当前位置： SCI文献检索 > ANNALS OF INTERNAL MEDICINE期刊下所有文献 > The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study.

The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study.

Abstract：

BACKGROUND:Primary prevention of Alzheimer disease and other types of dementia (all-cause dementia) is an important public health goal. Evidence to date is insufficient to recommend any lifestyle change to prevent or delay the onset of dementia. OBJECTIVE:To assess the association between objectively measured midlife cardiorespiratory fitness ("fitness") levels and development of all-cause dementia in advanced age. DESIGN:Prospective, observational cohort study. SETTING:Preventive medicine clinic. PATIENTS:19 458 community-dwelling, nonelderly adults who had a baseline fitness examination. MEASUREMENTS:Fitness levels, assessed using the modified Balke treadmill protocol between 1971 and 2009, and incident all-cause dementia using Medicare Parts A and B claims data from 1999 to 2009. RESULTS:1659 cases of incident all-cause dementia occurred during 125 700 person-years of Medicare follow-up (median follow-up, 25 years [interquartile range, 19 to 30 years]). After multivariable adjustment, participants in the highest quintile of fitness level had lower hazard of all-cause dementia than those in the lowest quintile (hazard ratio, 0.64 [95% CI, 0.54 to 0.77]). Higher fitness levels were associated with lower hazard of all-cause dementia with previous stroke (hazard ratio, 0.74 [CI, 0.53 to 1.04]) or without previous stroke (hazard ratio, 0.74 [CI, 0.61 to 0.90]). LIMITATIONS:Dementia diagnoses were based on Medicare claims, and participants generally were non-Hispanic white, healthy, and well-educated and had access to preventive health care. This study evaluated fitness levels, so a specific exercise prescription cannot be generated from results and the findings may not be causal. CONCLUSION:Higher midlife fitness levels seem to be associated with lower hazards of developing all-cause dementia later in life. The magnitude and direction of the association were similar with or without previous stroke, suggesting that higher fitness levels earlier in life may lower risk for dementia later in life, independent of cerebrovascular disease. PRIMARY FUNDING SOURCE:The Cooper Institute; University of Texas Southwestern Medical Center; National Heart, Lung, and Blood Institute; and American Heart Association.

journal_name

Ann Intern Med

journal_title

Annals of internal medicine

authors

Defina LF,Willis BL,Radford NB,Gao A,Leonard D,Haskell WL,Weiner MF,Berry JD

doi

10.7326/0003-4819-158-3-201302050-00005

subject

Has Abstract

pub_date

2013-02-05 00:00:00

pages

162-8

issue

eissn

0003-4819

issn

1539-3704

pii

1567851

journal_volume

158

pub_type

杂志文章

在线工具

The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study.