Abstract:
OBJECTIVE:To present our current understanding of oxytocin and its receptors during pregnancy and parturition and their potential clinical applications. DATA SOURCES:A MEDLINE search was conducted for pertinent articles from 1966 to October 1996 related to oxytocin and its receptor and their clinical implications during pregnancy and parturition. Review articles, book chapters, and published trials were also searched. METHODS OF STUDY SELECTION:Only references in English that were deemed relevant were used. When possible, human data and sometimes animal data pertinent to understanding the interaction of oxytocin and its receptors were selected. TABULATION, INTEGRATION, AND RESULTS:Oxytocin is synthesized in the hypothalamus and in many reproductive tissues during pregnancy, whereas the receptors are synthesized in reproductive tissues. The genes for oxytocin and its receptors are on chromosomes 20 and 3, respectively. Oxytocin and its receptors are regulated by sex steroids and by oxytocin itself. The paracrine and autocrine mechanisms regulating oxytocin and its receptor within the fetoplacental-uterine unit are central to the control of uterine contractions and parturition. Such current understanding provides the basis for appropriate oxytocin regimens to induce or augment labor, to inhibit preterm labor by blockade of oxytocin receptors, and to achieve cervical ripening. CONCLUSION:Advances in our knowledge of oxytocin and its receptor have provided rational and sound principles for current concepts about their role in parturition, the appropriate use of oxytocin to stimulate the pregnant uterus or ripen the cervix, and the use of oxytocin antagonist to inhibit uterine contractions and preterm labor.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Zeeman GG,Khan-Dawood FS,Dawood MYdoi
10.1016/s0029-7844(97)00056-2subject
Has Abstractpub_date
1997-05-01 00:00:00pages
873-83issue
5 Pt 2eissn
0029-7844issn
1873-233Xjournal_volume
89pub_type
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000002734
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Cyclic vomiting syndrome is a condition that consists of recurrent episodes of vomiting occurring between periods of normal health, with no apparent organic cause of vomiting. We report the sentinel case of pregnancy complicated by preexisting cyclic vomiting syndrome. CASE:A primigravida presented at 8 wee...
journal_title:Obstetrics and gynecology
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doi:10.1097/AOG.0b013e3181a458e0
更新日期:2009-08-01 00:00:00
abstract::Worldwide, sterilization (tubal sterilization and vasectomy) is used by more people than any other method of contraception. All techniques of tubal sterilization in widespread use in the United States have low risks of surgical complications. Although tubal sterilization is highly effective, the risk of pregnancy vari...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,评审
doi:10.1097/01.AOG.0000298621.98372.62
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abstract:BACKGROUND:Erythrasma is an uncommon vulvar infection, best diagnosed by its fluorescence under the Wood lamp. This report shows that despite a negative Wood lamp examination, the diagnosis can be made histologically. CASE:A 42-year-old woman was referred to our clinic with a persistent candidal infection. Evaluation ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::The outcome of delivery of infants weighing more than 4000 g born during two time periods 15 years apart was studied retrospectively. The increased use of cesarean section and other obstetric advances did not reduce the risk of fetal asphyxia and trauma associated with large fetal size. Maternal factors were identifie...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
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abstract::The phenomenon of adolescent childbearing is complex and far reaching, affecting not only the adolescents but also their children and their community. The prevalence and public health effect of adolescent pregnancy reflect complex structural social problems and an unmet need for acceptable and effective contraceptive ...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000002632
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To estimate whether the urinary force of stream method is noninferior to a standard fill voiding trial for rate of catheterization within 6 weeks after apical prolapse surgery in those discharged without a catheter. METHODS:A noninferiority randomized controlled trial was conducted in postoperative women com...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章,随机对照试验
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更新日期:2019-04-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/00006250-198812000-00020
更新日期:1988-12-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/00006250-197805000-00018
更新日期:1978-05-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000004247
更新日期:2021-02-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Preeclampsia is a leading cause of morbidity and mortality during pregnancy. The variability of clinical features suggests that preeclampsia is not a single disease. Atypical hemolytic uremic syndrome, resulting from defective regulation of the alternative complement pathway, is less well known and may be mi...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0000000000001340
更新日期:2016-05-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-06-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/AOG.0000000000000231
更新日期:2014-06-01 00:00:00
abstract::Both herpes simplex virus (HSV) type I and HSV type 2 can cause genital herpes. Because the infection is chronic, genital herpes has become the most common sexually transmitted disease among women. The prevalence of the HSV-2 antibody among women in the United States is 26%, although genital herpes has been diagnosed ...
journal_title:Obstetrics and gynecology
pub_type: 指南,杂志文章,实务指引
doi:
更新日期:2004-11-01 00:00:00
abstract::The American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine recently published consensus guidelines on periviable birth recommending that obstetric interventions (antenatal corticosteroids, tocolysis, magnesium sulfate, antibiotics for preterm premature rupture of membranes or g...
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pub_type: 杂志文章
doi:10.1097/AOG.0000000000001391
更新日期:2016-05-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章,随机对照试验
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journal_title:Obstetrics and gynecology
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更新日期:1993-05-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/s0029-7844(98)00106-9
更新日期:1998-06-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章,评审
doi:10.1097/AOG.0000000000001305
更新日期:2016-02-01 00:00:00
abstract::Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine (Phe) metabolism characterized by a deficiency of the hepatic enzyme, phenylalanine hydroxylase, an enzyme responsible for the conversion of phenylalanine to tyrosine, and elevated levels of Phe and Phe metabolite. All women with PKU or hyperphe...
journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e3181c6f93d
更新日期:2009-12-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
doi:10.1097/AOG.0b013e31822864af
更新日期:2012-02-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章,实务指引
doi:10.1097/AOG.0b013e31817d250e
更新日期:2008-06-01 00:00:00
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journal_title:Obstetrics and gynecology
pub_type: 杂志文章
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更新日期:1980-11-01 00:00:00