Role of perfusion CT in assessing tumor blood flow and malignancy level of gastric cancer.

Abstract:

BACKGROUND/AIMS:Intratumoral hemodynamics or tumor perfusion is useful in understanding the pathological background of the cancer. A parameter for a non-invasive, preoperative assessment of tumor perfusion has yet to be developed. METHODS:The study included 50 patients who underwent surgery for gastric cancer. Perfusion computed tomography (P-CT) was performed using a 16-row multidetector CT, and tumor blood flow (ml/min/100 g tissue) values were measured. We compared blood flow with histopathological characteristics and evaluated its correlation with microvessel density and tumor stromal density and calculated the ratio of vessels and stromal tissue. RESULTS:There was a significant decrease in blood flow in advanced tumor depth, peritoneal dissemination and undifferentiated subtypes. Cases with Lauren's diffuse type carcinoma were found to have decreased blood flow compared to the mixed or intestinal type. As for the stromal structure, despite the lack of correlation with microvessel density, blood flow significantly decreased with increased stromal density. CONCLUSIONS:Decreased blood flow value acquired from P-CT may reflect a progressive state of gastric cancer. The pathological background for this relation involves the tumor stroma. Tumor perfusion decreased as the stage and malignant character of the tumor advanced, and therefore P-CT could be a better strategy to estimate the malignancy level of cancer.

journal_name

Dig Surg

journal_title

Digestive surgery

authors

Satoh A,Shuto K,Okazumi S,Ohira G,Natsume T,Hayano K,Narushima K,Saito H,Ohta T,Nabeya Y,Yanagawa N,Matsubara H

doi

10.1159/000288703

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

253-60

issue

4

eissn

0253-4886

issn

1421-9883

pii

000288703

journal_volume

27

pub_type

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