Compartmentalized and internally structured particles for drug delivery--a review.

Abstract:

:Recent advances in the fabrication, characterization and application of micro- and nano-particles that possess a non-uniform internal structure are reviewed. The particle structures include core-shell particles, particles with multiple cores or a multi-layered structure, porous particles with both regular and random pore structure, as well as complex composite particles possessing several of the above features. Particles based on "hard" inorganic materials such as silica, "soft" organic materials such as polymers and their composites are considered. The fabrication approaches include bottom-up self-assembly techniques, templating methods, microfluidics, and various emulsion-based routes to structured micro- and nano-particle formation, combined with both physical (e.g. Pickering emulsions) and chemical (e.g. polymerization, precipitation) processes for the material deposition. The applications of the structured particles for the encapsulation and controlled delivery of active substances are then reviewed with emphasis on those systems where the complex particle structure can provide specific benefits such as in-situ formation of the active substance or precise control over the release profile. Likely future research directions and prospects are discussed.

journal_name

Curr Pharm Des

authors

Čejková J,Štêpánek F

doi

10.2174/1381612811319350007

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

6298-314

issue

35

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-20130304-3

journal_volume

19

pub_type

杂志文章,评审
  • Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.

    abstract::We set up two models of gastric bleeding in rats using low-dose aspirin (ASA) and the antiplatelet drug clopidogrel, a P2Y₁₂ receptor antagonist, and examined the effect of antiulcer drugs on gastric bleeding and ulcerogenic responses under such conditions. Under urethane anesthesia, two catheters were inserted into t...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/13816128113199990418

    authors: Takeuchi K,Izuhara C,Takayama S,Momode T,Kojo M,Hara D,Amagase K

    更新日期:2014-01-01 00:00:00

  • Mechanisms of anti-cancer agents: emphasis on oxidative stress and electron transfer.

    abstract::A large body of evidence has accumulated indicating involvement of oxidative stress (OS) in the mode of action of various bioactive substances, including those of the immune system. The data for anticancer drugs (main and miscellaneous) are summarized herein. Although diverse origins pertain, reactive oxygen species (...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612003401046

    authors: Kovacic P,Osuna JA Jr

    更新日期:2000-02-01 00:00:00

  • Non-analgesic effects of opioids: the cognitive effects of opioids in chronic pain of malignant and non-malignant origin. An update.

    abstract::Opioids constitute the basis for pharmacological treatment of moderate to severe pain in cancer pain and non-cancer pain patients. Their action is mediated by the activation of opioid receptors, which integrates the pain modulation system with other effects in the central nervous system including cognition resulting i...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161212803582522

    authors: Højsted J,Kurita GP,Kendall S,Lundorff L,de Mattos Pimenta CA,Sjøgren P

    更新日期:2012-01-01 00:00:00

  • Recent Advances in Non-Invasive Delivery of Macromolecules using Nanoparticulate Carriers System.

    abstract:BACKGROUND:The drug delivery of macromolecules such as proteins and peptides has become an important area of research and represents the fastest expanding share of the market for human medicines. The most common method for delivering macromolecules is parenterally. However parenteral administration of some therapeutic ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612822666161026163201

    authors: Shadab M,Haque S,Sheshala R,Meng LW,Meka VS,Ali J

    更新日期:2017-01-01 00:00:00

  • The effect of Endovascular Aneurysm Repair on Renal Function in Patients Treated for Abdominal Aortic Aneurysm.

    abstract:AIM:The effect of endovascular aneurysm repair in patients treated for abdominal aortic aneurysm has not been clearly defined. The objective of the present article was to provide a contemporary literature review and perform an analysis to determine the effect of EVAR on renal function in the early post-operative period...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612825666191129094923

    authors: Nana P,Kouvelos G,Brotis A,Spanos K,Giannoukas A,Matsagkas M

    更新日期:2019-01-01 00:00:00

  • Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is the most common neurodegenerative disorder that affects the elderly. The increase of life-expectancy is transforming AD into a major health-care problem. AD is characterized by a progressive impairment of memory and other cognitive skills leading to dementia. The major pathogenic factor ass...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161210793176572

    authors: Agostinho P,Cunha RA,Oliveira C

    更新日期:2010-01-01 00:00:00

  • Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands.

    abstract::The serotonergic system is involved in pathomechanisms of both epilepsy and neuropathic pain. So far, participation in the epileptogenesis and maintenance of epilepsy was proved for 5-HT1A, 5-HT2C, 5-HT3, 5-HT4 and 5-HT7 receptors as well as 5-HTT serotonin transporter. Depending on the receptor type or its localizati...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666141121114917

    authors: Panczyk K,Golda S,Waszkielewicz A,Zelaszczyk D,Gunia-Krzyzak A,Marona H

    更新日期:2015-01-01 00:00:00

  • Angiogenesis: new targets for the development of anticancer chemotherapies.

    abstract::Angiogenesis is the process by which new blood vessels are formed from preexisting microvasculature. To ensure an adequate blood supply, tumor cells release angiogenic factors that are capable of promoting nearby blood vessels to extend vascular branches to the tumor. In addition, larger tumors have been shown to rele...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612003400867

    authors: Gourley M,Williamson JS

    更新日期:2000-03-01 00:00:00

  • Hypertension - Current Natural Strategies to Lower Blood Pressure.

    abstract::The prevalence of hypertension (HTN) worldwide is high and is constantly rising. HTN is considered to be a silent killer since often there are no obvious symptoms but long-term, HTN significantly increases the risk of coronary heart disease and cerebrovascular diseases. Those with diagnosed HTN or at high risk of its ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612823666170215144649

    authors: Rysz J,Franczyk B,Banach M,Gluba-Brzozka A

    更新日期:2017-01-01 00:00:00

  • Edible Mushrooms: Novel Medicinal Agents to Combat Metabolic Syndrome and Associated Diseases.

    abstract::Metabolic syndrome is an aggregation of conditions and associated with an increased risk of developing diabetes, obesity and cardiovascular diseases (CVD). Edible mushrooms are widely consumed in many countries and are valuable components of the diet because of their attractive taste, aroma, and nutritional value. Med...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200831151316

    authors: Tung YT,Pan CH,Chien YW,Huang HY

    更新日期:2020-01-01 00:00:00

  • Blood serum atherogenicity and coronary artery calcification.

    abstract::The phenomenon of blood serum atherogenicity was described as the ability of human serum to induce lipid accumulation in cultured cells. The results of recent two-year prospective study in asymptomatic men provided the evidence for association between the changes in serum atherogenicity and dynamics of carotid intima-...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612820666140212194614

    authors: Sobenin IA,Myasoedova VA,Anisimova EV,Pavlova XN,Möhlenkamp S,Schmermund A,Seibel R,Berenbein S,Lehmann N,Moebus S,Jöckel K,Orekhov AN,Erbel R

    更新日期:2014-01-01 00:00:00

  • Peripheral Corticotropin Releasing Factor Signaling Inhibits Gastric Emptying: Mechanisms of Action and Role in Stress-related Gastric Alterations of Motor Function.

    abstract::The activation of Corticotrophin Releasing-Factor (CRF) receptors in the brain is well established to coordinate the endocrine, behavioral, autonomic and visceral responses to stress. In addition, CRF receptors are also expressed within the gut where they exert biological actions and play a role in modulating stress-r...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612823666170228142428

    authors: Czimmer J,Tache Y

    更新日期:2017-01-01 00:00:00

  • Psychoneuroimmunology - psyche and autoimmunity.

    abstract::Psychoneuroimmunology is a relatively young field of research that investigates interactions between central nervous and immune system. The brain modulates the immune system by the endocrine and autonomic nervous system. Vice versa, the immune system modulates brain activity including sleep and body temperature. Based...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161212802502305

    authors: Ziemssen T

    更新日期:2012-01-01 00:00:00

  • Atenolol: differences in mode of action compared with other antihypertensives. An opportunity to identify features that influence outcome?

    abstract::The beneficial effect of antihypertensive treatment on the risk of major vascular events is well established. Several trials comparing older and newer drugs in the treatment of primary hypertension suggested that it is the blood pressure achieved, rather than choice of the drug that determines most of the primary outc...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161207779313713

    authors: Karagiannis A,Mikhailidis DP,Kakafika AI,Tziomalos K,Athyros VG

    更新日期:2007-01-01 00:00:00

  • Pharmacological Treatments for Fragile X Syndrome Based on Synaptic Dysfunction.

    abstract:BACKGROUND:Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive impairment, including intellectual disability, autism, hyperactivity, and epilepsy. METHODS:This article reviews the literature pertaining to the role of synaptic dysfunction in FXS. RESULTS:In FXS, synaptic dysfunction alte...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612825666191102165206

    authors: Telias M

    更新日期:2019-01-01 00:00:00

  • The role of protonation states in ligand-receptor recognition and binding.

    abstract::In this review we discuss the role of protonation states in receptor-ligand interactions, providing experimental evidences and computational predictions that complex formation may involve titratable groups with unusual pKa's and that protonation states frequently change from unbound to bound states. These protonation ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612811319230004

    authors: Petukh M,Stefl S,Alexov E

    更新日期:2013-01-01 00:00:00

  • Potential cardio-protective agents: A Resveratrol review (2000-2019).

    abstract::With a 2030 projection of 23.6 million deaths per year the prevalence and severity of cardiovascular disease is at an astounding high. Thus, a definitive need for the identification of novel compounds with potential to prevent or treat the disease and associated states. Moreover, there is also an ever-increasing need ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200909125354

    authors: Houacine C,Khan I,Yousaf SS

    更新日期:2020-09-09 00:00:00

  • Up-date on diagnostic strategies of invasive aspergillosis.

    abstract::Invasive fungal infections are a major cause of morbidity and mortality in immunosuppressed patients with fatality rates ranging from 30 % to 80 % in neutropenic patients. This results at least partly in difficulties obtaining a reliable and early diagnosis, followed by the fact that clinical symptoms are unspecific a...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990323

    authors: Lackner M,Lass-Flörl C

    更新日期:2013-01-01 00:00:00

  • Radiopharmaceuticals for oncology drug development: a pharmaceutical industry perspective.

    abstract::Oncology remains an increasingly important focus of therapeutic development yet there remain many scientific and operational bottlenecks to deliver optimum treatments efficiently. Radiopharmaceuticals constitute a group of methodologies able to support the many stages of drug development. Methods such as [(18)F]-FDG-P...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161209787581977

    authors: Murphy PS,Bergström M

    更新日期:2009-01-01 00:00:00

  • Targeted drugs and nanomedicine: present and future.

    abstract::Packaging small-molecule drugs into nanoparticles improves their bio-availability, bio-compatibility and safety profiles. Multifunctional particles carrying large drug payloads for targeted transport, immune evasion and favourable drug release kinetics at the target site, require a certain minimum size usually 30-300 ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161209787002870

    authors: Debbage P

    更新日期:2009-01-01 00:00:00

  • Role of neurotrophins in spinal plasticity and locomotion.

    abstract::Synaptic transmission through descending motor pathways to lumbar motoneurons and then to leg muscles is essential for walking in humans and rats. Spinal cord injury (SCI), even when incomplete, results in diminished transmission to motoneurons and very limited recovery of motor function. Neurotrophins have emerged as...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990378

    authors: Arvanian V

    更新日期:2013-01-01 00:00:00

  • Novel approach to cardiovascular diseases: a promising probability of (pro)renin receptor [(P)RR].

    abstract::Inhibition of the renin-angiotensin system (RAS) has been shown to have beneficial effects in cardiovascular disease prognosis and therapy.Discovery of (pro)renin receptor [(P)RR] revealed that (P)RR upon binding to both renin or prorenin in their proenzyme inactive form made them enzymatically active, thus aiding the...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990472

    authors: Ando T,Ichihara A

    更新日期:2014-01-01 00:00:00

  • An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors.

    abstract::Adenosine A(2A)-dopamine D(2) receptor interactions play a very important role in striatal function. A(2A)-D(2) receptor interactions provide an example of the capabilities of information processing by just two different G protein-coupled receptors. Thus, there is evidence for the coexistence of two reciprocal antagon...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208784480108

    authors: Ferré S,Quiroz C,Woods AS,Cunha R,Popoli P,Ciruela F,Lluis C,Franco R,Azdad K,Schiffmann SN

    更新日期:2008-01-01 00:00:00

  • Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity.

    abstract::Obesity was first described as a low-grade inflammatory condition more than a decade ago. However, it is only relatively recently that obese individuals have been described with increased macrophage infiltration of adipose tissue, as well as an increase in the number of "M1" or "classically activated" macrophages. Fur...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208784246153

    authors: Heilbronn LK,Campbell LV

    更新日期:2008-01-01 00:00:00

  • Gene vectors for cytokine expression in vivo.

    abstract::The understanding of cytokine networks and the exploitation of these networks for the treatment of immune and inflammatory diseases as well as cancer depend on in vivo delivery of cytokines. Due to instability of recombinant cytokine proteins, investigators have employed cytokine-encoding gene therapy vectors to induc...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612003400551

    authors: Hitt MM,Gauldie J

    更新日期:2000-04-01 00:00:00

  • Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections.

    abstract::Heme oxygenase-1 (HO-1) catalyzes the degradation of heme to generate carbon monoxide, biliverdin and free iron. Increased HO-1 levels constitute an anatomopathological feature of many neurological diseases, such as neurodegenerative disorders and brain infections, which correlate with exacerbated oxidative stress and...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161208783597407

    authors: Cuadrado A,Rojo AI

    更新日期:2008-01-01 00:00:00

  • Systemic sclerosis-related pulmonary hypertension: unique characteristics and future treatment targets.

    abstract::Pulmonary arterial hypertension (PAH) is a severe vascular complication of connective tissue diseases. In the context of systemic sclerosis (SSc), PAH is a devastating disease with a dramatic impact on prognosis and survival. Despite advances in early diagnosis and the development of new targeted treatments, SSc-relat...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161212799504704

    authors: Dimitroulas T,Giannakoulas G,Karvounis H,Settas L,Kitas GD

    更新日期:2012-01-01 00:00:00

  • Angiotensin II and Abdominal Aortic Aneurysms: An update.

    abstract::Abdominal aortic aneurysm (AAA) is a devastating disease associated with high prevalence of death due to aortic rupture. Currently the therapy is restricted to surgical procedures to prevent aortic rupture, which in turn has a risk for postoperative mortality. There are no proven pharmacological therapies available to...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666150826093318

    authors: Liu J,Daugherty A,Lu H

    更新日期:2015-01-01 00:00:00

  • Peptides targeting angiogenesis related growth factor receptors.

    abstract::Growth factors (GFs) are extracellular signaling polypeptides regulating cell proliferation, differentiation and survival. They exert a wide spectrum of biological activities selectively binding to and activating specific membrane receptors which then transfer the message to cell interior inducing specific biochemical...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161209788682235

    authors: D'Andrea LD,Del Gatto A,De Rosa L,Romanelli A,Pedone C

    更新日期:2009-01-01 00:00:00

  • Antibiotics Associated Disorders and Post-biotics Induced Rescue in Gut Health.

    abstract::The gut microbiota plays significant roles in the human body during all spheres' of life and influences innate immunity, promotes granulocyte signaling and provides resistance during pathogenic colonization of the gut; crucial for a healthy life. Antibiotics directly affect the gut microbiota that consequently alters ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612824666171227221731

    authors: Paul D,Manna S,Mandal SM

    更新日期:2018-01-01 00:00:00