Yield and mode of diagnosis of cervical intraepithelial neoplasia 3 or cancer among women with negative cervical cytology and positive high-risk human papillomavirus test results.

Abstract:

OBJECTIVE:In women with negative cervical cytology and positive high-risk human papillomavirus (HR-HPV) test results, we compared the risk of cervical intraepithelial neoplasia 3 (CIN 3) or cancer (CIN 3+) in women with previous abnormal cervical cytology, CIN, or HR-HPV with that in women without this history, and we determined their cumulative risk of CIN 3+. MATERIALS AND METHODS:We reviewed colposcopies for negative cytology and positive HR-HPV test results from 2007 to 2009 (colposcopy was done for previous abnormal cytology, HR-HPV, or CIN or if negative cytology and positive HR-HPV test results for 20-35 months). Women with negative cytology and positive HR-HPV test results in 2007 were reviewed to determine their cumulative risk of CIN 3+. RESULTS:Of the 513 women with colposcopy for negative cytology and positive HR-HPV test results, 367 had previous abnormal cytology, CIN, or HR-HPV greater than 35 months ago and 146 had negative cytology and positive HR-HPV test results for 20 to 35 months. Risk of CIN 3+ for women with negative cytology and positive HR-HPV test results with previous abnormal cytology, HR-HPV, or CIN who did not have previous colposcopy was 11.9% (8/67); for similar women with previous colposcopy, it was 2.7% (8/300); and for women with positive HR-HPV test result for 20 to 35 months, it was 7.5% (11/146). In 2007 to 2009, risk of CIN 3+ for women with cytology of atypical squamous cells of undetermined significance (ASC-US) with positive HR-HPV test result was 3.9% (60/1,540). Of the 1,726 women with negative cytology and positive HR-HPV test result in 2007, 381 (22.1%) were lost to follow-up. Of the 1,345 women with median follow-up of 44 months, 602 (44.8%) had 1 or 2 subsequent negative cytology and negative HR-HPV test results and 180 had subsequent positive HR-HPV test result without biopsy. Of the 563 women with biopsy, there were 711 evaluations. Invasive cancer was found in 4 and CIN 3 in 54 (cumulative CIN 3+ of 4.3%, 58/1,345). Half (29/58) of the cumulative CIN 3+ was diagnosed after subsequent abnormal cytology and positive HR-HPV test result. CONCLUSIONS:If referral to colposcopy of women with cervical cytology of ASC-US and positive HR-HPV test result (CIN 3+, 3.9%) is justified, referral to colposcopy of women with negative cytology and positive HR-HPV test results is justified if they have previous abnormal cervical cytology, CIN, or HR-HPV greater than 35 months ago but have not had previous colposcopy (CIN 3+=11.9%) or are persistently HR-HPV positive for 20 to 35 months (CIN 3+, 7.5%). The risk of CIN 3+ in women with previous abnormal cytology, CIN, or HR-HPV who have previous colposcopy (2.7%) is lower because these women have incident rather than prevalent CIN 3+.

journal_name

J Low Genit Tract Dis

authors

Pretorius RG,Belinson JL,Peterson P,Azizi F,Lo A

doi

10.1097/LGT.0b013e318281f182

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

430-9

issue

4

eissn

1089-2591

issn

1526-0976

journal_volume

17

pub_type

杂志文章
  • A Randomized Trial of Human Papillomavirus Self-Sampling as an Intervention to Promote Cervical Cancer Screening Among Women With HIV.

    abstract:OBJECTIVE:Women living with HIV experience higher risk of cervical cancer, but screening rates in the United States are lower than recommended. The purpose of this study was to examine whether an intervention using self-sampling of cervicovaginal cells for human papillomavirus (HPV) with results counseling would increa...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/LGT.0000000000000195

    authors: Murphy J,Mark H,Anderson J,Farley J,Allen J

    更新日期:2016-04-01 00:00:00

  • A rare case of ectopic adrenocorticotropic hormone syndrome in small cell carcinoma of the vagina: a case report.

    abstract:OBJECTIVE:To describe ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) to increase awareness of this condition when treating patients with gynecological small cell carcinoma (SmCC). MATERIALS AND METHODS:This is a review of a 61-year-old woman with primary vaginal SmCC and an atypical presentation of Cushing ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31815cda1e

    authors: Weberpals J,Djordjevic B,Khalifa M,Oza A

    更新日期:2008-04-01 00:00:00

  • ASCCP Colposcopy Standards: Role of Colposcopy, Benefits, Potential Harms, and Terminology for Colposcopic Practice.

    abstract:OBJECTIVES:The American Society for Colposcopy and Cervical Pathology Colposcopy Standards address the role of and approach to colposcopy and biopsy for cervical cancer prevention in the United States. Working Group 1 was tasked with defining the role of colposcopy, describing benefits and potential harms, and developi...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0000000000000338

    authors: Khan MJ,Werner CL,Darragh TM,Guido RS,Mathews C,Moscicki AB,Mitchell MM,Schiffman M,Wentzensen N,Massad LS,Mayeaux EJ Jr,Waxman AG,Conageski C,Einstein MH,Huh WK

    更新日期:2017-10-01 00:00:00

  • The accuracy of the Papanicolaou smear in the screening and diagnostic settings.

    abstract:OBJECTIVE:We evaluated the performance of the Papanicolaou smear in screening and diagnostic settings. STUDY DESIGN:We analyzed Papanicolaou smear results of 1,850 women recruited into a clinical trial to evaluate an emerging technology for the detection of cervical cancer. Screening and diagnosis groups were based on...

    journal_title:Journal of lower genital tract disease

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/LGT.0b013e31816b44bc

    authors: Cárdenas-Turanzas M,Follen M,Nogueras-Gonzalez GM,Benedet JL,Beck JR,Cantor SB

    更新日期:2008-10-01 00:00:00

  • Treatment of cervical intraepithelial neoplasia levels 2 and 3 with adapalene, a retinoid-related molecule.

    abstract:OBJECTIVES:This study examined dose scheduling, safety, and efficacy of adapalene in the treatment of CIN2 and CIN3. METHODS:Patients were instructed on insertion and removal of an adapalene delivery system. Treatment regimens of 4, 8, and 14 days were utilized. Biopsies were performed on day 90 to assess efficacy. Sa...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1046/j.1526-0976.2001.51007.x

    authors: DiSilvestro PA,DiSilvestro JM,Lernhardt W,Pfahl M,Mannel RS

    更新日期:2001-01-01 00:00:00

  • Fabric-based exocervical and endocervical biopsy in comparison with punch biopsy and sharp curettage.

    abstract:OBJECTIVES:Fabric-based endocervical and exocervical biopsy tools were compared with exocervical punch biopsy and sharp endocervical curettage. We compared the level of pain reported by the patient and the amount of bleeding rated by the physician relative to the type of biopsy used. MATERIALS AND METHODS:This was a 2...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/LGT.0b013e318234262d

    authors: Winter M,Cestero RM,Burg A,Felix JC,Han C,Raffo AM,Vasilev S

    更新日期:2012-04-01 00:00:00

  • Allergic Contact Dermatitis of the Anogenital Region in Men and Women.

    abstract:OBJECTIVES:Allergic contact dermatitis is an uncommon but important cause of skin disease in the anogenital region. Relevant allergens are described in women and less commonly in men. The aim of this study was to describe outcomes of patch testing in men and women presenting with anogenital dermatoses. MATERIALS AND M...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000516

    authors: Cheng HS,Fernández-Peñas P

    更新日期:2020-04-01 00:00:00

  • Papanicolaou smears showing atypical glandular cells of undetermined significance: a case series.

    abstract:BACKGROUND:The authors' objective was to determine retrospectively the methods used to follow up atypical glandular cells of undetermined significance (AGUS) on Papanicolaou smears and to evaluate the effectiveness of those methods. MATERIAL AND METHODS:The charts of all patients with AGUS smears obtained between Febr...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-199704000-00007

    authors: Landry MS,Julian TM

    更新日期:1997-04-01 00:00:00

  • Vaginal stenosis after toxic epidermal necrolysis.

    abstract::A 17-year-old adolescent girl developed severe toxic epidermal necrolysis after inhalation of methamphetamine. Recovery was complicated by vaginal synechiae and occlusion necessitating surgery. ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3181ddf5da

    authors: Rowan DM,Jones RW,Oakley A,de Silva H

    更新日期:2010-10-01 00:00:00

  • The Impact of Varying Numbers of Quadrivalent Human Papillomavirus Vaccine Doses on Anogenital Warts in the United States: A Database Study.

    abstract:OBJECTIVE:The aim of the study was to investigate the effects of 3 or less quadrivalent human papillomavirus (HPV) vaccine doses on anogenital warts in both males and females in the United States. MATERIALS AND METHODS:We conducted a retrospective database study that included males and females aged 9 to 26 years who r...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000401

    authors: Zeybek B,Lin YL,Kuo YF,Rodriguez AM

    更新日期:2018-07-01 00:00:00

  • Detection of bacterial vaginosis, Trichomonas vaginalis infection, and vaginal Candida infection: a comparative study of methods of extracting exudates, with and without a speculum, during pregnancy.

    abstract:PURPOSE:To compare the collection of vaginal exudates with and without the use of a speculum to diagnose vaginal infections. MATERIAL AND METHODS:We examined 45 patients with vaginal discharge. Two vaginal swabs were taken, one with and the other without a speculum. Both were examined by wet mount microscopy to detect...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/01.lgt.0000179859.29456.ba

    authors: Audisio T,Penacino M,Cannistraci R,Bertolotto P

    更新日期:2005-10-01 00:00:00

  • Clinical Characteristics and Treatment Response With Checkpoint Inhibitors in Malignant Melanoma of the Vulva and Vagina.

    abstract:OBJECTIVES:The aims of the study were to assess the clinical and histopathological characteristics of a comprehensive cohort of women with vulvovaginal melanoma (VVM) treated at our institution and to study the treatment response of checkpoint inhibitors in this patient cohort. MATERIALS AND METHODS:This is a retrospe...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000583

    authors: Wohlmuth C,Wohlmuth-Wieser I,Laframboise S

    更新日期:2020-11-24 00:00:00

  • Management of adenocarcinoma in situ of the uterine cervix: a comparison of loop electrosurgical excision procedure and cold knife conization.

    abstract:OBJECTIVE:This study aimed to compare loop electrosurgical excision procedure (LEEP) with cold knife conization (CKC) as therapeutic management procedures for women with adenocarcinoma in situ (ACIS) of the cervix. METHODS:We conducted a retrospective chart review of all patients who underwent a conization procedure w...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000055

    authors: Latif NA,Neubauer NL,Helenowski IB,Lurain JR

    更新日期:2015-04-01 00:00:00

  • Massive localized lymphedema of the vulva: report of a case and review of the literature.

    abstract:BACKGROUND:Massive localized lymphedema (MLL) is a recently described entity associated with obesity, most often on the thighs. It rarely occurs on the vulva, and it may pose diagnostic difficulty for both clinician and pathologist in this setting. CASE:An obese 55-year-old woman underwent excision of bilateral polypo...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0b013e31829cf432

    authors: Heller DS,Fitzhugh VA,Cracchiolo B,Barrett T Jr,Suidan RS

    更新日期:2014-04-01 00:00:00

  • Performance of the Affirm VP-III using residual vaginal discharge collected from the speculum to characterize vaginitis in symptomatic women.

    abstract:OBJECTIVE:To evaluate the ability of collecting the Affirm VP-III test sample using the residual vaginal discharge found on the speculum. METHODS AND METHODS:One hundred nine symptomatic women (≥18 y) participated in this study. During pelvic examination, vaginal fluid was collected onto 3 swabs for office-based diagn...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000025

    authors: Mulhem E,Boyanton BL Jr,Robinson-Dunn B,Ebert C,Dzebo R

    更新日期:2014-10-01 00:00:00

  • Vulvovaginal pyoderma gangrenosum secondary to rituximab therapy.

    abstract::Rituximab is being used increasingly for the treatment of B-cell malignancies and nonmalignant conditions. Pyoderma gangrenosum is a rare neutrophilic dermatosis, which can be either idiopathic or associated with underlying systemic inflammatory conditions. We present a series of 4 patients who presented with ulcerati...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000043

    authors: Dixit S,Selva-Nayagam P,Hamann I,Fischer G

    更新日期:2015-01-01 00:00:00

  • Efficacy of treatment of inflammatory cytologic abnormalities detected by papanicolaou smears: a pilot study.

    abstract:OBJECTIVE:To evaluate the efficacy of metronidazole versus no treatment for the empiric treatment of inflammatory cytologic changes. MATERIALS AND METHODS:Patients with inflammatory changes on Pap smear were serially assigned to receive no treatment or metronidazole by one of three regimens: 2 grams orally as a single...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1046/j.1526-0976.2001.005002082.x

    authors: Webb JC,Wharton GG,Hawley-Bowland C,Carlson JW

    更新日期:2001-04-01 00:00:00

  • Coverage and factors associated with cervical cancer screening: results from the AFRODITA study: a population-based survey in Spain.

    abstract:OBJECTIVE:To quantify the coverage and monitor the factors associated with opportunistic cervical cytological screening in Spain. MATERIALS AND METHODS:Population-based survey of selected women through the Access Panel technique representative of the general population. A total of 6,852 women (60%) replied to the ques...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3181599c16

    authors: Puig-Tintoré LM,Castellsagué X,Torné A,de Sanjosé S,Cortés J,Roura E,Méndez C,Bosch FX

    更新日期:2008-04-01 00:00:00

  • Cervical Cancer Screening of Adolescents Should Not Be Encouraged.

    abstract:OBJECTIVE:The study aims to assess the frequency of cytological abnormalities in adolescents and young women, to establish the optimum age to start screening. METHODS:A retrospective study of cervical cytology results were obtained from the data center at the Santa Casa Hospital of São Paulo between January 2006 and D...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000273

    authors: Henrique LQ,Campaner AB,dʼAvila FS

    更新日期:2017-01-01 00:00:00

  • Is colposcopy warranted in women with external anogenital warts?

    abstract::OBJECTIVES.: To determine the prevalence of cervical dysplasia, diagnosed cytologically (squamous intraepithelial lesion [SIL]) or histologically (cervical intraepithelial neoplasia [CIN]), in women with external anogenital warts, and to determine the discriminating risk factors between those with and without cervical...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200301000-00006

    authors: Li J,Rousseau MC,Franco EL,Ferenczy A

    更新日期:2003-01-01 00:00:00

  • Assessment of Anal Cancer Screening Tools in Detecting High-Grade Anal Squamous Intraepithelial Lesions in Women.

    abstract:OBJECTIVE:The aim of the study was to evaluate the validity of anal cytology against high-resolution anoscopy in the detection of anal high-grade squamous intraepithelial lesions (HSILs) among women in a clinical setting in Puerto Rico, alone and in combination with high-risk human papillomavirus (HR-HPV) typing. MATE...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000497

    authors: Ramos-Cartagena JM,Pérez CM,Guiot HM,Amaya-Ardilla CP,Tirado-Gómez M,Ortiz AP

    更新日期:2020-01-01 00:00:00

  • Preparing digitized cervigrams for colposcopy research and education: determination of optimal resolution and compression parameters.

    abstract:OBJECTIVE:Visual assessment of digitized cervigrams through the Internet needs to be optimized. The National Cancer Institute and National Library of Medicine are involved in a large effort to improve colposcopic assessment and, in preparation, are conducting methodologic research. MATERIALS AND METHODS:We selected 50...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/01.lgt.0000192696.93172.ae

    authors: Jeronimo J,Long R,Neve L,Ferris D,Noller K,Spitzer M,Mitra S,Guo J,Nutter B,Castle P,Herrero R,Rodriguez AC,Schiffman M

    更新日期:2006-01-01 00:00:00

  • The association of p16(INK4A) and fragile histidine triad gene expression and cervical lesions.

    abstract:OBJECTIVE:This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16 and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions. MATERIALS AND METHODS:Women seen at Pérola Byington Hospital, São Paulo, Brazil, with histologically confirmed ce...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31802efb9e

    authors: Longatto-Filho A,Etlinger D,Pereira SM,Kanamura CT,di Loreto C,Santos Gda C,Makabe S,Marques JA,Santoro CL,das Dores GB,Castelo A

    更新日期:2007-07-01 00:00:00

  • Interpretation of Nondiagnostic Vulvar Biopsies.

    abstract:OBJECTIVE:The aim of the study was to assess clinical and histopathologic characteristics of symptomatic women who underwent a nondiagnostic biopsy of the inner vulva. MATERIALS AND METHODS:Consecutive nondiagnostic biopsies from medial labia minora, posterior fourchette, and vestibule obtained from symptomatic women ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000366

    authors: Day T,Knight V,Dyall-Smith D,Dennerstein G,Pagano R,Tran H,Tan Y,Yap D,Weigner J,Scurry J

    更新日期:2018-01-01 00:00:00

  • Conservative treatment of microinvasive adenocarcinoma of uterine cervix: long-term follow-up.

    abstract:UNLABELLED:OBIECTIVE: This study aimed to evaluate the safety of conservative treatment in women desiring preservation of fertility with stage IA adenocarcinoma of the cervix. MATERIALS AND METHODS:Clinical report of all women with stage IA adenocarcinoma of the cervix, endocervical subtype, with clear margins on cone...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182446b3a

    authors: Sopracordevole F,Canzonieri V,Giorda G,De Piero G,Lucia E,Campagnutta E

    更新日期:2012-10-01 00:00:00

  • Molecular epidemiology of human papillomavirus infections in cervical samples from cuban women older than 30 years.

    abstract:OBJECTIVE:This study aimed to provide information about the molecular epidemiology of human papillomavirus (HPV) in a group of Cuban women. MATERIALS AND METHODS:DNA from cervical samples was analyzed using a quantitative real-time polymerase chain reaction (PCR), which detects 6 of the clinically most relevant high-r...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182a7bb89

    authors: Soto Y,Torres G,Kourí V,Limia CM,Goicolea A,Capó V,Pérez L,de la Torre AI,López LX,Govín A,Correa CB,Alemán Y,Alvarez AA,Manzano BR

    更新日期:2014-07-01 00:00:00

  • Recommendations and administration of the HPV vaccine to 11- to 12-year-old girls and boys: a statewide survey of Georgia vaccines for children provider practices.

    abstract:OBJECTIVE:This study explores the prevalence and provider- and practice-related correlates of physician recommendation and administration of the quadrivalent human papillomavirus (HPV) vaccine, Gardasil, to 11- to 12-year-old girls and the intention to recommend the HPV vaccine to 11- to 12-year-old boys in Georgia. Th...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000011

    authors: Luque JS,Tarasenko YN,Dixon BT,Vogel RL,Tedders SH

    更新日期:2014-10-01 00:00:00

  • Pagetoid spread of bladder urothelial carcinoma to the vagina and vulva.

    abstract:OBJECTIVE:To study the clinicopathologic features of a rare disease of pagetoid urothelial intraepithelial neoplasia (PUIN) in the vulva. MATERIALS AND METHODS:We reviewed a case of PUIN in a Chinese woman with a long history of bladder urothelial carcinoma. RESULTS:The patient presented with vulvar pruritus for more...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000020

    authors: Lu B,Liang Y

    更新日期:2015-01-01 00:00:00

  • Risk factors for progression or persistence of squamous intraepithelial lesions diagnosed during pregnancy.

    abstract:OBJECTIVE:This study aimed to assess the risk of progression/persistence of squamous intraepithelial lesions (SILs) during pregnancy according to the age of the woman, the grade of the lesion, the type of human papillomavirus (HPV) infection, and the mode of delivery. MATERIALS AND METHODS:Eighty pregnant women with a...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31822e83cf

    authors: Cubo-Abert M,Centeno-Mediavilla C,Franco-Zabala P,Merced-Vázquez C,Castellví J,García A,Gil-Moreno A,Xercavins J

    更新日期:2012-01-01 00:00:00

  • Biopsy site selection during colposcopy and distribution of cervical intraepithelial neoplasia.

    abstract:OBJECTIVE:To determine if sites selected for colposcopic biopsy and histologically proven cervical intraepithelial neoplasia are distributed randomly across the cervix. MATERIALS AND METHODS:Data were evaluated from all patients who visited the Walter Reed Army Medical Center Colposcopy Clinic during a 20-month period...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200501000-00008

    authors: Allard JE,Rodriguez M,Rocca M,Parker MF

    更新日期:2005-01-01 00:00:00