当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, AP-1-dependent pathway.

Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, AP-1-dependent pathway.

Abstract：

:Proliferation of tubular epithelial cells underlies the development of cystic lesions and the subsequent impairment of renal function after renal mass reduction. The effect of HMG CoA reductase inhibitors (HRI) on cell proliferation was investigated in rat renal proximal tubular epithelial cells in primary culture. Treatment of renal tubular epithelial cells with three different HRI reduced fetal calf serum (FCS)-induced [3H]-thymidine incorporation (IC50 values were 0.7 microM, 1.7 microM, and 1.6 microM for simvastatin, lovastatin, and compactin, respectively), and lovastatin blocked BrdUrd incorporation, as assessed by immunocytochemical studies. The proliferative effect of epidermal growth factor (EGF) was similarly abolished by lovastatin. The effect of lovastatin (1 microM) was prevented by 100 microM mevalonate, 5 microM farnesyl-pyrophosphate and 5 microM geranylgeranyl-pyrophosphate (in percent of control value, 31% vs. 102%, 60%, and 82%, respectively) while cholesterol and other products of the mevalonate pathway were inactive. Immunoblot analysis showed that lovastatin decreased membrane-bound p21ras and inhibited FCS-induced c-fos and c-jun protein expression. Furthermore, electrophoretic mobility shift assay demonstrated the functional impairement of AP-1 DNA binding activity in lovastatin-treated cells. In conclusion, these results demonstrate that HRI are antiproliferative in epithelial tubule cells and that this effect is exerted, at least in part, via inhibition of the p21ras-activated and AP-1 dependent mitogenic cascade.

journal_name

Kidney Int

journal_title

Kidney international

authors

Vrtovsnik F,Couette S,Prié D,Lallemand D,Friedlander G

doi

10.1038/ki.1997.423

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

1016-27

issue

4

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)60263-0

journal_volume

52

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Cystatin C is not a better estimator of GFR than plasma creatinine in the general population.

    abstract：:Accurate measurement of glomerular filtration rate (GFR) is complicated and costly; therefore, GFR is commonly estimated by assessing creatinine or cystatin C concentrations. Because estimates based on cystatin C predict cardiovascular disease better than creatinine, these estimates have been hypothesized to be superi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.321

    authors： Eriksen BO,Mathisen UD,Melsom T,Ingebretsen OC,Jenssen TG,Njølstad I,Solbu MD,Toft I

    更新日期：2010-12-01 00:00:00

  • Dense intramembranous deposit disease: new pathologic features.

    abstract：:The pathologic and clinical features of 16 patients with dense intramembranous deposit disease are described. By light microscopy nine patients had membranoproliferative glomerulonephritis, five had focal segmental necrotizing glomerulonephritis with segmental epithelial crescents, four of whom also had a prominent tu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1984.71

    authors： Sibley RK,Kim Y

    更新日期：1984-04-01 00:00:00

  • T-cell deficiency in immune complex glomerulonephritis.

    abstract：:Mice chronically infected with the virus of lymphocytic choriomeningitis (LCM) develop immune complex glomerulonephritis. Others have shown that adoptive immunization of these mice by the i.p. injection of syngeneic immune spleen cells terminates the chronic viral carrier state. The present studies were designed to de...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1977.49

    authors： Hoffsten PE,Villalobos R,Hill C,Klahr S

    更新日期：1977-05-01 00:00:00

  • Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication.

    abstract：BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00604.x

    authors： Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

    更新日期：1999-08-01 00:00:00

  • Identification of a monocyte phagocytic defect in a subpopulation of patients with nephritis.

    abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1983.105

    authors： Ooi YM,Ooi BS

    更新日期：1983-06-01 00:00:00

  • Vitamin D: a new hope for chronic kidney disease?

    abstract：:Vitamin D analogs may slow the progression of chronic kidney disease. Tan et al. report that paricalcitol has additive effects with an angiotensin-converting enzyme inhibitor (ACEI) in suppressing extracellular matrix expression, interstitial inflammation, and myofibroblast activation in obstructive nephropathy. Paric...

    journal_title：Kidney international

    pub_type： 评论,杂志文章,评审

    doi：10.1038/ki.2009.390

    authors： Li M,Batuman V

    更新日期：2009-12-01 00:00:00

  • Growth hormone receptor abundance in tibial growth plates of uremic rats: GH/IGF-I treatment.

    abstract：BACKGROUND:Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH or GH/IGF-I can partially restore linear growth. The molecular basis for decreased longitudinal growth is not known but may ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00141.x

    authors： Edmondson SR,Baker NL,Oh J,Kovacs G,Werther GA,Mehls O

    更新日期：2000-07-01 00:00:00

  • Predicting long-term kidney allograft outcomes: pitfalls and progress.

    abstract：:Early identification of kidney transplant recipients at risk of progressive allograft dysfunction may allow clinicians to provide closer monitoring and more aggressive risk factor modification. In this issue, Raynaud et al. presented a latent class model that clustered kidney transplant recipients into 8 risk categori...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2020.07.031

    authors： Dinh A,McCulloch CE,Ku E

    更新日期：2021-01-01 00:00:00

  • Podocyte foot process effacement as a diagnostic tool in focal segmental glomerulosclerosis.

    abstract：:Podocyte foot process effacement is characteristic of proteinuric renal diseases. In minimal change nephrotic syndrome (MCNS) foot processes are diffusely effaced whereas the extent of effacement varies in focal segmental glomerulosclerosis (FSGS). Here we measured foot process effacement in FSGS and compared it to th...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.413

    authors： Deegens JK,Dijkman HB,Borm GF,Steenbergen EJ,van den Berg JG,Weening JJ,Wetzels JF

    更新日期：2008-12-01 00:00:00

  • Demographics of blood pressure and hypertension in children on renal replacement therapy in Europe.

    abstract：:Hypertension is a well-known complication in children on renal replacement therapy and an important risk factor for cardiovascular disease in later life. In order to define the prevalence of and risk factors for hypertension among children, we enrolled 3337 pediatric patients from 15 countries in the ESPN/ERA-EDTA Reg...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1038/ki.2011.232

    authors： Kramer AM,van Stralen KJ,Jager KJ,Schaefer F,Verrina E,Seeman T,Lewis MA,Boehm M,Simonetti GD,Novljan G,Groothoff JW

    更新日期：2011-11-01 00:00:00

  • Idiopathic membranous nephropathy: the natural history of untreated patients.

    abstract：:We reviewed the diagnostic features and clinical course of 140 patients with idiopathic membranous nephropathy who had their index renal biopsies performed at the Mayo Clinic between 1972 and 1984. There were 93 males and 47 females (average age, 50.8 +/- 17 years); 116 patients (83%) had the nephrotic syndrome and 42...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.56

    authors： Donadio JV Jr,Torres VE,Velosa JA,Wagoner RD,Holley KE,Okamura M,Ilstrup DM,Chu CP

    更新日期：1988-03-01 00:00:00

  • Effect of antibody charge and concentration on deposition of antibody to glomerular basement membrane.

    abstract：:Fixed anionic sites within the glomerular capillary wall influence the permeation of serum proteins, the localization of various antigens, and the deposition of antibody in the subepithelial space. In anti-GBM nephritis antibody deposition occurs very rapidly to antigenic sites located relatively proximal in the glome...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1984.188

    authors： Madaio MP,Salant DJ,Adler S,Darby C,Couser WG

    更新日期：1984-10-01 00:00:00

  • Diverse diuretics regimens differentially enhance the antialbuminuric effect of renin-angiotensin blockers in patients with chronic kidney disease.

    abstract：:The addition of spironolactone or hydrochlorothiazide enhances the antialbuminuric effect of renin-angiotensin blockers. However, comparative studies on the effect of different diuretics are lacking. We conducted a prospective randomized crossover study to compare the effects of spironolactone (25 mg/day), hydrochloro...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.249

    authors： Morales E,Caro J,Gutierrez E,Sevillano A,Auñón P,Fernandez C,Praga M

    更新日期：2015-12-01 00:00:00

  • Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism.

    abstract：:We compared the effects of calcitriol and doxercalciferol, in combination with either calcium carbonate or sevelamer, on bone, mineral, and fibroblast growth factor-23 (FGF-23) metabolism in patients with secondary hyperparathyroidism. A total of 60 pediatric patients treated with peritoneal dialysis were randomized t...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ki.2010.352

    authors： Wesseling-Perry K,Pereira RC,Sahney S,Gales B,Wang HJ,Elashoff R,Jüppner H,Salusky IB

    更新日期：2011-01-01 00:00:00

  • Acute renal allograft rejection with intimal arteritis: histologic predictors of response to therapy and graft survival.

    abstract：BACKGROUND:Acute renal allograft rejection with intimal arteritis is designated by the widely used Banff 97 classification as type 2A or 2B depending on the extent of arteritis, without regard to interstitial inflammation or tubulitis. We examined whether the distinction between type 2A and 2B is relevant to short- and...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00254.x

    authors： Haas M,Kraus ES,Samaniego-Picota M,Racusen LC,Ni W,Eustace JA

    更新日期：2002-04-01 00:00:00

  • Progranulin protects against renal ischemia/reperfusion injury in mice.

    abstract：:Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory function of PGRN in rheumatoid arthritis encouraged us to examine the role of PGRN in acute kidney injury (AKI). We found that levels ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.403

    authors： Zhou M,Tang W,Fu Y,Xu X,Wang Z,Lu Y,Liu F,Yang X,Wei X,Zhang Y,Liu J,Geng X,Zhang C,Wan Q,Li N,Yi F

    更新日期：2015-05-01 00:00:00

  • Effect of fluvastatin on renal end points in the Assessment of Lescol in Renal Transplant (ALERT) trial.

    abstract：BACKGROUND:Hyperlipidemia is a risk factor for long-term renal transplant dysfunction, but no prospective clinical trials have investigated the effects of statin treatment on graft function in renal transplant recipients. The aim of the present study was to evaluate the effect of fluvastatin on long-term renal transpla...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1523-1755.2004.00919.x

    authors： Fellström B,Holdaas H,Jardine AG,Holme I,Nyberg G,Fauchald P,Grönhagen-Riska C,Madsen S,Neumayer HH,Cole E,Maes B,Ambühl P,Olsson AG,Hartmann A,Logan JO,Pedersen TR,Assessment of Lescol in Renal Transplantation Study Inve

    更新日期：2004-10-01 00:00:00

  • Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line.

    abstract：:The hormonal responsiveness profile of the cortical collecting duct varies from one species to another. To identify the hormones and agonists that modulate the functions of this tubule segment in the human species, we generated a cell line (HCD) immortalized by SV40 virus. The tubular origin of this cell line was asse...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.186

    authors： Prié D,Friedlander G,Coureau C,Vandewalle A,Cassingéna R,Ronco PM

    更新日期：1995-05-01 00:00:00

  • Production of hyaluronan by glomerular mesangial cells in response to fibronectin and platelet-derived growth factor.

    abstract：:The formation of the non-sulphated glycosaminoglycan hyaluronan by cells of the renal glomerulus in diabetes may contribute to altered matrix composition. We describe an increased production of hyaluronan from mesangial cell-enriched glomerular cores from diabetic animals, and further show that increased hyaluronan pr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.284

    authors： Dunlop ME,Clark S,Mahadevan P,Muggli E,Larkins RG

    更新日期：1996-07-01 00:00:00

  • Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury.

    abstract：:Innate lymphoid cells are a recently recognized group of immune cells with critical roles in tissue homeostasis and inflammation. Regulatory innate lymphoid cells are a newly identified subset of innate lymphoid cells, which play a suppressive role in the innate immune response, favoring the resolution of intestinal i...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2019.07.019

    authors： Cao Q,Wang R,Wang Y,Niu Z,Chen T,Wang C,Jin L,Huang Q,Li Q,Wang XM,Azmi F,Lee VWS,Wang YM,Zheng G,Alexander SI,Harris DCH

    更新日期：2020-01-01 00:00:00

  • FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis.

    abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis involves innate and adaptive immune cells in the induction of autoimmunity and in autoimmune effector responses. Most Fcγ receptors (FcγRs) activate immune cells, but FcγRIIB, found in humans and mice on B cells and innate cells, is an inhibitor...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.189

    authors： Ooi JD,Gan PY,Chen T,Eggenhuizen PJ,Chang J,Alikhan MA,Odobasic D,Holdsworth SR,Kitching AR

    更新日期：2014-12-01 00:00:00

  • Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel.

    abstract：BACKGROUND:Neointimal hyperplasia occurs commonly at the anastomoses of arteriovenous grafts for chronic hemodialysis, causing stenosis and occlusion. Antiproliferative drugs may be effective in inhibiting hyperplasia, but local drug delivery would be required to minimize systemic side effects. We examined the feasibil...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00985.x

    authors： Masaki T,Rathi R,Zentner G,Leypoldt JK,Mohammad SF,Burns GL,Li L,Zhuplatov S,Chirananthavat T,Kim SJ,Kern S,Holman J,Kim SW,Cheung AK

    更新日期：2004-11-01 00:00:00

  • Effect of acute potassium load on reabsorption in Henle's loop in chronic renal failure in the rat.

    abstract：:To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed and branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied before (period 1) and af...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.100

    authors： Milanes CL,Jamison RL

    更新日期：1985-06-01 00:00:00

  • Phosphate: despite advances in research, the benefits to patients remain limited.

    abstract：:Tremendous progress has been made over recent years in the understanding of the mechanisms regulating calcium, phosphorus, vitamin D, and parathyroid hormone homeostasis in the normal human body and in patients with different degrees of renal failure. In addition, some of these findings have been translated into clini...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.692

    authors： De Broe ME

    更新日期：2009-05-01 00:00:00

  • Renal involvement in von Hippel-Lindau disease.

    abstract：:Renal involvement in von Hippel-Lindau (VHL) disease has emerged as the most prevalent cause of death in this hereditary disorder. In a group of 43 VHL patients (23 unrelated families) with renal lesions we examined whether severity of renal disease is affected by parental inheritance and VHL subtype (1, without pheoc...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.395

    authors： Chauveau D,Duvic C,Chrétien Y,Paraf F,Droz D,Melki P,Hélénon O,Richard S,Grünfeld JP

    更新日期：1996-09-01 00:00:00

  • Clinical performance characteristics of hemodialysis graft monitoring.

    abstract：BACKGROUND:Regular monitoring of dialysis grafts is recommended, but the value of dialysis graft blood flow monitoring and venous pressures in predicting subsequent outcomes are controversial. METHODS:Over a period of one month, we performed simultaneous flow and venous pressure monitoring in 71 dialysis patients with...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.2001.060002762.x

    authors： McDougal G,Agarwal R

    更新日期：2001-08-01 00:00:00

  • Influence of pyruvate on ammonia metabolism by renal cortical mitochondria.

    abstract：:The effect of the tricarboxylic acid (TCA) cycle precursor, pyruvate, on glutamine metabolism by isolated renal cortical mitochondria was assessed by quantitating its key nitrogen and carbon metabolites. When mitochondria from normal rats were incubated at pH 7.4, pyruvate (2 mM) inhibited ammonia production by almost...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.166

    authors： Tannen RL,Kunin AS

    更新日期：1982-09-01 00:00:00

  • Glomerular expression of neuronal activity-regulated pentraxin precedes the development of anti-Thy-1-induced progressive glomerulosclerosis.

    abstract：:Although it is clear that genetic predispositions play a role in progressive glomerulosclerosis, identification of specific genes is difficult because of natural genetic heterogeneity among individuals. We have reported a differential susceptibility to progressive glomerulosclerosis after induction of experimental glo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5001757

    authors： Aben JA,Ijpelaar DH,Baelde H,Worley P,Noble N,Bruijn JA,de Heer E

    更新日期：2006-10-01 00:00:00

  • Gene delivery using human cord blood-derived CD34+cells into inflamed glomeruli in NOD/SCID mice.

    abstract：BACKGROUND:Bone marrow reconstitution using genetically-modified hematopoietic stem cells has been reported to confer resistance to inflammation and prevent renal injury in glomerulonephritis. Although this strategy has potentials for clinical use, taking hematopoietic stem cells from bone marrow is highly stressful fo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00046.x

    authors： Yokoo T,Ohashi T,Utsunomiya Y,Okamoto A,Suzuki T,Shen JS,Tanaka T,Kawamura T,Hosoya T

    更新日期：2003-07-01 00:00:00

  • Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.

    abstract：:Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the glomerular filtration rate. This study aimed to define the transporters involved in creatinine secretion, applying that knowledge to establish the mechanism for xe...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.66

    authors： Lepist EI,Zhang X,Hao J,Huang J,Kosaka A,Birkus G,Murray BP,Bannister R,Cihlar T,Huang Y,Ray AS

    更新日期：2014-08-01 00:00:00