A model for predicting the risk of carotid artery disease.

Abstract:

OBJECTIVE:To develop a model for the identification of individuals at risk for carotid stenosis (CS) that could be useful in a clinical setting when trying to decide whether screening is worthwhile. BACKGROUND:Evidence that aggressive medical therapy and life style changes reduce the risk of stroke in individuals with CS is increasing and has led to a renewed interest in screening for CS. METHODS:Data on demographics and risk factors were obtained from 2,885,257 individuals who had carotid Duplex scans by Life Line Screening between 2003 and 2008. Multivariable logistic regression analysis was used to identify independent risk factors for CS (>50% stenosis). A scoring system was developed where risk factors were assigned a weighted score. Predictive ability was assessed by calculating C statistics and r2. RESULTS:In the screened cohort, 71,004 patients (2.4%) had CS. Independent risk factors include advanced age, smoking, peripheral arterial disease, high blood pressure, coronary artery disease, diabetes, cholesterol, and abdominal aortic aneurysm. African Americans, Asians, and Hispanics had reduced risk than whites. Exercise and consumption of fruit, vegetables, and nuts had a modest protective effect. A predictive scoring system was created that identifies individuals with CS more efficiently (C statistic = 0.753) than previously published models. CONCLUSIONS:We provide a model that enables identification of individuals who have a high probability of having CS. This model can be helpful in designing targeted screening programs that are cost-effective.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Greco G,Egorova NN,Moskowitz AJ,Gelijns AC,Kent KC,Manganaro AJ,Zwolak RM,Riles TS

doi

10.1097/SLA.0b013e31827b9761

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

1168-73

issue

6

eissn

0003-4932

issn

1528-1140

journal_volume

257

pub_type

杂志文章
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    abstract:OBJECTIVE:Marked variations in sentinel lymph node dissection (SLND) technique have been identified, and definitive qualifications for SLND performance remain controversial. Based on previous reports and expert opinion, we predicted that 20 to 30 cases of SLND with axillary lymph node dissection (ALND) would enable sur...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/01.sla.0000184210.68646.77

    authors: Posther KE,McCall LM,Blumencranz PW,Burak WE Jr,Beitsch PD,Hansen NM,Morrow M,Wilke LG,Herndon JE 2nd,Hunt KK,Giuliano AE

    更新日期:2005-10-01 00:00:00

  • Impact of statistical approaches for handling missing data on trauma center quality.

    abstract:OBJECTIVE:To determine whether imputed data can be used to produce unbiased hospital quality measures. BACKGROUND:Different methods for handling missing data may influence which hospitals are designated as quality outliers. METHODS:Monte-Carlo simulation study based on 63,020 patients with no missing data in 68 hospi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818e544b

    authors: Glance LG,Osler TM,Mukamel DB,Meredith W,Dick AW

    更新日期:2009-01-01 00:00:00

  • Gastrointestinal manifestations of multiple endocrine neoplasia type 2.

    abstract:OBJECTIVE:To determine the clinical features, natural history, and role of surgery for gastrointestinal manifestations of the multiple endocrine neoplasia type 2 (MEN 2) syndromes. SUMMARY BACKGROUND DATA:The MEN 2 syndromes are characterized by medullary thyroid carcinoma and other endocrinopathies. In addition, some...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200205000-00006

    authors: Cohen MS,Phay JE,Albinson C,DeBenedetti MK,Skinner MA,Lairmore TC,Doherty GM,Balfe DM,Wells SA Jr,Moley JF

    更新日期:2002-05-01 00:00:00

  • Long-term Results of a Randomized Double-blinded Prospective Trial of a Lightweight (Ultrapro) Versus a Heavyweight Mesh (Prolene) in Laparoscopic Total Extraperitoneal Inguinal Hernia Repair (TULP-trial).

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    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000001579

    authors: Burgmans JP,Voorbrood CE,Simmermacher RK,Schouten N,Smakman N,Clevers G,Davids PH,Verleisdonk EM,Hamaker ME,Lange JF,van Dalen T

    更新日期:2016-05-01 00:00:00

  • Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation.

    abstract:OBJECTIVE:To evaluate the effects of artesunate on organ injury and dysfunction associated with hemorrhagic shock (HS) in the rat. BACKGROUND:HS is still a common cause of death in severely injured patients and is characterized by impairment of organ perfusion, systemic inflammatory response, and multiple organ failur...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001664

    authors: Sordi R,Nandra KK,Chiazza F,Johnson FL,Cabrera CP,Torrance HD,Yamada N,Patel NS,Barnes MR,Brohi K,Collino M,Thiemermann C

    更新日期:2017-02-01 00:00:00

  • Tacrolimus and Single Intraoperative High-dose of Anti-T-lymphocyte Globulins Versus Tacrolimus Monotherapy in Adult Liver Transplantation: One-year Results of an Investigator-driven Randomized Controlled Trial.

    abstract:OBJECTIVE:The aim of the study is to evaluate whether intra-operative induction with anti-lymphocytic serum (ALS) is superior to no induction in adult liver transplantation (LT). BACKGROUND:The efficacy of ALS induction remains inconclusive in LT, because of poorly designed trials. METHODS:A randomized controlled tri...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000002943

    authors: Iesari S,Ackenine K,Foguenne M,De Reyck C,Komuta M,Bonaccorsi Riani E,Ciccarelli O,Coubeau L,Lai Q,Gianello P,Lerut J

    更新日期:2018-11-01 00:00:00

  • Risk factors for surgery and postoperative recurrence in Crohn's disease.

    abstract:OBJECTIVE:To assess the impact of possible risk factors on intestinal resection and postoperative recurrence in Crohn's disease (CD) and to evaluate the disease course. SUMMARY BACKGROUND DATA:The results of previous studies on possible risk factors for surgery and recurrence in Crohn's disease have been inconsistent....

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200001000-00006

    authors: Bernell O,Lapidus A,Hellers G

    更新日期:2000-01-01 00:00:00

  • Transplantation of pediatric donor kidneys to adult recipients. Is there a critical donor age?

    abstract::Cadaver kidneys remain a scarce resource, yet single pediatric donor kidneys are underutilized at some centers. Between 1967 and 1984, 133 single pediatric and 318 adult donor cadaver transplants were performed. Patient and graft survival, renal function, and complications in adult recipients grouped by donor age were...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198608000-00011

    authors: Wengerter K,Matas AJ,Tellis VA,Quinn T,Soberman R,Veith FJ

    更新日期:1986-08-01 00:00:00

  • Current Surgical Management of Pediatric Idiopathic Constipation: A Systematic Review of Published Studies.

    abstract:OBJECTIVE:Surgery for pediatric idiopathic constipation (IC) is undertaken after failure of bowel management programs. Decisions are influenced by rectal biopsy, transit studies, megacolon/megarectum, degree of soiling/incontinence, and anorectal manometry profile(s). A systematic review of ALL published studies critic...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000001191

    authors: Siminas S,Losty PD

    更新日期:2015-12-01 00:00:00

  • Impact of a clinical pathway for elective infrarenal aortic reconstructions.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199805000-00009

    authors: Huber TS,Carlton LM,Harward TR,Russin MM,Phillips PT,Nalli BJ,Flynn TC,Seeger JM

    更新日期:1998-05-01 00:00:00

  • The influence of injury severity on complication rates after primary closure or colostomy for penetrating colon trauma.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198904000-00009

    authors: Nelken N,Lewis F

    更新日期:1989-04-01 00:00:00

  • Bariatric Surgery in Medicare Patients: Examining Safety and Healthcare Utilization in the Disabled and Elderly.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004526

    authors: Chao GF,Chhabra KR,Yang J,Thumma JR,Arterburn DE,Ryan AM,Telem DA,Dimick JB

    更新日期:2020-11-17 00:00:00

  • Prolonged continuous or intermittent vascular inflow occlusion during hemihepatectomy in pigs.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199903000-00011

    authors: van Wagensveld BA,van Gulik TM,Gelderblom HC,Scheepers JJ,Bosma A,Endert E,Gouma DJ

    更新日期:1999-03-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200201000-00015

    authors: Erdag G,Morgan JR

    更新日期:2002-01-01 00:00:00

  • Comparison of Postoperative Outcomes Between Donation After Circulatory Death and Donation After Brain Death Liver Transplantation Using the Comprehensive Complication Index.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002419

    authors: Kalisvaart M,de Haan JE,Polak WG,Metselaar HJ,Wijnhoven BPL,IJzermans JNM,de Jonge J

    更新日期:2017-11-01 00:00:00

  • Endovascular repair of abdominal aortic aneurysms: risk stratified outcomes.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200206000-00011

    authors: Chaikof EL,Lin PH,Brinkman WT,Dodson TF,Weiss VJ,Lumsden AB,Terramani TT,Najibi S,Bush RL,Salam AA,Smith RB 3rd

    更新日期:2002-06-01 00:00:00

  • Studies of the modified venous allograft.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197708000-00018

    authors: Perloff LJ,Rowlands DT,Barker CF

    更新日期:1977-08-01 00:00:00

  • Autologous blood in the treatment of intraoperative hemorrhage.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197703000-00013

    authors: Bonfils-Roberts EA,Stutman L,Nealon TF Jr

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  • When Do DCD Donors Die?: Outcomes and Implications of DCD at a High-volume, Single-center OPO in the United States.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001298

    authors: Scalea JR,Redfield RR,Rizzari MD,Bennett R,Anderson ME,Anderson JE,Kaufman DB,Sollinger HW,Fernandez LA,D'Alessandro AM,Mezrich J

    更新日期:2016-02-01 00:00:00

  • Renal blood flow and intrarenal distribution of blood flow after decapsulation in the postischemic kidney.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198004000-00011

    authors: Stothert JC Jr

    更新日期:1980-04-01 00:00:00

  • Use of abdominal ultrasonography to assess pediatric splenic trauma. Potential pitfalls in the diagnosis.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199704000-00010

    authors: Krupnick AS,Teitelbaum DH,Geiger JD,Strouse PJ,Cox CS,Blane CE,Polley TZ

    更新日期:1997-04-01 00:00:00

  • Accuracy of gadofosveset-enhanced MRI for nodal staging and restaging in rectal cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31820b01f1

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    更新日期:2011-03-01 00:00:00

  • Current concepts in the mediastinal lymph node staging of nonsmall cell lung cancer.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.SLA.0000081086.37779.1a

    authors: Kramer H,Groen HJ

    更新日期:2003-08-01 00:00:00

  • Impaired nonspecific cellular immunity in experimental cholestasis.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198711000-00004

    authors: Roughneen PT,Drath DB,Kulkarni AD,Rowlands BJ

    更新日期:1987-11-01 00:00:00

  • Reconstruction for chronic dysfunction of ileoanal pouches.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199902000-00006

    authors: Fonkalsrud EW,Bustorff-Silva J

    更新日期:1999-02-01 00:00:00

  • Studies on the possible role of thyroid hormone in altered muscle protein turnover during sepsis.

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    pub_type: 杂志文章

    doi:10.1097/00000658-198707000-00003

    authors: Hasselgren PO,Chen IW,James JH,Sperling M,Warner BW,Fischer JE

    更新日期:1987-07-01 00:00:00

  • Intraperitoneal povidone-iodine in experimental peritonitis.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197806000-00005

    authors: Lagarde MC,Bolton JS,Cohn I Jr

    更新日期:1978-06-01 00:00:00

  • A multifactorial analysis of melanoma: III. Prognostic factors in melanoma patients with lymph node metastases (stage II).

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198103000-00023

    authors: Balch CM,Soong SJ,Murad TM,Ingalls AL,Maddox WA

    更新日期:1981-03-01 00:00:00

  • Troponin Elevation After Colorectal Surgery: Significance and Management.

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    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001854

    authors: Gorgun E,Lan BY,Aydinli HH,Reed GW,Menon V,Sessler DI,Stocchi L,Remzi FH

    更新日期:2016-10-01 00:00:00

  • Multicenter Canadian study of prehospital trauma care.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.SLA.0000048374.46952.10

    authors: Liberman M,Mulder D,Lavoie A,Denis R,Sampalis JS

    更新日期:2003-02-01 00:00:00