[Anti-inflammatory treatment in dry eye disease].

Abstract:

:Dry-eye is a multifactorial disease consisting of different pathomechanisms including instability of the tearfilm, increase of tearfilm osmolarity and most importantly inflammation of the ocular surface. In this context numerous signalling pathways and related immune mechanisms were identified all pointing towards autoimmune reactions as key parameters within this complex system. As autoimmunity tends to act independently from regulatory mechanisms, inhibition of related inflammatory processes is crucial in dry-eye therapy. Currently therapeutic agents such as steroids, cyclosporin, antibiotics, omega-3 and -6 fatty acids, etc. are available and readily used in daily practice. However, these therapies possess functional or legal restrictions that may limit their application. New strategies such as anti-lymphangiogenic therapies may have the potential to substitute or enhance current treatments. Independent of any anti-inflammatory therapy a detailed examination of the individual patient is necessary due to the complexity of the disease to provide individual and successful treatment.

journal_name

Klin Monbl Augenheilkd

authors

Steven P,Cursiefen C

doi

10.1055/s-0031-1299519

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

500-5

issue

5

eissn

0023-2165

issn

1439-3999

journal_volume

229

pub_type

杂志文章,评审
  • ["Physical eyes" for evaluating various intraocular lenses for monocular and binocular use].

    abstract::We developed a "physical eye system" to evaluate visual impression after physical implantation of monofocal and multifocal intraocular lenses (IOLs). The system is constructed as two identical astronomical telescopes. The objectives imitate the cornea and behind this cornea the IOL is inserted. The image quality repre...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045702

    authors: Jacobi KW,Reiner J

    更新日期:1993-12-01 00:00:00

  • [A new orthoptic training device (author's transl)].

    abstract::Diagnosis and treatment of disturbances of binocular vision are made possible by a new orthoptic training device, which is a combination of Bagolini glasses, double prisms and a fixation target which can be shifted sagitally. It combines fusion, accommodation and convergence. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057445

    authors: Reitz M

    更新日期:1980-02-01 00:00:00

  • [Long-term radiation damage to the skin and eye after combined beta- and gamma- radiation exposure during the reactor accident in Chernobyl].

    abstract:BACKGROUND:In April 1986, numerous reactor workers and firemen were exposed to high doses of ionizing radiation during the Chernobyl nuclear power plant accident. Apart from high ambient gamma-ray exposures they received inhomogeneous contamination with beta-rays from fission products, resulting in severe skin exposure...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034732

    authors: Junk AK,Egner P,Gottloeber P,Peter RU,Stefani FH,Kellerer AM

    更新日期:1999-12-01 00:00:00

  • [Occurrence of diffusions shown by fluorescence angiography of the laser coagulation in animals (author's transl)].

    abstract::Laser treated rat fundi were observed angiographically and with the fluorescence microscope for 3 months. Angiographically diffusions have been observable up to about one week post laser, fluorescence microscopically, however, for the whole observation time of 3 months. From the 2nd week, these diffusions were produce...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Baurmann H,Chioralia G,Schomacher L,Sasaki K

    更新日期:1976-04-01 00:00:00

  • [Fusion amplitude and aniseikonia. Experimental studies of aniseikonia tolerance in unilateral aphakia].

    abstract::The fusion amplitude of image pairs with aniseikonia was measured using the synoptophore. Aniseikonia was produced in five subjects by alteration of slide drawings. The subject's right eye was in cycloplegia after paralysis with cycloplegic eye drops. To compare these measurements with aniseikonic pictures to those us...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050555

    authors: Pittke EC

    更新日期:1987-12-01 00:00:00

  • Multifocal electroretinogram (mfERG) in a family with occult macular dystrophy (OMD).

    abstract:BACKGROUND:Localized macular dysfunction, in Stargardt macular dystrophy for example, is frequently not detected by Ganzfeld electroretinography (ERG) but it may be detected by methods such as focal macular electroretinogram and pattern electroretinogram at the posterior pole of the eye or indirectly by recording of th...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2003-38161

    authors: Wildberger H,Niemeyer G,Junghardt A

    更新日期:2003-03-01 00:00:00

  • [Convergence insufficiency and school difficulties (author's transl)].

    abstract::124 lowgrade hypermetropic pupils aged from 6 to 9 years, with normal I.Q. showed exophoria for near vision combined with weakness of convergence and school difficulties in several disciplines. These were treated as follows: training of the physiological diplopy, training of convergence, and surgical treatment by unil...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Kurz M,Bauer G,de Graaf ME

    更新日期:1975-11-01 00:00:00

  • [Trabeculotomy and cataract-extraction: simultaneously or step by step? (author's transl)].

    abstract::In 64 eyes the combined procedure (group I) and in 67 aphacic eyes a trabeculotomy (group II) was performed. There were different types of glaucoma. Re-examinations wer done 6 months and 1--10 years postoperatively. No definite differences of operative or postoperative complications existed between the two groups. In ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Dannheim R,Hetzinger A

    更新日期:1978-10-01 00:00:00

  • [Cure of scleromalacia perforans manifesting in the course of rheumatoid arthritis with d-penicillamine and fascia lata-autograft (author's transl)].

    abstract::A new treatment of a case of scleromalacia perforans, complicating rheumatoid arthritis is reported. To save the eye fascia lata was transplanted, preoperatively prednisolone and d-penicillamine was started, and this therapy was continued for one year thereafter. The effect was favorable, as pains vanished, and the gr...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Balla L,Sziklai P,Oláh M,Kiss G

    更新日期:1975-09-01 00:00:00

  • [An approach to diabetic retinopathy].

    abstract::Presentation of ophthalmological taking in charge program of the diabetic patients, program elaborated during a symposium in London under the supervision of the World's Health Organisation and the International Federation of Diabetes. A calendar of the necessary controls is worked out. A scheme of the proposed treatme...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045832

    authors: Ducrey N

    更新日期:1992-05-01 00:00:00

  • [Ultrastructure of the hyaloid canal and its retraction during gestation (author's transl)].

    abstract::1. The cells of the hyaloid canal originate from the primitive meningeal cells; 2. The lumen of the hyaloid canal can be observed through the optic nerve up to the subarachnoid space around the optic nerve; 3. Injections of tracer substances into the subarachnoid space of the optic nerve have shown that a communicatio...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1055078

    authors: van der Zypen E,Fankhauser F

    更新日期:1982-05-01 00:00:00

  • ["Blow-out" orbital trauma and diplopia. Conservative or surgical approach?].

    abstract::The treatment of orbital fractures, type blow-out, has always been discussed about. One hundred-twenty patients, subdivided in four groups were examined. Incarceration of the peri-muscular structures or not. Surgical or conservative treatment. These four groups have been studied with the purpose of establishing a trea...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045799

    authors: Magnocavallo M,Klainguti G

    更新日期:1992-05-01 00:00:00

  • [Results of Cüpper's "thread fixation" in squinters with inconstant angle (author's transl)].

    abstract::The results of strabismus operations on strabismus patients with variable angles are presented. The so-called "Fadenfixation" (Cüppers) is compared with the usual recess-resect method. Of the 62 cases of strabismus with variable angle which were operated without the "Fixation", only 3 cases were parallel post-operatio...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Behrens-Baumann W,Wölz U

    更新日期:1978-12-01 00:00:00

  • [Comparison between ray-tracing and IOL calculation formulae of the 3rd generation].

    abstract:PURPOSE:The aim of this study was to compare the different calculation methods in large patient collectives, including eyes with extreme axial lengths. METHOD AND MATERIAL:The prediction errors of the Haigis, SRK/T, Hoffer-Q and Holladay formulae and of the OKULIX ray-tracing are compared in 2888 normal eyes implanted...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1027966

    authors: Preussner PR,Hoffmann P,Petermeier K

    更新日期:2009-02-01 00:00:00

  • [Retinal detachment in children and adolescents].

    abstract::During a 4-year period 22 eyes with rhegmatogenous retinal detachment in children and young adults up to 20 years of age were operated on. This group comprised 6.3 percent of all rhegmatogenous retinal detachments operated on during the same period. In 9 eyes (40.9%) the detachment was due to a direct ocular trauma. I...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054561

    authors: Laatikainen L,Tarkkanen A,Harju H

    更新日期:1984-07-01 00:00:00

  • [Diagnostic Strategy and Therapeutic Dilemma in Acute Posterior and Panuveitis].

    abstract::Acute posterior and panuveitis mostly affect younger patients and affect both eyes in more than half of cases. Because of the severe consequences in the clinical course, rapid and broad differential diagnosis are critical steps. Permanent loss of vision after a delay in starting therapy and the initiation of ineffecti...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-0828-7395

    authors: Garweg JG,Messerli J

    更新日期:2019-04-01 00:00:00

  • [Bilateral dendritic pseudokeratitis (Richner-Hanhart syndrome)].

    abstract::A Turkish baby was treated several times for bilateral "recurrent dendritic keratitis" before a diagnosis of Richner-Hanhart syndrome could be made (recessively inherited keratosis palmaris et plantaris with pathognomonic corneal dystrophy). No effective conservative treatment has been reported in the literature for t...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Sundmacher R

    更新日期:1977-01-01 00:00:00

  • [Exogenous keratitis due to chromomycosis (author's transl)].

    abstract::The author presents a case of exogenous, retrocorneal, limbal infiltration due to chromomycosis, following cataractextraction. Since the etiology of this keratitis was not recognized at the beginning, steroids were applied causing an exacerbation of the keratitis with hypopyoniritis. A perforating, excentric keratopla...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Hamann KU

    更新日期:1977-01-01 00:00:00

  • [Quiz on an unusual orbital masquerade syndrome].

    abstract:BACKGROUND:After consulting the here presented CT-images of the orbit, the question was raised whether the ocular bulbus was really enucleated or the anamnesis was wrong and a lymphoma existed in the orbit. We will therefore discuss a case of a special follow-up after an enucleation with implantation of a "Bangerter Pl...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035393

    authors: Gloor B,Schuknecht B,Valavanis A

    更新日期:1995-12-01 00:00:00

  • [Inflammatory glaucomas].

    abstract::The prevalence of glaucoma in patients with intra- or extraocular inflammation is five to twenty percent. The etiopathogenesis is manifold, including classical secondary open and closed angle mechanisms as well as specific inflammatory elements. Diagnosis and follow-up studies of inflammatory glaucomas are often diffi...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-858310

    authors: Grüb M,Deuter CM,Zierhut M

    更新日期:2005-10-01 00:00:00

  • [Functional and Anatomic Outcomes of Primary and Secondary Internal Limiting Membrane Transplantation in Large and Persistent Macular Holes].

    abstract:BACKGROUND:The gold standard therapy for full-thickness macular holes (FTMH) is vitrectomy (PPV) with peeling of the internal limiting membrane (ILM), gas tamponade of the vitreous cavity and postoperative face-down positioning. Nevertheless, eyes with large macular holes (> 400 µm) and surgical failures remain difficu...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0043-121032

    authors: Hess JA,Michels S,Becker MD

    更新日期:2018-10-01 00:00:00

  • [Ophthalmologic and roentgenologic findings in a rare case of mucopolysaccharidosis 4 B].

    abstract::A rare case of mucopolysaccharidosis, i.e., Morquio's disease with spondyloepiphyseal dysplasia, corneal clouding, normal intelligence, and deficiency of beta-galactosidase activity is described. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054350

    authors: Faschinger C,Schmidberger H

    更新日期:1985-11-01 00:00:00

  • [Timolol: long-term results, tolerance test and early-morning measurements (author's transl)].

    abstract::In a study lasting 16 months, Timolol was tested on 57 eyes of a group of selected patients with open-angle glaucoma. Patients whose IOP could not be stabilized with the 0.25% solution were treated with 0.5% drops twice a day. In five separate cases, where regulation was inadequate, pilocarpine 2% twice a day was pres...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:

    authors: Strempel I

    更新日期:1979-11-01 00:00:00

  • [Drug side-effects of the eye--a contribution to quality assurance in ophthalmology].

    abstract:BACKGROUND:The aim of this research is to catalogue the increasing number of side effects of medications on the eyes and, by putting this catalogue into a data bank, to make it available for use in hospitals. Here a deliberate search is made for medications, which could possibly cause certain side effects as well as a ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1035248

    authors: Dangelmaier S,Weindler J,Ruprecht KW

    更新日期:1996-05-01 00:00:00

  • Intravitreal triamcinolone injection for unresponsive cystoid macular oedema in probable Behçet's disease as an additional therapy.

    abstract:BACKGROUND:We present the description of a successful outcome of intravitreal triamcinolone injection (IVTA) in a patient with cystoid macular oedema (CME) and severe retinal vasculitis suggestive of ocular Behçet's disease. HISTORY AND SIGNS:A healthy 32 year-old Caucasian man presented initially with right retinal v...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1027351

    authors: Oueghlani E,Pavésio CE

    更新日期:2008-05-01 00:00:00

  • [Simulation of anterior ischemic optic neuropathy by optic nerve sheath meningioma].

    abstract:BACKGROUND:The optic nerve sheath meningioma usually presents with a diffuse atrophy of the disc and a diffuse depression of the visual field. Applying this rule too rigidly can lead to a false diagnosis. PATIENT:A 45y-old-woman presented with atrophy of the upper disc and a corresponding altitudinal field defect in h...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035368

    authors: Guhlmann M,Kommerell G

    更新日期:1995-09-01 00:00:00

  • [Treatment with azathioprine of peripheral chronic cyclitis with cystoid edema of the macula (author's transl)].

    abstract::Nine patients with peripheral chronic cyclitis and cystic edema of the macula were treated with azathioprine and small doses of corticosteroids. The results were quite good. In fact the inflammatory signs subsided nearly completely, while the cystic edema was still present in 2 cases. Besides excellent compatibility, ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:

    authors: Charamis I,Skouras I

    更新日期:1977-03-01 00:00:00

  • [Use of a new optoelectronic vision aid for highly visually handicapped patients].

    abstract:UNLABELLED:A new low vision aid (LVA)-the Low Vision Enhancement System or LVES, which were as developed at the Johns Hopkins University in Baltimore, is now commercially available. This instrument allows a magnification up to 10 times with control of contrast and luminance while the field of view is very large: 60 x 4...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035025

    authors: Rohrschneider K,Bruder I,Aust R,Blankenagel A

    更新日期:1997-02-01 00:00:00

  • [Long-term follow-up after surgery for exodeviation].

    abstract:BACKGROUND:In strabismus surgery the challenge is the preoperative determination of the surgical dosage. We assessed the long-term follow-up after strabismus surgery for exodeviations and evaluated the employed dosage. PATIENTS AND METHODS:We present a study of 53 consecutive patients who underwent surgery for exodevi...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-0028-1109265

    authors: Kordic H,Sturm V,Landau K

    更新日期:2009-04-01 00:00:00

  • [Results of long-term treatment of glaucoma with timolol ophthalmic solution (author's transl)].

    abstract::A previous double-blind study carried out for 17 weeks on 50 patients with open-angle glaucoma reported on the results of treatment with Timolol and Pilocarpine eye drops. On completion of a long-term study with Timolol over a two-year period, the remaining findings can now be given. Of the 25 patients treated twice a...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章

    doi:

    authors: Merté HJ,Merkle W

    更新日期:1980-11-01 00:00:00