Oral nanotherapeutics: effect of redox nanoparticle on microflora in mice with dextran sodium sulfate-induced colitis.

Abstract:

BACKGROUND:Patients with ulcerative colitis (UC) exhibit overproduction of reactive oxygen species (ROS) and imbalance of colonic microflora. We previously developed a novel redox nanoparticle (RNP(O)), which effectively scavenged ROS in the inflamed mucosa of mice with dextran sodium sulfate (DSS)-induced colitis after oral administration. The objective of this study was to examine whether the orally administered RNP(O) changed the colonic microflora in healthy mice and those with colitis. METHODS:RNP(O) was synthesized by self-assembly of an amphiphilic block copolymer that contains stable nitroxide radicals in hydrophobic side chain via ether linkage. Colitis was induced in mice by supplementing DSS in drinking water for 7 days, and RNP(O) was orally administered daily during DSS treatment. The alterations of fecal microflora during treatment of DSS and RNP(O) were investigated using microbiological assays. RESULTS:We investigated that RNP(O) did not result in significant changes to the fecal microflora in healthy mice. Although total aerobic and anaerobic bacteria were not significantly different between experimental groups, a remarkable increase in commensal bacteria (Escherichia coli and Staphylococcus sp.) was observed in mice with DSS-induced colitis. Interestingly, orally administered RNP(O) remarkably reduced the rate of increase of these commensal bacteria in mice with colitis. CONCLUSIONS:On the basis of the obtained results, it was confirmed that the oral administration of RNP(O) did not change any composition of bacteria in feces, which strongly suggests a protective effect of RNP(O) on healthy environments in intestinal microflora. RNP(O) may become an effective and safe medication for treatment of UC.

journal_name

J Gastroenterol

authors

Vong LB,Yoshitomi T,Morikawa K,Saito S,Matsui H,Nagasaki Y

doi

10.1007/s00535-013-0836-8

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

806-13

issue

5

eissn

0944-1174

issn

1435-5922

journal_volume

49

pub_type

杂志文章
  • Cancer risk in patients with cholelithiasis and after cholecystectomy: a nationwide cohort study.

    abstract:BACKGROUND:This study examined the association of cholelithiasis post-cholecystectomy with subsequent cancers and evaluated the risk of cancer in patients with both cholelithiasis and cholecystectomy. METHODS:The Taiwanese National Health Insurance Research Database was used to identify 15545 newly diagnosed cholelith...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-013-0846-6

    authors: Chen YK,Yeh JH,Lin CL,Peng CL,Sung FC,Hwang IM,Kao CH

    更新日期:2014-05-01 00:00:00

  • Serum trace metals in chronic viral hepatitis and hepatocellular carcinoma in Thailand.

    abstract::This study was conducted to determine and compare serum trace metal levels in viral hepatitis-associated chronic liver disease. Of 98 patients aged 43 (+/- 13) [mean (+/- SD)] years, 83 (85%) were seropositive for hepatitis B surface antigen (HBsAg) and 15 (15%) were seropositive for anti-hepatitis C virus (HCV). Twen...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02365444

    authors: Pramoolsinsap C,Promvanit N,Komindr S,Lerdverasirikul P,Srianujata S

    更新日期:1994-10-01 00:00:00

  • Gallstones, a cholecystectomy, chronic pancreatitis, and the risk of subsequent pancreatic cancer in diabetic patients: a population-based cohort study.

    abstract:BACKGROUND:The causal association between diabetes and pancreatic cancer remains unclear in Asian populations. This study examined whether gallstones, a cholecystectomy, chronic pancreatitis and the treatment of antidiabetic agents affect the risk of subsequent pancreatic cancer for patients with diabetes in a Taiwanes...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-012-0674-0

    authors: Lai HC,Tsai IJ,Chen PC,Muo CH,Chou JW,Peng CY,Lai SW,Sung FC,Lyu SY,Morisky DE

    更新日期:2013-06-01 00:00:00

  • Nitric oxide: a regulator of mucosal defense and injury.

    abstract::There is an abundance of evidence that nitric oxide plays a critical role in regulating several components of gastrointestinal mucosal defense. Suppression of nitric oxide synthesis increases susceptibility to injury, while administration of nitric oxide donors increases resistance to injury. On the other hand, nitric...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s005350050178

    authors: Elliott SN,Wallace JL

    更新日期:1998-12-01 00:00:00

  • Ciliated foregut cyst in cirrhotic liver.

    abstract::We encountered a patient with a ciliated hepatic foregut cyst with accompanying liver cirrhosis, which was hard to distinguish from well-differentiated hepatocellular carcinoma. A lesion 2 cm in diameter was found in the subcapsular region of the medial segment of the liver. It was slightly hypoechoic on ultrasonograp...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02355038

    authors: Murakami T,Imai A,Nakamura H,Tsuda K,Kanai T,Wakasa K

    更新日期:1996-06-01 00:00:00

  • Acetylcholine regulates glucagon secretion from human glucagonoma cells.

    abstract::Human glucagonoma cells were isolated and maintained in vitro. Incubation experiments showed that carbachol (Cch) induced the simultaneous release of glucagon, VIP (vasoactive intestinal polypeptide), and pancreatic polypeptide (PP) at levels significantly higher than basal levels. Atropine abolished the stimulatory e...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02349291

    authors: Funakoshi A,Yasunami Y,Ryu S,Shinozaki H,Jimi A,Ikeda S

    更新日期:1994-12-01 00:00:00

  • Strain differences in the induction of intestinal metaplasia by X-irradiation in rats.

    abstract::Strain differences in the susceptibility of rats to induction of intestinal metaplasia by X-irradiation were examined. The gastric regions of 5-week-old males of five inbred strains of rats (F344/NSlc, Copenhagen, Buffalo/NacJcl, and ACI/NHos) and three strains of randomly bred rats (HOS:Donryu, Slc:Wistar, Slc:SD) we...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02934483

    authors: Watanabe H,Fujimoto N,Masaoka Y,Ohtaki M,Ito A

    更新日期:1997-06-01 00:00:00

  • A child with simple ulcer of the colon effectively treated with the combination of prednisolone, azathioprine, and pentoxifylline.

    abstract::A rare case of simple ulcer of the colon in a 7-year-old girl is reported. Simple ulcer is clinically and pathologically recognized as a serious disease linked to intestinal Behcet's disease. Recently, some immunomodulators, such as thalidomide and antitumor necrosis factor monoclonal antibody, have been used to treat...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350200122

    authors: Kasahara E,Yamagishi N,Tanaka M,Yashiro K

    更新日期:2002-01-01 00:00:00

  • Portal venous blood flow while breath-holding after inspiration or expiration and during normal respiration in controls and cirrhotics.

    abstract::In this study, we used magnetic resonance (MR) imaging to measure portal blood flow in 12 healthy controls and 17 cirrhotics while they were breath-holding after inspiration and after expiration. We then compared the results with measurements made during normal respiration in the healthy controls and cirrhotics. Blood...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050381

    authors: Sugano S,Yamamoto K,Sasao K,Watanabe M

    更新日期:1999-10-01 00:00:00

  • Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease.

    abstract:BACKGROUND:For patients with chronic hepatitis due to hepatitis B virus (HBV), factors predicting hepatocellular carcinoma (HCC) other than high levels of HBV-DNA and alanine aminotransferase (ALT) are needed to prevent HCC development, as many patients with chronic HBV infection fulfill these conditions. The purpose o...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-010-0266-9

    authors: Shoji B,Ikeda F,Fujioka S,Kobashi H,Yasunaka T,Miyake Y,Shiraha H,Takaki A,Nouso K,Iwasaki Y,Yamamoto K

    更新日期:2010-11-01 00:00:00

  • Cyclooxygenase, NSAIDs, and colorectal cancer.

    abstract::Prevention of human diseases has become a major focus of biomedical investigators around the world. Our current screening and treatment regimens for colorectal cancer are not effective, as indicated by the fact that this disease is the second leading cause of death from cancer in the United States. Recently published ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02358623

    authors: DuBois RN,Smalley WE

    更新日期:1996-12-01 00:00:00

  • Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights.

    abstract::Changes of hepatic sinusoids are crucial in the pathogenesis of liver cirrhosis and portal hypertension. Liver injury leads to distinct morphological abnormalities such as loss of sinusoidal fenestration, vasoconstriction, and angiogenesis as well as molecular changes. Communication between the two key cells in this h...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s00535-016-1190-4

    authors: Greuter T,Shah VH

    更新日期:2016-06-01 00:00:00

  • Alpha-fetoprotein-producing gastric carcinoma: biological properties of a cultured cell line.

    abstract::We describe a gastric carcinoma cell line that has been maintained in vitro for more than 10 years and retains the capacity to produce a large amount of alpha-fetoprotein. This cell line was isolated from a metastatic lymph node of a 63-year-old male patient with advanced gastric carcinoma (T2N3P0H0M0) who showed high...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/BF02367784

    authors: Sekiguchi M,Fujii Y,Saito A,Suzuki T,Shiroko Y,Nakamura H,Hasumi K

    更新日期:1995-10-01 00:00:00

  • CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation.

    abstract:BACKGROUND:Cytotoxin-associated gene A (CagA) product is a bacterial virulence factor contributing to the pathogenicity of Helicobacter pylori (HP) infection in humans. Host factors, which vary in different countries, interact with bacterial factors to determine the disease state. Our objective was to investigate the f...

    journal_title:Journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00535-006-1788-z

    authors: Sökücü S,Ozden AT,Süoğlu OD,Elkabes B,Demir F,Cevikbaş U,Gökçe S,Saner G

    更新日期:2006-06-01 00:00:00

  • Hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL) for pancreatic stones.

    abstract::We present a patient with complication of huge hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL) for pancreatic lithotripsy. The hematoma measured 78-110mm. Angiography showed a subcapsular hematoma, rather than a hematoma in the liver. In the arterial phase, the distal end of the small v...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050325

    authors: Hirata N,Kushida Y,Ohguri T,Wakasugi S,Kojima T,Fujita R

    更新日期:1999-12-01 00:00:00

  • Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects.

    abstract:BACKGROUND:Although previous studies have indicated that serum pepsinogen I levels, as well as the pepsinogen I/II ratio, were positively correlated with maximal gastric output, the relationship may be different between Helicobacter pylori-negative and -positive subjects. The aim of this study was to investigate the re...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-005-1677-x

    authors: Iijima K,Sekine H,Koike T,Imatani A,Ohara S,Shimosegawa T

    更新日期:2005-10-01 00:00:00

  • Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells.

    abstract:BACKGROUND:Ursodeoxycholic acid (UDCA) partly exerts choleretic effects by modifying the function of the bile salt export pump (Bsep, ABCB11). UDCA induces insertion of Bsep into the canalicular membrane of hepatocytes; however, underlying mechanisms remain unknown. We aimed to elucidate molecular mechanisms behind UDC...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-013-0833-y

    authors: Kagawa T,Orii R,Hirose S,Arase Y,Shiraishi K,Mizutani A,Tsukamoto H,Mine T

    更新日期:2014-05-01 00:00:00

  • Anemia in patients with colorectal cancer.

    abstract::Although anemia is one of the signs of colorectal cancer, the relationships between histological findings and hematological findings other than hemoglobin level have not been adequately investigated. We investigated the relationship between hematological findings, serum iron, and histological findings in 358 patients ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s005350050120

    authors: Sadahiro S,Suzuki T,Tokunaga N,Mukai M,Tajima T,Makuuchi H,Saito T

    更新日期:1998-08-01 00:00:00

  • Computed tomography in the diagnosis of adult midgut rotational anomalies: a report of two cases.

    abstract::Adult midgut rotational anomalies are difficult to diagnose. Any symptoms present in adults may be the result of intermittent volvulus of the midgut. Successful outcome of this clinical condition depends on prompt diagnosis and timely surgical intervention. Computed tomography (CT) is useful in early identification of...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1007/s005350050052

    authors: Wang TK,Yeh CH

    更新日期:1998-02-01 00:00:00

  • Serum Mac-2 binding protein glycosylation isomer predicts grade F4 liver fibrosis in patients with biliary atresia.

    abstract:BACKGROUND AND AIM:Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) is a novel fibrosis marker. We examined the ability of M2BPGi to predict liver fibrosis in patients with biliary atresia. METHODS:Sixty-four patients who underwent living donor liver transplantation (LDLT) were included [median age, 1.1 years (rang...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-016-1235-8

    authors: Yamada N,Sanada Y,Tashiro M,Hirata Y,Okada N,Ihara Y,Urahashi T,Mizuta K

    更新日期:2017-02-01 00:00:00

  • The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury.

    abstract:BACKGROUND:Acute liver failure is a potentially fatal disease of various etiologies for which liver transplantation is the only known curative treatment. Although the decision-making on transplantation is largely dependent on the severity of liver injury (based on predicting a fatal outcome), a statistical analysis to ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-017-1421-3

    authors: Mawatari S,Moriuchi A,Ohba F,Kawano T,Oda K,Takikawa Y,Takikawa H,Ido A,Tsubouchi H

    更新日期:2018-07-01 00:00:00

  • Novel interleukin 1beta polymorphism increased the risk of gastric cancer in a Korean population.

    abstract:BACKGROUND:Polymorphisms in the gene for interleukin 1beta (IL-1B) have been found to increase the risks of gastric cancer and its precursors in response to Helicobacter pylori infection in white populations. however, there has been no independent confirmation of the role of IL-1B markers in gastric cancer patients fro...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-003-1315-4

    authors: Lee KA,Ki CS,Kim HJ,Sohn KM,Kim JW,Kang WK,Rhee JC,Song SY,Sohn TS

    更新日期:2004-01-01 00:00:00

  • Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing.

    abstract:BACKGROUND:Dual oral therapy with daclatasvir plus asunaprevir yielded an SVR rate of 85% among patients with genotype 1b HCV. Treatment failure mainly occurred in patients with pre-existing HCV with NS5A-Y93H mutation. The significance of the mutation was evaluated. METHODS:The percent of serum NS5A-Y93H strains rela...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-015-1106-8

    authors: Uchida Y,Kouyama J,Naiki K,Sugawara K,Ando S,Nakao M,Motoya D,Inao M,Imai Y,Nakayama N,Mochida S

    更新日期:2016-03-01 00:00:00

  • Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.

    abstract:BACKGROUND:Neutrophil elastase (NE) is a major secretory product from activated neutrophils and a major contributor to tissue destruction. However, little is known about the pathogenic contribution of NE to ulcerative colitis (UC). This study was designed to investigate the contribution of NE by measuring NE activity i...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-005-1768-8

    authors: Morohoshi Y,Matsuoka K,Chinen H,Kamada N,Sato T,Hisamatsu T,Okamoto S,Inoue N,Takaishi H,Ogata H,Iwao Y,Hibi T

    更新日期:2006-04-01 00:00:00

  • Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT.

    abstract:BACKGROUND:We aimed to evaluate gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the detection of hepatocellular carcinomas (HCCs) and dysplastic nodules (DNs) compared with dynamic multi-detector row computed tomography (MDCT), and to discriminate ...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-012-0571-6

    authors: Inoue T,Kudo M,Komuta M,Hayaishi S,Ueda T,Takita M,Kitai S,Hatanaka K,Yada N,Hagiwara S,Chung H,Sakurai T,Ueshima K,Sakamoto M,Maenishi O,Hyodo T,Okada M,Kumano S,Murakami T

    更新日期:2012-09-01 00:00:00

  • The efficacy of nocturnal administration of branched-chain amino acid granules to improve quality of life in patients with cirrhosis.

    abstract:BACKGROUND:Nocturnal administration of branched-chain amino acid (BCAA) granules improves serum albumin levels in patients with cirrhosis. However, it is unclear whether or not this administration method can improve the patients' quality of life (QOL). In this study, we aimed to investigate the efficacy of BCAA granule...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00535-012-0632-x

    authors: Hidaka H,Nakazawa T,Kutsukake S,Yamazaki Y,Aoki I,Nakano S,Asaba N,Minamino T,Takada J,Tanaka Y,Okuwaki Y,Watanabe M,Shibuya A,Koizumi W

    更新日期:2013-02-01 00:00:00

  • Longitudinal association of fatty pancreas with the incidence of type-2 diabetes in lean individuals: a 6-year computed tomography-based cohort study.

    abstract:BACKGROUND:Only a few studies have longitudinally evaluated whether fatty pancreas increases the risk of type-2 diabetes (T2D), and their results were inconsistent. Fatty pancreas is closely linked to overweight and obesity, but previous studies did not exclude overweight or obese individuals. Therefore, in this cohort...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-020-01683-x

    authors: Yamazaki H,Tauchi S,Wang J,Dohke M,Hanawa N,Kodama Y,Katanuma A,Saisho Y,Kamitani T,Fukuhara S,Yamamoto Y

    更新日期:2020-07-01 00:00:00

  • Nitric oxide regulates polarity of guinea pig distal colon pellet propagation and circular muscle motor response.

    abstract:BACKGROUND:Peristaltic reflex does not fully explain the polarity of peristalsis. In the distal colon, we propose that the balance of circular muscle contraction proximal and distal to the pellet is a local reflex that predicts polarity of peristalsis. METHODS:Guinea pig distal colon segments were harvested, and fecal...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-013-0842-x

    authors: Gribovskaja-Rupp I,Kwak JM,Takahashi T,Ludwig K

    更新日期:2014-05-01 00:00:00

  • A Japanese case of eosinophilic esophagitis.

    abstract::Eosinophilic esophagitis (EE) is a rarely diagnosed condition involving eosinophilic infiltration of the esophageal mucosa. Here we present a case of EE in a 69-year-old Japanese man, who presented with abdominal pain, appetite loss, and a history of bronchial asthma. Laboratory findings included peripheral eosinophil...

    journal_title:Journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1007/s00535-006-1827-9

    authors: Furuta K,Adachi K,Kowari K,Mishima Y,Imaoka H,Kadota C,Koshino K,Miyake T,Kadowaki Y,Furuta K,Kazumori H,Sato S,Ishihara S,Amano Y,Honda M,Kinoshita Y

    更新日期:2006-07-01 00:00:00

  • Correction to: High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codon 18 rendering the NUDT15 diplotype.

    abstract::The correct name of the last author should be. ...

    journal_title:Journal of gastroenterology

    pub_type: 已发布勘误

    doi:10.1007/s00535-019-01646-x

    authors: Kakuta Y,Izumiyama Y,Okamoto D,Nakano T,Ichikawa R,Naito T,Moroi R,Kuroha M,Kanazawa Y,Kimura T,Shiga H,Kudo H,Minegishi N,Kawai Y,Tokunaga K,Nagasaki M,Kinouchi Y,Suzuki Y,Masamune A,MENDEL study group.

    更新日期:2020-01-01 00:00:00