When Do DCD Donors Die?: Outcomes and Implications of DCD at a High-volume, Single-center OPO in the United States.

Abstract:

OBJECTIVE:The objective of this study was to determine the fate of patients who attempted to donate organs after circulatory death (DCD) using a standardized DCD protocol. BACKGROUND:Successful donation is not always possible after attempted DCD. METHODS:Data were collected for all DCD donors between 1/2011 and 9/2014. DCDs were carried out using a uniform protocol at a single-center organ procurement organization. RESULTS:During the timeframe considered, DCD donation was attempted in 169 patients. In 46 patients (27.2%), no organs were recovered because the patients did not die within 2 hours. Successful donation was more likely if withdrawal of support occurred in the operating room versus the intensive care unit (P = 0.006). Time from extubation to death was available for 161/169 donors (95.3%). Of 161 donors, 111 (66.9%) died in under 1 hour. The mean time from withdrawal of support to patient death for unsuccessful donations was 33 hours, 37 minutes (range, 24 minutes-242 hours) versus 29 minutes (range, 5 minutes-2 hours, 4 minutes) for successful donations. Twenty-seven patients who unsuccessfully donated (67.5%) died within 24 hours. Were unsuccessful donations converted to successful donations, as many as 837 abdominal transplants could have been carried out in the United States, during the study period. CONCLUSIONS:DCD is an important form of organ donation. A large number of abdominal transplants are not possible due to unsuccessful DCD organ donation. It may be useful to explore DCD donor family satisfaction to identify other options for improving DCD donation.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Scalea JR,Redfield RR,Rizzari MD,Bennett R,Anderson ME,Anderson JE,Kaufman DB,Sollinger HW,Fernandez LA,D'Alessandro AM,Mezrich J

doi

10.1097/SLA.0000000000001298

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

211-6

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

263

pub_type

杂志文章
  • Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases.

    abstract:OBJECTIVE:To determine overall survival and disease-free survival in selected patients with nonresectable liver-only colorectal cancer receiving liver transplantation. BACKGROUND:Patients with nonresectable colorectal cancer receiving palliative chemotherapy has a 5-year overall survival of about 10%. Liver transplant...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000003404

    authors: Dueland S,Syversveen T,Solheim JM,Solberg S,Grut H,Bjørnbeth BA,Hagness M,Line PD

    更新日期:2020-02-01 00:00:00

  • Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease.

    abstract:OBJECTIVE:The purpose of the study was to test the hypothesis that cardiac mucosa, carditis, and specialized intestinal metaplasia at an endoscopically normal-appearing cardia are manifestations of gastroesophageal reflux disease. SUMMARY BACKGROUND DATA:In the absence of esophageal mucosal injury, the diagnosis of ga...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199710000-00013

    authors: Oberg S,Peters JH,DeMeester TR,Chandrasoma P,Hagen JA,Ireland AP,Ritter MP,Mason RJ,Crookes P,Bremner CG

    更新日期:1997-10-01 00:00:00

  • Lymphoma of the breast.

    abstract::Thirteen patients with lymphoma of the breast are presented. In addition, 163 previously reported cases of lymphoma of the breast are reviewed. Complete staging was performed on all patients. No patient had a diagnosis of lymphoma prior to breast biopsy. The histologic findings were diffuse histiocytic lymphoma (DHL) ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198112000-00015

    authors: Schouten JT,Weese JL,Carbone PP

    更新日期:1981-12-01 00:00:00

  • Main pancreatic ductal anatomy can direct choice of modality for treating pancreatic pseudocysts (surgery versus percutaneous drainage).

    abstract:OBJECTIVE:To test the hypothesis that pancreatic ductal anatomy may predict the likely success of percutaneous drainage of pseudocysts of the pancreas. SUMMARY BACKGROUND DATA:Various modalities are currently applied to pseudocysts, with little or no data to aid in the choice of management strategy. Pancreatic ductal ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200206000-00001

    authors: Nealon WH,Walser E

    更新日期:2002-06-01 00:00:00

  • Comparison of surgical outcomes between teaching and nonteaching hospitals in the Department of Veterans Affairs.

    abstract:OBJECTIVE:To determine whether the investment in postgraduate education and training places patients at risk for worse outcomes and higher costs than if medical and surgical care was delivered in nonteaching settings. SUMMARY BACKGROUND DATA:The Veterans Health Administration (VA) plays a major role in the training of...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200109000-00011

    authors: Khuri SF,Najjar SF,Daley J,Krasnicka B,Hossain M,Henderson WG,Aust JB,Bass B,Bishop MJ,Demakis J,DePalma R,Fabri PJ,Fink A,Gibbs J,Grover F,Hammermeister K,McDonald G,Neumayer L,Roswell RH,Spencer J,Turnage RH,V

    更新日期:2001-09-01 00:00:00

  • Resection for pancreatitis in patients with pancreas divisum.

    abstract::Pancreas divisum is an anatomic duct variant, which may predispose to pancreatitis. Most patients are managed conservatively, but some patients justify attempts to improve drainage. The correct surgical approach is not yet established, and there has been no series published concerning pancreatic resection in this cont...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198411000-00006

    authors: Blair AJ 3rd,Russell CG,Cotton PB

    更新日期:1984-11-01 00:00:00

  • The spectrum of portal vein thrombosis in liver transplantation.

    abstract::Thrombosis of the portal vein with or without patency of its tributaries used to be a contraindication to orthotopic liver transplantation (OLTX) until quite recently. Rapid progress in the surgical technique of OLTX in the last few years has demonstrated that most patients with portal vein thrombosis can be safely an...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199103000-00003

    authors: Stieber AC,Zetti G,Todo S,Tzakis AG,Fung JJ,Marino I,Casavilla A,Selby RR,Starzl TE

    更新日期:1991-03-01 00:00:00

  • Impact of current management practices on early and late death in more than 500 consecutive cardiac transplant recipients.

    abstract:OBJECTIVE:To study risk factors for early and late death after heart transplantation in the current era. SUMMARY BACKGROUND DATA:The current cardiac transplant population differs from earlier periods in that an increasing number of sicker patients, such as those with ventricular assist device (LVAD) support, prior car...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200009000-00002

    authors: John R,Rajasinghe H,Chen JM,Weinberg AD,Sinha P,Itescu S,Lietz K,Mancini D,Oz MC,Smith CR,Rose EA,Edwards NM

    更新日期:2000-09-01 00:00:00

  • Is ambulatory laparoscopic Roux-en-Y gastric bypass associated with higher adverse events?

    abstract:OBJECTIVE:To determine the impact of length of stay upon 30-day outcomes. BACKGROUND:It has been recommended the goal length of stay (LOS) after laparoscopic Roux-en-Y gastric bypass (LRYGB) should be 1 day to improve resource utilization. This study's aim was to assess LRYGB outcomes by LOS. METHODS:Data were obtain...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000227

    authors: Morton JM,Winegar D,Blackstone R,Wolfe B

    更新日期:2014-02-01 00:00:00

  • 24-hour ambulatory dual gastroduodenal pH monitoring. The role of acid in duodenal ulcer disease.

    abstract::A new system for long-term, 24-hour, ambulatory dual gastroduodenal pH monitoring is described. Eighteen patients with active duodenal ulcers and ten healthy subjects were studied. Simultaneous gastric and duodenal bulb pH were measured during fasting, the ingestion of a solid meal, and for the remainder of the 24-hou...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198812000-00005

    authors: Eriksen CA,Sadek SA,Cuschieri A

    更新日期:1988-12-01 00:00:00

  • Endothelial-directed hepatic regeneration after partial hepatectomy.

    abstract:OBJECTIVE:To determine the role of the microvascular endothelium in the regulation of regenerating liver mass after partial hepatectomy. SUMMARY BACKGROUND DATA:Angiogenesis is critical for both pathologic and physiologic processes. The ability of certain tissues, such as the liver, kidney, and spleen, to regenerate a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000059986.96051.EA

    authors: Greene AK,Wiener S,Puder M,Yoshida A,Shi B,Perez-Atayde AR,Efstathiou JA,Holmgren L,Adamis AP,Rupnick M,Folkman J,O'Reilly MS

    更新日期:2003-04-01 00:00:00

  • Incidence and outcome of biliary strictures after pancreaticoduodenectomy.

    abstract:OBJECTIVE:This single-institution review examined the incidence of biliary stricture formation after pancreaticoduodenectomy (PD) for benign and malignant periampullary disease. BACKGROUND:The incidence and course of stricture of the hepaticojejunostomy have not been documented after PD. METHODS:Between January 1995 ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000216285.07069.fc

    authors: House MG,Cameron JL,Schulick RD,Campbell KA,Sauter PK,Coleman J,Lillemoe KD,Yeo CJ

    更新日期:2006-05-01 00:00:00

  • Hospital Volume of Antireflux Surgery in Relation to Endoscopic and Surgical Re-interventions.

    abstract:OBJECTIVE:To test the hypothesis that higher hospital volume decreases endoscopic and surgical re-intervention rates after antireflux surgery. BACKGROUND:Antireflux surgery for gastro-esophageal reflux disease is followed by varying rates of re-interventions. Whether hospital volume influences re-intervention rates is...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003776

    authors: Markar S,Santoni G,Maret-Ouda J,Artama M,Färkkilä M,Lynge E,Pukkala E,Ness-Jensen E,von Euler-Chelpin M,Lagergren J

    更新日期:2020-01-06 00:00:00

  • Risk and location of cancer in patients with preoperative colitis-associated dysplasia undergoing proctocolectomy.

    abstract:OBJECTIVE:To evaluate the influence of preoperative dysplasia grade, appearance, and site on risk and location of cancer in patients with colitis. BACKGROUND:The ability to predict the presence and location of cancer in colitis patients with dysplasia is essential to facilitate recommendations regarding the necessity ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31828e7417

    authors: Kiran RP,Ahmed Ali U,Nisar PJ,Khoury W,Gu J,Shen B,Remzi FH,Hammel JP,Lavery IC,Fazio VW,Goldblum JR

    更新日期:2014-02-01 00:00:00

  • Remission of type 2 diabetes after Roux-en-Y gastric bypass or sleeve gastrectomy is associated with a distinct glycemic profile.

    abstract:BACKGROUND:Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such remission is associated with full restoration of postprandial glucose profile and/or the potentially nonrestored glycemic profile is associate...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000586

    authors: Jiménez A,Ceriello A,Casamitjana R,Flores L,Viaplana-Masclans J,Vidal J

    更新日期:2015-02-01 00:00:00

  • Treatment of symptomatic gastroesophageal reflux using the Angelchik prosthesis.

    abstract::During the past 20 months, 28 patients with symptomatic gastroesophageal reflux were treated with the Angelchik anti-reflux prosthesis. The patients ranged in age from 12 to 75 years, with symptoms present from one to 24 years. Vigorous medical management had failed with all patients prior to surgery. Before operation...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198206000-00002

    authors: Starling JR,Reichelderfer MO,Pellett JR,Belzer FO

    更新日期:1982-06-01 00:00:00

  • Short-term surgical outcomes from a randomized controlled trial to evaluate laparoscopic and open D3 dissection for stage II/III colon cancer: Japan Clinical Oncology Group Study JCOG 0404.

    abstract:OBJECTIVE:A randomized controlled trial to confirm the non-inferiority of laparoscopic surgery to open surgery in terms of overall survival was conducted, and short-term surgical outcomes are demonstrated. BACKGROUND:The efficacy and safety outcome of laparoscopic surgery for clinical stages II/III colon cancer underg...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000000499

    authors: Yamamoto S,Inomata M,Katayama H,Mizusawa J,Etoh T,Konishi F,Sugihara K,Watanabe M,Moriya Y,Kitano S,Japan Clinical Oncology Group Colorectal Cancer Study Group.

    更新日期:2014-07-01 00:00:00

  • Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors.

    abstract:OBJECTIVE:The authors determined the molecular mechanisms for the failure of transforming growth factor-beta (TGF-beta) to inhibit the growth of SW1116 and SW48 colon cancer cell lines. BACKGROUND:Transforming growth factor-beta is a bifunctional regulator of cell growth that typically stimulates proliferation of mese...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199506000-00015

    authors: MacKay SL,Yaswen LR,Tarnuzzer RW,Moldawer LL,Bland KI,Copeland EM 3rd,Schultz GS

    更新日期:1995-06-01 00:00:00

  • Strategies in the surgical treatment of malignant ventricular arrhythmias. An 8-year experience.

    abstract::Introduction of the automatic implantable cardioverter defibrillator (AICD) has dramatically affected the surgical treatment of malignant ventricular tachyarrhythmias. The authors continue to perform electrophysiologically directed subendocardial resection (SER) of left ventricular (LV) scars in selected patients, and...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199209000-00010

    authors: Geha AS,Elefteriades JA,Hsu J,Biblo LA,Hoch DH,Batsford WP,Rosenfeld LE,Carlson MD,Johnson NJ,Waldo AL

    更新日期:1992-09-01 00:00:00

  • Permanent Pancreatic Duct Occlusion With Neoprene-based Glue Injection After Pancreatoduodenectomy at High Risk of Pancreatic Fistula: A Prospective Clinical Study.

    abstract:OBJECTIVE:The aim of this study was to assess safety and efficacy of pancreatic duct occlusion (PDO) with neoprene-based glue in selected patients undergoing pancreatoduodenectomy (PD) at high risk of postoperative pancreatic fistula (POPF). BACKGROUND DATA:PD is the reference standard approach for tumors of the pancr...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000003514

    authors: Mazzaferro V,Virdis M,Sposito C,Cotsoglou C,Droz Dit Busset M,Bongini M,Flores M,Prinzi N,Coppa J

    更新日期:2019-11-01 00:00:00

  • Influence of Depression on Recovery After Major Noncardiac Surgery: A Prospective Cohort Study.

    abstract:OBJECTIVES:To determine the influence of patient depression (and anxiety) on postoperative outcome and surgeons' consideration of it. BACKGROUND:Patients' mental state influences the course of nonpsychiatric diseases. Evidence in the surgical setting comes mainly from cardiac-surgery patients and no predictive-model o...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001448

    authors: Orri M,Boleslawski E,Regimbeau JM,Barry C,Hassler C,Gregoire E,Bachellier P,Scatton O,Mabrut JY,Adham M,Vibert E,Revah-Levy A,Farges O

    更新日期:2015-11-01 00:00:00

  • Treatment of anal incontinence by an implantable prosthetic anal sphincter.

    abstract::Twelve patients with anal incontinence due to neurologic disease or failure of previous incontinence surgery underwent implantation of an artificial anal sphincter. The system used was a modification of the AMS 800 artificial urinary sphincter. In two patients, infection necessitated removal of the system, and in four...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199204000-00013

    authors: Christiansen J,Sparsø B

    更新日期:1992-04-01 00:00:00

  • Improving the AJCC/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade.

    abstract:PURPOSE:Though histological grade is known to have a major prognostic impact in metastatic mucinous appendiceal adenocarcinomas, the prognostic impact of grade in localized disease, and the validity of the American Joint Committee on Cancer AJCC Staging Manual 7th edition's decision to combine moderately and poorly dif...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318269d680

    authors: Overman MJ,Fournier K,Hu CY,Eng C,Taggart M,Royal R,Mansfield P,Chang GJ

    更新日期:2013-06-01 00:00:00

  • Embryonic Origin of Primary Colon Cancer Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colon Cancer Liver Metastases.

    abstract:BACKGROUND:The aim of this study was to determine the prognostic value of embryonic origin in patients undergoing resection after chemotherapy for colon cancer liver metastases (CCLM). METHODS:We identified 725 patients with primary colon cancer and known RAS mutation status who underwent hepatic resection after preop...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002087

    authors: Yamashita S,Brudvik KW,Kopetz SE,Maru D,Clarke CN,Passot G,Conrad C,Chun YS,Aloia TA,Vauthey JN

    更新日期:2018-03-01 00:00:00

  • Relevance of the ISGLS definition of posthepatectomy liver failure in early prediction of poor outcome after liver resection: study on 680 hepatectomies.

    abstract:OBJECTIVE:To assess the relevance of the International Study Group of Liver Surgery (ISGLS) definition of posthepatectomy liver failure compared with 2 well-established criteria, 50-50 and PeakBili>7, as early predictors of posthepatectomy outcome. BACKGROUND:There is limited data on the postoperative use of ISGLS def...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000944

    authors: Skrzypczyk C,Truant S,Duhamel A,Langlois C,Boleslawski E,Koriche D,Hebbar M,Fourrier F,Mathurin P,Pruvot FR

    更新日期:2014-11-01 00:00:00

  • The treatment of venous leg ulcers: a new therapeutic use of iloprost.

    abstract:BACKGROUND:We conducted a study using an intravenous (i.v.) infusion of iloprost in the treatment of venous ulcers to verify whether the association of i.v. iloprost + local therapy + elastic compression has a favorable effect when compared with traditional treatment with local therapy and elastic compression. STUDY D...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e3180caa44c

    authors: Ferrara F,Meli F,Raimondi F,Amato C,Bonura F,Mulè G,Novo G,Novo S S

    更新日期:2007-11-01 00:00:00

  • The value of thymectomy in myasthenia gravis: a computer-assisted matched study.

    abstract::In the absence of a prospective randomized study of patients treated conservatively or with thymectomy, a computer-assisted retrospective matches study was devised. Of 563 patients treated for myasthenia gravis without thymoma up to 1965, 104 had thymectomy. With computer assistance, each surgical patient was matched ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197610000-00008

    authors: Buckingham JM,Howard FM Jr,Bernatz PE,Payne WS,Harrison EG Jr,O'Brien PC,Weiland LH

    更新日期:1976-10-01 00:00:00

  • Classification of pathologic response to neoadjuvant therapy in esophageal and junctional cancer: assessment of existing measures and proposal of a novel 3-point standard.

    abstract:OBJECTIVE:To assess existing measures of pathologic response to neoadjuvant therapy in esophageal and junctional cancer, and to recommend an optimum classification. BACKGROUND:Multimodal therapy is increasingly the standard of care for locally advanced esophageal cancer. Numerous measures of pathologic response have b...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182a66588

    authors: Donohoe CL,O'Farrell NJ,Grant T,King S,Clarke L,Muldoon C,Reynolds JV

    更新日期:2013-11-01 00:00:00

  • Methodological Quality of Surgical Mortality Studies Using Large Hospital Databases: A Systematic Review.

    abstract:OBJECTIVE:To review the methodology employed in surgical mortality studies to control for potential confounders. SUMMARY BACKGROUND DATA:Nationwide hospital data are increasingly used to investigate surgical outcomes. However, poor data granularity and coding inaccuracies may lead to flawed findings. METHODS:We condu...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000002119

    authors: Payet C,Lifante JC,Carty MJ,Rabilloud M,Duclos A

    更新日期:2017-06-01 00:00:00

  • Subclassification of Microscopic Vascular Invasion in Hepatocellular Carcinoma.

    abstract:OBJECTIVE:To investigate whether subclassification of microscopic vascular invasion (MiVI) affects the long-term outcome after curative surgical resection or liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). SUMMARY OF BACKGROUND DATA:The most important factor for TNM staging in HCC is MiVI, ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003781

    authors: Kang I,Jang M,Lee JG,Han DH,Joo DJ,Kim KS,Kim MS,Choi JS,Kim SI,Park YN,Choi GH

    更新日期:2020-01-14 00:00:00