Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats.

abstract：OBJECTIVES:Despite the universal proliferation of emergency medical services programs throughout the United States since 1970, only a few have ever documented a valid lifesaving effect, particularly in large, urban centers. The purpose of this study was to demonstrate the effect of specialized physician supervision on ...

journal_title：Critical care medicine

authors： Pepe PE,Mattox KL,Duke JH,Fisher PB,Prentice FD

更新日期：1993-09-01 00:00:00

abstract：:Reimbursement policies are a critical step in the incorporation of new technologies and therapies into the clinical armamentarium. Reimbursement is an umbrella concept describing the process to manage and pay for healthcare services, including benefit coverage, coding, and payment processes. The technologies and servi...

journal_title：Critical care medicine

authors： Reaven NL,Rosenbloom J

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To study the effects of high-dose epinephrine, compared with standard-dose epinephrine, on the dynamics of superficial cortical cerebral blood flow as well as global cerebral oxygenation during experimental cardiopulmonary resuscitation. We hypothesized that high-dose epinephrine might be unable to improve ce...

journal_title：Critical care medicine

authors： Gedeborg R,Silander HC,Ronne-Engström E,Rubertsson S,Wiklund L

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVES:Previous workers have demonstrated that controlled mechanical ventilation results in diaphragm inactivity and elicits a rapid development of diaphragm weakness as a result of both contractile dysfunction and fiber atrophy. Limited data exist regarding the impact of pressure support ventilation, a commonly us...

journal_title：Critical care medicine

authors： Hudson MB,Smuder AJ,Nelson WB,Bruells CS,Levine S,Powers SK

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Cytokine response after cardiac surgery may be genetically influenced. A study was carried out to investigate the relation between cytokine gene expression in peripheral blood mononuclear cells, genotype, and clinical events after cardiac surgery. DESIGN:A case-control study was performed. SETTING:Cardiac i...

journal_title：Critical care medicine

authors： Duggan E,Caraher E,Gately K,O'Dwyer M,McGovern E,Kelleher D,McManus R,Ryan T

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:Brain death induces a massive inflammatory response. However, the influence of this inflammatory response on organ procurement, transplantation, and recipient outcome is unknown. We describe the inflammatory response characteristics in brain-dead organ donors and examine associations with organ transplantati...

journal_title：Critical care medicine

authors： Murugan R,Venkataraman R,Wahed AS,Elder M,Hergenroeder G,Carter M,Madden NJ,Powner D,Kellum JA,HIDonOR Study Investigators.

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:Case fatality in pregnancy-associated severe sepsis or septic shock appears reduced compared with nonpregnant women with severe sepsis or septic shock. It remains unclear if this difference is due to pregnancy or better baseline health status, among others. Our study compared adverse outcomes of pregnancy-as...

journal_title：Critical care medicine

authors： Kidson KM,Henderson WR,Hutcheon JA

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Sepsis results in organ dysfunction caused by a dysregulated host response, in part related to the immune response of a severe infection. Mesenchymal stromal cells are known to modulate the immune response, and expression of stromal cell-derived factor-1 regulates mobilization of neutrophils from the bone ma...

journal_title：Critical care medicine

authors： Kwon MY,Ghanta S,Ng J,Tsoyi K,Lederer JA,Bronson RT,El-Chemaly S,Chung SW,Liu X,Perrella MA

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:To determine whether chest wall vibration with tracheal gas insufflation during bronchoconstriction maintains gas exchange at lower airway and intrathoracic pressures than those that occur during positive pressure ventilation. DESIGN:Prospective study. SETTING:Experimental laboratory. SUBJECTS:Six anesthet...

journal_title：Critical care medicine

authors： Eckmann DM

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:The objectives of this article are to introduce and explore a novel paradigm based on complex nonlinear systems, and to evaluate its application to critical care research regarding the systemic host response and multiple organ dysfunction syndrome (MODS). DATA SOURCES:Published original work, review article...

journal_title：Critical care medicine

authors： Seely AJ,Christou NV

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and risk factors of chronic critical illness after severe blunt trauma. DESIGN:Prospective observational cohort study (NCT01810328). SETTING:Two level-one trauma centers in the United States. PATIENTS:One hundred thirty-five adult blunt trauma patients with hemorrhagic shock who ...

journal_title：Critical care medicine

authors： Mira JC,Cuschieri J,Ozrazgat-Baslanti T,Wang Z,Ghita GL,Loftus TJ,Stortz JA,Raymond SL,Lanz JD,Hennessy LV,Brumback B,Efron PA,Baker HV,Moore FA,Maier RV,Moldawer LL,Brakenridge SC

更新日期：2017-12-01 00:00:00

abstract：:Oxygen availability during cardiopulmonary bypass was assessed in 22 patients under hypothermic and relatively normothermic conditions. The patients were divided into two groups, 17 of whom received ACD blood and 5, CPD blood. The mean P50 for all patients fell from a preoperative value of 25.9 +/- 2.4 (SD) to 15.6 +/...

journal_title：Critical care medicine

authors： Fisher A,Foëx P,Emerson PM,Darley JH,Rauscher LA

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:To determine if selective decontamination of the digestive tract (SDD) influences the proinflammatory immune response of the gut after hemorrhage. DESIGN:Random assignment to either unmanipulated control after 7 days of SDD or conventional rat chow, or hemorrhagic shock group after the same time of conventio...

journal_title：Critical care medicine

authors： Kahlke V,Fändrich F,Brötzmann K,Zabel P,Schröder J

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:To compare the ability of two methods--Acute Physiology and Chronic Health Evaluation (APACHE II) and Mortality Prediction Model (MPM)--to predict hospital outcome for a large group of intensive care patients from Britain and Ireland. DESIGN:Prospective, multicenter, cohort study. SETTING:Twenty-six general...

journal_title：Critical care medicine

authors： Rowan KM,Kerr JH,Major E,McPherson K,Short A,Vessey MP

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To evaluate a novel combination of preoperative, intraoperative, and postoperative variables (including the Parsonnet, and the Acute Physiology and Chronic Health Evaluation II and III [APACHE II and III] scores) in cardiac surgery patients in order to predict hospital outcome, complications, and length of st...

journal_title：Critical care medicine

authors： Turner JS,Morgan CJ,Thakrar B,Pepper JR

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVES:Procalcitonin (PCT) has been described as an early, discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, in part because no appropriate animal models have been available. We tested the hypothesis that plasma PCT increases during various pathophy...

journal_title：Critical care medicine

authors： Redl H,Schlag G,Tögel E,Assicot M,Bohuon C

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:The Accreditation Council for Graduate Medical Education recently released new standards for supervision and duty hours for residency programs. These new standards, which will affect over 100,000 residents, take effect in July 2011. In response to these new guidelines, the Society of Critical Care Medicine c...

journal_title：Critical care medicine

authors： Pastores SM,O'Connor MF,Kleinpell RM,Napolitano L,Ward N,Bailey H,Mollenkopf FP Jr,Coopersmith CM

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To compare compliance and end-expiratory lung volume during reexpansion of normal and surfactant-deficient ex vivo atelectatic lungs with either gas or total liquid ventilation. DESIGN:Controlled, animal study using an ex vivo lung preparation. SETTING:A research laboratory at a university medical center. ...

journal_title：Critical care medicine

authors： Tooley R,Hirschl RB,Parent A,Bartlett RH

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:To define the impact of prehospital hypotension on the dynamic, systemic acute inflammatory response to blunt trauma. DESIGN:Retrospective study. SETTINGS:Tertiary care institution. PATIENTS:Twenty-two hypotensive blunt trauma patients matched with 28 normotensive blunt trauma patients. INTERVENTION:None....

journal_title：Critical care medicine

authors： Almahmoud K,Namas RA,Zaaqoq AM,Abdul-Malak O,Namas R,Zamora R,Sperry J,Billiar TR,Vodovotz Y

更新日期：2015-07-01 00:00:00

abstract：:Vecuronium's short half-life and minimal cardiopulmonary side-effects make it a suitable drug for continuous infusion. Vecuronium is used frequently in critically ill patients to increase their total compliance and to minimize the adverse effects of mechanical ventilation. This crossover, prospective study evaluates t...

journal_title：Critical care medicine

authors： Eldadah MK,Newth CJ

更新日期：1989-10-01 00:00:00

abstract：:Recent strides in computational biology and high-throughput technologies have generated considerable interest in understanding complex biological systems. The application of these technologies to critical illness and injury offers the potential to define adaptive and maladaptive programs of gene expression induced by ...

journal_title：Critical care medicine

authors： Cobb JP,Suffredini AF,Danner RL

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Transfusion of red blood cells has been linked to disappointing clinical outcomes in the critically ill, but specific mechanisms of organ dysfunction after transfusion remain poorly understood. We tested the hypothesis that red blood cell storage impairs the ability of red blood cells to release adenosine-5'-...

journal_title：Critical care medicine

authors： Zhu H,Zennadi R,Xu BX,Eu JP,Torok JA,Telen MJ,McMahon TJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:One form of sepsis, or endotoxic shock, is a hyperactivated systemic response caused by excessive expression of proinflammatory mediators, which results from Gram-negative bacterial lipopolysaccharide-stimulated Toll-like receptor-4 signaling. This lipopolysaccharide signaling is known to consist of a MyD88-...

journal_title：Critical care medicine

authors： Benavides U,Gonzalez-Murguiondo M,Harii N,Lewis CJ,Schwartz AL,Giuliani C,Napolitano G,Dagia NM,Malgor R,McCall KD,Kohn LD

更新日期：2012-03-01 00:00:00

abstract：:Hemodynamic effects of controlled mechanical ventilation (CMV), intermittent mandatory ventilation (IMV), and intermittent mandatory ventilation with 5 cm H20 PEEP (IMV 5 peep) were studied in 20 patients after aortocoronary bypass surgery. Significant increases in cardiac index (CI) and stroke volume index (SI) (p le...

journal_title：Critical care medicine

authors： Mathru M,Rao TL,El-Etr AA,Pifarre R

更新日期：1982-07-01 00:00:00

abstract：OBJECTIVE:Antibiotic therapy is a major risk factor for the development of diarrhea and colitis with varying severity. Often the origin of antibiotic-associated gastrointestinal deterioration remains elusive and no specific infectious agents could be discerned. PATIENTS:We represent three cases of intractable high-vol...

journal_title：Critical care medicine

authors： Wurm P,Spindelboeck W,Krause R,Plank J,Fuchs G,Bashir M,Petritsch W,Halwachs B,Langner C,Högenauer C,Gorkiewicz G

更新日期：2017-06-01 00:00:00

abstract：:The objectives of this article were to review the causes and extent of hospital-associated infectious diarrhea and associated risks in the general hospital ward and intensive care unit (ICU), to compare microorganisms with similar symptoms to aid in recognition that will lead to timely and appropriate treatment and co...

journal_title：Critical care medicine

authors： Bobo LD,Dubberke ER

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Our goal was to demonstrate explicitly that lower-frequency positive-pressure ventilation not only preserves adequate oxygenation and acid-base status in hemorrhagic states, but also that "normal" or higher respiratory rates significantly compromise hemodynamics, even with moderate degrees of hemorrhage. DES...

journal_title：Critical care medicine

authors： Pepe PE,Lurie KG,Wigginton JG,Raedler C,Idris AH

更新日期：2004-09-01 00:00:00

abstract：CONTEXT:The results of studies on noninvasive positive pressure ventilation (NPPV) for acute hypoxemic respiratory failure unrelated to cardiogenic pulmonary edema have been inconsistent. OBJECTIVE:To assess the effect of NPPV on the rate of endotracheal intubation, intensive care unit and hospital length of stay, and...

journal_title：Critical care medicine

authors： Keenan SP,Sinuff T,Cook DJ,Hill NS

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To examine the effects of mechanical ventilation with a tidal volume of 6 mL/kg compared with 12 mL/kg predicted body weight on hemodynamics, vasopressor use, fluid balance, diuretics, sedation, and neuromuscular blockade within 48 hrs in patients with acute lung injury and acute respiratory distress syndrome...

journal_title：Critical care medicine

authors： Cheng IW,Eisner MD,Thompson BT,Ware LB,Matthay MA,Acute Respiratory Distress Syndrome Network.

更新日期：2005-01-01 00:00:00

abstract：:Conventional wisdom suggests that the "human factor" in critical care environments is reason for inadequate medication and patient safety. "Human factors" (or human factors engineering) is also a scientific discipline and practice of improving human performance. Using decades of human factors research, this paper eval...

journal_title：Critical care medicine

authors： Scanlon MC,Karsh BT

更新日期：2010-06-01 00:00:00