Cholinergic activation of startle motoneurons by a pair of cerebral interneurons in the pteropod mollusk Clione limacina.

Abstract:

:The holoplanktonic pteropod mollusk Clione limacina exhibits an active escape behavior that is characterized by fast swimming away from the source of potentially harmful stimuli. The initial phase of escape behavior is a startle response that is controlled by pedal motoneurons whose activity is independent of the normal swim pattern generator. In this study, a pair of cerebral interneurons is described that produces strong activation of the d-phase startle motoneurons, which control dorsal flexion of the wings. These interneurons were designated cerebral startle (Cr-St) interneurons. Each Cr-St neuron has a small cell body on the dorsal surface of the cerebral ganglia and one large axon that runs into the ipsilateral cerebral-pedal connective and the neuropile of the ipsilateral pedal ganglion. Each spike in a Cr-St neuron produces a fast, high-amplitude (up to 50 mV) excitatory postsynaptic potential (EPSP) in the d-phase startle motoneurons. This 1:1 ratio of spikes to EPSPs and the stable short synaptic latencies (2 ms) persist in high-Mg2+, high-Ca2+ seawater, suggesting monosynaptic connections. Synaptic transmission between Cr-St neurons and startle motoneurons exhibits a very slow synaptic depression, because a number of spikes in Cr-St neurons is required to achieve a noticeable decrease in EPSP amplitude. Synaptic transmission between Cr-St interneurons and startle motoneurons appears to be cholinergic. In startle neurons, 20 microM atropine and 50 microM d-tubocurarine reversibly block EPSPs produced by spike activity in Cr-St interneurons. Hexamethonium only partially blocks EPSPs in startle neurons, and much higher concentrations are required. Exogenous acetylcholine (1 microM) produces a dramatic depolarization of startle motoneurons in high-Mg2+ seawater, and this depolarization is reversibly blocked by atropine. Nicotine also has a depolarizing effect on startle motoneurons, although higher concentrations are required. Cr-St interneurons and startle motoneurons are also electrically coupled; however, the coupling is weak. Stimuli that are known to initiate escape responses in intact animals, such as tactile stimulation of the tail or wings, produce excitatory inputs to Cr-St interneurons. In addition, tactile stimulation of the lips and buccal cones, which is known to trigger prey capture reactions in Clione, also produces excitatory inputs to Cr-St interneurons and startle motoneurons, suggesting involvement of the startle neuronal system in prey capture behavior of Clione.

journal_name

J Neurophysiol

authors

Norekian TP,Satterlie RA

doi

10.1152/jn.1997.77.1.281

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

281-8

issue

1

eissn

0022-3077

issn

1522-1598

journal_volume

77

pub_type

杂志文章
  • Reflex response to imposed bilateral hip oscillations in human spinal cord injury.

    abstract::In human spinal cord injury (SCI), imposed unilateral hip movements trigger multijoint, coordinated reflexes that might incorporate interneuronal circuitry involved in normal motor control, such as neural pathways associated with the reflex control of locomotion. To further investigate the complexity of these hip-trig...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00461.2007

    authors: Onushko T,Schmit BD

    更新日期:2007-10-01 00:00:00

  • Organization of reaching and grasping movements in the primate cerebellar nuclei as revealed by focal muscimol inactivations.

    abstract::Two monkeys were trained to point to targets and to retrieve fruit bits from a Kluver board, bottles, and tubes. Once proficient in the tasks, the macaques underwent aseptic surgical implantation of a recording chamber over the cerebellar nuclei on the side of their preferred hand. After recovery from surgery, a serie...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.2.537

    authors: Mason CR,Miller LE,Baker JF,Houk JC

    更新日期:1998-02-01 00:00:00

  • Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxide.

    abstract::The structural elements of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) signaling pathway have been described in the vestibular peripheral system. However, the functions of NO in the vestibular endorgans are still not clear. We evaluated the action of NO on the Ca(2+) currents in hair cells isolated from ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00849.2006

    authors: Almanza A,Navarrete F,Vega R,Soto E

    更新日期:2007-02-01 00:00:00

  • Visuomotor adaptation does not recalibrate kinesthetic sense of felt hand path.

    abstract::Motor control relies on multiple sources of information. To estimate the position and motion of the hand, the brain uses both vision and body-position (proprioception and kinesthesia) senses from sensors in the muscles, tendons, joints, and skin. Although performance is better when more than one sensory modality is pr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1152/jn.90544.2008

    authors: Wong T,Henriques DY

    更新日期:2009-02-01 00:00:00

  • Postural muscle tone in the body axis of healthy humans.

    abstract::Across the entire human body, postural tone might play its most critical role in the body's axis because the axis joins the four limbs and head into a single functioning unit during complex motor tasks as well as in static postures. Although postural tone is commonly viewed as low-level, tonic motor activity, we hypot...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00406.2006

    authors: Gurfinkel V,Cacciatore TW,Cordo P,Horak F,Nutt J,Skoss R

    更新日期:2006-11-01 00:00:00

  • P2 receptor-mediated signaling in spherical bushy cells of the mammalian cochlear nucleus.

    abstract::Purinoreceptors of the P2 family contribute strongly to signaling in the cochlea, but little is known about the effects of purinergic neurotransmission in the central auditory system. Here we examine P2 receptor-mediated signaling in the large spherical bushy cells (SBCs) of Mongolian gerbils around the onset of acous...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00186.2009

    authors: Milenkovic I,Rinke I,Witte M,Dietz B,Rübsamen R

    更新日期:2009-09-01 00:00:00

  • Using spatiotemporal correlations to learn topographic maps for invariant object recognition.

    abstract::The retinal image of visual objects can vary drastically with changes of viewing angle. Nevertheless, our visual system is capable of recognizing objects fairly invariant of viewing angle. Under natural viewing conditions, different views of the same object tend to occur in temporal proximity, thereby generating tempo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90651.2008

    authors: Michler F,Eckhorn R,Wachtler T

    更新日期:2009-08-01 00:00:00

  • Odor specificity of habituation in the rat anterior piriform cortex.

    abstract::Exposure to odorants results in a rapid (<10 s) reduction in odor-evoked activity in the rat piriform cortex despite relatively maintained afferent input from olfactory bulb mitral cells. To further understand this form of cortical plasticity, a detailed analysis of its odor specificity was performed. Habituation of o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.83.1.139

    authors: Wilson DA

    更新日期:2000-01-01 00:00:00

  • Pattern of convergence of the receptors of the barnacle's three ocelli onto second-order cells.

    abstract::The giant barnacle, Balanus nubilus, has three simple eyes, two lateral and one median. We have studied the convergence of the receptors of these ocelli by recording from the second-order cell (I-cell) and from the receptors' terminals. The I-cell's responses to illumination of the median and lateral eyes are similar ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1986.55.5.882

    authors: Oland LA,Stuart AE

    更新日期:1986-05-01 00:00:00

  • Confidence estimation as a stochastic process in a neurodynamical system of decision making.

    abstract::Evaluation of confidence about one's knowledge is key to the brain's ability to monitor cognition. To investigate the neural mechanism of confidence assessment, we examined a biologically realistic spiking network model and found that it reproduced salient behavioral observations and single-neuron activity data from a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00793.2014

    authors: Wei Z,Wang XJ

    更新日期:2015-07-01 00:00:00

  • Mechanisms involved in persistent facilitation of neuromuscular synapses in aplysia.

    abstract::Synaptic plasticity can last from a fraction of a second to weeks depending on how it was induced. The mechanisms that underlie short-, intermediate-, and long-term plasticity have been intensively studied at central synapses of both vertebrates and invertebrates; however, peripheral plasticity has not received as muc...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00142.2001

    authors: Fox LE,Lloyd PE

    更新日期:2002-04-01 00:00:00

  • Explaining autism spectrum disorders: central coherence vs. predictive coding theories.

    abstract::In this article, we review a recent paper by Stevenson et al. (J Neurosci 34: 691-697, 2014). This paper illustrates the need to present different forms of stimuli in order to characterize the perceptual abilities of people with autism spectrum disorder (ASD). Furthermore, we will discuss their behavioral results and ...

    journal_title:Journal of neurophysiology

    pub_type: 评论,杂志文章

    doi:10.1152/jn.00242.2014

    authors: Chan JS,Naumer MJ

    更新日期:2014-12-01 00:00:00

  • The raccoon lateral cervical nucleus: a single-unit analysis.

    abstract::1. Properties of 90 lateral cervical nucleus (LCN) neurons responsive to light tactile stimulation of ipsilateral body surfaces were examined in pentobarbital sodium-anesthetized raccoons. Peripheral receptive fields (RFs) of 60 of these lay totally or partially on glabrous skin of the forepaw. There were 71 neurons a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.65.6.1411

    authors: Simone DA,Pubols BH Jr

    更新日期:1991-06-01 00:00:00

  • Single-subject fMRI mapping at 7 T of the representation of fingertips in S1: a comparison of event-related and phase-encoding designs.

    abstract::A desirable goal of functional MRI (fMRI), both clinically and for basic research, is to produce detailed maps of cortical function in individual subjects. Single-subject mapping of the somatotopic hand representation in the human primary somatosensory cortex (S1) has been performed using both phase-encoding and block...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00499.2012

    authors: Besle J,Sánchez-Panchuelo RM,Bowtell R,Francis S,Schluppeck D

    更新日期:2013-05-01 00:00:00

  • To look or not to look? Reward, selection history, and oculomotor guidance.

    abstract::The current eye-tracking study examined the influence of reward on oculomotor performance, and the extent to which learned stimulus-reward associations interacted with voluntary oculomotor control with a modified paradigm based on the classical antisaccade task. Participants were shown two equally salient stimuli simu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00275.2018

    authors: Preciado D,Theeuwes J

    更新日期:2018-10-01 00:00:00

  • Mechanisms within the spinal cord are involved in the movement-induced attenuation of an H reflex in the dog.

    abstract::1. H reflexes were elicited in the second interosseous muscle of the hindpaw of the anesthetized dog during passive rotation of the shank about the ipsilateral or contralateral knee. Reflexes sampled at four points in the cycle of movement were compared with stationary controls. For both the ipsilateral and contralate...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1996.76.5.3589

    authors: Misiaszek JE,Barclay JK,Brooke JD

    更新日期:1996-11-01 00:00:00

  • A limited set of muscle synergies for force control during a postural task.

    abstract::Recently developed computational techniques have been used to reduce muscle activation patterns of high complexity to a simple synergy organization and to bring new insights to the long-standing degrees of freedom problem in motor control. We used a nonnegative factorization approach to identify muscle synergies durin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00681.2004

    authors: Ting LH,Macpherson JM

    更新日期:2005-01-01 00:00:00

  • Charybdotoxin and apamin sensitivity of the calcium-dependent repolarization and the afterhyperpolarization in neostriatal neurons.

    abstract::1. Intracellular recordings from neostriatal neurons in an in vitro slice preparation of the rat brain were used to analyze the pharmacological sensitivity of the action potential (AP) repolarization and the afterhyperpolarization (AHP) that follows a single action potential. The interspike voltage trajectory and the ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1992.68.1.287

    authors: Pineda JC,Galarraga E,Bargas J,Cristancho M,Aceves J

    更新日期:1992-07-01 00:00:00

  • Identification of the physical stimulus and the neural basis of fabric-evoked prickle.

    abstract::1. The neurophysiological basis for the sensation of prickle evoked by contact of some fabrics with the skin is reported. 2. Single-unit sensory nerve recordings from the rabbit saphenous nerve were used to identify the receptors responsible for fabric-evoked prickle. These recordings showed that all low-threshold mec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.59.4.1083

    authors: Garnsworthy RK,Gully RL,Kenins P,Mayfield RJ,Westerman RA

    更新日期:1988-04-01 00:00:00

  • Early and late beta-band power reflect audiovisual perception in the McGurk illusion.

    abstract::The McGurk illusion is a prominent example of audiovisual speech perception and the influence that visual stimuli can have on auditory perception. In this illusion, a visual speech stimulus influences the perception of an incongruent auditory stimulus, resulting in a fused novel percept. In this high-density electroen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00783.2014

    authors: Roa Romero Y,Senkowski D,Keil J

    更新日期:2015-04-01 00:00:00

  • Neural substrates of graphomotor sequence learning: a combined FMRI and kinematic study.

    abstract::The goal of this study was to characterize the dynamics and functional connectivity of brain networks associated with fast (short-term) learning of handwriting using functional magnetic resonance imaging. Participants (n = 12) performed a graphomotor sequence learning task (naïve subjects learning to draw simple, 3-st...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00449.2009

    authors: Swett BA,Contreras-Vidal JL,Birn R,Braun A

    更新日期:2010-06-01 00:00:00

  • Planar directional contributions to optic flow responses in MST neurons.

    abstract::Many neurons in the dorsal region of the medial superior temporal area (MSTd) of monkey cerebral cortex respond to optic flow stimuli in which the center of motion is shifted off the center of the visual field. Each shifted-center-of-motion stimulus presents both different directions of planar motion throughout the vi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.77.2.782

    authors: Duffy CJ,Wurtz RH

    更新日期:1997-02-01 00:00:00

  • Panulirus interruptus Ih-channel gene PIIH: modification of channel properties by alternative splicing and role in rhythmic activity.

    abstract::We cloned 10 full-length variants of PIIH, the gene for I(h) from the spiny lobster, Panulirus interruptus, using reverse transcription-PCR (RT-PCR) and rapid amplification of cDNA ends (RACE). This gene shows a significant amount of alternative splicing in the S3-S4 and S4-S5 linkers, in the P-loop and the entire S6 ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00246.2007

    authors: Ouyang Q,Goeritz M,Harris-Warrick RM

    更新日期:2007-06-01 00:00:00

  • Comparison of odor receptive field plasticity in the rat olfactory bulb and anterior piriform cortex.

    abstract::Recent work in the anterior piriform cortex (aPCX) has demonstrated that cortical odor receptive fields are highly dynamic, showing rapid changes of both firing rate and temporal patterning within relatively few inhalations of an odor, despite relatively maintained, patterned input from olfactory bulb mitral/tufted ce...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2000.84.6.3036

    authors: Wilson DA

    更新日期:2000-12-01 00:00:00

  • Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats.

    abstract::Whole cell membrane currents induced by the inflammatory mediators, bradykinin, 5-hydroxytryptamine (5-HT) and prostaglandin E2, were investigated in capsaicin-sensitive dorsal root ganglion (DRG) neurons from newborn rats grown on a monolayer of hippocampal glia without nerve growth factor (NGF). When firmly attached...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.2.670

    authors: Vyklický L,Knotková-Urbancová H,Vitásková Z,Vlachová V,Kress M,Reeh PW

    更新日期:1998-02-01 00:00:00

  • Early stages of melody processing: stimulus-sequence and task-dependent neuronal activity in monkey auditory cortical fields A1 and R.

    abstract::To explore the effects of acoustic and behavioral context on neuronal responses in the core of auditory cortex (fields A1 and R), two monkeys were trained on a go/no-go discrimination task in which they learned to respond selectively to a four-note target (S+) melody and withhold response to a variety of other nontarg...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00828.2007

    authors: Yin P,Mishkin M,Sutter M,Fritz JB

    更新日期:2008-12-01 00:00:00

  • Sound-level-dependent representation of frequency modulations in human auditory cortex: a low-noise fMRI study.

    abstract::Recognition of sound patterns must be largely independent of level and of masking or jamming background sounds. Auditory patterns of relevance in numerous environmental sounds, species-specific vocalizations and speech are frequency modulations (FM). Level-dependent activation of the human auditory cortex (AC) in resp...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00187.2001

    authors: Brechmann A,Baumgart F,Scheich H

    更新日期:2002-01-01 00:00:00

  • Processing of retinal and extraretinal signals for memory-guided saccades during smooth pursuit.

    abstract::It is an essential feature for the visual system to keep track of self-motion to maintain space constancy. Therefore the saccadic system uses extraretinal information about previous saccades to update the internal representation of memorized targets, an ability that has been identified in behavioral and electrophysiol...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00543.2004

    authors: Blohm G,Missal M,Lefèvre P

    更新日期:2005-03-01 00:00:00

  • Zn2+ blocks the NMDA- and Ca2+ -triggered postexposure current ipe in hippocampal pyramidal cells.

    abstract::Whole cell voltage-clamp recordings from acutely isolated hippocampal CA1 pyramidal cells from adult guinea pigs were used to evaluate divalent cations as possible blockers of the postexposure current (Ipe). Ipe is a cation current that is triggered by the rise in intracellular Ca2+ concentration that occurs after the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.2.1124

    authors: Chen QX,Perkins KL,Wong RK

    更新日期:1998-02-01 00:00:00

  • Physiological properties of primary sensory neurons appropriately and inappropriately innervating skin in the adult rat.

    abstract::1. We have studied the physiology of sensory neurons innervating skin of the rat hindlimb, in three groups of animals: 1) normal animals; 2) animals in which the sural nerve (Sn) had regenerated to its original cutaneous target; and 3) animals in which the gastrocnemius muscle nerve (Gn) had previously been cut and cr...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.4.1205

    authors: Lewin GR,McMahon SB

    更新日期:1991-10-01 00:00:00