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Gene-environment interaction: definitions and study designs.

Abstract：

:Study of gene-environment interaction is important for improving accuracy and precision in the assessment of both genetic and environmental influences. This overview presents a simple definition of gene-environment interaction and suggests study designs for detecting it. Gene-environment interaction is defined as "a different effect of an environmental exposure on disease risk in persons with different genotypes," or, alternatively, "a different effect of a genotype on disease risk in persons with different environmental exposures." Under this strictly statistical definition, the presence or absence of interaction depends upon the scale of measurement (additive or multiplicative). The decision of which scale is appropriate will be governed by many factors, including the main objective of an investigation (discovery of etiology, public health prediction, etc.) and the hypothesized pathophysiologic model. Five biologically plausible models are described for the relations between genotypes and environmental exposures, in terms of their effects on disease risk. Each of these models leads to a different set of predictions about disease risk in individuals classified by presence or absence of a high-risk genotype and environmental exposure. Classification according to the exposure is relatively easy, using conventional epidemiologic methods. Classification according to the high-risk genotype is more difficult, but several alternative strategies are suggested.

journal_name

Prev Med

journal_title

Preventive medicine

authors

Ottman R

doi

10.1006/pmed.1996.0117

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

764-70

issue

6

eissn

0091-7435

issn

1096-0260

pii

S0091743596901176

journal_volume

25

pub_type

杂志文章

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