Neural modulation of gut motility by myomodulin peptides and acetylcholine in the snail Lymnaea.

Abstract:

:Families of peptide neuromodulators are believed to play important roles in neural networks that control behaviors. Here, we investigate the expression and role of one such group of modulators, the myomodulins, in the feeding system of Lymnaea stagnalis. Using a combination of in situ hybridization and antibody staining, expression of the myomodulin gene was confirmed in a number of identified behaviorally significant neuronal types, including the paired B2 motor neurons. The B2 cells were shown to project axons to the proesophagus, where they modulate foregut contractile activity. The presence of the five myomodulin peptide structures was confirmed in the B2 cells, the proesophagus, and the intervening nerve by mass spectrometry. Using a sensitive cell culture assay, evidence that the B2 cells are cholinergic also is presented. Application of four of the five myomodulin peptides to the isolated foregut increased both contraction frequency and tonus, whereas the main effect of acetylcholine (ACh) application was a large tonal contraction. The fifth myomodulin peptide (pQIPMLRLamide) appeared to have little or no effect on gut motility. Coapplication of all five myomodulin peptides gave a greater increase in tonus than that produced by the peptides applied individually, suggesting that corelease of the peptides onto the gut would produce an enhanced response. The combined effects that the myomodulin peptides and ACh have on foregut motility can mimic the main actions of B2 cell stimulation.

journal_name

J Neurophysiol

authors

Perry SJ,Straub VA,Kemenes G,Santama N,Worster BM,Burke JF,Benjamin PR

doi

10.1152/jn.1998.79.5.2460

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

2460-74

issue

5

eissn

0022-3077

issn

1522-1598

journal_volume

79

pub_type

杂志文章
  • Choice ball: a response interface for two-choice psychometric discrimination in head-fixed mice.

    abstract::The mouse is an important model system for investigating the neural circuits mediating behavior. Because of advances in imaging and optogenetic methods, head-fixed mouse preparations provide an unparalleled opportunity to observe and control neural circuits. To investigate how neural circuits produce behavior, these m...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00669.2012

    authors: Sanders JI,Kepecs A

    更新日期:2012-12-01 00:00:00

  • L-glutamic acid, a possible neurotransmitter to anterior aorta of Aplysia.

    abstract::The effect of L-glutamate on muscle fibers of the anterior aorta of the marine gastropod Aplysia are characterized. Iontophoretically applied L-glutamate depolarized anterior aorta muscle fibers in 14% of the applications; no response was detected in the other applications. Responses to iontophoretically applied L-glu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1984.51.2.375

    authors: Sawada M,Gibson D,McAdoo DJ

    更新日期:1984-02-01 00:00:00

  • A quantitative study of neuronal discharge in areas 5, 2, and 4 of the monkey during fast arm movements.

    abstract::1. The properties of parietal neurons were studied in four adult rhesus monkeys during fast arm movements. The animals were trained to perform flexion or extension of the forearm about the elbow in response to specific auditory cues. Single neuron activity was recorded in 272 area 5 neurons, 81 neurons of the somatose...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.2.429

    authors: Burbaud P,Doegle C,Gross C,Bioulac B

    更新日期:1991-08-01 00:00:00

  • Two-Photon Processor and SeNeCA: a freely available software package to process data from two-photon calcium imaging at speeds down to several milliseconds per frame.

    abstract::Two-Photon Processor (TPP) is a versatile, ready-to-use, and freely available software package in MATLAB to process data from in vivo two-photon calcium imaging. TPP includes routines to search for cell bodies in full-frame (Search for Neural Cells Accelerated; SeNeCA) and line-scan acquisition, routines for calcium s...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00087.2013

    authors: Tomek J,Novak O,Syka J

    更新日期:2013-07-01 00:00:00

  • Forebrain pathway for auditory space processing in the barn owl.

    abstract::The forebrain plays an important role in many aspects of sound localization behavior. Yet, the forebrain pathway that processes auditory spatial information is not known for any species. Using standard anatomic labeling techniques, we used a "top-down" approach to trace the flow of auditory spatial information from an...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.2.891

    authors: Cohen YE,Miller GL,Knudsen EI

    更新日期:1998-02-01 00:00:00

  • Initiation of saccades during fixation or pursuit: evidence in humans for a single mechanism.

    abstract::1. In four human subjects, we measured the latency of saccadic eye movements made to a second, eccentric target after an initial, foveated target was extinguished. In separate interleaved trails, the targets were either both stationary ("fixation") or both moving with the same velocity ("pursuit"). For both fixation a...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1152/jn.1996.76.6.4175

    authors: Krauzlis RJ,Miles FA

    更新日期:1996-12-01 00:00:00

  • Submodality distribution in sensorimotor cortex of the unanesthetized monkey.

    abstract::1. Neuronal responses to cutaneous and noncutaneous stimulation were examined in the hindlimb representation of the precentral motor cortex (MI) and the first somatosensory cortex (SI) of unanesthetized monkeys. 2. MI can be divided into two distinct parts of the basis of its afferent input. The rostral part receives ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1981.45.3.467

    authors: Tanji J,Wise SP

    更新日期:1981-03-01 00:00:00

  • Visual feedback during pedaling allows individuals poststroke to alter inappropriately prolonged paretic vastus medialis activity.

    abstract::Individuals who have experienced a stroke often demonstrate inappropriate muscle activity phasing in the paretic leg during locomotion. Past research has demonstrated that inappropriate paretic phasing varies between behavioral contexts and is reduced during unilateral pedaling with the nonparetic leg inactive. We inv...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00256.2017

    authors: Mullens CH,Brown DA

    更新日期:2018-06-01 00:00:00

  • Computer model for action potential propagation through branch point in myelinated nerves.

    abstract::A mathematical model is developed for simulation of action potential propagation through a single branch point of a myelinated nerve fiber with a parent branch bifurcating into two identical daughter branches. This model is based on a previously published multi-layer compartmental model for single unbranched myelinate...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2001.85.1.197

    authors: Zhou L,Chiu SY

    更新日期:2001-01-01 00:00:00

  • Effects of anoxia on rat midbrain dopamine neurons.

    abstract::1. Dopamine-containing neurons of the rat midbrain were recorded intracellularly in vitro. Anoxia (2-5 min) caused reversible membrane hyperpolarization (4-25 mV), which blocked spontaneous firing of action potentials. Under voltage clamp, anoxia produced an outward current (100-1,000 pA) associated with an increase i...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.71.3.1165

    authors: Mercuri NB,Bonci A,Johnson SW,Stratta F,Calabresi P,Bernardi G

    更新日期:1994-03-01 00:00:00

  • Nonprimary auditory thalamic representation of acoustic change.

    abstract::1. The mismatch response, or mismatch negativity (MMN), is a neurophysiologic response to stimulus change. In humans and other animals, the MMN may underlie the ability to discriminate acoustic differences, a fundamental aspect of auditory perception. 2. This study investigated the role of the thalamus in the generati...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1994.72.3.1270

    authors: Kraus N,McGee T,Littman T,Nicol T,King C

    更新日期:1994-09-01 00:00:00

  • Interactions with compliant loads alter stretch reflex gains but not intermuscular coordination.

    abstract::The human motor system regulates arm mechanics to produce stable postures during interactions with different physical environments. This occurs partly via involuntary mechanisms, including stretch reflexes. Previous single-joint studies demonstrated enhanced reflex sensitivity during interactions with compliant enviro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01094.2007

    authors: Perreault EJ,Chen K,Trumbower RD,Lewis G

    更新日期:2008-05-01 00:00:00

  • Neuromuscular adaptation during skill acquisition on a two degree-of-freedom target-acquisition task: isometric torque production.

    abstract::In this study we attempted to identify the principles that govern the changes in neural control that occur during repeated performance of a multiarticular coordination task. Eight participants produced isometric flexion/extension and pronation/supination torques at the radiohumeral joint, either in isolation (e.g., fl...

    journal_title:Journal of neurophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1152/jn.00670.2004

    authors: Shemmell J,Forner M,Tresilian JR,Riek S,Barry BK,Carson RG

    更新日期:2005-11-01 00:00:00

  • Evidence against perfect integration of sensory information during perceptual decision making.

    abstract::Perceptual decision making is often modeled as perfect integration of sequential sensory samples until the accumulated total reaches a fixed decision bound. In that view, the buildup of neural activity during perceptual decision making is attributed to temporal integration. However, an alternative explanation is that ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00264.2015

    authors: Carland MA,Marcos E,Thura D,Cisek P

    更新日期:2016-02-01 00:00:00

  • Vagal afferent inhibition of primate thoracic spinothalamic neurons.

    abstract::Spinothalamic (ST) neurons in the C8-T5 segments of the spinal cord were examined for responses to electrical stimulation of the left thoracic vagus nerve (LTV). Seventy-one ST neurons were studied in 39 anesthetized monkeys (Macaca fascicularis). Each neuron could be excited by manipulation of its somatic field and b...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.50.4.926

    authors: Ammons WS,Blair RW,Foreman RD

    更新日期:1983-10-01 00:00:00

  • Concept of neuron types in gustation in the rat.

    abstract::1. In taste neurophysiology, from Pfaffmann's (49, 50) pioneering work until the present, the possibility of types of neurons corresponding in some sense with the "primary" taste qualities of Henning (33) has been entertained: recently types of gustatory neurons in peripheral nerves have been established according to ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1979.42.5.1390

    authors: Woolston DC,Erickson RP

    更新日期:1979-09-01 00:00:00

  • Excitatory actions of ventral root stimulation during network activity generated by the disinhibited neonatal mouse spinal cord.

    abstract::To further understand the excitatory effects of motoneurons on spinal network function, we investigated the entrainment of disinhibited rhythms by ventral root (VR) stimulation in the neonatal mouse spinal cord. A brief train of stimuli applied to a VR triggered bursting reliably in 31/32 experiments. The same roots t...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.90740.2008

    authors: Bonnot A,Chub N,Pujala A,O'Donovan MJ

    更新日期:2009-06-01 00:00:00

  • Identification of the physical stimulus and the neural basis of fabric-evoked prickle.

    abstract::1. The neurophysiological basis for the sensation of prickle evoked by contact of some fabrics with the skin is reported. 2. Single-unit sensory nerve recordings from the rabbit saphenous nerve were used to identify the receptors responsible for fabric-evoked prickle. These recordings showed that all low-threshold mec...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.59.4.1083

    authors: Garnsworthy RK,Gully RL,Kenins P,Mayfield RJ,Westerman RA

    更新日期:1988-04-01 00:00:00

  • A step toward understanding the human ventral visual pathway.

    abstract::The human ventral visual pathway is implicated in higher order form processing, but the organizational principles within this region are not yet well understood. Recently, Lafer-Sousa, Conway, and Kanwisher (J Neurosci 36: 1682-1697, 2016) used functional magnetic resonance imaging to demonstrate that functional respo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00358.2016

    authors: Goddard E

    更新日期:2017-03-01 00:00:00

  • Effects of treadmill training on functional recovery following peripheral nerve injury in rats.

    abstract::Exercise, in the form of moderate daily treadmill training following nerve transection and repair leads to enhanced axon regeneration, but its effect on functional recovery is less well known. Female rats were exercised by walking continuously, at a slow speed (10 m/min), for 1 h/day on a level treadmill, beginning 3 ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00946.2012

    authors: Boeltz T,Ireland M,Mathis K,Nicolini J,Poplavski K,Rose SJ,Wilson E,English AW

    更新日期:2013-06-01 00:00:00

  • Dynamics of stimulus-evoked spike timing correlations in the cat lateral geniculate nucleus.

    abstract::Precisely synchronized neuronal activity has been commonly observed in the mammalian visual pathway. Spike timing correlations in the lateral geniculate nucleus (LGN) often take the form of phase synchronized oscillations in the high gamma frequency range. To study the relations between oscillatory activity, synchrony...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01000.2009

    authors: Ito H,Maldonado PE,Gray CM

    更新日期:2010-12-01 00:00:00

  • Comparison between offset and onset responses of primary auditory cortex ON-OFF neurons in awake cats.

    abstract::Primary auditory cortex (A1) neurons are believed not to carry much information about tonal offsets because A1 neurons in barbiturate-anesthetized animals are usually described as having only onset responses. We investigated tonal offset responses in comparison with onset responses in the caudal part of A1 of awake ca...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00184.2007

    authors: Qin L,Chimoto S,Sakai M,Wang J,Sato Y

    更新日期:2007-05-01 00:00:00

  • Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation.

    abstract::Gain-of-function missense mutations in voltage-gated sodium channel Nav1.7 have been linked to small-fiber neuropathy, which is characterized by burning pain, dysautonomia and a loss of intraepidermal nerve fibers. However, the mechanistic cascades linking Nav1.7 mutations to axonal degeneration are incompletely under...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00195.2015

    authors: Estacion M,Vohra BP,Liu S,Hoeijmakers J,Faber CG,Merkies IS,Lauria G,Black JA,Waxman SG

    更新日期:2015-09-01 00:00:00

  • Discharge characteristics of medial rectus and abducens motoneurons in the goldfish.

    abstract::1. The discharge of antidromically identified medial rectus and abducens motoneurons was recorded in restrained unanesthesized goldfish during spontaneous eye movements and in response to vestibular and optokinetic stimulation. 2. All medial rectus and abducens motoneurons exhibited a similar discharge pattern. A burs...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1991.66.6.2125

    authors: Pastor AM,Torres B,Delgado-Garcia JM,Baker R

    更新日期:1991-12-01 00:00:00

  • Coexpression of multiple metabotropic glutamate receptors in axon terminals of single suprachiasmatic nucleus neurons.

    abstract::Glutamate is the primary excitatory transmitter in axons innervating the hypothalamic suprachiasmatic nucleus (SCN) and is responsible for light-induced phase shifts of circadian rhythms generated by the SCN. By using self-innervating single neuron cultures and patch-clamp electrophysiology, we studied metabotropic gl...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.4.1932

    authors: Chen G,van den Pol AN

    更新日期:1998-10-01 00:00:00

  • Structure-function relationships in the primate superior colliculus. II. Morphological identity of presaccadic neurons.

    abstract::1. Microelectrodes filled with horseradish peroxidase (HRP) were inserted in the superior colliculus (SC) of alert squirrel monkeys. Spontaneous eye movements were monitored in the dark during recording and intraaxonal injection of fibers carrying presaccadic signals. 2. Analysis of the relationship between neuronal a...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1988.60.1.263

    authors: Moschovakis AK,Karabelas AB,Highstein SM

    更新日期:1988-07-01 00:00:00

  • Chemical factors determine olfactory system beta oscillations in waking rats.

    abstract::Recent studies have pointed to olfactory system beta oscillations of the local field potential (15-30 Hz) and their roles both in learning and as specific responses to predator odors. To describe odorant physical properties, resultant behavioral responses and changes in the central olfactory system that may induce the...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00124.2007

    authors: Lowry CA,Kay LM

    更新日期:2007-07-01 00:00:00

  • Suppression of ih contributes to propofol-induced inhibition of mouse cortical pyramidal neurons.

    abstract::The contributions of the hyperpolarization-activated current, I(h), to generation of rhythmic activities are well described for various central neurons, particularly in thalamocortical circuits. In the present study, we investigated effects of a general anesthetic, propofol, on native I(h) in neurons of thalamus and c...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00389.2005

    authors: Chen X,Shu S,Bayliss DA

    更新日期:2005-12-01 00:00:00

  • The quality of visual information about the lower extremities influences visuomotor coordination during virtual obstacle negotiation.

    abstract::Successful negotiation of obstacles during walking relies on the integration of visual information about the environment with ongoing locomotor commands. When information about the body and the environment is removed through occlusion of the lower visual field, individuals increase downward head pitch angle, reduce fo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00931.2017

    authors: Kim A,Kretch KS,Zhou Z,Finley JM

    更新日期:2018-08-01 00:00:00

  • Frequency-dependent propagation of sodium action potentials in dendrites of hippocampal CA1 pyramidal neurons.

    abstract::1. The propagation of antidromically activated action potentials in CA1 pyramidal neurons was examined with intrasomatic and intradendritic electrical recording and optical measurements using the fluorescent calcium indicator Calcium Green-1. 2. In somatic recordings, trains of 40 action potentials, activated at rates...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.74.4.1395

    authors: Callaway JC,Ross WN

    更新日期:1995-10-01 00:00:00