Abstract：
:We have previously shown that indapamide [chloro-4-N-(methyl-2-indolinyl-1)-sulfamoyal-3-benzamide] has a direct action on the heart to alter ion fluxes. This study sought to examine the potential interaction between indapamide and epidermal growth factor (EGF). Cardiomyocytes were prepared as primary culture from 7-day-old chick embryo hearts as aggregates that have a pattern of consistent spontaneous contraction. Indapamide enhanced the positive chronotropic response to EGF observed in chick embryonic ventricular myocyte aggregates while indapamide itself did not alter cardiac contractile frequency. Taken in conjunction with data that calcium channel blockade, inhibition of sodium entry or Na(+)-Ca2+ exchange in the cardiomyocyte opposes the positive chronotropic action of EGF on the cardiomyocyte, this study has identified an agent, indapamide, that accentuates the cardiomyocyte response to EGF.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Rabkin SWdoi
10.1016/s0040-8166(96)80032-2subject
Has Abstractpub_date
1996-08-01 00:00:00pages
469-72issue
4eissn
0040-8166issn
1532-3072pii
S0040-8166(96)80032-2journal_volume
28pub_type
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