[Functional and structural abnormalities in the visual cortex in early childhood strabismus].

Abstract:

BACKGROUND:To investigate the structural basis for functional deficits in infantile strabismus we used a neuroanatomic tracer and a histochemical label to examine the primary visual cortex (area V1) of adult esotropic macaque monkeys. ANIMALS AND METHODS:The animals had developed natural esotropia in the first months of life, alternated fixation, and exhibited the ocular motor signs that typify strabismus with onset in infancy. After behavioral and VEP testing, ocular dominance columns (ODCs) in V1 were injected with a neuronal traser and labeled for cytochrome oxidase activity. RESULTS:The strabismic monkeys showed striking deficits in binocular luminance visually-evoked potentials (VEPs) and characteristic directional asymmetries in motion VEPs. Binocular horizontal connections between ODCs were reduced an average of 50-60% in strabismic as compared to normal monkeys. ODCs also showed unequal metabolic activity with contralaterally (i.e. nasal retina) driven ODCs showing greater activity in each V1. DISCUSSION AND CONCLUSION:The maldevelopment of connections in upper V1 layers correlates with the abnormalities in binocular and motion VEPs. The unequal metabolic activity suggests interocular suppression. These results provide the first neuroanatomic evidence for cerebral cortex maldevelopments in natural infantile esotropia.

journal_name

Klin Monbl Augenheilkd

authors

Tychsen L,Burkhalter A,Boothe RG

doi

10.1055/s-2008-1035162

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

18-22

issue

1

eissn

0023-2165

issn

1439-3999

journal_volume

208

pub_type

杂志文章
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  • [Differential diagnosis of leukokoria in opaque media].

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    doi:

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  • Diabetic Macular Edema in Diabetological Practices.

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    doi:

    authors: Cremer-Bartels G

    更新日期:1977-12-01 00:00:00

  • [Evidence of silicone oil deposits via high resolution ultrasound].

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    doi:10.1055/s-2002-36327

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    更新日期:2002-11-01 00:00:00

  • Advanced Cases of Birdshot HLA-A29 Retinochoroiditis: Prevalence and Characteristics.

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  • [Tear film diagnosis in contact lens wearers].

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    更新日期:1990-09-01 00:00:00

  • Normalisation of ocular pulse amplitude after embolisation of dural cavernous sinus arteriovenous fistula.

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    doi:10.1055/s-2004-812855

    authors: Kaufmann C,Thiel MA,Valavanis A,Landau K

    更新日期:2004-05-01 00:00:00

  • [Refraction after cataract surgery with posterior chamber lenses].

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    doi:10.1055/s-2008-1046055

    authors: Spitznas M,Werdermann D,Ohlhorst D

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  • [Anti-inflammatory treatment in dry eye disease].

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  • [Management of childhood glaucoma associated with Sturge-Weber syndrome].

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  • Inter-Rater Reliability of Cyclotorsion Measurements Using Fundus Photography.

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  • [Syphilis-associated uveitis in Switzerland].

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    更新日期:2011-04-01 00:00:00

  • [Gonioscopic changes following cyclocryocoagulation].

    abstract::Gonioscopic changes after cyclocryocoagulation are reported in 4 patients with angle-closure glaucoma resistant to all forms of therapy. During cryoapplication frozen aqueous humor was observed in the chamber angle near the treated area. Widening of the angle followed in the same place. Possible causes of this change ...

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    更新日期:1985-11-01 00:00:00

  • [Experimental studies of the significance of the renin-angiotensin system in the retina. A review].

    abstract::BACKGROUND Many peptides now identified in the brain were previously thought of as exclusively peripheral hormones. Among those, the renin-angiotensin system (RAS) is not only found to be of great importance in peripheral vasomotor and electrolyte homeostasis but also acts as neurotransmitter or modulator in the centr...

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  • [Atopic keratoconjunctivitis].

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  • [Indications for Retinal Laser Therapy Revisited].

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  • [Histology and therapy of diabetic traction detachment].

    abstract::Diabetic tractional detachment of the retina is caused by shrinking processes of the vitreous, which at most detaches only partially, and by shrinking of epiretinal proliferations. The shrinking of the vitreous results in tractional forces working centripetally and toward the base of the vitreous. The shrinking of the...

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    更新日期:1984-03-01 00:00:00

  • [Adhesive eyelid weights ("reversible lidloading") for treatment of lagophthalmos].

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  • [Hereditary Optic Neuropathies].

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  • [Sturge-Weber syndrome: glaucoma with elevated episcleral venous pressure].

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    更新日期:1987-10-01 00:00:00

  • [Spontaneous healing of a cataract with secondary glaucoma (author's transl)].

    abstract::A 55-year-old man was referred to our clinic with a mature, swollen cataractous lens and a secondary phakolytic glaucoma. However, the patient refused to undergo surgery. Twelve years later he returned. Meanwhile the lens had been almost completely absorbed; visual acuity was 20/32 and there had been no severe damage...

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    更新日期:1982-04-01 00:00:00

  • [Long-term observation of ablatio-prophylaxis with kryopexy (author's transl)].

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    更新日期:1976-06-01 00:00:00

  • [Treatment of retinal detachment with macular hole: scleral buckling with an absorbable fibrin sponge (author's transl)].

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    pub_type: 杂志文章

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    更新日期:1977-08-01 00:00:00

  • [Foreign body granuloma after lower eyelid avulsion and surgical revision with silicone tube splint].

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    更新日期:2000-04-01 00:00:00

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