Androgen receptor transcript level in benign hypertrophy and carcinoma of the human prostate.

Abstract:

OBJECTIVE:Current reports suggest the presence of androgen receptor (AR) defects in prostate cancer. We have detected the AR mRNA in normal, benign hypertrophied (BPH) and carcinomatous (CaP) prostate tissues and evaluated the difference in the level of AR transcript in these groups. MATERIALS AND METHODS:Cytoplasmic dot hybridization assay was used to measure the levels of AR mRNA in 21 normal, 45 BPH and 30 CaP specimens. Tissue samples of 14 CaP patients receiving endocrine treatment were also analyzed. Blots were autoradiographed and the intensity of the signal was measured by densitometry. RESULTS AND CONCLUSIONS:The majority of cases in all the 3 groups were positive for the AR mRNA. All the patients who had received endocrine treatment were also positive for the AR mRNA. The level of the AR mRNA was significantly higher in BPH and treated CaP cases as compared to normal cases (p < 0.05). Among the CaP cases the level of AR transcript was significantly higher in the treated group as compared to the untreated group.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Majumder PK,Wadhwa SN,Kumar VL

doi

10.1159/000283069

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

231-5

issue

4

eissn

0042-1138

issn

1423-0399

journal_volume

59

pub_type

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