Nasal continuous positive airway pressure and early surfactant therapy for respiratory distress syndrome in newborns of less than 30 weeks' gestation.

Abstract:

OBJECTIVE:To determine whether early versus late treatment with porcine surfactant (Curosurf) reduces the requirement of mechanical ventilation in very preterm infants primarily supported by nasal continuous positive airway pressure (nasal CPAP). DESIGN:Multicenter randomized, controlled trial. PATIENTS:The study population comprised 60 infants <30 weeks' gestation with respiratory distress syndrome (RDS) who had an arterial to alveolar oxygen tension ratio (a/APO2) of 0.35 to 0.22. The cohort from which the study population was generated comprised 397 infants. RESULTS:The need for mechanical ventilation or death within 7 days of age was reduced from 63% in the late-treated infants to 21% in early-treated infants. Increasing numbers of antenatal steroid doses also improved the outcome, especially in the early-treated infants. Six hours after randomization mean a/APO2 rose to 0.48 in the early-treated infants compared with 0.36 in the late-treated. The need of mechanical ventilation before discharge was reduced from 68% in the late-treated to 25% in the early-treated infants. CONCLUSIONS:Nasal CPAP in combination with early treatment with Curosurf significantly improves oxygenation and reduces the subsequent need for mechanical ventilation in infants <30 weeks' gestational age with RDS.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Verder H,Albertsen P,Ebbesen F,Greisen G,Robertson B,Bertelsen A,Agertoft L,Djernes B,Nathan E,Reinholdt J

doi

10.1542/peds.103.2.e24

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

E24

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

103

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    pub_type: 杂志文章

    doi:10.1542/peds.103.1.e10

    authors: Fox LM,Gerber MA,Penix L,Ricci A Jr,Hyams JS

    更新日期:1999-01-01 00:00:00

  • Outcomes of extremely premature infants related to their peak serum bilirubin concentrations and exposure to phototherapy.

    abstract:OBJECTIVES:To analyze, in extremely low birth weight infants, associations between peak bilirubin concentration and evidence of brain damage, and between peak bilirubin concentration and blindness attributable to retinopathy of prematurity. METHODS:Retrospective study of 128 infants of

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.6.1426

    authors: Yeo KL,Perlman M,Hao Y,Mullaney P

    更新日期:1998-12-01 00:00:00

  • Adolescent mothers and their infants.

    abstract::It is unclear why children of adolescent mothers experience more developmental problems than children of adult mothers. There has been minimal systematic investigation of whether there is a relationship between the young age of the mother and her mothering behaviors. Our data fail to demonstrate any relationship betwe...

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    pub_type: 杂志文章

    doi:

    authors: McAnarney ER,Lawrence RA,Aten MJ,Iker HP

    更新日期:1984-03-01 00:00:00

  • Chronic Conditions and Health Care Needs of Adolescents Born at 23 to 25 Weeks' Gestation.

    abstract:OBJECTIVE:We examined chronic conditions, functional limitations, and special health care needs in extremely preterm children (EPT; 23-25 weeks' gestation) born between 1992 and 1998 at 2 Swedish tertiary care centers that offered regional and active perinatal care to all live-born EPT infants. METHODS:Of 134 survivin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-2215

    authors: Holsti A,Adamsson M,Hägglöf B,Farooqi A,Serenius F

    更新日期:2017-02-01 00:00:00

  • Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions.

    abstract:OBJECTIVE:Children with chronic abdominal pain of nonorganic origin, termed functional abdominal pain (FAP), experience school absences and social withdrawal and report impaired physical ability. The aim of this study was to assess patients' and parents' perceptions of health-related quality of life (QoL) for children ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0114

    authors: Youssef NN,Murphy TG,Langseder AL,Rosh JR

    更新日期:2006-01-01 00:00:00

  • Carbon monoxide is a significant mediator of cardiovascular status following preterm birth.

    abstract:OBJECTIVE:With male gender as a strong predictor of cardiovascular instability, we hypothesized that gender-specific differences in circulating carbon monoxide levels contributed to dysregulated microvascular function in preterm male infants. METHODS:Infants born at 24 to 34 weeks of gestation (N = 84) were studied in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0877

    authors: Stark MJ,Clifton VL,Wright IM

    更新日期:2009-07-01 00:00:00

  • Improving the quality of discharge communication with an educational intervention.

    abstract:BACKGROUND:Communication between hospital providers and primary care physicians at the time of hospital discharge is necessary for optimal patient care and safety. Content of the inpatient discharge summary (DS) is not uniformly addressed by residency programs. OBJECTIVE:To improve DSs quality through a brief educatio...

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    authors: Key-Solle M,Paulk E,Bradford K,Skinner AC,Lewis MC,Shomaker K

    更新日期:2010-10-01 00:00:00

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    abstract::Using the sample of 1726 special education students from the Collaborative Study of Children With Special Needs, the authors describe the related services being provided to the children and then analyze the relationship between service provision and class placement. Related services are provided in all settings, with ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Palfrey JS,Singer JD,Raphael ES,Walker DK

    更新日期:1990-04-01 00:00:00

  • The increasing number of children using psychiatric services: analysis of a cumulative psychiatric case register.

    abstract::Psychosocial problems of children have received increasing attention in the pediatric literature, but it remains unclear to what extent psychiatric services are available and used for the treatment of these problems. This paper examines the utilization of psychiatric services by children over an 18-year period in Monr...

    journal_title:Pediatrics

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    doi:

    authors: Roghmann KJ,Babigian HM,Goldberg ID,Zastowny TR

    更新日期:1982-11-01 00:00:00

  • Colic and crying syndromes in infants.

    abstract::Colic or excessive crying is one of the most frequent problems presented to pediatricians by new parents. Organic disease accounts for <5% of infants presenting with colic syndrome. Colic may be best viewed as a clinical manifestation of normal emotional development, in which an infant has diminished capacity to regul...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Barr RG

    更新日期:1998-11-01 00:00:00

  • Effects of environmental exposures on the cardiovascular system: prenatal period through adolescence.

    abstract::Exposures to drugs, chemical and biological agents, therapeutic radiation, and other factors before and after birth can lead to pediatric or adult cardiovascular anomalies. Furthermore, nutritional deficiencies in the perinatal period can cause cardiovascular anomalies. These anomalies may affect heart structure, the ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Mone SM,Gillman MW,Miller TL,Herman EH,Lipshultz SE

    更新日期:2004-04-01 00:00:00

  • Financial burden of raising CSHCN: association with state policy choices.

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    journal_title:Pediatrics

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    doi:10.1542/peds.2009-1255P

    authors: Parish SL,Shattuck PT,Rose RA

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  • The Autism Speaks Autism Treatment Network Registry Data: Opportunities for Investigators.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2851E

    authors: Murray DS,Fedele A,Shui A,Coury DL

    更新日期:2016-02-01 00:00:00

  • Nonresponse bias in a follow-up study of 19-year-old adolescents born as preterm infants.

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    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

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    authors: Hille ET,Elbertse L,Gravenhorst JB,Brand R,Verloove-Vanhorick SP,Dutch POPS-19 Collaborative Study Group.

    更新日期:2005-11-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-1394D

    authors: Martin C

    更新日期:2014-10-01 00:00:00

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    abstract:OBJECTIVE:The first rotavirus vaccine that was licensed in the United States, RotaShield, could have prevented the enormous burden of rotavirus diarrhea in American children but left instead the unfortunate legacy that live oral rotavirus vaccines may be associated with a serious but rare adverse event: intussusception...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2874

    authors: Tai JH,Curns AT,Parashar UD,Bresee JS,Glass RI

    更新日期:2006-08-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ellison PH,Kopp CB

    更新日期:1985-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1542/peds.2009-3243

    authors: Lynch RE,Hack RA

    更新日期:2010-07-01 00:00:00

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    journal_title:Pediatrics

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    doi:

    authors: McMillan JA,Oski FA,Lourie G,Tomarelli RM,Landaw SA

    更新日期:1977-12-01 00:00:00

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    journal_title:Pediatrics

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    authors: Messinger Y,Sheaffer JW,Mrozek J,Smith CM,Sinaiko AR

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    doi:10.1542/peds.2010-3590

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    authors: Pierce MC,Kaczor K,Aldridge S,O'Flynn J,Lorenz DJ

    更新日期:2010-01-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bordley WC,Margolis PA,Lannon CM

    更新日期:1996-04-01 00:00:00

  • Blood-brain phenylalanine relationships in persons with phenylketonuria.

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    authors: Koch R,Moats R,Guttler F,Guldberg P,Nelson M Jr

    更新日期:2000-11-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:

    authors: Agostoni C,Riva E,Giovannini M

    更新日期:1995-11-01 00:00:00

  • Health outcomes of a community-based therapy program for children with cancer--a shared-management approach.

    abstract::Critical to providing cancer therapy to children in rural areas is finding dependable sources of therapy near the patients' homes. In this study, comparison was made of 668 visits by 24 patients to nearby private practitioners, who carried out 70% of the therapy, with 712 visits by 22 other patients for whom all care ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kisker CT,Strayer F,Wong K,Clarke W,Strauss R,Tannous R,Janco R,Spevak J

    更新日期:1980-12-01 00:00:00

  • Growth of hyperkinetic children taking methylphenidate, dextroamphetamine, or imipramine/desipramine.

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    更新日期:1976-09-01 00:00:00

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    更新日期:2006-05-01 00:00:00