The absence of human papillomavirus in amniotic fluid.

Abstract:

OBJECTIVES:The objective of this multicenter trial was to determine the incidence of human papillomavirus (HPV) in the amniotic fluid of pregnant patients. METHODS:Fifty-three pregnant patients undergoing genetic counseling or amniocentesis for preterm labor were entered into the study. Cervical swabs and amniotic fluid samples were ob-tained at the time of entry. Demographical questionnaires were completed by all patients. All samples underwent HPV analysis using polymerase chain reaction. RESULTS:The incidence of cervical HPV and cervical intraepithelial neoplasia in this population was 24% and 4%, respectively. The analysis of 49 amniotic fluid samples revealed the absence of HPV in each specimen. CONCLUSIONS:The absence of HPV in the amniotic fluid of patients with cervical colonization does not support a mechanism of prenatal transmission in the general population.

journal_name

J Low Genit Tract Dis

authors

Maxwell GL,Carlson J,Zakarean M,Veit B,Hoshaw N

doi

10.1097/00128360-199807000-00008

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

151-4

issue

3

eissn

1089-2591

issn

1526-0976

pii

00128360-199807000-00008

journal_volume

2

pub_type

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