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Treatment of obstructive sleep apnea reduces the risk of atrial fibrillation recurrence after catheter ablation.

Abstract：

OBJECTIVES:The aim of this study was to examine the effect of continuous positive airway pressure (CPAP) therapy on atrial fibrillation (AF) recurrence in patients with obstructive sleep apnea (OSA) undergoing pulmonary vein isolation (PVI). BACKGROUND:OSA is a predictor of AF recurrence following PVI. However, the impact of CPAP therapy on PVI outcome in patients with OSA is poorly known. METHODS:Among 426 patients who underwent PVI between 2007 and 2010, 62 patients had a polysomnography-confirmed diagnosis of OSA. While 32 patients were "CPAP users" the remaining 30 patients were "CPAP nonusers." The recurrence of any atrial tachyarrhythmia, use of antiarrhythmic drugs, and need for repeat ablations were compared between the groups during a follow-up period of 12 months. Additionally, the outcome of patients with OSA was compared to a group of patients from the same PVI cohort without OSA. RESULTS:CPAP therapy resulted in higher AF-free survival rate (71.9% vs. 36.7%; p = 0.01) and AF-free survival off antiarrhythmic drugs or repeat ablation following PVI (65.6% vs. 33.3%; p = 0.02). AF recurrence rate of CPAP-treated patients was similar to a group of patients without OSA (HR: 0.7, p = 0.46). AF recurrence following PVI in CPAP nonuser patients was significantly higher (HR: 2.4, p < 0.02) and similar to that of OSA patients managed medically without ablation (HR: 2.1, p = 0.68). CONCLUSIONS:CPAP is an important therapy in OSA patients undergoing PVI that improves arrhythmia free survival. PVI offers limited value to OSA patients not treated with CPAP.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Fein AS,Shvilkin A,Shah D,Haffajee CI,Das S,Kumar K,Kramer DB,Zimetbaum PJ,Buxton AE,Josephson ME,Anter E

doi

10.1016/j.jacc.2013.03.052

subject

Has Abstract

pub_date

2013-07-23 00:00:00

pages

300-5

issue

4

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(13)01590-8

journal_volume

62

pub_type

杂志文章

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