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Cardiodepressive mediators are released after ischemia from an isolated heart: role of coronary endothelial cells.

Abstract：

OBJECTIVES:This study was designed to ascertain whether cardiodepressive mediators released after ischemia originate from coronary endothelial cells. BACKGROUND:Endothelial cells modulate myocardial contractility under physiologic conditions. Few data are available describing the role of coronary endothelial cells on myocardial function after ischemia. METHODS:Using a model of sequential perfusion of two isolated rat hearts, the effect of the reoxygenated coronary effluent of heart I was investigated on myocardial contractility of heart II. After 40 min of separate perfusion at constant flow (10 ml/min), the two hearts were perfused sequentially with (group I) or without (control group) preceding ischemia (10 min) of heart I. In groups II and III, the coronary endothelium of heart I was functionally removed by Triton X-100 or hyperkalemic infusion before global ischemia. Endothelial damage was confirmed by functional tests and electron microscopy. RESULTS:Under control conditions no changes were observed in heart II during sequential perfusion. In contrast, after 10 min of ischemia in heart I, a marked reversible decrease in left ventricular pressure, left ventricular dP/dtmax and left ventricular dP/dtmin (-55%, -66% and -70%, respectively) was observed in heart II. Heart rate and coronary perfusion pressure did not change significantly. Selective endothelial damage of heart I before ischemia did not modify the negative inotropic effect observed in heart II. CONCLUSIONS:Cardiodepressive mediators are released after ischemia during reperfusion from an isolated heart and induce a reversible negative inotropic effect in a sequentially perfused heart. It is unlikely that these agents are derived from the coronary endothelium.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Stangl V,Felix SB,Meyer R,Berndt T,Kästner R,Wernecke KD,Baumann G

doi

10.1016/s0735-1097(97)82760-x

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

1390-6

issue

6

eissn

0735-1097

issn

1558-3597

pii

S073510979782760X

journal_volume

29

pub_type

杂志文章

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