Results of treatment of refractory interstitial cystitis with intravesical hyaluronic acid.

Abstract:

:Interstitial cystitis is a chronic benign disease of the bladder that causes bothersome and debilitating symptoms and mainly affects women. Since interstitial cystitis (IC) might result from a defective glycosaminoglycan layer of the bladder epithelium, we conducted a trial of hyaluronic acid (HA), used intravesically, to test its activity in the treatment of this disease. A total of 10 patients with typical findings of IC were included. Following bladder catheterisation, the patients received a dose of 40 mg, weekly for 6 weeks, and then monthly. Response to therapy was evaluated by comparing the pre-treatment and post-treatment symptom scores and voiding diaries. There was a 30% positive response rate at week 6, which was maintained until week 24. No significant local or general side-effects were noted during the course of treatment. Although we recorded a low incidence of success in our group of patients, the results of our limited study were satisfactory in the group of responsive patients (30%), who had no relapses during the observation period of 6 months. The intravesical administration of HA was well tolerated in all cases.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Porru D,Campus G,Tudino D,Valdes E,Vespa A,Scarpa RM,Usai E

doi

10.1159/000283012

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

26-9

issue

1

eissn

0042-1138

issn

1423-0399

journal_volume

59

pub_type

杂志文章
  • Collagen content in the rat urinary bladder following removal of an experimental infravesical outlet obstruction.

    abstract::A partial urethral obstruction was induced in female rats. After 6 weeks, detrusor weight had increased eightfold and collagen concentration had decreased to about 40% compared to controls. Due to the weight gain, the total amount of detrusor collagen had increased more than threefold. Removal of the obstruction led t...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282230

    authors: Uvelius B,Lindner P,Mattiasson A

    更新日期:1991-01-01 00:00:00

  • Cadaveric renal transplantation from a non-heart-beating pediatric donor into adult recipients.

    abstract:INTRODUCTION:The use of cadaveric pediatric kidneys has been suggested as a means to overcome organ shortage, but is debated because of technical complications and an increased incidence of functional allograft impairment. METHODS:We experienced 2 cases of cadaveric renal transplantation from a non-heart-beating pedia...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000068778

    authors: Nakatani T,Uchida J,Yamazaki T,Iwai T,Naganuma T,Kim T,Sugimura K

    更新日期:2003-01-01 00:00:00

  • Prognostic impact of intratumoral C-reactive protein expression in patients with clear cell renal cell carcinoma.

    abstract:BACKGROUND:Elevated serum C-reactive protein (CRP) level has been demonstrated to predict poorer survival of both localized and metastatic renal cell carcinoma. However, the prognostic value of intratumoral CRP expression has not been sufficiently studied. PATIENTS AND METHODS:In the present study, the expression of C...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000353401

    authors: Can C,Acikalin MF,Ozen A,Dundar E

    更新日期:2014-01-01 00:00:00

  • Comparisons of Therapeutic Efficacy and Safety of Solifenacin versus Tolterodine in Patients with Overactive Bladder: A Meta-Analysis.

    abstract:OBJECTIVES:This meta-analysis was to assess solifenacin and tolterodine in patients with overactive bladder. METHODS:We searched PubMed, the Cochrane Library, EMBASE, CNKI, Wanfang, and ClinicalTrials.gov databases for randomized controlled trials (RCTs). The efficacy endpoint was daily micturition frequency, daily ur...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,meta分析

    doi:10.1159/000497311

    authors: Wang HT,Xia M

    更新日期:2019-01-01 00:00:00

  • Prescription practice for LH-RH analogs and androgen receptor antagonists in the treatment of advanced prostate cancer in Germany (1993-2003).

    abstract:INTRODUCTION:Nearly 80% of the patients suffering from advanced stages of prostate cancer in Germany are treated currently with luteinizing hormone-releasing hormone (LH-RH) analogs alone or in combination with androgen receptor antagonists. The aim of this study was to assess whether the prescription practice for LH-R...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000096334

    authors: Rohde V,Diemer T,Hauck E,Bestmann B,Miller J,Schröder H,Weidner W,Katalinic A

    更新日期:2006-01-01 00:00:00

  • In-Hospital Outcomes after Radical Cystectomy for Bladder Cancer: Comparing National Trends in the United States and Germany from 2006 to 2014.

    abstract:BACKGROUND:Radical cystectomy (RC) still poses a significant risk for mortality and morbidity. OBJECTIVES:We compared in-hospital outcomes after RC in the United States and -Germany using population-based data. METHODS:We compared data from the US Nationwide Inpatient Sample to the German hospital billing database. M...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000496347

    authors: Groeben C,Koch R,Baunacke M,Borkowetz A,Wirth MP,Huber J

    更新日期:2019-01-01 00:00:00

  • Outcomes for Patients after Resection of Pulmonary Metastases from Clear Cell Renal Cell Carcinoma: 18 Years of Experience.

    abstract:INTRODUCTION:Clear cell renal cell carcinoma (ccRCC) is the most common kidney tumor. If feasible, metastasectomy is preferably indicated in metastatic disease. OBJECTIVE:The aim of this study was to determine the outcome of patients after pulmonary metastasectomy (PM). METHODS:PM for ccRCC was performed in 35 patien...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000502493

    authors: Procházková K,Vodička J,Fichtl J,Krákorová G,Šebek J,Roušarová M,Hošek P,Brookman May SD,Hes O,Hora M,Třeška V

    更新日期:2019-01-01 00:00:00

  • A study on staging bone scans in newly diagnosed prostate cancer.

    abstract:OBJECTIVE:This study aimed to evaluate the role of bone scan as a staging investigation in newly diagnosed untreated prostate cancers. MATERIALS AND METHODS:Bone scan results in patients with newly diagnosed prostate cancer were reviewed and correlated with clinical stage, prostate-specific antigen (PSA) and Gleason s...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000091620

    authors: Ayyathurai R,Mahapatra R,Rajasundaram R,Srinivasan V,Archard NP,Toussi H

    更新日期:2006-01-01 00:00:00

  • Captopril reduces interstitial renal fibrosis and preserves more normal renal tubules in neonatal dogs with partial urethral obstruction: a preliminary study.

    abstract:PURPOSE:Chronic renal damage due to tubulointerstitial fibrosis is one of several complications of posterior urethral valves in a significant number of children. As activation of the renin-angiotensin system plays an important role in this injury, we conducted this study to investigate whether administration of captopr...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000098078

    authors: Shirazi M,Noorafshan A,Bahri MA,Tanideh N

    更新日期:2007-01-01 00:00:00

  • Simple stratification of survival using bone scan and serum C-reactive protein in prostate cancer patients with metastases.

    abstract:BACKGROUND:IL-6 has been reported to be a significant prognostic factor for prostate cancer and induces synthesis of C-reactive protein (CRP) by hepatocytes. The present study was undertaken to evaluate the clinical value of serum CRP in prostate cancer patients with metastases. METHODS:The prognostic significance of ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000112601

    authors: Nakashima J,Kikuchi E,Miyajima A,Nakagawa K,Oya M,Ohigashi T,Murai M

    更新日期:2008-01-01 00:00:00

  • Negotiating ureteral stenoses and kinks with a hydrophilic wire.

    abstract::Negotiating a tortuous or obstructed ureter with a wire can be time-consuming and sometimes tiring. The principle of using a slippery floppy wire and then replacing it with a stiff wire through a 5-french open-ended ureteral catheter yields a high success rate. The ureteral catheter can be used for a radiocontrast stu...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282713

    authors: Hofmann R,Pickl U,Hartung R

    更新日期:1995-01-01 00:00:00

  • The Impact of Endourological Experience on Flexible Ureteroscopy Outcomes and Performance at Different Levels of Expertise: Retrospective Multifactorial Analysis.

    abstract:INTRODUCTION:The aim of this study was to analyze the influence of residents' participation in flexible ureteroscopy (fURS) on intra- and postoperative outcomes. MATERIALS AND METHODS:Intra- and postoperative parameters were compared in a retrospective monocentric setting between 3 groups: "resident group" (47 cases) ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000504989

    authors: Ozimek T,Kramer MW,Hupe MC,Laturnus JM,Struck JP,Hennig MJP,Merseburger AS,Cordes J

    更新日期:2020-01-01 00:00:00

  • Varicocele: in search of a human model.

    abstract:AIMS:To study the effects of left gonadal vein ligation on semen parameters and venous hemodynamics of the testis. SUBJECTS AND METHODS:All male voluntary kidney donors who were scheduled to have left donor nephrectomy between March 2004 and February 2005, by either open or laparoscopic technique, were considered for ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000277603

    authors: Das Adhikary S,Gopalakrishnan G

    更新日期:2010-01-01 00:00:00

  • Lymphoceles Post-Radical Retropubic Prostatectomy: A Retrospective Evaluation of Epidemiology, Risk Factors and Outcome.

    abstract:INTRODUCTION:We aimed at evaluating the incidence of lymphoceles, a common complication after radical retropubic prostatectomy (RRP), at a high volume centre, define risk factors and assess the clinical outcome. MATERIALS AND METHODS:454 patients receiving RRP and pelvic lymph node dissection were assessed for postope...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000381463

    authors: Heers H,Laumeier T,Olbert PJ,Hofmann R,Hegele A

    更新日期:2015-01-01 00:00:00

  • Diagnostic Performance of Radiolabeled Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography for Primary Lymph Node Staging in Newly Diagnosed Intermediate to High-Risk Prostate Cancer Patients: A Systematic Review and Meta-A

    abstract:INTRODUCTION:We aimed to assess the diagnostic accuracy of radiolabeled prostate-specific membrane antigen positron emission tomography (PSMA PET) or positron emission tomography/computed tomography (PET/CT) for primary lymph node (LN) staging in newly diagnosed intermediate to high-risk prostate cancer (PCa) patients....

    journal_title:Urologia internationalis

    pub_type: 杂志文章,meta分析

    doi:10.1159/000493169

    authors: Kim SJ,Lee SW,Ha HK

    更新日期:2019-01-01 00:00:00

  • Subjective pain scale and the need for analgesia during shock wave lithotripsy.

    abstract:OBJECTIVE:To investigate patients' opinions on the degree of pain during shock wave lithotripsy, and the need for analgesics in patients with urinary stone. METHODS:A prospective questionnaire study involving subjective pain assessment during and just after shock wave lithotripsy was performed in consecutive patients ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000082710

    authors: Oh SJ,Ku JH,Lim DJ,Byun SS,Kim HH

    更新日期:2005-01-01 00:00:00

  • Verapamil attenuates renal tubular apoptosis in response to partial unilateral ureteral obstruction.

    abstract:INTRODUCTION:Partial unilateral ureteral obstruction (PUUO) is the type of obstruction that is most often encountered in pediatric clinical practice. The majority of our knowledge on PUUO has been derived from experimental studies and the effects of PUUO on the kidney have still been a source of continual investigation...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000111736

    authors: Topcu SO,Erbagci A,Erturhan S,Yagci F,Ucak R

    更新日期:2008-01-01 00:00:00

  • Effect of ageing on blood flow to the bladder and bladder function.

    abstract::Ischemia, induced by atherosclerosis, is a common cause of disorders in the elderly. Bladder dysfunction in older people may be caused by detrusor ischemia. We compared blood flow to the bladder and detrusor function in vivo and in vitro in young (6-month-old) and aged (24-month-old) male Sprague-Dawley rats. In both ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000030365

    authors: Saito M,Ohmura M,Kondo A

    更新日期:1999-01-01 00:00:00

  • Renal cysts: can percutaneous ethanol injections be considered an alternative to surgery?

    abstract:AIM:To evaluate the efficacy of a new sclerotization technique with pure ethanol in the treatment of symptomatic renal cysts. PATIENTS AND METHODS:Fourteen patients having renal cysts with a meant diameter of 10 (range 5-15) cm were treated. Our technique includes: ultrasound-guided percutaneous puncture with an 18-ga...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000071846

    authors: Gasparini D,Sponza M,Valotto C,Marzio A,Luciani LG,Zattoni F

    更新日期:2003-01-01 00:00:00

  • Laparoscopic Transperitoneal Lateral Adrenalectomy for Large Adrenal Tumors.

    abstract:BACKGROUND:Laparoscopic adrenalectomy is the gold standard for treatment of benign adrenal lesions. Tumor size is a factor that might influence decision-making concerning the use of laparoscopic approach. The aim of this study was to analyze the results of adrenalectomy for tumors ≥6 cm in diameter. METHODS:Two groups...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000444146

    authors: Natkaniec M,Pędziwiatr M,Wierdak M,Major P,Migaczewski M,Matłok M,Budzyński A,Rembiasz K

    更新日期:2016-01-01 00:00:00

  • Urinary manometry in spinal cord injury patients. External urethral sphincter pressure recordings before and after sphincterotomy.

    abstract::Recordings of local pressure within the membranous urethra were performed in 15 male spinal cord injury patients before and after external sphincterotomy. Transurethral division of the external sphincter reduced the intraurethral pressure by 55% in the upper part of the membranous urethra and by 66% in the lower part....

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000279962

    authors: Ott R,Rossier AB

    更新日期:1975-01-01 00:00:00

  • Ectopic adrenal cortex tissue: an incidental finding during inguinoscrotal operations in pediatric patients.

    abstract:OBJECTIVE:The aim of the present study was to assess the occurrence of ectopic remnants of adrenal cortex tissue encountered in pediatric patients who underwent groin surgical explorations. MATERIALS AND METHODS:We studied 1,862 patients with groin surgical explorations during a period of 12 consecutive years (1995-20...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000151411

    authors: Ketata S,Ketata H,Sahnoun A,FakhFakh H,Bahloul A,Mhiri MN

    更新日期:2008-01-01 00:00:00

  • Clinical predictors of stone fragmentation using slow-rate shock wave lithotripsy.

    abstract:AIM:To determine efficacy and clinical predictors of stone fragmentation when using slow-rate shock wave lithotripsy (SWL). PATIENTS AND METHODS:In total, 116 patients with radiopaque urinary tract stones were randomized into two groups: 57 patients were treated with SWL at 90 shocks/min, and 59 patients were treated ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000106324

    authors: Li WM,Wu WJ,Chou YH,Liu CC,Wang CJ,Huang CH,Lee YC

    更新日期:2007-01-01 00:00:00

  • The Time of Spontaneous Resolution of Monosymptomatic Nocturnal Enuresis (MNE) Is Familial.

    abstract:PURPOSE:To investigate whether or not the age of spontaneous resolution of monosymptomatic nocturnal enuresis (MNE) was familial. PATIENTS AND METHODS:A questionnaire was administered to more than 1,500 people, and 100 appropriate participants were identified from four referral hospitals. We included the participants ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000370166

    authors: Oguz U,Aykac A,Demirelli E,Sancak EB,Resorlu B,Sarikaya S,Damar E,Bozkurt OF,Ogreden E,Yalcin O

    更新日期:2015-01-01 00:00:00

  • Supine versus Prone Position during Extracorporeal Shockwave Lithotripsy for Treating Distal Ureteral Calculi: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:We aimed at evaluating the efficacy of extracorporeal shockwave lithotripsy (SWL) for treating distal ureteral calculi performed in supine vs. prone position. MATERIALS AND METHODS:Eligible studies were identified by 2 reviewers using PubMed, Embase, and Web of Science databases. Outcomes included stone-free r...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000439140

    authors: Li T,Gao L,Chen P,Bu S,Cao D,Yang L,Wei Q

    更新日期:2016-01-01 00:00:00

  • Oxidative and antioxidative status in the testes of rats with acute epididymitis.

    abstract:INTRODUCTION:Epididymitis is an inflammation or infection of the epididymis, a convoluted duct that lies on the posterior surface of the testicle. Oxidative stress due to excessive production of reactive oxygen species in epididymitis, impaired antioxidant defense mechanisms, or both, precipitates a range of pathologie...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000092063

    authors: Kaya M,Boleken ME,Zeyrek F,Ozardali I,Kanmaz T,Erel O,Yücesan S

    更新日期:2006-01-01 00:00:00

  • Long-term acidification of urine in patients treated for infected renal stones.

    abstract::The effects of ammonium chloride, methenamine hippurate and ascorbic acid on urinary pH was studied in 14 normal subjects. A statistically significant reduction of urinary pH was recorded with ammonium chloride in daily doses of 1.5 and 3 g, but not with 2 g of methenamine hippurate or 1.8 g of ascorbic acid. Long-ter...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281732

    authors: Wall I,Tiselius HG

    更新日期:1990-01-01 00:00:00

  • Enhancement of the sensitivity of renal cell carcinoma cells to fas-mediated cytotoxicity and apoptosis by the selective cyclooxygenase-2 inhibitor JTE-522.

    abstract:BACKGROUND:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in syner...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000288243

    authors: Sato N,Mizutani Y,Li YN,Fujiwara J,Ishida H,Toiyama D,Abe K,Hayashi I,Nakanishi H,Kawauchi A,Miki T

    更新日期:2010-01-01 00:00:00

  • Determination of carcinoembryonic antigen in tissue, serum and urine in patients with transitional cell carcinoma of the urinary bladder.

    abstract::Carcinoembryonic antigen (CEA) is elevated in urine and/or serum of patients with transitional cell carcinoma (TCC) of the urinary bladder. A group of 26 patients with TCC of the urinary bladder were evaluated with regard to urine/serum CEA levels and CEA tissue content. CEA could be detected in normal, metaplastic an...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280875

    authors: Jakse G,Rauschmeier H,Rosmanith P,Hofstädter F

    更新日期:1983-01-01 00:00:00

  • [Progress in urolithiasis research. Report and comments on the Urolithiasis Symposium 1981, Bonn (author's transl)].

    abstract:EPIDEMIOLOGY:The annual incidence of urolithiasis in the population is at least 0.1%. In rural areas, there are remarkably less actual stone formers than in urban districts, and also vegetarians show less stone diseases. Calcium carbonate as a urinary calculus compound is not in the strict sense impossible, but often a...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280781

    authors: Asper R

    更新日期:1981-01-01 00:00:00