Different erythromycin resistance mechanisms in group C and group G streptococci.

abstract：:A clinical study was carried out to establish the influence of aluminum on the oral absorption of ofloxacin. Ten healthy volunteers were included in a crossover study based on a Latin square design. The treatments that all volunteers received were A, consisting of 400 mg of ofloxacin, and B, consisting of 400 mg of of...

journal_title：Antimicrobial agents and chemotherapy

authors： Sánchez Navarro A,Martínez Cabarga M,Dominguez-Gil Hurlé A

更新日期：1994-10-01 00:00:00

abstract：:Platelet microbicidal proteins (PMPs), small cationic peptides released at sites of endovascular damage, kill common bloodstream pathogens in vitro. Our group previously showed that in vitro resistance of clinical staphylococcal and viridans group streptococcal bacteremic strains to PMPs correlated with the diagnosis ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Cheng D,Yeaman MR,Corey GR,McClelland RS,Harrel LJ,Fowler VG Jr

更新日期：1998-12-01 00:00:00

abstract：:Spiramycins are clinically important 16-member macrolide antibiotics produced by Streptomyces ambofaciens. Biosynthetic studies have established that the earliest lactonic intermediate in spiramycin biosynthesis, the macrolactone platenolide I, is synthesized by a type I modular polyketide synthase (PKS). Platenolide ...

journal_title：Antimicrobial agents and chemotherapy

authors： Nguyen HC,Darbon E,Thai R,Pernodet JL,Lautru S

更新日期：2013-08-01 00:00:00

abstract：:Sublethal doses of vincristine (VNC) and bacterial lipopolysaccharide (LPS) administered simultaneously to adult male mice resulted in markedly enhanced mortality. All of 10 strains of Pseudomonas aeruginosa tested, 4 of 7 strains of Bacteroides, and 6 of 10 strains of Listeria monocytogenes were able to substitute fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Munson AE,Drummond DC,Adams AC,Bradley SG

更新日期：1976-05-01 00:00:00

abstract：:Beta-lactam resistance in Pseudomonas aeruginosa detected only during ceftazidime therapy of cystic fibrosis patients was studied. Evaluation of resistant and susceptible isolates from one patient and resistant laboratory derivatives indicated that elevated beta-lactamase levels were the primary determinant of resista...

journal_title：Antimicrobial agents and chemotherapy

authors： Schryvers AB,Ogunariwo J,Chamberland S,Godfrey AJ,Rabin HR,Bryan LE

更新日期：1987-09-01 00:00:00

abstract：:Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intra...

journal_title：Antimicrobial agents and chemotherapy

authors： van Wijk F,Waterval J,van Aerde K,Henriet SSV,Meijer FJA,Borra LC,Aarnoutse RE,van Ingen J

更新日期：2019-12-20 00:00:00

abstract：:It remains controversial whether combination therapy, given empirically or as definitive treatment, for Pseudomonas aeruginosa bacteremia is associated with a better outcome than monotherapy. The aim of the present study was to compare the rates of survival among patients who received either combination therapy or mon...

journal_title：Antimicrobial agents and chemotherapy

authors： Chamot E,Boffi El Amari E,Rohner P,Van Delden C

更新日期：2003-09-01 00:00:00

abstract：:The aim of the study was to identify the plasmid-encoded factors contributing to the emergence and spread of epidemic IncI1-Iγ plasmids obtained from Escherichia coli and Salmonella enterica isolates from animal and human reservoirs. For this, 251 IncI1-Iγ plasmids carrying various extended-spectrum β-lactamase (ESBL)...

journal_title：Antimicrobial agents and chemotherapy

authors： Smith H,Bossers A,Harders F,Wu G,Woodford N,Schwarz S,Guerra B,Rodríguez I,van Essen-Zandbergen A,Brouwer M,Mevius D

更新日期：2015-09-01 00:00:00

abstract：:Ampicillin-resistant Enterococcus faecium (ARE) and vancomycin-resistant E. faecium (VRE) are important nosocomial pathogens. We quantified effects of probiotics and antibiotics on intestinal acquisition of ARE colonization in patients hospitalized in two non-intensive care unit (non-ICU) wards with high ARE prevalenc...

journal_title：Antimicrobial agents and chemotherapy

authors： de Regt MJ,Willems RJ,Hené RJ,Siersema PD,Verhaar HJ,Hopmans TE,Bonten MJ

更新日期：2010-07-01 00:00:00

abstract：:We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaco...

journal_title：Antimicrobial agents and chemotherapy

authors： Fernández-Silva F,Capilla J,Mayayo E,Sutton DA,Hernández P,Guarro J

更新日期：2013-12-01 00:00:00

abstract：:Kingella kingae is the major pathogen causing osteoarticular infections (OAI) in young children in numerous countries. Plasmid-borne TEM-1 penicillinase production has been sporadically detected in a few countries but not in continental Europe, despite a high prevalence of K. kingae infections. We describe here for th...

journal_title：Antimicrobial agents and chemotherapy

authors： Basmaci R,Bidet P,Berçot B,Jost C,Kwon T,Gaumetou E,Bonacorsi S

更新日期：2014-10-01 00:00:00

abstract：:The cyclohexane triones are a novel group of synthetic antibacterial agents that are active against gram-positive bacteria, Haemophilus influenzae, and Mycobacterium smegmatis. In general, these compounds behaved in a manner similar to that of hexachlorophene, inhibiting the transport of low-molecular-weight hydrophil...

journal_title：Antimicrobial agents and chemotherapy

authors： Lloyd WJ,Broadhurst AV,Hall MJ,Andrews KJ,Barber WE,Wong-Kai-In P

更新日期：1988-06-01 00:00:00

abstract：:The rapid infusion of hyperosmolar solutions into the internal carotid artery transiently disrupts the integrity of the blood-brain barrier, permitting entry of substances normally excluded from the nervous system. This study examined the effect of such an infusion on the penetration of vancomycin and tobramycin into ...

journal_title：Antimicrobial agents and chemotherapy

authors： Perkins BA,Strausbaugh LJ

更新日期：1983-09-01 00:00:00

abstract：:We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spre...

journal_title：Antimicrobial agents and chemotherapy

authors： Escudero JA,San Millan A,Catalan A,de la Campa AG,Rivero E,Lopez G,Dominguez L,Moreno MA,Gonzalez-Zorn B

更新日期：2007-02-01 00:00:00

abstract：:Atazanavir (Reyataz; ATV) is a well-tolerated protease inhibitor (PI) that is indicated as a once-daily treatment for HIV infections. These features of ATV, combined with its virologic potency, make it particularly desirable for the treatment of HIV-infected pediatric patients. The objective of this study was to use a...

journal_title：Antimicrobial agents and chemotherapy

authors： Hong Y,Kowalski KG,Zhang J,Zhu L,Horga M,Bertz R,Pfister M,Roy A

更新日期：2011-12-01 00:00:00

abstract：:Multidrug-resistant Enterobacteriaceae (MRE) colonize the intestine asymptomatically from where they can breach into the bloodstream and cause life-threatening infections, especially in heavily colonized patients. Despite the clinical relevance of MRE colonization levels, we know little about how they vary in hospital...

journal_title：Antimicrobial agents and chemotherapy

authors： Djukovic A,González-Barberá EM,Sanz J,Artacho A,Peñaranda I,Herrera B,Garzón MJ,Salavert M,López-Hontangas JL,Xavier KB,Kuster B,Debrauwer L,Rolain JM,Sanz MA,Xavier JB,Ubeda C

更新日期：2020-01-27 00:00:00

abstract：:The mortality rate associated with Vibrio vulnificus sepsis remains high. An in vitro time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, com...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim SE,Kim HK,Choi SM,Yu Y,Kim UJ,Darboe KS,Kang SJ,Park KH,Kang G,Kim YR,Rhee JH,Jung SI,Jang HC

更新日期：2019-09-23 00:00:00

abstract：:We compared the in vitro activity of gemifloxacin, a new quinolone antibiotic, to the activities of levofloxacin, moxifloxacin, trovafloxacin, erythromycin, and doxycycline against 20 isolates of Chlamydia pneumoniae. Gemifloxacin was the most active quinolone tested, with a MIC at which 90% of the isolates are inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Roblin PM,Reznik T,Kutlin A,Hammerschlag MR

更新日期：1999-11-01 00:00:00

abstract：:Past genotypic studies of Mycobacterium tuberculosis may have incorrectly estimated the importance of specific drug resistance mutations due to a number of sampling biases including an overrepresentation of multidrug-resistant (MDR) isolates. An accurate assessment of resistance mutations is crucial for understanding ...

journal_title：Antimicrobial agents and chemotherapy

authors： Piatek AS,Telenti A,Murray MR,El-Hajj H,Jacobs WR Jr,Kramer FR,Alland D

更新日期：2000-01-01 00:00:00

abstract：:A sequential therapy of caspofungin (CAS) and fluconazole (FLC) administration for treatment of Candida albicans infection was investigated. Treatment with CAS followed by FLC was as effective as CAS treatment given alone for the same duration. Our data suggest that switching from CAS to FLC is a potentially explorabl...

journal_title：Antimicrobial agents and chemotherapy

authors： Barchiesi F,Spreghini E,Baldassarri I,Marigliano A,Arzeni D,Giannini D,Scalise G

更新日期：2004-10-01 00:00:00

abstract：:Ampicillin resistance in Enterococcus faecium is a serious concern worldwide, complicating the treatment of E. faecium infections. Penicillin-binding protein 5 (PBP5) is considered the main ampicillin resistance determinant in E. faecium The three known E. faecium clades showed sequence variations in the pbp5 gene tha...

journal_title：Antimicrobial agents and chemotherapy

authors： Montealegre MC,Roh JH,Rae M,Davlieva MG,Singh KV,Shamoo Y,Murray BE

更新日期：2016-12-27 00:00:00

abstract：:Iatrogenic Cushing's syndrome is an undesirable outcome of glucocorticoids treatment. It can be increased by pharmacologic interactions. Glucocorticoid therapy, given in association with ritonavir, and some azole treatments are causes of iatrogenic Cushing's syndrome. We present a patient with common-variable immunode...

journal_title：Antimicrobial agents and chemotherapy

authors： Pilmis B,Coignard-Biehler H,Jullien V,Hermine O,Touraine P,Lecuit M,Lortholary O

更新日期：2013-11-01 00:00:00

abstract：:Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminogly...

journal_title：Antimicrobial agents and chemotherapy

authors： Yoshiyama Y,Nishikawa S,Sugiyama T,Kobayashi T,Shimada H,Tomonaga F,Ohdo S,Ogawa N,Nakano S

更新日期：1993-09-01 00:00:00

abstract：:Immunoprecipitation of antigens translated in vitro from Echinococcus granulosus RNA revealed that albendazole treatment of human hydatidosis induced antibodies to previously undetectable antigens and that the response to most antigens was specific, although cross-reactivity was observed between Schistosoma mansoni an...

journal_title：Antimicrobial agents and chemotherapy

authors： Blanton RE,Okelo GB,Kijobe J,King CH

更新日期：1991-08-01 00:00:00

abstract：:There is increasing interest in the use of lipophilic copper (Cu)-containing complexes to combat bacterial infections. In this work, we showed that Cu complexes with bis(thiosemicarbazone) ligands [Cu(btsc)] exert antibacterial activity against a range of medically significant pathogens. Previous work using Neisseria ...

journal_title：Antimicrobial agents and chemotherapy

authors： Djoko KY,Goytia MM,Donnelly PS,Schembri MA,Shafer WM,McEwan AG

更新日期：2015-10-01 00:00:00

abstract：:The in vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against 50 Pseudomonas aeruginosa strains was studied by the broth dilution method and the time-kill curve method. The majority of the P. aeruginosa strains tested were resistant to ceftriaxone. Combining ceftriaxon...

journal_title：Antimicrobial agents and chemotherapy

authors： Watanakunakorn C

更新日期：1983-08-01 00:00:00

abstract：:MICs of 25 Abiotrophia defectiva and 109 Granulicatella adiacens isolates were determined by broth microdilution. Using CLSI breakpoints, the susceptibilities of A. defectiva and G. adiacens isolates were, respectively, 24% and 34% to penicillin, 92% and 22% to ceftriaxone, 48% and 3% to cefepime, 72% and 87% to merop...

journal_title：Antimicrobial agents and chemotherapy

authors： Mushtaq A,Greenwood-Quaintance KE,Cole NC,Kohner PC,Ihde SM,Strand GJ,Harper LW,Virk A,Patel R

更新日期：2016-07-22 00:00:00

abstract：:Despite the development of novel antibiotics active against Gram-positive bacteria, vancomycin generally remains the first treatment, although rapidly achieving concentrations associated with maximal efficacy provides an unresolved challenge. The objective of this study was to conduct a population pharmacokinetic anal...

journal_title：Antimicrobial agents and chemotherapy

authors： Roberts JA,Taccone FS,Udy AA,Vincent JL,Jacobs F,Lipman J

更新日期：2011-06-01 00:00:00

abstract：:The caspofungin clinical trial database offers an opportunity to assess susceptibility results for Candida pathogens obtained from patients with candidiasis and allows for correlations between efficacy outcomes and MICs. Candida isolates have been identified from patients enrolled in four studies of esophageal candidi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kartsonis N,Killar J,Mixson L,Hoe CM,Sable C,Bartizal K,Motyl M

更新日期：2005-09-01 00:00:00

abstract：:We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of d...

journal_title：Antimicrobial agents and chemotherapy

authors： Baltch AL,Ritz WJ,Bopp LH,Michelsen PB,Smith RP

更新日期：2007-04-01 00:00:00