[Anti-inflammatory treatment in dry eye disease].

Abstract:

:Dry-eye is a multifactorial disease consisting of different pathomechanisms including instability of the tearfilm, increase of tearfilm osmolarity and most importantly inflammation of the ocular surface. In this context numerous signalling pathways and related immune mechanisms were identified all pointing towards autoimmune reactions as key parameters within this complex system. As autoimmunity tends to act independently from regulatory mechanisms, inhibition of related inflammatory processes is crucial in dry-eye therapy. Currently therapeutic agents such as steroids, cyclosporin, antibiotics, omega-3 and -6 fatty acids, etc. are available and readily used in daily practice. However, these therapies possess functional or legal restrictions that may limit their application. New strategies such as anti-lymphangiogenic therapies may have the potential to substitute or enhance current treatments. Independent of any anti-inflammatory therapy a detailed examination of the individual patient is necessary due to the complexity of the disease to provide individual and successful treatment.

journal_name

Klin Monbl Augenheilkd

authors

Steven P,Cursiefen C

doi

10.1055/s-0031-1299519

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

500-5

issue

5

eissn

0023-2165

issn

1439-3999

journal_volume

229

pub_type

杂志文章,评审
  • [Mid- and Longterm Experiences with the Boston-Keratoprosthesis. The Cologne and Salzburg Perspective].

    abstract::Background Eyes with severe corneal opacifications and insufficient prognosis for high-risk corneal transplantation can be considered for the implantation of a Boston-keratoprosthesis. Since 2013, this technique of "artificial" corneal replacement is provided to high-risk eyes at the Department of Ophthalmology, Unive...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0043-110572

    authors: Schaub F,Bachmann BO,Seyeddain O,Moussa S,Reitsamer HA,Cursiefen C

    更新日期:2017-06-01 00:00:00

  • [A sudden inexplicable deterioration of vision caused by bromcarbamide drugs (author's transl)].

    abstract::On two female patients it was shown that intoxication by sedatives containing part bromecarbamide may result in various ocular diseases. The two patients complained of a sudden inexplicable deterioration of vision; semi-dilated slow-responding pupils were diagnosed. Only in one case could a sudden vertical nystagmus b...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Berndt K,Piper HF

    更新日期:1979-01-01 00:00:00

  • [The clinical picture, fluorescence angiography and histologie of a ringmelanoma of the iris (author's transl)].

    abstract::Report on a rare case of an iris-ringmelanoma. Arising from the iris base the primary tumor spread in a continuous line along the anterior chamber angle and a shedding of tumor cells in other places of the iris surface could be stated as well. A unilateral dark spotted colouring of the iris with a secondary glaucoma w...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Demeler U,von Domarus D

    更新日期:1976-03-01 00:00:00

  • [Influence of corneal transparency on the quality of topographies].

    abstract::Corneal topographs that measure the anterior and posterior corneal surface with optical methods need a clear cornea for precise measurements. Opacities cause artifacts in the corneal thickness (with measurements usually being too thin) and corneal curvatures. This is important to know as certain pathologies may repeat...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0032-1327956

    authors: Franko Zeitz P,Kohlhaas M

    更新日期:2012-12-01 00:00:00

  • [Imaging of the Lacrimal Gland and the Lacrimal Drainage System].

    abstract::Die Tränendrüse kann von einer Vielzahl neoplastischer, infektiöser und autoimmunologischer Erkrankungen betroffen sein. Eine radiologische Charakterisierung der Veränderungen kann Hinweise für die differenzialdiagnostische Einordnung liefern. Erkrankungen der ableitenden Tränenwege, insbesondere Tränenwegsverschlüsse...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0033-1358102

    authors: Pieper CC,Thomas D

    更新日期:2015-03-01 00:00:00

  • [Comparative studies of the pressure-lowering effect of timolol and phospholine iodide (author's transl)].

    abstract::A comparative study of the intraocular pressure-lowering effects of timolol and phospholine iodide in cases of aphakic glaucoma was carried out. The authors compared the I.O.P.-lowering effect of these two drugs in 30 eyes (30 patients) with aphakic glaucoma over an eight-month observation period. The following was es...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057292

    authors: Christakis C,Mangouritsas N

    更新日期:1981-09-01 00:00:00

  • [Topographic relation of dislocated lenses to the ciliary body and vitreous base].

    abstract::There are three forms of lens dislocation in the posterior segment: intravitreal, prebasal, and intrabasal. The location of the dislocated lens depends on gravity and the condition of the vitreous body. As a rule the dislocated lens lies at the bottom of the vitreous cavity; it may be completely embedded in the vitreo...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050310

    authors: Slezak H,Arocker-Mettinger E

    更新日期:1988-12-01 00:00:00

  • [Vascular retinal complication after long-time therapy with oral hormonal contraceptives (author's transl)].

    abstract::A case report is given of a vascular disease of right retina of a 37-year-old woman during treatment with contraceptives during 9 years. The retina shows at first a clinical picture of chorioretinitis centralis serosa. After stopping the hormonal preparation and prescription of Dexium (Kalziumdobesilat) the retinal ch...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Huismans H

    更新日期:1976-10-01 00:00:00

  • [Subretinal granuloma with calcinosis in toxocariasis].

    abstract::A 27 year old male patient with a subretinal granuloma was diagnosed as having a serologically established toxocara infection (Immunoprecipitation test in living larva). Calcifications could be demonstrated in X-ray and CT-scan imaging. The significance of calcifications for the differential diagnosis of retinoblastom...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046304

    authors: Schönherr U,Bialasiewicz AA

    更新日期:1990-11-01 00:00:00

  • [Results of combined cataract/glaucoma operations (author's transl)].

    abstract::In general the combined cataract/glaucoma operation is a good procedure for treating cataract and glaucoma simultaneously. The operation was performed in 157 eyes between 1976 and 1980. The mean IOP remained constant after surgery for a follow-up period of over three years on average. The review covered 136 eyes, of w...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1055119

    authors: Robert Y,Gloor B

    更新日期:1982-05-01 00:00:00

  • [Ophthalmic-pharmacological complications (author's transl)].

    abstract::The action of some drugs on the eye may lead to the occurrence of unforeseen ocular and extraocular reactions. Vincaleukoblastin (Velbe) provokes serious corneal lesions with a healing time of two weeks and a half. The local application of Neo-Synephrine eye drops (10%) and Mydrial-Atropine ointment may lead in the ca...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Lisch K

    更新日期:1976-07-01 00:00:00

  • [Actinomycetes granuloma of the upper eyelid].

    abstract::An African 40-year-old woman presented with a superior eyelid tumor. The diagnosis is a granuloma due to Actinomycetae. We briefly describe the pathogenesis, and the ancillary diagnostic methods. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035071

    authors: Tritten JJ,Uffer S

    更新日期:1997-05-01 00:00:00

  • [Management of childhood glaucoma associated with Sturge-Weber syndrome].

    abstract:PURPOSE:Sturge-Weber syndrome is a rare congenital disorder consisting of cutaneous, leptomeningeal and ocular vascular malformations. Glaucoma occurs in 30-70 % of patients. Treatment is challenging due to a high risk of severe complications such as expulsive haemorrhage, massive choroidal effusion and serous retinal ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1315217

    authors: Greslechner R,Helbig H,Oberacher-Velten IM

    更新日期:2012-10-01 00:00:00

  • [Treatment of retinal detachment with macular hole: scleral buckling with an absorbable fibrin sponge (author's transl)].

    abstract::In 21 patients with macular hole and retinal detachment a macular buckling procedure was performed including diathermic or cryogenic coagulation. An absorbable fibrin sponge (Fibrospum) was used as a new buckling material, which needs not to be sutured to the sclera at the posterior pole. In comparison to other proced...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Wollensak J,Engels T

    更新日期:1977-08-01 00:00:00

  • [Enhancements after Refractive Corneal Surgery].

    abstract::This review article focusses on the management of enhancements after corneal refractive laser surgery. Fundamental issues regarding enhancement embrace identification of the underlying reason for postoperative ametropia, assurance of stability of refraction, type of primary refractive laser treatment and thorough eval...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/a-1148-2744

    authors: Kook D,Mayer WJ,Shajari M,Steinwender G,Kohnen T

    更新日期:2020-07-01 00:00:00

  • [Therapy of herpetic diseases of the anterior eye segment].

    abstract::Clinico-virologic investigations and the availability of the new antiviral drug Acyclovir have changed our therapeutic approach to deep herpetic diseases. Treatment of the symptoms alone with steroids should now be avoided. Basic treatment should consist of optimal dosages of Acyclovir. However, additional steroid the...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050949

    authors: Sundmacher R

    更新日期:1985-06-01 00:00:00

  • [Dynamic Contour Tonometry and Goldmann Applanation Tonometry: Difference of Intraocular Pressure Values Between Eyes with and without Glaucomatous Damage in Thin Corneas].

    abstract:BACKGROUND:To examine the differences in intraocular pressure (IOP) measurements obtained with Goldmann applanation tonometry (GAT) and Pascal dynamic contour tonometry (DCT) in subjects with thin corneas and to correlate these with structural and functional parameters of glaucoma damage. PATIENTS AND METHODS:One hund...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0041-104772

    authors: Umurhan Akkan JC,Akkan F,Sezgin Akcay BI,Ayintap E,Tuncer K

    更新日期:2015-10-01 00:00:00

  • [Optic neuritis].

    abstract::Optic neuritis is a frequent neuro-ophthalmological disease in which the diagnosis can be based on just a few symptoms and findings. It is not only important to differentiate from other optic nerve disorders but also to recognise special types of optic neuritis, which is mostly only possible during the course of the d...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1382930

    authors: Wilhelm H,Heine C,Tonagel F

    更新日期:2014-11-01 00:00:00

  • [Photocoagulation of age-related juxtapapillary choroidal neovascularisation].

    abstract:BACKGROUND:The aim of this study was to evaluate retrospectively the clinical outcome of retinal photocoagulation of age-related juxtapapillary choroidal neovascularisation (CNV) with macular oedema. Juxtapapillary CNV represents a rare form of extrafoveal CNV in age-related macular degeneration (AMD). PATIENTS AND ME...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0031-1273430

    authors: Butros S,Cucera A,Lang GE

    更新日期:2011-11-01 00:00:00

  • [On the clinical picture and therapy of arachnitis optico-chiasmatica (author's transl)].

    abstract::From 20 cases of arachnitis optico-chiasmatica (a. o.) the symptoms of this relatively rare but pathologico-anatomically proved disuse of the brain base involving the optic nerves are described. In this description newer methods of investigation are mentioned which allow a differentiation of the clinical picture of o....

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Fuchs J

    更新日期:1977-12-01 00:00:00

  • [Laser treatment of diabetic maculopathy].

    abstract::The authors report on the techniques of laser treatment of diabetic maculopathy: focal direct laser coagulation of I.R.M.A. in exudative maculopathy; laser grid photocoagulation in edematous maculopathy. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050820

    authors: Giovannini A,Costantini G,Amato GP,Bottazzi M

    更新日期:1986-11-01 00:00:00

  • [Clinical use of a simplified suction-irrigation system for extracapsular cataract extraction].

    abstract::This paper discusses the clinical application of a simplified irrigation-aspiration system for extracapsular cataract extraction. This simplified apparatus represents a reasonably-priced alternative to the existing expensive and complicated systems. When the surgeon has gained sufficient practice in the use of this me...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Trinkmann R,Jungmann P

    更新日期:1984-12-01 00:00:00

  • [Long-term results of congenital glaucoma microsurgery--retrospective study].

    abstract::Medium and long term results of trabeculotomy and goniotomy operations for primary congenital glaucomas treated in Lausanne between 1965 and 1990 were studied retrospectively. Parameters evaluated were intraocular pressure (IOP) and final visual acuity (VA). Data on IOP were available for 38 eyes. 66% underwent trabec...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045775

    authors: de Ancos E,Faggioni R,de Courten C

    更新日期:1992-05-01 00:00:00

  • [Preferred techniques of eyelid reconstruction].

    abstract::The trend of lid reconstruction is to use less lid sharing operations. Free tarsoconjunctival or composite grafts in conjunction with covering skin muscle transplants have allowed suitable and cosmetically acceptable methods of full lid repairs. Our preferred surgical techniques are provided. Such methods of reconstru...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1045933

    authors: Beyer-Machule CK

    更新日期:1991-02-01 00:00:00

  • [Secondary glaucoma mechanisms (author's transl)].

    abstract::A new classification of the glaucomas concerned with the mechanisms of the intraocular pressure rise is presented. We differentiate hyperproduction and outflowblock glaucomas. The latter are divided into pre-, intra- and postrabecular forms. It is stressed that a gonioscopically open angle can be hydrodynamically clos...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Teichmann KD,Teichmann I

    更新日期:1979-09-01 00:00:00

  • [Computer-assisted multimedia interactive learning program "Primary Open-Angle Glaucoma"].

    abstract:INTRODUCTION:Advances in the area of information technology have opened up new possibilities for the use of interactive media in the training of medical students. Classical instructional technologies, such as video, slides, audio cassettes and computer programs with a textbook orientation, have been merged into one mul...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Dick VB,Zenz H,Eisenmann D,Tekaat CJ,Wagner R,Jacobi KW

    更新日期:1996-05-01 00:00:00

  • [Long-term therapy with timolol for three years (author's transl)].

    abstract::From an original group of 36 Patients (15 with relatively advanced chronic open-angle glaucoma and 21 with ocular hypertension) 21 (seven glucoma and 14 ocular hypertension) were well controlled with Timolol alone or in combination with other pressure-lowering drugs after a three years' observation period. Dropouts oc...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057259

    authors: Urner-Bloch U,Bischoff P

    更新日期:1981-07-01 00:00:00

  • [Nosocomial pseudomonas aeruginosa-associated keratitis in soft contact lens wearer].

    abstract:BACKGROUND:Pseudomonas aeruginosa is the most common cause of bacterial-associated keratitis in soft contact lens wearers, due to wrong use of soft contact lenses. Problems are often severe corneal ulcers and even corneal perforations. We report on a soft contact lens wearer with credibly correct use of soft contact le...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2003-812639

    authors: Grünauer-Kloevekorn C,Wilhelm F,Duncker GI,Hammer T

    更新日期:2004-01-01 00:00:00

  • [Alternate day squint (author's transl)].

    abstract::3 cases of cyclical convergent strabismus (48 hour rhythm) were investigated. In contrast to intermittant strabismus, cyclical strabismus is not fatigue dependant. An alteration in the rhythm of the cyclical esotropia was produced by wearing prisms, red glasses or occlusion for several days. This observation indicates...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Schmidt D,Mattheus S

    更新日期:1975-12-01 00:00:00

  • [Changes in corneal topography after using tear substitutes].

    abstract:BACKGROUND:Computer-controlled video keratoscopy is being employed ever more frequently and for various indications. PATIENTS:We have studied the effects of high-viscosity and low-viscosity tear substitutes on the corneal topography, one and five minutes after application to 14 normal eyes of 7 subjects, and compared ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035260

    authors: Emde CW,Brewitt H,Winter R

    更新日期:1996-06-01 00:00:00