1997-2006. The 1-month to 5-year survival rates of EC and ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000354854
更新日期:2013-01-01 00:00:00
abstract::Anastomotic leakage after colorectal surgery is correlated with considerable morbidity and mortality. Although many studies focus on risk factors and detection, studies on the treatment strategy for colorectal anastomotic leakage are scarce. A national questionnaire amongst 350 members of the Dutch Society for Gastroi...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000346348
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Recently, detections of early gastric cancer (EGC) have been increasing, and the treatment strategies for gastric cancer have been changing. To demonstrate recent clinical experience of EGC in Japan and to assess modern strategies for the treatment of EGC, we investigated the English-language literature of t...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000065829
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Despite decennia of experience, ileal pouch anal anastomosis for ulcerative colitis is still associated with high complication rates. The development of automatic vessel sealers has resulted in the revival of a promising surgical alternative to the conventional procedure: close rectal dissection. By preservi...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000331255
更新日期:2011-01-01 00:00:00
abstract::Tumour recurrence that obstructs the afferent limb, blocking outflow of bile and pancreatic juice, constitutes a major clinical problem after a Whipple procedure. The endoscopic route is often not a possible alternative. Surgery may be difficult and perhaps dangerous to the often very sick patient and decompression wi...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000071760
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Hepatic resection for hepatocellular carcinoma (HCC) is now established as the treatment most likely to yield the best outcome. We aimed to clarify the risk factors for HCC recurrence after curative resection of single HCC in patients with normal liver function (NLF). METHODS:The clinical records of 105 pat...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000451066
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To propose guidelines for treatment based on the study of early and late outcome after various surgical procedures for sclerosing encapsulating peritonitis (SEP). PRIMARY BACKGROUND DATA: SEP is rare. The main complication is intestinal obstruction. Ideal treatment is resection of the membrane, whenever possi...
journal_title:Digestive surgery
pub_type: 杂志文章,多中心研究,评审
doi:10.1159/000018681
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The optimal treatment for acute complicated diverticulitis is still a matter of debate. We evaluated outcomes of primary anastomosis with proximal diversion (PAD) versus Hartman's procedure (HP) in acute diverticulitis. METHODS:Using the National Inpatient Sample database, we examined the clinical data of p...
journal_title:Digestive surgery
pub_type: 杂志文章,多中心研究
doi:10.1159/000342549
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Despite the increasing number of reports on the favorable outcomes of laparoscopic surgery for gallbladder cancer (GBC), there is no consensus regarding this surgical procedure. OBJECTIVE:The study aimed to develop a consensus statement on the application of laparoscopic surgery for GBC based on expert opin...
journal_title:Digestive surgery
pub_type: 共识发展会议,杂志文章
doi:10.1159/000486207
更新日期:2019-01-01 00:00:00
abstract::The intestinal barrier function is considered to play an important role in protecting the penetration of luminal antigens, associated with the development of secondary infection and sepsis and the initiation of the multiple organ dysfunction syndrome. The intestinal mucosal barrier against luminal macromolecules and m...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018651
更新日期:1998-01-01 00:00:00
abstract::Surgery is the definitive tool in the management of patients with rectal carcinoma. Early failure of treatment remains problematic and is manifest in local recurrence. Development of surgical techniques and inclusion of other treatment modalities aim to reduce the incidence of local recurrence and improve survival. Th...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000085355
更新日期:2005-01-01 00:00:00
abstract::Behçet's disease (BD) is a multisystem disorder characterized by vasculitis. The aim of this report is to present a patient with BD and diverticular disease of the colon and discuss the possible association between BD and diverticulosis. To our knowledge, diverticular disease of the colon has not been previously repor...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000050185
更新日期:2001-01-01 00:00:00