The prognostic value of antinuclear antibodies in women with recurrent pregnancy losses: a prospective controlled study.

Abstract:

:Because autoimmune diseases are suspected of causing some cases of recurrent pregnancy loss, we sought clinical and serologic evidence of such diseases in a group of 277 women with recurrent pregnancy loss. Using HEp-2 cells as targets for an indirect immunofluorescence test for antinuclear antibodies, we compared the frequency of a positive antinuclear antibody test in the women with recurrent pregnancy loss to that in 299 pregnant controls and 119 nonpregnant controls. The frequency of positive antinuclear antibody tests at a titer of 1:40 or higher was 16.3% in cases, 16.6% in pregnant controls, and 16.8% in nonpregnant controls. Increasing the critical titer to 1:80, however, led to a statistically significant difference between cases (6.9%) and controls (0 and 0.8%, pregnant and nonpregnant, respectively; P less than .0001). Additional serologic tests failed to identify any subclinical autoimmune diseases, although two antinuclear antibody-negative patients later developed systemic lupus erythematosus. Pregnancy outcome in women with antinuclear antibody titers of 1:80 or higher included 52% live births, compared with 65.6% live births in women with three or more pregnancy losses and an entirely normal comprehensive evaluation, a nonsignificant difference. The combination of clinical evaluation and antinuclear antibody tests did not identify new cases of autoimmune disease in this population.

journal_name

Obstet Gynecol

authors

Harger JH,Rabin BS,Marchese SG

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

419-24

issue

3 Pt 1

eissn

0029-7844

issn

1873-233X

journal_volume

73

pub_type

杂志文章
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    authors: Berkus MD,Ramamurthy RS,O'Connor PS,Brown KJ,Hayashi RH

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  • Vaginal prostaglandin E1 analogue (ONO-802) to soften the cervix in first trimester abortion.

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    pub_type: 临床试验,杂志文章

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    authors: Stocker J,Evens L

    更新日期:1977-10-01 00:00:00

  • Effect of raloxifene on the response to conjugated estrogen vaginal cream or nonhormonal moisturizers in postmenopausal vaginal atrophy.

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  • Risk Factors for the Development of Obstetric Anal Sphincter Injuries in Modern Obstetric Practice.

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    doi:

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  • Practice Bulletin Summary No. 152: Emergency Contraception.

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  • Chorionic villus sampling: transabdominal versus transcervical approach in more than 4000 cases.

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