Abstract:
:The intestinal barrier function is considered to play an important role in protecting the penetration of luminal antigens, associated with the development of secondary infection and sepsis and the initiation of the multiple organ dysfunction syndrome. The intestinal mucosal barrier against luminal macromolecules and microorganisms consists of both non-immunological and immunological defence mechanisms. The main constituents of the intestinal barrier are the endothelial and epithelial barriers. The epithelial barrier selectively restricts micromolecular permeation and almost completely restricts macromolecular permeation, while the endothelial barrier has a very limited restriction to micromolecules and only partly to macromolecules. Maintenance of the barrier depends on the integrity of cellular plasma membranes and tight junctions, as well as the elaboration of endothelial and epithelial secretory products. Focal denudation of the barrier results in permeation of potentially threatening luminal compounds including antigens, proteases, H+, bacteria and endotoxin, and also other factors chemotactic for inflammatory cells. By initiating inflammation and thus acting on subepithelial tissues, such factors can further influence endothelial and epithelial transport and barrier function. The repair of endothelial and epithelial injury is also complex, and both restitution and enhanced endothelial and epithelial cell proliferation are likely to be important. At present, however, mechanisms for intestinal epithelial and endothelial permeation, their alterations in disease and potential ways to prevent or repair injury, are still not fully elucidated.
journal_name
Dig Surgjournal_title
Digestive surgeryauthors
Sun Z,Wang X,Andersson Rdoi
10.1159/000018651subject
Has Abstractpub_date
1998-01-01 00:00:00pages
386-97issue
5eissn
0253-4886issn
1421-9883pii
dsu15386journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Mechanical stapling devices are widely used in all fields of surgery as they can cut and sew tissue in a quick and easy manner. However, complications like bleeding or leakage at the staple line are frequently encountered and can have devastating consequences. Recent developments have led to the introduction...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000096648
更新日期:2006-01-01 00:00:00
abstract::Ectopic pancreas is an uncommon condition and is usually found in the gastrointestinal tract, such as stomach, duodenum and jejunum. However, ectopic pancreas in the ampulla of Vater is rare and its clinical presentations may be similar to periampullary cancer. It is difficult to diagnose preoperatively. We present su...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000096158
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Since carcinoma of the esophagus is usually diagnosed at an advanced stage, many cases of esophageal cancer are beyond possible radical resection and only palliative treatment can be performed in such cases. Therefore, a great deal of discussion has taken place concerning indications for treatment modality, ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018619
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Laparoscopic distal pancreatectomy (LDP) has been adopted relatively slowly despite the benefits of minimally invasive approach. The robotic approach can overcome the limitations of LDP, thus increasing the acceptance of minimally invasive distal pancreatectomy. METHODS:We performed a 1:1 retrospective case...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000501428
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:In the treatment of gastroesophageal reflux disease (GERD), anterior fundoplications are emphasized for their lower risk of complications compared to the posterior approach. AIM:The aim of this study was to evaluate the long-term results of laparoscopic anterior 180 degrees fundoplication in consideration o...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000235959
更新日期:2009-01-01 00:00:00
abstract::This report presents a case of a patient with a huge hepatocellular carcinoma in the right lobe of the liver with an extensive portal venous tumor thrombus extending into the main portal trunk and left portal branch. The patient underwent extended right hemihepatectomy with tumor thrombectomy with direct extraction fr...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000324596
更新日期:2011-01-01 00:00:00
abstract::The authors reported the magnetic resonance imaging (MRI) detection of manganese (Mn) deposition in the basal ganglia of a pancreatoduodenectomized patient following 30-day parenteral nutrition. A multi-trace element supplement solution including 20 micromol Mn/day was parenterally administered for 30 days postoperati...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018830
更新日期:2000-01-01 00:00:00
abstract::Resection of liver metastases for locally resectable pancreatic cancer has rarely been performed. Recently, promising results regarding morbidity and mortality as well as long-term survival have been shown. Thus, we conducted a systematic review of the literature on pancreatic cancer resection with associated liver me...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000184739
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Management of leakages of the gastrojejunal anastomosis after laparoscopic Roux-en-Y gastric bypass (LRYGB) can be complex. New endoscopic techniques such as covered stents and over-the-scope clips (OTCs) have been developed and are valuable alternative therapeutic options to reoperation and drainage. The ai...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000358849
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Although evidence is growing that most patients who need an operation for diverticular disease of the sigmoid colon can be treated by a single-stage procedure, a two-stage procedure will still be necessary in some patients because of significant sepsis or technical difficulties. The outcomes of 65 patients w...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000091444
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:A choice of retrosternal or orthotopic route for reconstruction exists after three-phase esophagectomy with cervical anastomosis. Whether the route of reconstruction affects postoperative morbidity, mortality and recurrence patterns remains controversial. STUDY DESIGN:Patients with cancer of the thoracic es...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000070387
更新日期:2003-01-01 00:00:00
abstract:AIMS:To compare the diagnostic value of endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) in the differentiation of malignant from benign masses in the pancreatic head. METHODS:Within 14 months 95 prospective patients with masses in the pancreatic head were assigned for preoperative...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000051942
更新日期:2000-01-01 00:00:00
abstract:BACKGROUNDS:Endoscopic submucosal dissection (ESD) has been widely performed in the treatment of early esophageal squamous cell carcinoma (ESCC). Few studies have compared the long-term outcomes of esophageal ESD based on absolute indications and relative indications. The aim of the current study was to investigate the...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000507437
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Pancreatic tuberculosis is usually unsuspected as it can present in various forms. Though an uncommon disease, once diagnosed it is potentially curable. PATIENTS AND METHODS:Retrospective review of the records of 9 patients with histologically proven tuberculosis of the pancreas. RESULTS:In none of the 9 p...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000065832
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Proinflammatory cytokines like TNF-alpha and IL-8 have been thought to play a pivotal role in the propagation of severe acute pancreatitis (AP) and the development of its systemic complications, particularly acute lung injury. OBJECTIVE:To investigate the effects of pretreatment with hydrocortisone on the p...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018730
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIM:We report an unusual case of metastatic testicular germ cell tumor with its unusual presentation. METHOD:A patient presented to the San Joaquin General Hospital with gastrointestinal bleeding and obstruction and a testicular mass is described. The patient's clinical course is followed and the literature...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018764
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:The management of patients with silent or asymptomatic gallstones remains controversial. The objective of this study is to determine the complications of laparoscopic cholecystectomy performed to treat patients under 50 years of age with asymptomatic gallstones. METHOD:207 patients, 13-49 years of age ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000018876
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:In the management of pancreatic cystic neoplasms (PCN), size plays a crucial role as the expression of disease progression. While many evidences regarding the natural history of growing pancreatic cysts exist, almost no data are available regarding cysts with a reduction in size. METHODS:Radiological and ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000485199
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Gas in the mesenteric or portal veins (PVG) is an uncommon entity. It was first described only in patients with mesenteric ischemia and bowel gangrene. Later, several reports described other causes for PVG in which conservative treatment was successful. In the past, the diagnosis was made by vague signs in a...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000069388
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIMS:Although the diagnostic value of fluorine-18 2-fluoro-2-deoxy-D-glucose (F-18-FDG) positron emission tomography/computed tomography (F-18-FDG-PET/CT) in patients with colorectal cancer (CRC) has been reported, the association between the F-18-FDG uptake in metastatic lymph nodes (FDGLN) and clinicopatho...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000448222
更新日期:2017-01-01 00:00:00
abstract::One of the main reasons for the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is its late diagnosis. At the time of presentation, only approximately 15-20% of all patients with PDAC are considered resectable and around 30% are considered borderline resectable. A surgical approach, which is the only curat...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000493466
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The prognosis of patients with pancreatic cancer is poor. This is mainly caused by the late diagnosis, the aggressive biology and the lack of effective treatment modalities. Adenoviral gene therapy has the potential to selectively treat both primary tumor and (micro)metastatic tissue. METHODS:This review pr...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000145981
更新日期:2008-01-01 00:00:00
abstract:AIMS:To describe the extremely rare case of an adenomyoma of the papilla of Vater. CASE REPORT:A 42-year-old woman was hospitalized for epigastralgia and high fever. The clinical presentation and endoscopic, biochemical, and radiologic findings led to the diagnostic impression of a dysfunction of the papilla of Vater....
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000050115
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:Little data is available on the prognosis of esophageal cancer (EC) in Iran. We studied the short- and long-term survival of EC patients treated at the Cancer Institute of Iran. METHODS:619 patients were followed who had been operated in the years 1997-2006. The 1-month to 5-year survival rates of EC and ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000354854
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Pancreatic serous cystic tumors are considered to have a benign biological and clinical course with only few malignant cases. METHODS:We retrospectively analyzed data from 26 patients affected by serous cystic tumors consecutively observed in our Pancreas Unit. We explored the different clinical pictures in...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000142947
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. The tumor size and mitotic count, typical risk category factors, are difficult to determine preoperatively. This study aimed to evaluate the usefulness of preoperative 18F-fluoro-2-deoxyglucose posit...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000357149
更新日期:2014-01-01 00:00:00
abstract::Surgery is the definitive tool in the management of patients with rectal carcinoma. Early failure of treatment remains problematic and is manifest in local recurrence. Development of surgical techniques and inclusion of other treatment modalities aim to reduce the incidence of local recurrence and improve survival. Th...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000085355
更新日期:2005-01-01 00:00:00
abstract::Minimally invasive surgery has been shown to offer many advantages to general surgical patients but has not been widely adopted for colorectal disease. Initial fears surrounding the oncological safety of laparoscopic colectomies have largely subsided but the technical challenges still remain. Surgical robots or telema...
journal_title:Digestive surgery
pub_type: 杂志文章,评审
doi:10.1159/000081350
更新日期:2004-01-01 00:00:00
abstract:AIM:To investigate the degree to which specialisation or case-load of the surgeon is associated with the number of lymph nodes isolated from pathology specimens after right-sided hemicolectomy. METHOD:Data from 6 hospitals with well-defined catchment areas included in the Uppsala/Örebro Regional Oncology Centre Colon ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000354857
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The prevalence and significance of joint symptoms appearing in patients with ulcerative colitis (UC) following a colectomy are unclear. AIM:We investigated the relationship between joint symptoms during steroid tapering following an ileal pouch-anal anastomosis (IPAA) and the cumulative risk for developing ...
journal_title:Digestive surgery
pub_type: 杂志文章
doi:10.1159/000093495
更新日期:2006-01-01 00:00:00