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Immunogenicity of oral poliovirus vaccine administered in mass campaigns versus routine immunization programmes.

Abstract：

:Reported are the results of a study to investigate the immunogenicity of oral poliovirus vaccine (OPV) when administered in mass campaigns compared with that following routine immunization programmes. For this purpose, paired sera were collected from a cohort of children before and after a mass vaccination with OPV in Morocco in 1987. Serum samples and information on vaccination status and other confounding factors that could influence antibody responses to OPV were collected. Neutralizing antibody titres to poliovirus types 1, 2 and 3 were determined using a standardized assay. OPV doses administered exclusively during the mass campaign were consistently associated with higher type-specific seroprevalence rates than the same number of doses administered in the routine programme. These findings could not be attributed to differences in confounding factors. Enhanced secondary spread of vaccine virus may have occurred but could not be demonstrated because of limitations in the study design. Mass campaigns appear to be highly effective in raising the dose-related poliovirus type-specific immunity of the population above that achieved by the routine immunization programme. Our findings support the continued use of mass campaigns as an adjunct to routine programmes in order to both enhance and catalyse current efforts to achieve the global eradication of poliomyelitis by the year 2000. :Reported are the results of a study to investigate the immunogenicity of oral poliovirus vaccine (OPV) when administered in mass campaigns compared with that following routine immunization programs. For this purpose, paired sera were collected from a cohort of children before and after a mass vaccination with OPV in Morocco in 1987. Serum samples and information on vaccination status and other confounding factors that could influence antibody responses to OPV were collected. Neutralizing antibody titers to poliovirus types 1, 2, and 3 were determined using a standardized assay. OPV doses administered exclusively during the mass campaign were consistently associated with higher type-specific seroprevalence rates than the same number of doses administered in the routine program. These findings could not be attributed to differences in confounding factors. Enhanced secondary spread of vaccine virus may have occurred but could not be demonstrated because of limitations in the study design. Mass campaigns appear to be highly effective in raising the dose-related poliovirus type-specific immunity of the population above that achieved by the routine immunization program. These findings support the continued use of mass campaigns as an adjunct to routine programs in order to both enhance and catalyze current efforts to achieve the global eradication of poliomyelitis by the year 2000. (author's)

journal_name

Bull World Health Organ

journal_title

Bulletin of the World Health Organization

authors

Richardson G,Linkins RW,Eames MA,Wood DJ,Campbell PJ,Ankers E,Deniel M,Kabbaj A,Magrath DI,Minor PD

keywords:

["Africa","Age Factors","Arab Countries","Child","Delivery Of Health Care","Demographic Factors","Developing Countries","Diseases","French Speaking Africa","Health","Health Services","Immunization","Mediterranean Countries","Morocco","Northern Africa","Organization And Administration","Poliomyelitis--prevention and control","Population","Population Characteristics","Primary Health Care","Program Design","Programs","Research Methodology","Sampling Studies","Studies","Surveys","Target Population","Vaccination","Vaccines","Viral Diseases","Youth"]

subject

Has Abstract,Author List Incomplete

pub_date

1995-01-01 00:00:00

pages

769-77

issue

eissn

0042-9686

issn

1564-0604

journal_volume

pub_type

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Immunogenicity of oral poliovirus vaccine administered in mass campaigns versus routine immunization programmes.