Fine-needle aspiration biopsy of metastatic small cell carcinoma from extrapulmonary sites.

Abstract:

:Like a pulmonary counterpart, extrapulmonary small cell carcinoma (SCC) is an aggressive tumor with a high rate of metastasis. Forty-nine fine-needle aspiration biopsies (FNABs) (36 patients) of various primary sites other than the lung diagnosed as metastatic SCC (including Merkel cell carcinoma) were reviewed. FNABs were derived from lymph nodes (20), liver (7), bone (2), breast (1), pancreas (1), and skin/soft tissue (18). Primary tumor sites included the prostate (14), skin (11; Merkel cell carcinoma), cervix (5), urinary bladder (3), urethra (1), ovary (1), and parotid (1). Aspirates revealed predominantly dispersed single tumor cells with occasional clustering. Tumor cells were small with scant cytoplasm, fine powdery chromatin, and inconspicuous nucleoli. Nuclear molding, mitotic figures, and apoptotic bodies were frequently observed. In four cases, findings from the FNABs were used to render the initial diagnosis of SCC. FNAB is useful for determining whether metastases contain a SCC component, a finding that may alter clinical management. Cytologically, SCC from different primary sites cannot be differentiated, and its distinction requires clinical and radiographic correlation.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Shin HJ,Caraway NP

doi

10.1002/(sici)1097-0339(199809)19:3<177::aid-dc4>3

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

177-81

issue

3

eissn

8755-1039

issn

1097-0339

pii

10.1002/(SICI)1097-0339(199809)19:3<177::AID-DC4>3

journal_volume

19

pub_type

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