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Accuracy of gadofosveset-enhanced MRI for nodal staging and restaging in rectal cancer.

Abstract：

OBJECTIVE:To prospectively assess the accuracy of gadofosveset-enhanced magnetic resonance imaging (MRI) for nodal staging and restaging in rectal cancer. BACKGROUND:Accurate preoperative assessment of nodal disease in rectal cancer impacts treatment management. Staging with modern imaging techniques (computed tomography, MRI and endorectal ultrasound) is insufficiently accurate for clinical decision making. This study aims to assess the accuracy of MRI using a novel lymph node magnetic resonance contrast, gadofosveset, for nodal staging and restaging in rectal cancer using a per node comparison with histology as the reference standard. METHODS:Sixty-eight patients underwent gadofosveset-enhanced MRI at 1.5T. Twenty-six patients (primary staging group I) were treated with total mesorectal excision (with or without preoperative 5 × 5 Gy) and 42 (restaging group II) underwent a long course of chemoradiation followed by a restaging MRI and resection. Nodes were scored as benign or malignant by 2 radiologists (experienced and junior reader) first on standard MRI, then on gadofosveset-enhanced MRI. For group I the primary staging MRI was compared with histology. In group II the second, restaging MRI was compared with histology. RESULTS:For the experienced reader, sensitivity, specificity, and area under the ROC-curve (AUC) improved from 76%, 82% and 0.84 on standard MRI to 80%, 97% and 0.96 on gadofosveset-MRI (P < 0.001). For the junior reader results improved from 69%, 85%, and 0.85 on standard MRI to 70%, 95%, and 0.93 on gadofosveset-MRI (P = 0.03). Interobserver agreement was good on both standard MRI (κ 0.73) and gadofosveset-MRI (κ 0.71). CONCLUSIONS:This study shows high reproducibility and significantly improved accuracy compared to standard MRI for gadofosveset-enhanced MRI for nodal staging and restaging in rectal cancer.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Lambregts DM,Beets GL,Maas M,Kessels AG,Bakers FC,Cappendijk VC,Engelen SM,Lahaye MJ,de Bruïne AP,Lammering G,Leiner T,Verwoerd JL,Wildberger JE,Beets-Tan RG

doi

10.1097/SLA.0b013e31820b01f1

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

539-45

issue

eissn

0003-4932

issn

1528-1140

journal_volume

253

pub_type

杂志文章

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Accuracy of gadofosveset-enhanced MRI for nodal staging and restaging in rectal cancer.