ACOG Committee Opinion No. 449: Maternal phenylketonuria.

Abstract:

:Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine (Phe) metabolism characterized by a deficiency of the hepatic enzyme, phenylalanine hydroxylase, an enzyme responsible for the conversion of phenylalanine to tyrosine, and elevated levels of Phe and Phe metabolite. All women with PKU or hyperphenylalaninemia should be strongly encouraged to receive family planning and preconception counseling. Women with PKU or hyperphenylalaninemia should begin appropriate, medically directed dietary phenylalanine restriction before conception.

journal_name

Obstet Gynecol

authors

doi

10.1097/AOG.0b013e3181c6f93d

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1432-1433

issue

6

eissn

0029-7844

issn

1873-233X

pii

00006250-200912000-00053

journal_volume

114

pub_type

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