Abstract：
:Since its invention in 1986, the atomic force microscope (AFM) has become one of the most widely used near-field microscopes. Surfaces of hard samples are imaged almost routinely with atomic resolution. Soft biological surfaces, however, are still challenging. In this brief review, the AFM technique is introduced to the experimental biologist. We discuss recent data on imaging molecular structures of biomembranes, and give detailed information on the application of the AFM with three representative examples. One is imaging plasma membrane turnover of transformed renal epithelial cells during migration in vivo, another is visualizing a cloned and isolated potassium channel usually located in kidney, and a third is imaging macromolecular pore complexes of the nuclear envelope of aldosterone-sensitive kidney cells and of Xenopus laevis oocytes. The review ends with the conclusion that nuclear pores can serve as birthday candles on a Guglhupf.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Oberleithner H,Geibel J,Guggino W,Henderson RM,Hunter M,Schneider SW,Schwab A,Wang Wsubject
Has Abstractpub_date
1997-06-27 00:00:00pages
419-23issue
12-13eissn
0043-5325issn
1613-7671journal_volume
109pub_type
杂志文章,评审abstract：:Over the past 8 years the Poison Information Centre of Vienna was confronted 24 times with acute chlorproxithene (CPTX) poisoning. In adults doses of 2 g and more caused severe intoxication, but serious toxic manifestations were observed already at low dosage in children (after the ingestion of less than 5 mg/kg body ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1982-03-19 00:00:00
abstract：:Infections occurring during the early postoperative phase after liver transplantation result in a significant rise in morbidity and mortality. The records of 279 orthoptic transplantations performed in 248 patients were analyzed retrospectively. 55.6% of all patients suffered from one or more episodes of bacterial and...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1996-12-27 00:00:00
abstract：:This article undertakes a critical evaluation of Adlerian dream theory. The main weakness of the theory is found to be its lack of an inherent instance of truth that shows the dreamer the way to a better and more feasible life style. Contemporary Adlerians' treatment of the master's dream dogmas and their practical us...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1988-05-13 00:00:00
abstract：:A case of metastasizing ectopic thymoma arising in the right thoracic cavity and infiltrating the right lung and pleura in a fashion reminiscent of diffuse pleural mesothelioma is presented. An involuted, non-neoplastic thymus was demonstrated microscopically in the anterior mediastinum. No case of thymoma showing the...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1986-01-10 00:00:00
abstract：:The tocolytic effect of hexoprenaline was determined in 20 women by internal cardiotocography during labour. After 30 minutes of intravenous medication (0.3 microgram/min = dosage for massive tocolysis) the uterine activity decreased on average by 73.6%; the maternal pulse rate increased by 25.0%; the fetal heart rate...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1981-09-18 00:00:00
abstract：:Correction: Wien Klin Wochenschr 2014 https://doi.org/10.1007/s00508-014-0571-z The disclosure needs to additionally mention the following:Erika von Mutius is listed as inventor on the following patents: Publication number EP 1411977: Composition containing bacterial antigens used for the prophylaxis …. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00508-019-01546-3
更新日期：2019-09-01 00:00:00
abstract：:Since 1997 minimally invasive surgical techniques are used for the treatment of diseases of the adrenals, thyroid, parathyroid and the endocrine pancreas. In contrast to open surgical procedures special radiological examinations are the basis for minimally invasive techniques after biochemical testing. The basis of ex...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Addressing the growing burden of mental diseases is a public health priority. Nevertheless, many countries lack reliable estimates of the proportion of the population affected, which are crucial for health and social policy planning. This study aimed to collect existing evidence on the prevalence of mental d...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-018-1316-1
更新日期：2018-02-01 00:00:00
abstract：:187 patients were checked up over 4 years by the secretin-ceruletide test. Independently of the test results they were assigned to various disease groups on the basis of clinical assessment. 131 subjects were divided in a pilot investigation into: subjects with a healthy pancreas (n = 55); subjects with chronic pancre...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is defined as a glucose tolerance disorder with onset during pregnancy and is associated with increased feto-maternal morbidity as well as long-term complications in mother and child. Women who fulfil the criteria of a manifest diabetes in early pregnancy (fasting plasma glucose >12...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：10.1007/s00508-018-1419-8
更新日期：2019-05-01 00:00:00
abstract：:The following parameters have been examined in twenty-one patients suffering from chronic renal failure (creatinine level between 4.5 and 18.8 mg/100 ml serum): maximum motor nerve conduction of the peroneal nerve, amplitude of the compound muscle action potential of the extensor digitorum brevis muscle, serum creatii...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1976-12-10 00:00:00
abstract：:Clinical and genetic investigations were performed on seven members of a family suffering from multiple hereditary fibromatosis. These studies indicate that the responsible gene appears to be coupled and transmitted with that of the rhesus system, located at chromosome one. The diagnosis, differential diagnosis and th...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1976-02-06 00:00:00
abstract：:The Zollinger-Ellison syndrome is characterized pathophysiologically by a significant hypergastrinemia derived from a gastrin-secreting neuroendocrine tumor with a primary location in the pancreas or duodenum. Chronic hypergastrinemia in turn triggers gastric acid hypersecretion yielding in chronic or recurrent or ref...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-007-0884-2
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND AND AIMS:The impact of hemodialysis on liver stiffness is still unclear. The aim of the study was to assess liver fibrosis by real-time two-dimensional shear wave elastography (RT 2D-SWE) and to quantify the influence of net fluid withdrawal on liver stiffness during one hemodialysis session. The second aim ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-019-01577-w
更新日期：2019-11-28 00:00:00
abstract：:In an extensive series of experimental studies conducted on the common carotid artery in rats, a combined technique involving suture and gluing with human fibrin glue has been developed. In view of the good results achieved, this technique was then applied in 12 patients in whom anastomosis between the superficial tem...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1978-06-09 00:00:00
abstract：:Urea and cyanate, spontaneously transformed from urea, are increased with decreased renal function becoming potential toxins. Isocyanic acid, the active form of cyanate, carbamoylates proteins, amino acids and other molecules, changing molecular structure and function in vivo. Carbamoylation can occur at multiple site...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1998-08-21 00:00:00
abstract：:Chronic recurrent pulmonary embolism can lead to extensive pulmonary hypertension by obstruction of the pulmonary vessels. Pulmonary thrombendarteriectomy is a new approach to normalizing the elevated pulmonary vascular resistance by removal of the adsorbed thrombi. Between 1992 and 1994 we have operated on 8 patients...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION:Autologous bone graft is still considered to be the gold standard for treating non-unions in trauma and orthopedic surgery. Intramedullary bone graft harvest appears to be an alternative to other bone graft options such as iliac crest bone graft and synthetic bone substitutes. A one-step reamer-irrigator-a...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-011-1565-8
更新日期：2011-05-01 00:00:00
abstract：:Endemic nephropathy (EN) is a renal disease of unknown etiology. In Croatia it occurs in the rural population in 14 villages located in the western part of Brodsko-Posavska county. This region also has an unusually high incidence of otherwise rare upper urothelial cancers. Between 1991 and 2002 the average general mor...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-005-0426-8
更新日期：2005-09-01 00:00:00
abstract：:Apoptosis of renal tubular epithelial cells plays a major role in acute renal failure. Several external and internal signals can induce apoptosis, which is then effectuated via several pathways. These pathways are either the FAS/FAS-L pathway and downstream MAPK (mitogen-activated protein kinases) and JNK (c-Jun N-ter...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：2002-08-30 00:00:00
abstract：:Morphological examination of the fundus has improved considerably over the past decade. By means of identation biomicroscopy, hitherto inaccessible, extremely-peripheral areas of the fundus can be examined by the slit lamp now; this of importance in the study of intraocular inflammation and the judgement of retinal te...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1978-06-23 00:00:00
abstract：:Metabolic derangements in diabetic coma are the sequelae of insulin deficiency. These defects are aggravated by the actions of insulin counteracting ("diabetogenic") hormones and hypertonic dehydration, which both impair insulin action. Conversely, it has been shown that hypo-osmolar rehydration of a hyperosmolar, sev...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1984-04-27 00:00:00
abstract：:In a case of disputed paternity mother and child showed a genetic incompatibility in the Kidd system of the erythrocytes: mother Jk(a-b+), child Jk (a+b-). For the first time the RFLP technique solved this problem, using four different Jeffreys' highly polymorphic single locus DNA probes MS 1, MS 31, g 3 and MS 43. We...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1990-05-11 00:00:00
abstract：:This review deals with the physiological and clinical importance of human atrial natriuretic peptide (hANP). This peptide, which is produced by the myocardial cells of the right atrium, induces a diuretic and natriuretic response and has an inhibitory effect on aldosterone secretion. Recent elucidation of the peptide'...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1987-03-06 00:00:00
abstract：:35 mobilized patients received continuous parenteral nutrition consisting of an all-in-one solution mixed together in this department right before use over a total period of 1155 days (mean per patient 33 days). The primary complication rate was: second puncture in 14%, pneumothorax in 11% and haemothorax in 3% of cas...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1982-08-06 00:00:00
abstract：:The impact factor (Institute for Scientific Information, ISI, Philadelphia, PA, USA) is a widespread used and acknowledged source for judging the quality of a researcher. In addition the "Science Citation Index (SCI)" [Institute for Scientific Information (ISI)] provides the scientific community with a citations datab...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：2001-08-16 00:00:00
abstract：:The article summarizes the first results of an attempt to reconstruct the destinies of the Jewish pediatricians of Vienna after the German occupation of Austria in March 1938. Traditionally pediatrics in Vienna were characterized by a high percentage of Jewish specialists. In 1938 they were confronted with abrupt humi...
journal_title：Wiener klinische Wochenschrift
pub_type： 历史文章,杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:48 patients with nonseminomatous testicular tumours were treated between 1980 and 1984. 19 patients had bulky stage II c or disseminated disease; according the Royal Marsden staging classification 5 patients had stage II c, 2 patients III and 12 patients stage IV. The pT stage of the primary tumour showed no correlati...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1986-08-08 00:00:00
abstract：BACKGROUND AND PURPOSE:The aim of this retrospective study was to determine in-hospital mortality and morbidity secondary to intracerebral hemorrhage and to analyse variables considered to be significantly associated with survival in these patients. PATIENTS AND METHODS:The study cohort consisted of 135 consecutive pa...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：2000-02-25 00:00:00
abstract：:IgM (Immunoglobin M) antibodies to the antigen T (Thomsen-Friedenreich antigen, transformation antigen) were detected by normal agglutination technique in the serum of 7 out of 73 newborn children. Neither the mother's anti-T titre, nor the quantity of IgM and IgG (Immunoglobulin G) in the sera of mother and child was...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1982-08-06 00:00:00
