Abstract:
:Toxaphene is a pesticide whose use was banned in North America because of concerns regarding its toxicity. To obtain better data on the metabolism and toxicity of toxaphene in primates, a one year feeding study was carried out in cynomologous monkeys at a dose of 1 mg/kg/day for one year. Levels of toxaphene residues in blood and adipose tissue during the dosing period were measured by GC-ECD and ECNI GCMS. The dosing toxaphene mixture was found to be extensively metabolized. Four chlorinated bornane congeners were the predominate residues found in the tissue samples. Blood levels of toxaphene residues plateaued at 40 ppb, adipose levels at approximately 4000 ppb. Kidney, liver, feces and urine were analyzed for toxaphene residues after necropsy.
journal_name
Chemospherejournal_title
Chemosphereauthors
Andrews P,Headrick K,Pilon JC,Bryce F,Iverson Fdoi
10.1016/0045-6535(96)00024-0subject
Has Abstractpub_date
1996-03-01 00:00:00pages
1043-53issue
6eissn
0045-6535issn
1879-1298pii
0045-6535(96)00024-0journal_volume
32pub_type
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