Simultaneous and sequential determinations of steroid hormone receptors in human breast cancer. Influence of intervening therapy.

Abstract:

:Estrogen (ER), progesterone (PgR), and androgen (AR) receptors were measured in two simultaneous or subsequent specimens taken each from 259 patients with breast cancer. We studied in 182 patients results from receptor assays, either from one tumor or from the primary tumor, and a lymph node metastasis, and in 77 sequential biopsies with or without intervening therapy. All assays were performed in a single laboratory, considering 10 fmol/mg cytosol protein bound ligand as receptor positive. The concordance rate in simultaneous ER assays was 85%; however, we found a considerable high discordance rate for PgR in primary tumor and lymph node metastasis (25%). The overall discordance rate in sequential biopsies for ER was 38% and for PgR 25%. This discordance rate was primarily dependent on the receptor quality of the first assay (ER+: 50%, ER-: 24%, PgR+: 68%, PgR-: 9%). Considering only the ER+ and PgR+ cases, we found the greatest discordance rate in the patients having endocrine treatment following the first biopsy (55% and 84%, respectively). We conclude that the receptor status of one tumor biopsy is highly representative for other tumor or lymph node biopsies. Because of the high discordance rate of primarily receptor + cases in subsequent recurrences, the receptor quality of these lesions should be analyzed whenever possible.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Jakesz R,Dittrich C,Hanusch J,Kolb R,Lenzhofer R,Moser K,Rainer H,Reiner G,Schemper M,Spona J

doi

10.1097/00000658-198503000-00008

subject

Has Abstract,Author List Incomplete

pub_date

1985-03-01 00:00:00

pages

305-10

issue

3

eissn

0003-4932

issn

1528-1140

journal_volume

201

pub_type

杂志文章
  • Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid.

    abstract::Midgestation fetal wound healing is characterized by healing without fibrosis or scar formation. The mechanisms that underlie this remarkable process are mediated in part through a fetal wound extracellular matrix rich in hyaluronic acid. In this study a newly developed assay was used to determine the hyaluronic acid ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199104000-00003

    authors: Longaker MT,Chiu ES,Adzick NS,Stern M,Harrison MR,Stern R

    更新日期:1991-04-01 00:00:00

  • Laparoscopic Heller myotomy versus endoscopic balloon dilatation for the treatment of achalasia: a network meta-analysis.

    abstract:OBJECTIVE:Comparison of short- and long-term effects after laparoscopic Heller myotomy (LHM) and endoscopic balloon dilation (EBD) considering the need for retreatment. BACKGROUND:Previously published studies have indicated that LHM is the most effective treatment for Achalasia. In contrast to that a recent randomized...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/SLA.0000000000000212

    authors: Schoenberg MB,Marx S,Kersten JF,Rösch T,Belle S,Kähler G,Vassiliou MC,Lüth S,von Renteln D

    更新日期:2013-12-01 00:00:00

  • Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients.

    abstract:OBJECTIVE:To determine the effectiveness of early, routine antioxidant supplementation using alpha-tocopherol and ascorbic acid in reducing the rate of pulmonary morbidity and organ dysfunction in critically ill surgical patients. SUMMARY BACKGROUND DATA:Oxidative stress has been associated with the development of the...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200212000-00014

    authors: Nathens AB,Neff MJ,Jurkovich GJ,Klotz P,Farver K,Ruzinski JT,Radella F,Garcia I,Maier RV

    更新日期:2002-12-01 00:00:00

  • A model for predicting the risk of carotid artery disease.

    abstract:OBJECTIVE:To develop a model for the identification of individuals at risk for carotid stenosis (CS) that could be useful in a clinical setting when trying to decide whether screening is worthwhile. BACKGROUND:Evidence that aggressive medical therapy and life style changes reduce the risk of stroke in individuals with...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31827b9761

    authors: Greco G,Egorova NN,Moskowitz AJ,Gelijns AC,Kent KC,Manganaro AJ,Zwolak RM,Riles TS

    更新日期:2013-06-01 00:00:00

  • Accuracy of gadofosveset-enhanced MRI for nodal staging and restaging in rectal cancer.

    abstract:OBJECTIVE:To prospectively assess the accuracy of gadofosveset-enhanced magnetic resonance imaging (MRI) for nodal staging and restaging in rectal cancer. BACKGROUND:Accurate preoperative assessment of nodal disease in rectal cancer impacts treatment management. Staging with modern imaging techniques (computed tomogra...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31820b01f1

    authors: Lambregts DM,Beets GL,Maas M,Kessels AG,Bakers FC,Cappendijk VC,Engelen SM,Lahaye MJ,de Bruïne AP,Lammering G,Leiner T,Verwoerd JL,Wildberger JE,Beets-Tan RG

    更新日期:2011-03-01 00:00:00

  • Mitral replacement: clinical experience with a ball-valve prosthesis. Twenty-five years later.

    abstract::The purpose of this report is to review the results of mitral valve replacement since a first report in the Annals of Surgery in 1961, in order to determine the relative importance of new valve designs versus other surgical variables. The continued use of the silastic ball valve in its 1966 configuration (Model 6120),...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198509000-00016

    authors: Cobanoglu A,Grunkemeier GL,Aru GM,McKinley CL,Starr A

    更新日期:1985-09-01 00:00:00

  • The effect of sacral nerve modulation on cerebral evoked potential latency in fecal incontinence and constipation.

    abstract:OBJECTIVE:Influence of sacral nerve modulation (SNM) on cerebral somatosensory evoked potentials (SEP) was determined in patients with incontinence and constipation. BACKGROUND:Selection of patients with incontinence and constipation for SNM could be improved. METHODS:The latency (ms) of SEP induced by pudendal nerve...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182196ff4

    authors: Giani I,Novelli E,Martina S,Clerico G,Luc AR,Trompetto M,Malaguti S,Nicholls J,Ganio E

    更新日期:2011-07-01 00:00:00

  • Variceal recurrence, rebleeding, and survival after endoscopic injection sclerotherapy in 287 alcoholic cirrhotic patients with bleeding esophageal varices.

    abstract:OBJECTIVE:This study tested the validity of the hypothesis that eradication of esophageal varices by repeated injection sclerotherapy would reduce recurrent variceal bleeding and death from bleeding varices in a high-risk cohort of alcoholic patients with cirrhosis. SUMMARY BACKGROUND DATA:Although banding of esophage...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000231704.45005.4e

    authors: Krige JE,Kotze UK,Bornman PC,Shaw JM,Klipin M

    更新日期:2006-11-01 00:00:00

  • Hyperparathyroidism associated with the enlargement of two or three parathyroid glands.

    abstract::Eighty-five (23%) of 375 patients undergoing surgery for primary hyperparathyroidism were found to have enlargement (greater than 50 mg) of two or three parathyroid glands. Of 76 patients followed from 12 to 140 months after surgery, eight (10.5%) developed hypercalcemia at 1, 4, 45, 64, 74, 79, 84, and 133 months. In...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198511000-00001

    authors: Wells SA Jr,Leight GS,Hensley M,Dilley WG

    更新日期:1985-11-01 00:00:00

  • Carotid endarterectomy: neurologic complications as related to surgical techniques.

    abstract::Three hundred seventeen carotid endarterectomies performed on 240 consecutive patients in four Charleston hospitals were reviewed. The overall incidence of stroke was 10.7% and the mortality 3.2%. From these 317 operations a standardized series of 253 operations performed on neurologically stable patients was analyzed...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197706000-00010

    authors: Prioleau WH Jr,Alken AF,Hairston P

    更新日期:1977-06-01 00:00:00

  • Pylorus Resection Does Not Reduce Delayed Gastric Emptying After Partial Pancreatoduodenectomy: A Blinded Randomized Controlled Trial (PROPP Study, DRKS00004191).

    abstract:OBJECTIVES:The aim of this study was to investigate the effect of pylorus resection on postoperative delayed gastric emptying (DGE) after partial pancreatoduodenectomy (PD). BACKGROUND:PD is the standard treatment for tumors of the pancreatic head. Preservation of the pylorus has been widely accepted as standard proce...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000002480

    authors: Hackert T,Probst P,Knebel P,Doerr-Harim C,Bruckner T,Klaiber U,Werner J,Schneider L,Michalski CW,Strobel O,Ulrich A,Diener MK,Büchler MW

    更新日期:2018-06-01 00:00:00

  • The spectrum and natural history of common bile duct stenosis in chronic alcohol-induced pancreatitis.

    abstract::Sixty patients with chronic alcohol-induced pancreatitis with endoscopic retrograde cholangiopancreatography evidence of common bile duct stenosis were studied to determine the clinical spectrum and natural history of this complication, as well as the indications for biliary bypass. In 17% of patients, common bile duc...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198911000-00007

    authors: Kalvaria I,Bornman PC,Marks IN,Girdwood AH,Bank L,Kottler RE

    更新日期:1989-11-01 00:00:00

  • Appendectomy: a contemporary appraisal.

    abstract:OBJECTIVE:The authors present an accurate and comprehensive snapshot of appendicitis and the practice of appendectomy in the 1990s. METHODS:Appendectomies were performed on 4950 patients in 147 Department of Defense hospitals worldwide over a 12-month period ending January 31, 1993. RESULTS:The median age was 23 year...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199703000-00003

    authors: Hale DA,Molloy M,Pearl RH,Schutt DC,Jaques DP

    更新日期:1997-03-01 00:00:00

  • Gastroesophageal reflux: prevalence in adults older than 28 years after correction of esophageal atresia.

    abstract:OBJECTIVE:To study the incidence of gastroesophageal reflux (GER)related complications after correction of esophageal atresia (EA). SUMMARY BACKGROUND DATA:The association of EA and GER in children is well known. However, little is known about the prevalence of GER and its potential complications in adults who have un...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000094303.07910.05

    authors: Deurloo JA,Ekkelkamp S,Bartelsman JF,Ten Kate FJ,Schoorl M,Heij HA,Aronson DC

    更新日期:2003-11-01 00:00:00

  • Delayed presentation of traumatic diaphragmatic hernia.

    abstract::Twenty-five patients with traumatic diaphragmatic hernia discovered at least five months after injury are described, of whom 18 were male and seven female. All but one hernia occurred on the left side. Stab wounds were the etiological factor in 22 patients and blunt trauma in three. The diagnosis was most often made b...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197808000-00016

    authors: Hegarty MM,Bryer JV,Angorn IB,Baker LW

    更新日期:1978-08-01 00:00:00

  • The Influence of Hospital Volume on Circumferential Resection Margin Involvement: Results of the Dutch Surgical Colorectal Audit.

    abstract:UNLABELLED:This population-based study evaluates the association between hospital volume and CRM (circumferential resection margin) involvement, adjusted for other confounders, in rectal cancer surgery. A low hospital volume (<20 cases/year) was independently associated with a higher risk of CRM involvement (odds ratio...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001009

    authors: Gietelink L,Henneman D,van Leersum NJ,de Noo M,Manusama E,Tanis PJ,Tollenaar RA,Wouters MW,Dutch Surgical Colorectal Cancer Audit Group.

    更新日期:2016-04-01 00:00:00

  • Metabolic consequences of (regional) total pancreatectomy.

    abstract::Little information has been reported on the metabolic characteristics of the totally pancreatectomized patient or the efficacy of medical management after radical pancreatic surgery. The prospective evaluation of 49 such patients, with 31% followed for 48 or more months, forms the basis of this report. The major immed...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199108000-00007

    authors: Dresler CM,Fortner JG,McDermott K,Bajorunas DR

    更新日期:1991-08-01 00:00:00

  • Complete versus partial atrioventricular canal: equal risks of repair in the modern era.

    abstract:OBJECTIVE:To assess the authors' hypothesis that with modern techniques, the current risks of repair for both complete and partial atrioventricular canal (AVC) are equal. SUMMARY BACKGROUND DATA:Repair of complete AVC in infancy has traditionally carried a substantial mortality. In contrast, partial AVC has been consi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200210000-00014

    authors: Cope JT,Fraser GD,Kouretas PC,Kron IL

    更新日期:2002-10-01 00:00:00

  • Desmoid tumors in familial polyposis coli.

    abstract::Desmoid tumors are locally invasive, nonmetastasizing fibrous tumors most frequently seen in patients with familial polyposis coli (FPC). Of 325 patients with FPC treated at the Cleveland Clinic, 29 (8.9%) were found to have a total of 36 desmoid tumors. These tumors occur in young patients (mean age: 29.8 years), par...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198607000-00014

    authors: Jones IT,Jagelman DG,Fazio VW,Lavery IC,Weakley FL,McGannon E

    更新日期:1986-07-01 00:00:00

  • Blunt carotid artery trauma: report of two cases and review of the literature.

    abstract::Blunt carotid artery trauma is uncommon but has been associated with severe, permanent neurologic deficits in 42% and mortality in 30% of 96 patients previously reported in the English literature. Since neurologic symptoms characteristically develop only after a latent interval and since physical evidence of significa...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198003000-00014

    authors: Krajewski LP,Hertzer NR

    更新日期:1980-03-01 00:00:00

  • Visceral blood flow following thermal injury.

    abstract::To determine if visceral blood flow was altered by thermal injury, effective renal blood flow (ERBF) was measured by para-aminohippurate clearance in five control subjects and 13 nonbacteremic burn patients (mean burn size: 50% total body surface, range: 24.5-83.5) 6-25 days after burn injury. Splanchnic blood flow (S...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198101000-00018

    authors: Aulick LH,Goodwin CW Jr,Becker RA,Wilmore DW

    更新日期:1981-01-01 00:00:00

  • Lymphedema after complete axillary node dissection for melanoma: assessment using a new, objective definition.

    abstract:OBJECTIVES:The objectives of this study were to define appropriate criteria for assessing the presence of lymphedema, and to report the prevalence and risk factors for development of upper limb lymphedema after level I-III axillary dissection for melanoma. SUMMARY BACKGROUND DATA:The lack of a consistent and reliable ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000143271.32568.2b

    authors: Starritt EC,Joseph D,McKinnon JG,Lo SK,de Wilt JH,Thompson JF

    更新日期:2004-11-01 00:00:00

  • Preoperative evaluation of patients for liver resection. Appropriate CT imaging.

    abstract:OBJECTIVE:The authors determined which combination of computed tomography scans is most helpful for preoperative assessment of patients with liver tumors. SUMMARY BACKGROUND DATA:Multi-institutional studies have shown that the most important prognostic factors for selection of patients with metastatic colorectal cance...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199303000-00002

    authors: Karl RC,Morse SS,Halpert RD,Clark RA

    更新日期:1993-03-01 00:00:00

  • Multicenter Canadian study of prehospital trauma care.

    abstract:OBJECTIVE:To evaluate whether the type of on-site care a trauma patient receives affects outcome. SUMMARY BACKGROUND DATA:The controversy regarding the prehospital care of trauma patients between Advanced Life Support (ALS) and Basic Life Support (BLS) is ongoing. Due to this unresolved controversy, as well as histori...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.SLA.0000048374.46952.10

    authors: Liberman M,Mulder D,Lavoie A,Denis R,Sampalis JS

    更新日期:2003-02-01 00:00:00

  • Fetal wound healing. The ontogeny of scar formation in the non-human primate.

    abstract:OBJECTIVE:This study determined how scar formation develops in a non-human primate model of fetal skin repair. SUMMARY BACKGROUND DATA:A transition from healing scarlessly to healing with scar formation characterizes skin repair in rat and sheep fetuses. New knowledge of the regulatory processes occurring in the fetal...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199304000-00011

    authors: Lorenz HP,Whitby DJ,Longaker MT,Adzick NS

    更新日期:1993-04-01 00:00:00

  • Technical skills assessment toolbox: a review using the unitary framework of validity.

    abstract:OBJECTIVE:The purpose of this study was to create a technical skills assessment toolbox for 35 basic and advanced skills/procedures that comprise the American College of Surgeons (ACS)/Association of Program Directors in Surgery (APDS) surgical skills curriculum and to provide a critical appraisal of the included tools...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000000520

    authors: Ghaderi I,Manji F,Park YS,Juul D,Ott M,Harris I,Farrell TM

    更新日期:2015-02-01 00:00:00

  • Proposed Modification of the 8th Edition of the AJCC Staging System for Pancreatic Ductal Adenocarcinoma.

    abstract:OBJECTIVE:The aim of this study was to improve the 8th edition (8th) of the American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC). BACKGROUND:The new 8th AJCC staging system for PDAC was released in October, 2016, and will be applied in clinical practice in 2018. METHODS...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002668

    authors: Shi S,Hua J,Liang C,Meng Q,Liang D,Xu J,Ni Q,Yu X

    更新日期:2019-05-01 00:00:00

  • Ten-year experience with cyclosporine as primary immunosuppression in recipients of renal allografts.

    abstract::Cyclosporine has been used as primary immunosuppression in renal allograft recipients in our unit for the past decade. The overall clinical experience and long-term effects of the agent are reviewed. There were 461 consecutive recipients of kidney grafts; 379 received grafts from cadaver donors (CAD) and 82 from livin...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199107000-00007

    authors: Tilney NL,Chang A,Milford EL,Whitley WD,Lazarus JM,Ramos EL,Strom TB,Carpenter CB,Kirkman RL

    更新日期:1991-07-01 00:00:00

  • Role of Serum Carcinoma Embryonic Antigen (CEA) Level in Localized Pancreatic Adenocarcinoma: CEA Level Before Operation is a Significant Prognostic Indicator in Patients With Locally Advanced Pancreatic Cancer Treated With Neoadjuvant Therapy Followed by

    abstract:OBJECTIVE:The aim of the study was to identify the prognostic factors before neoadjuvant chemoradiotherapy (NCRT) in the patients with localized PDAC. Furthermore, to identify the post-surgical survival predictors of patients with LAPC. SUMMARY OF BACKGROUND DATA:Surgical resection may occupy an important position in ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004148

    authors: Kato H,Kishiwada M,Hayasaki A,Chipaila J,Maeda K,Noguchi D,Gyoten K,Fujii T,Iizawa Y,Tanemura A,Murata Y,Kuriyama N,Usui M,Sakurai H,Isaji S,Mizuno S

    更新日期:2020-07-24 00:00:00

  • Comparison of four provocative tests for the diagnosis of gastrinoma.

    abstract::In an attempt to determine the best provocative test for the diagnosis of gastrinoma, ten normal subjects, 13 patients with known gastrinoma, and one patient with presumed gastrinoma were administered four regimens: (1) rapid calcium infusion (2 mg Ca++/kg/min), (2) secretin (2 clinical units (CU)/kg/bolus), (3) long ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198305000-00015

    authors: Romanus ME,Neal JA,Dilley WG,Leight GS,Linehan WM,Santen RJ,Farndon JR,Jones RS,Wells SA Jr

    更新日期:1983-05-01 00:00:00