Chronic vulvar fissure--a rare manifestation of mycosis fungoides.

Abstract:

BACKGROUND:Vulvar fissures are a common cause of vulvar pain and discomfort. The differential diagnosis of the underlying process is broad, and some cases remain undiagnosed. Mycosis fungoides, the dominant component of cutaneous T-cell lymphoma, rarely present as fissures. We report a case of a chronic vulvar fissure due to mycosis fungoides. CASE:A 55-year-old woman was referred to the vaginitis clinic for evaluation of a chronic vulvar fissure, 6 cm in length, located at the left interlabial sulcus. A detailed history and examination for other skin lesions revealed an erythematous pruritic patch on left breast that had been present for years. Repeat biopsies from both sites showed a dense dermal lymphocytic infiltrate composed predominantly of CD3- and CD4-positive T cell with minimal epidermotropism. A T-gamma polymerase chain reaction analysis demonstrated a clonal T-cell rearrangement. Based on a diagnostic algorithm that combines clinical features, histopathology, and molecular biology, a diagnosis of mycosis fungoides was confirmed. CONCLUSIONS:Patients presenting with vulvar lesions should always be suspected of having an underlying dermatosis, and a detailed examination for other skin lesions should be performed. In the presented case, once both skin lesions were linked clinically, repeat biopsies of both sites led to a confirmed diagnosis of mycosis fungoides.

journal_name

J Low Genit Tract Dis

authors

Reichman O,Sobel JD,Bentley G

doi

10.1097/LGT.0b013e31819d09ad

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

65-7

issue

1

eissn

1089-2591

issn

1526-0976

pii

00128360-201001000-00012

journal_volume

14

pub_type

杂志文章
  • Telomerase activity as a potential diagnostic marker for triage of abnormal Pap smears.

    abstract:OBJECTIVES:To determine whether there is an association between high levels of telomerase and premalignant cervical disease and to provide a preliminary analysis of telomerase activity as a potential triage strategy. MATERIALS AND METHODS:Premenopausal women were invited to participate in the study during routine gyne...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200504000-00005

    authors: Ault KA,Allen HK,Phillips SL,Zimmerman MB,Klingelhutz AJ

    更新日期:2005-04-01 00:00:00

  • The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology.

    abstract::The terminology for human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0b013e31825c31dd

    authors: Darragh TM,Colgan TJ,Cox JT,Heller DS,Henry MR,Luff RD,McCalmont T,Nayar R,Palefsky JM,Stoler MH,Wilkinson EJ,Zaino RJ,Wilbur DC,Members of LAST Project Work Groups.

    更新日期:2012-07-01 00:00:00

  • The accuracy of the Papanicolaou smear in the screening and diagnostic settings.

    abstract:OBJECTIVE:We evaluated the performance of the Papanicolaou smear in screening and diagnostic settings. STUDY DESIGN:We analyzed Papanicolaou smear results of 1,850 women recruited into a clinical trial to evaluate an emerging technology for the detection of cervical cancer. Screening and diagnosis groups were based on...

    journal_title:Journal of lower genital tract disease

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/LGT.0b013e31816b44bc

    authors: Cárdenas-Turanzas M,Follen M,Nogueras-Gonzalez GM,Benedet JL,Beck JR,Cantor SB

    更新日期:2008-10-01 00:00:00

  • High Rates of High-Grade Cervical Dysplasia in High-Risk Young Women With Low-Grade Cervical Cytology.

    abstract:OBJECTIVE:The aim of the study was to determine rates of cervical intraepithelial neoplasia (CIN) 2 or greater in high-risk, racially diverse, young women with low-grade cytology. MATERIALS AND METHODS:After institutional review board approval, a cross-sectional study of 21- to 24-year-old women with low-grade cytolog...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000381

    authors: Daily LR,Erickson BK,Pasko DN,Straughn JM Jr,Huh WK,Leath CA 3rd

    更新日期:2018-07-01 00:00:00

  • Systematic Review of Treatment Outcome Measures for Vulvodynia.

    abstract:OBJECTIVES OF THE STUDY:To systematically evaluate the literature regarding vulvodynia treatment outcome measures. METHODS:A systematic literature search on OVID, PubMed, and PsycINFO databases was conducted from inception until May 2016. Studies were included/excluded based on prespecified criteria. Reported outcome ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,评审

    doi:10.1097/LGT.0000000000000406

    authors: Sadownik LA,Yong PJ,Smith KB

    更新日期:2018-07-01 00:00:00

  • Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review.

    abstract:OBJECTIVE:The aim of the study was to examine whether high-grade cervical intraepithelial neoplasia (CIN) was more closely associated with human papillomavirus (HPV) same-genotype persistence (SGTP) versus clearance of prior infection with a subsequent infection by a new genotype (genotype switch [GS]), clearance of HP...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000573

    authors: Bonde J,Bottari F,Iacobone AD,Cocuzza CE,Sandri MT,Bogliatto F,Khan KS,Ejegod DM,Gary DS,Andrews JC

    更新日期:2021-01-01 00:00:00

  • Emphysematous vaginitis.

    abstract:BACKGROUND:Emphysematous vaginitis is a rare condition, characterized by the presence of multiple gas-filled cysts in the vaginal and/or exocervical mucosa. Although its etiology is not completely understood, it is self-limited, with a benign clinical course. Vaginal discharge, sometimes bloody, and pruritus are the mo...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000092

    authors: Lima-Silva J,Vieira-Baptista P,Cavaco-Gomes J,Maia T,Beires J

    更新日期:2015-04-01 00:00:00

  • Direct visual inspection of the cervix with Lugol iodine for the detection of premalignant lesions.

    abstract:OBJECTIVE:To evaluate the feasibility and efficiency of direct visual inspection after Lugol iodine painting in detecting cervical premalignant and malignant lesions. MATERIALS AND METHODS:This study included 1,012 women recruited from gynecology outpatient clinic screened for premalignant or malignant lesions of the ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31815f527c

    authors: El-Shalakany AH,Saeed MM,Abdel-Aal MR,El-Nakeeb AH,Noseirat N,Ayyad SB,El Din ZS

    更新日期:2008-07-01 00:00:00

  • Human papillomavirus prevalence in invasive anal cancers in the United States before vaccine introduction.

    abstract:OBJECTIVE:This study aimed to conduct a representative survey of human papillomavirus (HPV) prevalence and its genotype distribution in invasive anal cancer specimens in the United States. MATERIALS AND METHODS:Population-based archival anal cancer specimens were identified from Florida, Kentucky, Louisiana, and Michi...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31827ed372

    authors: Steinau M,Unger ER,Hernandez BY,Goodman MT,Copeland G,Hopenhayn C,Cozen W,Saber MS,Huang Y,Peters ES,Lynch CF,Wilkinson EJ,Rajeevan MS,Lyu C,Saraiya M

    更新日期:2013-10-01 00:00:00

  • High-risk HPV infection and CIN grade correlates to the expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a.

    abstract:OBJECTIVE:: This study aimed to investigate correlations between a panel of biomarkers/tumor markers and high-risk (HR) human papillomavirus (HPV)-positive versus HR-HPV-negative cervical lesions. MATERIALS AND METHODS:: The study included 188 women who consecutively attended a colposcopy clinic because of PAP smears ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e318215170c

    authors: Samir R,Asplund A,Tot T,Pekar G,Hellberg D

    更新日期:2011-10-01 00:00:00

  • Unusual locations of primary subepithelial squamous cell carcinomas of the vulva.

    abstract:OBJECTIVE:This study aimed to report 2 cases of squamous cell carcinoma (SCC) of the vulva, arising from unusual subepithelial locations. MATERIALS AND METHODS:The first case was of an 85-year-old woman with a 65-year history of a mass in the left labium majus. The second case was of a 54-year-old woman who presented ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31827a8c95

    authors: Scurry JP,Yu TT,Otton GR

    更新日期:2013-10-01 00:00:00

  • Performance of the Affirm VP-III using residual vaginal discharge collected from the speculum to characterize vaginitis in symptomatic women.

    abstract:OBJECTIVE:To evaluate the ability of collecting the Affirm VP-III test sample using the residual vaginal discharge found on the speculum. METHODS AND METHODS:One hundred nine symptomatic women (≥18 y) participated in this study. During pelvic examination, vaginal fluid was collected onto 3 swabs for office-based diagn...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000025

    authors: Mulhem E,Boyanton BL Jr,Robinson-Dunn B,Ebert C,Dzebo R

    更新日期:2014-10-01 00:00:00

  • Use of Smartphones as Adjuvant Tools for Cervical Cancer Screening in Low-Resource Settings.

    abstract:OBJECTIVES:Our aim was to evaluate the feasibility and performance of smartphone digital images for the detection of cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) as an adjunct to a conventional visual inspection approach with acetic acid (VIA) and Lugol's iodine (VILI), in comparison with detection by...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000136

    authors: Ricard-Gauthier D,Wisniak A,Catarino R,van Rossum AF,Meyer-Hamme U,Negulescu R,Scaringella S,Jinoro J,Vassilakos P,Petignat P

    更新日期:2015-10-01 00:00:00

  • Post-Loop Electrosurgical Excision Procedure High-Risk Human Papillomavirus Testing as a Test of Cure: The British Columbia Experience.

    abstract:OBJECTIVES:To determine whether Hybrid Capture 2 High-Risk HPV DNA Test (HC2) can be used as a test of cure in women treated for cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) and allow discharge from colposcopy follow-up with a return to a cytology-based screening program for HC2-negative women. MATERIA...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000349

    authors: Ceballos KM,Lee M,Cook DA,Smith LW,Gondara L,Krajden M,van Niekerk DJ,Coldman AJ

    更新日期:2017-10-01 00:00:00

  • Molecular epidemiology of human papillomavirus infections in cervical samples from cuban women older than 30 years.

    abstract:OBJECTIVE:This study aimed to provide information about the molecular epidemiology of human papillomavirus (HPV) in a group of Cuban women. MATERIALS AND METHODS:DNA from cervical samples was analyzed using a quantitative real-time polymerase chain reaction (PCR), which detects 6 of the clinically most relevant high-r...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182a7bb89

    authors: Soto Y,Torres G,Kourí V,Limia CM,Goicolea A,Capó V,Pérez L,de la Torre AI,López LX,Govín A,Correa CB,Alemán Y,Alvarez AA,Manzano BR

    更新日期:2014-07-01 00:00:00

  • Chronic granulomatous inflammation of the vulva: an unusual presentation with diagnostic and therapeutic difficulties.

    abstract::Inflammation of the vulva can present as a manifestation of a localized problem or as part of a systemic disorder. Granulomatous vulvitis is a rare inflammatory condition that has histologic similarities to Crohn disease. Clinically, it presents with painless, chronic relapsing erythema, and edema, typically affecting...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e318216aaac

    authors: Ghosh D,Woodrow S,Mathew J,Lopes A,Das N

    更新日期:2011-10-01 00:00:00

  • History of Abuse in Women With Vulvar Pruritus, Vulvodynia, and Asymptomatic Controls.

    abstract:OBJECTIVE:Chronic vulvar pruritus and vulvodynia are common vulvar diseases. The aim of this study was to compare gynecologic and sexual and physical abuse histories from patients with these diagnoses and from healthy controls. MATERIALS AND METHODS:Questionnaires were self-completed by patients diagnosed with vulvar ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000075

    authors: Cohen-Sacher B,Haefner HK,Dalton VK,Berger MB

    更新日期:2015-07-01 00:00:00

  • Fabric-based exocervical and endocervical biopsy in comparison with punch biopsy and sharp curettage.

    abstract:OBJECTIVES:Fabric-based endocervical and exocervical biopsy tools were compared with exocervical punch biopsy and sharp endocervical curettage. We compared the level of pain reported by the patient and the amount of bleeding rated by the physician relative to the type of biopsy used. MATERIALS AND METHODS:This was a 2...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/LGT.0b013e318234262d

    authors: Winter M,Cestero RM,Burg A,Felix JC,Han C,Raffo AM,Vasilev S

    更新日期:2012-04-01 00:00:00

  • Adherence to Management Recommendations in Patients Diagnosed With Cervical Intraepithelial Neoplasia 2 or 3.

    abstract:OBJECTIVE:The aim of the study was to evaluate the rate of patient adherence to provider recommendations for biopsy proven cervical intraepithelial neoplasia (CIN) 2 or 3 in an academic safety-net hospital. MATERIALS AND METHODS:This is a case series of patients with biopsy-proven CIN 2 or 3 identified via pathology r...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000148

    authors: Alston MJ,Scaparotti AC,Krull MB,Mazzoni SE

    更新日期:2016-01-01 00:00:00

  • Risk factors for progression or persistence of squamous intraepithelial lesions diagnosed during pregnancy.

    abstract:OBJECTIVE:This study aimed to assess the risk of progression/persistence of squamous intraepithelial lesions (SILs) during pregnancy according to the age of the woman, the grade of the lesion, the type of human papillomavirus (HPV) infection, and the mode of delivery. MATERIALS AND METHODS:Eighty pregnant women with a...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e31822e83cf

    authors: Cubo-Abert M,Centeno-Mediavilla C,Franco-Zabala P,Merced-Vázquez C,Castellví J,García A,Gil-Moreno A,Xercavins J

    更新日期:2012-01-01 00:00:00

  • Spray Versus Forced Coagulation in Large Loop Excision of the Transformation Zone: A Randomized Trial.

    abstract:OBJECTIVE:Large loop excision of the transformation zone (LLETZ) is the standard surgical treatment for cervical dysplasia. The optimal way to achieve local hemostasis in women undergoing LLETZ is unknown. MATERIALS AND METHODS:In a prospective, randomized trial, we compared spray coagulation and forced coagulation in...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/LGT.0000000000000177

    authors: Hilal Z,Mavrommati G,Foerster C,Rezniczek GA,Hefler LA,Tempfer CB

    更新日期:2016-04-01 00:00:00

  • Cavernous hemangioma of the cervix: a rare cause of vaginal bleeding.

    abstract::Cavernous hemangiomas of the cervix are extremely rare, benign lesions. To date, fewer than 50 cases have been reported. Here reported is a case of cavernous hemangioma of the cervix in a 53-year-old patient with the complaint of postcoital spotting. Most of these lesions are asymptomatic incidental findings, but some...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/01.lgt.0000210120.78145.b8

    authors: Ozyer S,Uzunlar O,Gocmen M,Bal S,Srvan L,Mollamahmutoğlu L

    更新日期:2006-04-01 00:00:00

  • Abnormal pap tests and human papillomavirus infections among HIV-infected and uninfected women who have sex with women.

    abstract:OBJECTIVE:To estimate the frequency of abnormal Pap and human papillomavirus (HPV) positivity among human immunodeficiency virus (HIV)-seropositive and -seronegative women who have sex with women (WSW). METHODS:Pap and HPV DNA polymerase chain reaction tests were obtained every 6 months from women in a US cohort of HI...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/LGT.0b013e3182942733

    authors: Massad LS,Xie X,Minkoff H,Darragh TM,D'Souza G,Sanchez-Keeland L,Watts DH,Colie C,Strickler HD

    更新日期:2014-01-01 00:00:00

  • Non-albicans Candida Vulvovaginitis: Treatment Experience at a Tertiary Care Vaginitis Center.

    abstract:OBJECTIVES:The aims of this study are to analyze a cohort of women with vulvovaginal symptoms and positive cultures for non-albicans Candida (NAC) to determine whether yeast was responsible for their symptoms and to evaluate the mycological effectiveness of various regimens. METHODS:This observational study was perfor...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000126

    authors: Powell AM,Gracely E,Nyirjesy P

    更新日期:2016-01-01 00:00:00

  • Vaginal stenosis after toxic epidermal necrolysis.

    abstract::A 17-year-old adolescent girl developed severe toxic epidermal necrolysis after inhalation of methamphetamine. Recovery was complicated by vaginal synechiae and occlusion necessitating surgery. ...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3181ddf5da

    authors: Rowan DM,Jones RW,Oakley A,de Silva H

    更新日期:2010-10-01 00:00:00

  • Histologic and colposcopic correlates of ASCUS pap smears in pregnancy.

    abstract:OBJECTIVE:A historic cohort analysis was performed to assess the colposcopic and histologic correlates of atypical squamous cells of undetermined significance (ASCUS) Pap smears in pregnant and nonpregnant women. MATERIALS AND METHODS:A chart review of all gynecologic and obstetric patients seen in the outpatient clin...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/00128360-200204000-00008

    authors: Broderick D,Matityahu D,Dudhbhai M,Alter S

    更新日期:2002-04-01 00:00:00

  • Cervical Screening Practices and Outcomes for Young Women in Response to Changed Guidelines in Calgary, Canada, 2007-2016.

    abstract:OBJECTIVE:The aim of the study was to describe temporal trends in screening and outcomes for women, after changes in guidelines in Alberta, Canada, that raised starting age to 21 years, then to 25 years of age, and reduced frequency to 3 yearly. MATERIALS AND METHODS:Calgary Laboratory Information System data were use...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000574

    authors: Sayed SA,Naugler C,Chen G,Dickinson JA

    更新日期:2021-01-01 00:00:00

  • Acceptability of Women Self-Sampling versus Clinician-Collected Samples for HPV DNA Testing: A Systematic Review.

    abstract:OBJECTIVES:Female self-sampling for human papillomavirus (HPV) DNA testing is an alternative screening method that can potentially increase cervical cancer screening coverage. This review addresses the acceptability of HPV DNA testing using self-sampling compared with conventional clinician-collected sampling. Barriers...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0000000000000476

    authors: Morgan K,Azzani M,Khaing SL,Wong YL,Su TT

    更新日期:2019-07-01 00:00:00

  • Conservative treatment of microinvasive adenocarcinoma of uterine cervix: long-term follow-up.

    abstract:UNLABELLED:OBIECTIVE: This study aimed to evaluate the safety of conservative treatment in women desiring preservation of fertility with stage IA adenocarcinoma of the cervix. MATERIALS AND METHODS:Clinical report of all women with stage IA adenocarcinoma of the cervix, endocervical subtype, with clear margins on cone...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3182446b3a

    authors: Sopracordevole F,Canzonieri V,Giorda G,De Piero G,Lucia E,Campagnutta E

    更新日期:2012-10-01 00:00:00

  • eC3--a modern telecommunications matrix for cervical cancer prevention in Zambia.

    abstract:OBJECTIVES:Low physician density, undercapacitated laboratory infrastructures, and limited resources are major limitations to the development and implementation of widely accessible cervical cancer prevention programs in sub-Saharan Africa. MATERIALS AND METHODS:We developed a system operated by nonphysician health pr...

    journal_title:Journal of lower genital tract disease

    pub_type: 杂志文章

    doi:10.1097/LGT.0b013e3181cd6d5e

    authors: Parham GP,Mwanahamuntu MH,Pfaendler KS,Sahasrabuddhe VV,Myung D,Mkumba G,Kapambwe S,Mwanza B,Chibwesha C,Hicks ML,Stringer JS

    更新日期:2010-07-01 00:00:00