Value of human factors to medication and patient safety in the intensive care unit.

abstract：OBJECTIVE:To examine the role of platelets, fibrin, and adhesion molecules in mediating neutrophil-endothelial cell interactions in septic shock. DESIGN:Controlled experiments using phase contrast microscopy to examine neutrophil, platelet, and endothelial cell interactions in flowing cell suspensions under simulated ...

journal_title：Critical care medicine

authors： Kirschenbaum LA,McKevitt D,Rullan M,Reisbeck B,Fujii T,Astiz ME

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Our intent was to evolve a prognosticator that would predict the likelihood that an electrical shock would restore a perfusing rhythm. Such a prognosticator was to be based on conventional electrocardiographic signals but without constraints caused by artifacts resulting from precordial compression. The adver...

journal_title：Critical care medicine

authors： Marn-Pernat A,Weil MH,Tang W,Pernat A,Bisera J

更新日期：2001-12-01 00:00:00

abstract：:Reproducibility of thermal-dye extravascular lung water (EVLW) estimation by a lung water computer was studied by performing ten consecutive measurements in 45 critically ill patients. EVLW ranged over a wide spectrum from 187 to 1163 ml (2.4 to 18.6 ml/kg). The mean coefficient of variation of ten consecutive measure...

journal_title：Critical care medicine

authors： Laggner AN,Lenz K,Druml W,Kleinberger G

更新日期：1987-06-01 00:00:00

abstract：OBJECTIVE:To characterize the endothelium-dependent and endothelium-independent components of abnormal pulmonary vascular tone in canine oleic acid lung injury. DESIGN:Prospective, interventional study. SETTING:University laboratory. SUBJECTS:Twenty anesthetized mongrel dogs. INTERVENTIONS:Right heart catheterizati...

journal_title：Critical care medicine

authors： Kafi SA,Scillia P,Mélot C,Gevenois PA,Pagnamenta A,Naeije R

更新日期：2002-07-01 00:00:00

abstract：:Although ICUs generate attention as consumers of resources, no national data on utilization and costs were available in Canada. U.S. estimates are too old for current comparison. Based on national hospital survey data from Statistics Canada, we calculated the utilization of ICUs in all Canadian general hospitals from ...

journal_title：Critical care medicine

authors： Jacobs P,Noseworthy TW

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:Toxic free radicals cause dysfunction of respiratory muscles, probably leading to respiratory distress. Exposure to high concentrations of oxygen generates plenty of free radicals. Lidocaine scavenges the reactive molecules. The purposes of the current study were first to examine whether hyperoxia impairs dia...

journal_title：Critical care medicine

authors： Nishina K,Mikawa K,Shiga M,Kodama S,Kagawa T,Maekawa N,Obara H

更新日期：2000-06-01 00:00:00

abstract：:One hundred patients were ventilated with high-frequency jet ventilation (HFJV) during the initial 24-h postoperative period in the surgical and neurosurgical ICUs. Eighty-three were successfully weaned, 2 could not be ventilated adequately with HFJV, and 15 with criteria of acute respiratory failure received HFJV for...

journal_title：Critical care medicine

authors： Sladen A,Guntupalli K,Marquez J,Klain M

更新日期：1984-09-01 00:00:00

abstract：OBJECTIVES:Administration of eicosapentaenoic acid and docosahexanoic acid, omega-3 fatty acids in fish oil, has been associated with improved patient outcomes in acute lung injury when studied in a commercial enteral formula. However, fish oil has not been tested independently in acute lung injury. We therefore sought...

journal_title：Critical care medicine

authors： Stapleton RD,Martin TR,Weiss NS,Crowley JJ,Gundel SJ,Nathens AB,Akhtar SR,Ruzinski JT,Caldwell E,Curtis JR,Heyland DK,Watkins TR,Parsons PE,Martin JM,Wurfel MM,Hallstrand TS,Sims KA,Neff MJ

更新日期：2011-07-01 00:00:00

abstract：RATIONALE:Despite recent advances in critical care and ventilator management, acute lung injury and acute respiratory distress syndrome continue to cause significant morbidity and mortality. Granulocyte-macrophage colony stimulating factor may be beneficial for patients with acute respiratory distress syndrome. OBJECT...

journal_title：Critical care medicine

authors： Paine R 3rd,Standiford TJ,Dechert RE,Moss M,Martin GS,Rosenberg AL,Thannickal VJ,Burnham EL,Brown MB,Hyzy RC

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Acinetobacter baumannii complex bacteremia has been identified increasingly in critical patients admitted in ICUs. Notably, A. baumannii complex bacteremia has a high mortality rate, yet the risk factors associated with mortality remain unclear and controversial. DESIGN:Retrospective study. SETTING:All adu...

journal_title：Critical care medicine

authors： Lee HY,Chen CL,Wu SR,Huang CW,Chiu CH

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Sympathetic vasoconstriction regulates peripheral circulation and controls blood pressure, but sepsis is associated with hypotension. We evaluated whether apparent loss of sympathetic vasoconstrictor responsiveness relates to distended smooth muscles or to endotoxemia and/or hypoxia. DESIGN:Prospective descr...

journal_title：Critical care medicine

authors： Brassard P,Zaar M,Thaning P,Secher NH,Rosenmeier JB

更新日期：2016-04-01 00:00:00

abstract：:In a prospective randomized trial in patients with a history of preoperative pulmonary hypertension who were undergoing surgery for valvular replacement or annuloplasty, the effects of ketanserin (KET) (12 patients) and sodium nitroprusside (SNP) (14 patients) on the systemic and pulmonary circulation and pulmonary sh...

journal_title：Critical care medicine

authors： van der Starre PJ,Feld RJ,Reneman RS

更新日期：1989-07-01 00:00:00

abstract：:The present trend in managed care has meant downsizing expectations concerning the availability of support for resuscitation research. This trend applies to funding possibilities from industry, governmental agencies, and nongovernmental agencies (Table 1). There will be increasing barriers to making innovations. Truth...

journal_title：Critical care medicine

authors： Thompson WL,Bellamy R,Cummins RO,Delooz HH,Dick W,Kochanek PM,Ornato JP,Ricci EM,Weil MH,Winter PM

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVES:To track compliance by an interprofessional team with the Awakening and Breathing Coordination, Choice of drugs, Delirium monitoring and management, Early mobility, and Family engagement (ABCDEF) bundle in implementing the Pain, Agitation, and Delirium guidelines. The aim was to study the association between...

journal_title：Critical care medicine

authors： Barnes-Daly MA,Phillips G,Ely EW

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:Thrombotic microangiopathy syndromes are a heterogeneous group of severe diseases that often require ICU admission. Prompt initiation of targeted therapies is required for atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, whereas there is no specific consensus therapy for Shiga toxi...

journal_title：Critical care medicine

authors： Joseph A,Rafat C,Zafrani L,Mariani-Kurkdjian P,Veyradier A,Hertig A,Rondeau E,Mariotte E,Azoulay E

更新日期：2018-09-01 00:00:00

abstract：:The use of epidural opioids for postoperative analgesia has been associated with respiratory depression. This report demonstrates the ability of nalbuphine to rapidly reverse the respiratory depression caused by epidural sufentanil while maintaining postoperative pain relief. ...

journal_title：Critical care medicine

authors： Cheng EY,May J

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVES:To characterize the landscape of process of care and safety outcomes for tracheal intubation across pediatric intensive care units BACKGROUND:Procedural process of care and safety outcomes of tracheal intubation across pediatric intensive care units has not been described. We hypothesize that the novel Nati...

journal_title：Critical care medicine

authors： Nishisaki A,Turner DA,Brown CA 3rd,Walls RM,Nadkarni VM,National Emergency Airway Registry for Children (NEAR4KIDS).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of amino acid profiles in septic encephalopathy. DESIGN:Retrospective analysis. SETTING:Medical wards and medical ICU of a university hospital. PATIENTS:Patients with infections and normal mental status were compared with patients with septic shock and altered sensorium. INTERVENTIONS...

journal_title：Critical care medicine

authors： Sprung CL,Cerra FB,Freund HR,Schein RM,Konstantinides FN,Marcial EH,Pena M

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:To examine the effect of glycosylated recombinant human tumor necrosis factor binding protein-1 (r-hTNF binding protein-1), the extracellular domain of the tumor necrosis factor receptor p55 produced in mammalian cells, in a rabbit model of circulatory shock due to Escherichia coli. DESIGN:Prospective, rando...

journal_title：Critical care medicine

authors： Porat R,Paddock HN,Schwaitzberg SD,Connolly RJ,Wilkens T,Dasch JR,Gascon MP,Hutchison JS,Ythier A,Wallach D

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:Nitric oxide regulates epithelial permeability and other properties of the intestinal mucosal barrier. It previously has been shown in animals that intestinal mucosal nitric oxide production is impaired during gut hypoperfusion. The study was performed to confirm the presence of intestinal mucosal nitric oxid...

journal_title：Critical care medicine

authors： Snygg J,Aneman A,Pettersson A,Fändriks L

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVES:Capillary refill time is a noninvasive method to assess tissue perfusion to determine shock status. Capillary refill time is defined as the time required to regain skin color after blanching pressure is applied. Although common methods to measure capillary refill time depend on clinicians' visual assessment,...

journal_title：Critical care medicine

authors： Nickel AJ,Jiang S,Napolitano N,Yehya N,Fitzgerald JC,Bruins BB,Lockman JL,Nadkarni VM,Nishisaki A

更新日期：2020-10-01 00:00:00

abstract：:These guidelines were developed to provide a reference for preparing policies on admission and discharge for pediatric intensive care units (PICUs). They represent a consensus opinion of physicians, nurses, and allied health care professionals. By using this document as a framework for developing multidisciplinary adm...

journal_title：Critical care medicine

authors：

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:To describe blood conservation strategies for critically ill patients. DATA SOURCES:By using a predefined strategy, we searched the electronic databases of Medline, EMBASE, CINAHL, the Cochrane database of systematic reviews, Cochrane central register of controlled trials, ACP Journal Club, Database of abstr...

journal_title：Critical care medicine

authors： Fowler RA,Berenson M

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Insulin reduces morbidity and mortality among critically ill patients, but the molecular mechanisms of its effect remain unknown. Insulin is a well-known inhibitor of glycogen synthase kinase-3, which may play an important role in systemic inflammation and shock. Here we investigate the role of blood glucose ...

journal_title：Critical care medicine

authors： Dugo L,Collin M,Allen DA,Murch O,Foster SJ,Yaqoob MM,Thiemermann C

更新日期：2006-05-01 00:00:00

abstract：:The educational objectives in use in our Pediatric ICU are described. These have importance for educational programs in critical care medicine, in particular, where patient care needs can easily overwhelm educational needs. It is important not to overlook our role as teachers in the development of proper attitudes and...

journal_title：Critical care medicine

authors： Kravath RE

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:To examine variations in case-mix, structure, resource use, and outcome performance among teaching and nonteaching intensive care units (ICU). DESIGN:Prospective inception cohort study. PATIENTS:A consecutive sample of 15,297 patients at 35 hospitals, which compared 8,269 patients admitted to 20 teaching IC...

journal_title：Critical care medicine

authors： Zimmerman JE,Shortell SM,Knaus WA,Rousseau DM,Wagner DP,Gillies RR,Draper EA,Devers K

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To determine whether extreme obesity (morbid obesity; body mass index > or =40 kg/m(2)) is an independent risk factor for death among critically ill patients; this objective is most salient in the subset of patients who sustain a prolonged intensive care unit stay during which the burdens of care imposed by o...

journal_title：Critical care medicine

authors： Nasraway SA Jr,Albert M,Donnelly AM,Ruthazer R,Shikora SA,Saltzman E

更新日期：2006-04-01 00:00:00

abstract：:Instantaneous heart rate, indices of long-term and short-term heart-rate variability (HRV), and transcutaneous O2 (PtcO2) and CO2 (PtcCO2) tensions were recorded simultaneously on 164 occasions in 16 neonates. There was significant inverse correlation between PtcCO2 and both HRV indices, while no linear correlation wa...

journal_title：Critical care medicine

authors： Aärimaa T,Kero P,Välimäki I

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:Acute hemolysis is associated with organ damage, inflammation, and impaired vascular function. Stimulation of the cholecystokinin-1 receptor-dependent vagal anti-inflammatory reflex with lipid-rich enteral nutrition was demonstrated to prevent tissue damage and attenuate inflammation. This study investigates...

journal_title：Critical care medicine

authors： de Haan JJ,Windsant IV,Lubbers T,Hanssen SJ,Hadfoune M,Prinzen FW,Greve JW,Buurman WA

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To determine nuclear factor kappa B (NF-kappa B) activation in mononuclear and neutrophils from critically ill patients and to compare NF-kappa B activation with circulating concentrations of interleukin (IL)-6, IL-8, and soluble intercellular adhesion molecule (sICAM)-1. DESIGN:Observational study. SETTIN...

journal_title：Critical care medicine

authors： Paterson RL,Galley HF,Dhillon JK,Webster NR

更新日期：2000-04-01 00:00:00