Vecuronium by continuous infusion for neuromuscular blockade in infants and children.

Abstract:

:Vecuronium's short half-life and minimal cardiopulmonary side-effects make it a suitable drug for continuous infusion. Vecuronium is used frequently in critically ill patients to increase their total compliance and to minimize the adverse effects of mechanical ventilation. This crossover, prospective study evaluates the use of vecuronium by continuous infusion vs. hourly boluses. Patients were assigned randomly to either method; 12 h later each group was transferred to the other method. Neuromuscular blockade (NMB) was followed with the Train-of-Four method. Cardiopulmonary variables were followed hourly. The total dosage/kg body weight was calculated for each method. Six patients were started with continuous drip and the other six with hourly boluses. There were no significant differences in the cardiopulmonary variables through the two periods, although statistically there was a significant difference in the total dosage/kg body weight required for each method. The mean of total vecuronium used in the drip was 0.79 mg/kg.12 h (range 0.1 to 1.8). The mean of the hourly boluses was 1.34 mg/kg.12 h (range 1.0 to 2.55). Patients on continuous infusion required less vecuronium to maintain a similar NMB (p less than .01).

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Eldadah MK,Newth CJ

doi

10.1097/00003246-198910000-00004

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

989-92

issue

10

eissn

0090-3493

issn

1530-0293

journal_volume

17

pub_type

临床试验,杂志文章,随机对照试验
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