Immunotherapy for acne vulgaris: current status and future directions.

abstract：:A recent study demonstrated an association between psoriasis and dilated cardiomyopathy. Tumour necrosis factor alpha (TNFalpha) may be involved in the pathogenesis of dilated cardiomyopathy and therefore, anti-TNFalpha agents may play a role in the treatment of dilated cardiomyopathy. The case of a 51-year-old woman ...

journal_title：American journal of clinical dermatology

authors： De Simone C,Carbone A,Caldarola G

更新日期：2010-01-01 00:00:00

abstract：:Rituximab is a chimeric monoclonal antibody that selectively binds to the CD20 molecule on B cells, resulting in their lysis. In autoimmune blistering diseases, the auto-antibody-producing B cells are destroyed and auto-antibody levels are reduced or eliminated. In the majority of patients, rituximab produces rapid cl...

journal_title：American journal of clinical dermatology

authors： Ahmed AR,Shetty S

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Topical coal tar is a well known and effective treatment for psoriasis, but the messiness, staining, odor, and inconvenience associated with its use make patient satisfaction and compliance a challenge. OBJECTIVE:To determine the efficacy, patient tolerability, and cosmetic acceptability of a new topical li...

journal_title：American journal of clinical dermatology

authors： Alora-Palli MB,Perkins AC,Van Cott A,Kimball AB

更新日期：2010-01-01 00:00:00

abstract：:Immunotherapy has revolutionized the treatment of melanoma. Targeting of the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 has led to improved survival in a subset of patients. Unfortunately, the use of immune checkpoint inhibitors is associated with significant sid...

journal_title：American journal of clinical dermatology

authors： Rizk EM,Seffens AM,Trager MH,Moore MR,Geskin LJ,Gartrell-Corrado RD,Wong W,Saenger YM

更新日期：2020-02-01 00:00:00

abstract：:Cutaneous reactions to tattoos are not uncommon and various histologic patterns have been reported, including lichenoid, granulomatous, eczematous, and pseudolymphomatous reactions. Such patterns may develop with highly variable delay after the tattooing procedure. We report three strikingly similar cases of a fast-oc...

journal_title：American journal of clinical dermatology

authors： Kluger N,Durand L,Minier-Thoumin C,Plantier F,Cotten H,Berteloot E,Blatière V,Dereure O

更新日期：2008-01-01 00:00:00

abstract：:Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Many treatments are available; however, the efficacy of these treatments has ...

journal_title：American journal of clinical dermatology

authors： Gupta AK,Carviel J,Abramovits W

更新日期：2017-02-01 00:00:00

abstract：:Halobetasol propionate (HP) 0.5% ointment and cream are class I topical corticosteroids. We review the efficacy and tolerability of HP for treatment of plaque psoriasis in the English language literature. The efficacy of HP ointment and cream is consistently superior to other super-potent topical corticosteroids. Loca...

journal_title：American journal of clinical dermatology

authors： Rivera AM,Hsu S

更新日期：2005-01-01 00:00:00

abstract：:The etiologies of a variety of skin conditions associated with diabetes have not been fully explained. One possible etiological factor is diabetic microangiopathy, which is known to affect the eyes and kidneys in patients with diabetes. There are many mechanisms by which diabetes may cause microangiopathy. These inclu...

journal_title：American journal of clinical dermatology

authors： Ngo BT,Hayes KD,DiMiao DJ,Srinivasan SK,Huerter CJ,Rendell MS

更新日期：2005-01-01 00:00:00

abstract：:Acne vulgaris is one of the most common inflammatory dermatoses and is seen in both the hospital setting and in general practice. Multiple factors are involved in the pathophysiology of acne, including: an alteration in the pattern of keratinization within the pilosebaceous follicles resulting in comedone formation; a...

journal_title：American journal of clinical dermatology

authors： Layton AM

更新日期：2001-01-01 00:00:00

abstract：:Microdermabrasion is a simple, safe, office cosmetic procedure in which aluminum oxide crystals or other abrasive substances are blown onto the face, then vacuumed off, using a single handpiece. This procedure has rapidly become widely utilized for a variety of cosmetic objectives, including the improvement of photoag...

journal_title：American journal of clinical dermatology

authors： Spencer JM

更新日期：2005-01-01 00:00:00

abstract：:Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is important in the hematological and nervous systems, and it has a complex relationship with the skin. Altered cobalamin levels can lead to dermatological manifestations, which may indicate a deficiency or excess of this vitamin. The biochemistry a...

journal_title：American journal of clinical dermatology

authors： Brescoll J,Daveluy S

更新日期：2015-02-01 00:00:00

abstract：:Viral skin infections are common findings in organ transplant recipients. The most important etiological agents are the group of human herpesviruses (HHV), human papillomaviruses (HPV), and molluscum contagiosum virus. HHV that are important in this group of patients are herpes simplex virus (HSV) types 1 and 2, varic...

journal_title：American journal of clinical dermatology

authors： Tan HH,Goh CL

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Efforts have been recently made to investigate simple, objective, accurate, and reproducible methods of clinical/noninvasive assessment of nonsegmental vitiligo. However, studies have mostly considered quantitative or semiquantitative parameters, almost neglecting the purely qualitative appearance of vitilig...

journal_title：American journal of clinical dermatology

authors： Menchini G,Comacchi C,Cappugi P,Torchia D

更新日期：2013-02-01 00:00:00

abstract：:Tildrakizumab (tildrakizumab-asmn in the USA) [Ilumetri®; Ilumya™] is a humanized monoclonal antibody (mAb) that selectively targets the p19 subunit of interleukin (IL)-23, thereby inhibiting the IL-23/IL-17 axis, the signalling pathway primarily implicated in the immunopathogenesis of psoriasis. Administered subcutan...

journal_title：American journal of clinical dermatology

authors： Frampton JE

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:A meta-analysis of 3 major German studies conducted between 1989 and 1994 with cyclosporine in severe psoriasis was performed to allow an integrated evaluation of the efficacy and tolerability of cyclosporine in this indication. DESIGN AND SETTING:All 3 studies were prospective, randomized, parallel group st...

journal_title：American journal of clinical dermatology

authors： Faerber L,Braeutigam M,Weidinger G,Mrowietz U,Christophers E,Schulze HJ,Mahrle G,Meffert H,Drechsler S

更新日期：2001-01-01 00:00:00

abstract：:Recent advances in our understanding of the pathophysiology of atopic dermatitis (AD) have revealed that skin microbiome dysbiosis plays an important role in the disease. In this review, we describe how changes in the structure and function of the microbiome are involved in the pathogenesis of AD. We highlight recent ...

journal_title：American journal of clinical dermatology

authors： Li W,Yosipovitch G

更新日期：2020-09-01 00:00:00

abstract：:Disorders of cornification are a group of diseases that share abnormalities in the manufacture or desquamation of corneocytes. This paper reviews the major and a few of the rarer ones with a concentration on their therapy. Ichthyosis vulgaris is probably a post-translational defect in pro-filaggrin expression. It show...

journal_title：American journal of clinical dermatology

authors： Shwayder T

更新日期：2004-01-01 00:00:00

abstract：SIGNIFICANCE:Psoriasis, a common immune-mediated disease, affects approximately 2% of the population worldwide. Sudden sensorineural hearing loss (SSNHL) might be a manifestation of systemic vascular involvement in autoimmune disease. However, to the best of our knowledge, there is no systematic English-language examin...

journal_title：American journal of clinical dermatology

authors： Yen YC,Lin YS,Weng SF,Lai FJ

更新日期：2015-06-01 00:00:00

abstract：:A 46-year-old man developed Stevens-Johnson syndrome and toxic epidermal necrolysis overlap, with severe localized denudation of the skin on the head and neck, following radiotherapy and oral temozolomide therapy for cranial glioblastoma multiforme. He also had a primary malignant fibrous histiocytoma of the thigh tha...

journal_title：American journal of clinical dermatology

authors： Sarma N

更新日期：2009-01-01 00:00:00

abstract：:Ocular diseases associated with atopic dermatitis (AD) may be sight-threatening. A general understanding of the pathophysiology, diagnosis, and treatment of atopic eye disease may assist dermatologists in knowing when to refer to ophthalmology and in co-managing these diseases with ophthalmologists. Ocular diseases as...

journal_title：American journal of clinical dermatology

authors： Beck KM,Seitzman GD,Yang EJ,Sanchez IM,Liao W

更新日期：2019-12-01 00:00:00

abstract：:The objective of this article is to provide a brief, but critical, overview of the evidence related to complementary/alternative medicine (CAM) use, and to offer valid and useful information for dermatologists in clinical practice. Systematic literature searches were conducted on these databases: Medline, EMBASE, The ...

journal_title：American journal of clinical dermatology

authors： Ernst E,Pittler MH,Stevinson C

更新日期：2002-01-01 00:00:00

abstract：UNLABELLED:Topical application of the antibacterial agent metronidazole is effective in the treatment of moderate to severe rosacea, although its mechanism of action has yet to be clearly established. Metronidazole preparations (0.75 and 1% cream, 0.75% gel and 0.75% lotion) were significantly more effective than place...

journal_title：American journal of clinical dermatology

authors： McClellan KJ,Noble S

更新日期：2000-05-01 00:00:00

abstract：:After a marked decline in the number of syphilis cases in the context of AIDS prevention campaigns, a significant increase has been observed in states of the former Soviet Union since 1994. In recent years, outbreaks have also been reported in the US, Canada, and several European countries. The current epidemic in the...

journal_title：American journal of clinical dermatology

authors： Lautenschlager S

更新日期：2006-01-01 00:00:00

abstract：:Chronic venous insufficiency (CVI) occurs in a relatively large proportion of the population and is associated with significant morbidity, high cost of healthcare, loss of productivity and reduced quality of life. Lower extremity ulcers related to CVI have been estimated to affect 0.2-1% of the population in developed...

journal_title：American journal of clinical dermatology

authors： Simka M,Majewski E

更新日期：2003-01-01 00:00:00

abstract：:Systemic sclerosis is an extremely variable disease in its manifestations and consequently, treatment needs to be individualized depending on the specific problems that each patient has. Limited scleroderma patients have a prolonged duration of Raynaud's phenomenon and puffy fingers before they develop any skin thicke...

journal_title：American journal of clinical dermatology

authors： Steen VD

更新日期：2001-01-01 00:00:00

abstract：:Pantothenic acid is essential to normal epithelial function. It is a component of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions that are important in the metabolism of carbohydrates, fatty acids, proteins, gluconeogenesis, sterols, steroid hormones, and porphyrins. The topical use ...

journal_title：American journal of clinical dermatology

authors： Ebner F,Heller A,Rippke F,Tausch I

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Botulinum toxin (BTX) is a potent neurotoxin with a long history of therapeutic application in neurological and dermatological conditions, with a strong efficacy and safety profile. OBJECTIVE:Our aim was to assess whether intradermal injection with BTX-B is an effective treatment for hidradenitis suppurativ...

journal_title：American journal of clinical dermatology

authors： Grimstad Ø,Kvammen BØ,Swartling C

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Confluent and reticulate papillomatosis of Gougerot and Carteaud (CRP) is a rare dermatological condition, which has not been reported widely in Asian populations. AIM:To characterize the clinicopathological and diagnostic features of CRP in a South-East Asian population. METHODS:The medical records of 29 ...

journal_title：American journal of clinical dermatology

authors： Huang W,Ong G,Chong WS

更新日期：2015-04-01 00:00:00

abstract：:Topical retapamulin (Altabax, Altargo) is the first pleuromutilin antibacterial approved for the treatment of uncomplicated superficial skin infections caused by Staphylococcus aureus (excluding methicillin-resistant S. aureus [MRSA]) and Streptococcus pyogenes in patients aged > or = 9 months. In the EU, retapamulin ...

journal_title：American journal of clinical dermatology

authors： Yang LP,Keam SJ

更新日期：2008-01-01 00:00:00

abstract：:Eruptive melanocytic nevi (EMN) is a phenomenon characterized by the sudden onset of nevi. Our objective was to compile all published reports of EMN to identify possible precipitating factors and to evaluate the clinical appearance and course. We conducted a systematic bibliographic search and selected 93 articles, re...

journal_title：American journal of clinical dermatology

authors： Burian EA,Jemec GBE

更新日期：2019-10-01 00:00:00