Current Surgical Management of Pediatric Idiopathic Constipation: A Systematic Review of Published Studies.


OBJECTIVE:Surgery for pediatric idiopathic constipation (IC) is undertaken after failure of bowel management programs. Decisions are influenced by rectal biopsy, transit studies, megacolon/megarectum, degree of soiling/incontinence, and anorectal manometry profile(s). A systematic review of ALL published studies critically evaluates outcomes of surgery for IC. METHODS:MEDLINE (PubMed), Google Scholar, and EMBase were searched for English-language articles only. Studies included (1) peer-review publications with 3 or more patients, and (2) clinical outcomes defined by authors. RESULTS:Forty-five reports (1157 patients) met full inclusion criteria. Only 2 papers were randomized controlled trials. Many had small patient numbers (median n = 16; range: 3-114). Twenty-three described heterogenous populations with variant pathology. Follow-up was short (median = 1.5 years: range: 3 months-14 years). The antegrade continence enema operation (ACE)-[open/laparoscopic assisted, cecostomy, or "left sided" ACE]-was judged as successful in 82% of cases, although high morbidity and reoperations were reported. Colon resection and pull through operations had "good" outcome(s) in 79% of children with 17% reporting significant morbidity and a 10% incidence of revisional surgery. Anal dilatation did not improve outcome(s). Botulinum toxin injection scored equally effective compared to internal sphincter myectomy in short-term follow-up. Permanent colostomy was considered successful in 86% of refractory IC cases. CONCLUSIONS:Surgical management and outcome(s) for pediatric IC are based on low-quality evidence. No single operation was considered "best practice." This study crucially highlights that surgeons must develop better care strategies.


Ann Surg


Annals of surgery


Siminas S,Losty PD




Has Abstract


2015-12-01 00:00:00












  • K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.

    abstract:OBJECTIVE:To evaluate clinical parameters, presurgical diagnostic tests, histologic findings, and the presence of K-ras oncogene mutations in cystic tumors of the pancreas to determine which best predict malignancy. SUMMARY BACKGROUND DATA:Because presurgical, intraoperative, and final pathologic differentiation is di...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Bartsch D,Bastian D,Barth P,Schudy A,Nies C,Kisker O,Wagner HJ,Rothmund M

    更新日期:1998-07-01 00:00:00

  • Incidence and consequence of an hepatic artery injury in patients with postcholecystectomy bile duct strictures.

    abstract:OBJECTIVE:To compare the clinical presentation and results of treatment of postcholecystectomy bile duct injuries in patients with and without arterial injuries. SUMMARY BACKGROUND DATA:Incidence and impact of arterial injuries in patients with a postcholecystectomy biliary injury are unknown, although they are claime...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Alves A,Farges O,Nicolet J,Watrin T,Sauvanet A,Belghiti J

    更新日期:2003-07-01 00:00:00

  • Growth-inhibitory effects of epidermal growth factor on human breast cancer and carcinoma of the esophagus transplanted into nude mice.

    abstract::The present work was performed to clarify the effects of epidermal growth factor (EGF) on the growth of human breast cancer and carcinoma of the esophagus. Human breast cancer MX-1, UM-1, and esophageal cancer ES-4 were transplanted to the subcutaneous tissue of nude mice. Human EGF (2 micrograms) was injected locally...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Murayama Y

    更新日期:1990-03-01 00:00:00

  • Villous tumors of the duodenum.

    abstract::Records of 32 patients with 34 villous and tubulovillous adenomas of the duodenum, treated at the Cleveland Clinic over the past 21 years, were reviewed. Twenty-two patients (69%) had complete resection of the adenoma; the incidence of malignancy was 47%. Five patients underwent a Whipple procedure; 4 patients had seg...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Galandiuk S,Hermann RE,Jagelman DG,Fazio VW,Sivak MV

    更新日期:1988-03-01 00:00:00

  • Computed tomographic angiography for the diagnosis of blunt carotid/vertebral artery injury: a note of caution.

    abstract:OBJECTIVE:Computed tomographic angiography (CTA) by 16-channel multidetector scanner is increasingly replacing conventional digital subtraction angiography (DSA) for diagnosing or excluding blunt carotid/vertebral injuries (BCVI). To date there has been only 1 study in which all patients received both examinations. Tha...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Malhotra AK,Camacho M,Ivatury RR,Davis IC,Komorowski DJ,Leung DA,Grizzard JD,Aboutanos MB,Duane TM,Cockrell C,Wolfe LG,Borchers CT,Martin NR

    更新日期:2007-10-01 00:00:00

  • Biostatistical basis of elective node dissection for malignant melanoma.

    abstract::During the years 1954 through 1964, 259 individuals with primary malignant melanoma had an elective node dissection. Microscopic metastases were found in 15% of these patients. The presence of only a microscopic focus of involvement gave a 10-year cure rate of 67%; metastasis larger than a microscopic focus in a singl...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Fortner JG,Woodruff J,Schottenfeld D,Maclean B

    更新日期:1977-07-01 00:00:00

  • Influence of acute epinephrine infusion on endotoxin-induced parameters of heart rate variability: a randomized controlled trial.

    abstract:OBJECTIVE:To determine whether the acute anti-inflammatory influence of epinephrine (EPI) extends to changes in heart rate variability (HRV) induced by the prototypical inflammatory stimulus, endotoxin (lipopolysaccharide [LPS]). SUMMARY BACKGROUND DATA:HRV reflects fluctuating cardiac autonomic inputs and is acutely ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验


    authors: Jan BU,Coyle SM,Oikawa LO,Lu SE,Calvano SE,Lehrer PM,Lowry SF

    更新日期:2009-05-01 00:00:00

  • Laparoscopic resection does not adversely affect early survival curves in patients undergoing surgery for colorectal adenocarcinoma.

    abstract:OBJECTIVE:To determine the survival curves for laparoscopic resection (LR) of colorectal cancer. SUMMARY BACKGROUND DATA:Laparoscopic resection for cure of colorectal cancer is controversial, and survival curves have not been determined. METHODS:A prospective database of 177 consecutive LRs of colorectal cancers perf...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章


    authors: Poulin EC,Mamazza J,Schlachta CM,Grégoire R,Roy N

    更新日期:1999-04-01 00:00:00

  • Incidence and Risk Factors for Anastomotic Failure in 1594 Patients Treated by Transanal Total Mesorectal Excision: Results From the International TaTME Registry.

    abstract:OBJECTIVE:To determine the incidence of anastomotic-related morbidity following Transanal Total Mesorectal Excision (TaTME) and identify independent risk factors for failure. BACKGROUND:Anastomotic leak and its sequelae are dreaded complications following gastrointestinal surgery. TaTME is a recent technique for recta...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究


    authors: Penna M,Hompes R,Arnold S,Wynn G,Austin R,Warusavitarne J,Moran B,Hanna GB,Mortensen NJ,Tekkis PP,International TaTME Registry Collaborative.

    更新日期:2019-04-01 00:00:00

  • Evaluation of hepatic venous congestion: proposed indication criteria for hepatic vein reconstruction.

    abstract:OBJECTIVE:To establish criteria for venous reconstruction of middle hepatic vein (MHV) tributaries of the right liver graft in adult-to-adult living donor liver transplantation (LDLT). SUMMARY BACKGROUND DATA:In adult LDLT using the right hemiliver, the MHV is usually separated from the graft, which results in potenti...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章


    authors: Sano K,Makuuchi M,Miki K,Maema A,Sugawara Y,Imamura H,Matsunami H,Takayama T

    更新日期:2002-08-01 00:00:00

  • Prevalence and Risk Factors for Bariatric Surgery Readmissions: Findings From 130,007 Admissions in the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program.

    abstract:OBJECTIVE:To evaluate readmissions following laparoscopic adjustable gastric banding (LAGB), laparoscopic sleeve gastrectomy (LSG), and laparoscopic Roux-en-Y gastric bypass (LRYGB). BACKGROUND:Few studies have evaluated national readmission rates for primary bariatric surgery with national, bariatric-specific data. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究


    authors: Berger ER,Huffman KM,Fraker T,Petrick AT,Brethauer SA,Hall BL,Ko CY,Morton JM

    更新日期:2018-01-01 00:00:00

  • Relevance of the ISGLS definition of posthepatectomy liver failure in early prediction of poor outcome after liver resection: study on 680 hepatectomies.

    abstract:OBJECTIVE:To assess the relevance of the International Study Group of Liver Surgery (ISGLS) definition of posthepatectomy liver failure compared with 2 well-established criteria, 50-50 and PeakBili>7, as early predictors of posthepatectomy outcome. BACKGROUND:There is limited data on the postoperative use of ISGLS def...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Skrzypczyk C,Truant S,Duhamel A,Langlois C,Boleslawski E,Koriche D,Hebbar M,Fourrier F,Mathurin P,Pruvot FR

    更新日期:2014-11-01 00:00:00

  • Biologic determinants of tumor growth in healing wounds.

    abstract::The morphologic characteristics of a scar may render it an "immunologically privileged site" providing fertile ground for tumor occurrence and growth. We sought to extend this concept and to determine the effect of different stages of wound healing on tumor occurrence. Syngeneic strain-2 guinea pigs and a methylcholan...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Pendergrast WJ Jr,Futrell JW

    更新日期:1979-02-01 00:00:00

  • Clinical application of cytochrome a(plus a3) assay of mitochondria from liver specimens: an aid in determining metabolic tolerance of liver remnant for hepatic resection.

    abstract::Measurement of cytochrome a(+a(3)) contents in liver mitochondria was made on 52 biopsy specimens of patients with liver tumor. Patients having higher cytochrome a(+a(3)) contents in mitochondria from remaining liver than those of normal human liver mitochondria could survive well major liver resections whether or not...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Ozawa K,Yamaoka Y,Kitamura O,Nambu H,Kamiyama Y

    更新日期:1974-12-01 00:00:00

  • HER-3 overexpression is prognostic of reduced breast cancer survival: a study of 4046 patients.

    abstract:INTRODUCTION:Advances in molecular biology have led to the identification of potential markers of prognostic and therapeutic importance in human cancers. HER-2 testing and targeted therapy now represents a critical cornerstone in the management of breast cancer. The objectives of the current study were to determine the...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Chiu CG,Masoudi H,Leung S,Voduc DK,Gilks B,Huntsman DG,Wiseman SM

    更新日期:2010-06-01 00:00:00

  • Liver Resection and Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria.

    abstract:OBJECTIVES:To assess survival after liver resection and transplantation in patients with hepatocellular carcinoma (HCC) beyond Milan criteria. BACKGROUND:The role of liver resection and transplantation remains controversial for patients with HCC beyond Milan criteria. Resection of advanced tumors and transplantation u...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Zaydfudim VM,Vachharajani N,Klintmalm GB,Jarnagin WR,Hemming AW,Doyle MB,Cavaness KM,Chapman WC,Nagorney DM

    更新日期:2016-10-01 00:00:00

  • Wnt pathway activation predicts increased risk of tumor recurrence in patients with stage I nonsmall cell lung cancer.

    abstract:OBJECTIVE:To determine the incidence of Wnt pathway activation in patients with stage I NSCLC and its influence on lung cancer recurrence. BACKGROUND:Despite resection, the 5-year recurrence with localized stage I nonsmall cell lung cancer (NSCLC) is 18.4%-24%. Aberrant Wnt signaling activation plays an important role...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Shapiro M,Akiri G,Chin C,Wisnivesky JP,Beasley MB,Weiser TS,Swanson SJ,Aaronson SA

    更新日期:2013-03-01 00:00:00

  • Carotid artery disease following external cervical irradiation.

    abstract::A retrospective study of 910 patients surviving at least five years after cervical irradiation for Hodgkin's disease, non-Hodgkin's lymphoma, or primary head an neck neoplasms showed the incidence of stroke following cervical irradiation was 63 of 910 patients (6.3%) during a mean period of observation of nine years. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Elerding SC,Fernandez RN,Grotta JC,Lindberg RD,Causay LC,McMurtrey MJ

    更新日期:1981-11-01 00:00:00

  • An Implementation Assessment of the Virtual Acute Care for Elders Program From the Perspective of Key Stakeholders.

    abstract:OBJECTIVE:The aim of this study was to obtain feedback from key stakeholders and end users to identify program strengths and weaknesses to plan for wider dissemination and implementation of the Virtual Acute Care for Elders (Virtual ACE) program, a novel intervention that improves outcomes for older surgical patients. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Balentine CJ,Morris M,Knight SJ,Turan JM,Flood KL,Gutierrez-Meza D,Macdonald CL,Bhatia S,Brown CJ

    更新日期:2020-11-16 00:00:00

  • Impact of Surgical Quality Improvement on Payments in Medicare Patients.

    abstract:OBJECTIVE:To examine the financial impact of quality improvement using Medicare payment data. BACKGROUND:Demonstrating a business case for quality improvement--that is, that fewer complications translates into lower costs--is essential to justify investment in quality improvement. Prior research is limited to cross-se...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Scally CP,Thumma JR,Birkmeyer JD,Dimick JB

    更新日期:2015-08-01 00:00:00

  • Subareolar versus peritumoral injection for location of the sentinel lymph node.

    abstract:BACKGROUND:Sentinel lymph node (SLN) biopsy is fast becoming the standard for testing lymph node involvement in many institutions. However, questions remain as to the best method of injection. The authors hypothesized that a subareolar injection of material would drain to the same lymph node as a peritumoral injection,...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章


    authors: Klimberg VS,Rubio IT,Henry R,Cowan C,Colvert M,Korourian S

    更新日期:1999-06-01 00:00:00

  • The role of tumor necrosis factor and nitric oxide in the acute cardiovascular response to endotoxin.

    abstract:OBJECTIVE:This study was designed to examine the differential effects of tumor necrosis factor (TNF) and nitric oxide on the acute cardiovascular changes that occur in response to endotoxemia. SUMMARY BACKGROUND DATA:Recent studies have suggested that some, if not all, of the cardiovascular effects of TNF are mediated...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Fahey TJ 3rd,Yoshioka T,Shires GT,Fantini GA

    更新日期:1996-01-01 00:00:00

  • Opioid Use After Discharge in Postoperative Patients: A Systematic Review.

    abstract:BACKGROUND:Over the past 2 decades, there has been an increase in opioid use and subsequently, opioid deaths. The amount of opioid prescribed to surgical patients has also increased. The aim of this systematic review was to determine postdischarge opioid consumption in surgical patients compared with the amount of opio...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Feinberg AE,Chesney TR,Srikandarajah S,Acuna SA,McLeod RS,Best Practice in Surgery Group.

    更新日期:2018-06-01 00:00:00

  • The effect of sacral nerve modulation on cerebral evoked potential latency in fecal incontinence and constipation.

    abstract:OBJECTIVE:Influence of sacral nerve modulation (SNM) on cerebral somatosensory evoked potentials (SEP) was determined in patients with incontinence and constipation. BACKGROUND:Selection of patients with incontinence and constipation for SNM could be improved. METHODS:The latency (ms) of SEP induced by pudendal nerve...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Giani I,Novelli E,Martina S,Clerico G,Luc AR,Trompetto M,Malaguti S,Nicholls J,Ganio E

    更新日期:2011-07-01 00:00:00

  • Use of fibrin sealant for prosthetic mesh fixation in laparoscopic extraperitoneal inguinal hernia repair.

    abstract:OBJECTIVE:To evaluate the efficacy of mesh fixation with fibrin sealant (FS) in laparoscopic preperitoneal inguinal hernia repair and to compare it with stapled fixation. SUMMARY BACKGROUND DATA:Laparoscopic hernia repair involves the fixation of the prosthetic mesh in the preperitoneal space with staples to avoid dis...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Katkhouda N,Mavor E,Friedlander MH,Mason RJ,Kiyabu M,Grant SW,Achanta K,Kirkman EL,Narayanan K,Essani R

    更新日期:2001-01-01 00:00:00

  • Association Between Intraoperative Platelet Transfusion and Early Graft Regeneration in Living Donor Liver Transplantation.

    abstract:OBJECTIVE:To evaluate the association between anesthetic management before and after graft reperfusion and early graft regeneration in living donor liver transplantation (LDLT). BACKGROUND:Sufficient graft regeneration is essential for the success of LDLT. Diverse signals start to trigger liver regeneration immediatel...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Han S,Park HW,Song JH,Gwak MS,Lee WJ,Kim G,Lee SK,Ko JS

    更新日期:2016-12-01 00:00:00

  • Cultured epidermis for the coverage of massive burn wounds. A single center experience.

    abstract::Seven patients with a mean burn size of 69.6% total body-surface area underwent skin grafting with autologous cultured epidermis. They were compared with a historical group of 18 controls, with a mean burn size of 60%, who underwent grafting with conventional meshed split-thickness autograft. There were no statistical...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Munster AM,Weiner SH,Spence RJ

    更新日期:1990-06-01 00:00:00

  • Surgical strategy for hilar cholangiocarcinoma of the left-side predominance: current role of left trisectionectomy.

    abstract:OBJECTIVE:To evaluate recent surgical strategy for hilar cholangiocarcinoma (HC) of the left-side predominance. BACKGROUND:When employing left hemihepatectomy (LH) for HC, vasculobiliary anatomy of the right liver often makes it difficult to achieve a tumor-free margin of the right posterior sectional bile duct (RPSBD...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Hosokawa I,Shimizu H,Yoshidome H,Ohtsuka M,Kato A,Yoshitomi H,Miyazaki M

    更新日期:2014-06-01 00:00:00

  • Blood cardioplegia delivery. Deleterious effects of potassium versus lidocaine.

    abstract::Delivery of cardioplegic (CP) solutions to all regions of the myocardium is critical for optimal myocardial protection during cardiac surgery. However, there are little data regarding the effects of CP agents upon coronary vascular resistance (CVR) and CP delivery. Accordingly, we evaluated blood CP (Hct 30) delivery ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Leicher FG,Magrassi P,LaRaia PJ,Derkac WM,Buckley MJ,Austen WG

    更新日期:1983-09-01 00:00:00

  • Surgery for post-myocardial infarct ventricular septal defect.

    abstract::Forty-three patients (mean age 62 +/- 1 years) were treated for ventricular septal defect (VSD) secondary to myocardial infarction. Whenever possible, operation was postponed until six weeks post-onset chest pain. However, hemodynamic instability, evidenced by cardiogenic shock, refractory pulmonary edema, or a rising...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Daggett WM,Guyton RA,Mundth ED,Buckley MJ,McEnany MT,Gold HK,Leinbach RC,Austen WG

    更新日期:1977-09-01 00:00:00