Fetal wound healing. The ontogeny of scar formation in the non-human primate.


OBJECTIVE:This study determined how scar formation develops in a non-human primate model of fetal skin repair. SUMMARY BACKGROUND DATA:A transition from healing scarlessly to healing with scar formation characterizes skin repair in rat and sheep fetuses. New knowledge of the regulatory processes occurring in the fetal wound at the initial stages of scar formation may provide insights into the early mechanisms of scar formation. METHODS:Full-thickness wounds were made in fetal rhesus monkey lips from 75 through 114 days gestation (n = 6, term = 165 days). Wounds were harvested at 14 days postwounding and processed for histology (hematoxylin & eosin, Masson's trichrome) as well as immunohistochemistry (human type I or type III collagen). RESULTS:Wounds healed with complete restoration of normal tissue architecture in the 75-day gestation fetus. However in the 85-100 day gestation fetuses, wounds healed with an absence of hair follicles and sebaceous glands, but the dermal collagen pattern remained reticular and similar to that in unwounded dermis. At 107 days, a thin scar was present in the wound, thereby demonstrating a transition to scar formation between 100 and 107 days gestation (early 3rd trimester) in the non-human primate. CONCLUSIONS:In the non-human primate fetus, a transition from scarless repair to adult-type repair with scar formation occurs in the early third trimester. These data provide insight into the transition process; the ontogeny of scar formation is characterized initially by wounds healing without the presence of epidermal appendages but with a normal reticular dermal collagen pattern, which we term the "transition wound."


Ann Surg


Annals of surgery


Lorenz HP,Whitby DJ,Longaker MT,Adzick NS




Has Abstract


1993-04-01 00:00:00












  • Increased Rate of Long-term Mortality Among Burn Survivors: A Population-based Matched Cohort Study.

    abstract:OBJECTIVE:To estimate long-term mortality following major burn injury compared with matched controls. SUMMARY BACKGROUND DATA:The effect of sustaining a major burn injury on long-term life expectancy is poorly understood. METHODS:Using health administrative data, all adults who survived to discharge after major burn ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Mason SA,Nathens AB,Byrne JP,Diong C,Fowler RA,Karanicolas PJ,Moineddin R,Jeschke MG

    更新日期:2019-06-01 00:00:00

  • Reoperation for persistent and recurrent hyperparathyroidism.

    abstract::As a consequence of an experience with 175 patients undergoing reoperation for persistent or recurrent hyperparathyroidism, the authors have evolved an approach to management. The emphasis is on the confirmation of the diagnosis; the critical evaluation of invasive and noninvasive localization tests, techniques of int...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Brennan MF,Norton JA

    更新日期:1985-01-01 00:00:00

  • Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels.

    abstract:OBJECTIVE:To evaluate the survival and function of hepatocytes (HCs) on a novel three-dimensional (3D) synthetic biodegradable polymer scaffold with an intrinsic network of interconnected channels under continuous flow conditions. SUMMARY BACKGROUND DATA:The authors' laboratory has investigated HC transplantation usin...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Kim SS,Utsunomiya H,Koski JA,Wu BM,Cima MJ,Sohn J,Mukai K,Griffith LG,Vacanti JP

    更新日期:1998-07-01 00:00:00

  • Clinical characteristics and current management of medically refractory unstable angina.

    abstract::Of 531 patients admitted to the Duke Coronary Care Unit with unstable angina (UA) from June 1981 to September 1982, 100 had persistent angina despite optimal medical therapy of nitrates, propranolol, and nifedipine. At catheterization, 70% of the refractory patients had left main (LM) or three-vessel disease (TVD), 68...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Rankin JS,Newton JR Jr,Califf RM,Jones RH,Wechsler AS,Oldham HN Jr,Wolfe WG,Lowe JE

    更新日期:1984-10-01 00:00:00

  • Surgical treatment of gastroesophageal reflux in infants.

    abstract::Thirty-one infants less than a year of age underwent surgery for correction of pernicious gastroesophageal reflux. Severe growth retardation from persistent vomiting was the single most important indication for surgery (25 patients). Recurrent aspiration penumonitis was another serious sequella of reflux and necessita...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Randolph JG,Lilly JR,Anderson KD

    更新日期:1974-10-01 00:00:00

  • Improving the Quality of Ward-based Surgical Care With a Human Factors Intervention Bundle.

    abstract:OBJECTIVE:This study aimed to explore the impact of a human factors intervention bundle on the quality of ward-based surgical care in a UK hospital. SUMMARY OF BACKGROUND DATA:Improving the culture of a surgical team is a difficult task. Engagement with stakeholders before intervention is key. Studies have shown that ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Johnston MJ,Arora S,King D,Darzi A

    更新日期:2018-01-01 00:00:00

  • Surgical Complications in a Multicenter Randomized Trial Comparing Preoperative Chemoradiotherapy and Immediate Surgery in Patients With Resectable and Borderline Resectable Pancreatic Cancer (PREOPANC Trial).

    abstract:OBJECTIVES:To investigate the effect of preoperative chemoradiotherapy on surgical complications in patients after pancreatic resection for (borderline-)resectable pancreatic cancer. SUMMARY OF BACKGROUND DATA:Preoperative chemoradiotherapy is increasingly used in patients with (borderline-)resectable pancreatic cance...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: van Dongen JC,Suker M,Versteijne E,Bonsing BA,Mieog JSD,de Vos-Geelen J,van der Harst E,Patijn GA,de Hingh IH,Festen S,Ten Tije AJ,Busch OR,Besselink MG,van Tienhoven G,Groot Koerkamp B,van Eijck CHJ,Dutch Pancreatic Canc

    更新日期:2020-11-12 00:00:00

  • Impact of Surgical Resection of the Primary Tumor on Overall Survival in Patients With Metastatic Pheochromocytoma or Sympathetic Paraganglioma.

    abstract:OBJECTIVE:To determine whether primary tumor resection in patients with metastatic pheochromocytoma or paraganglioma (PPG) is associated with longer overall survival (OS). BACKGROUND:Patients with metastatic PPG have poor survival outcomes. The impact of surgical resection of the primary tumor on OS is not known. MET...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Roman-Gonzalez A,Zhou S,Ayala-Ramirez M,Shen C,Waguespack SG,Habra MA,Karam JA,Perrier N,Wood CG,Jimenez C

    更新日期:2018-07-01 00:00:00

  • The pregnant motor vehicle accident casualty: adherence to basic workup and admission guidelines.

    abstract:OBJECTIVE:To investigate the workup/treatment provided to pregnant motor vehicle accident (MVA) casualties in a mature trauma system. Adherence to recommendations was used to measure quality of care. BACKGROUND:MVAs affect approximately 3% of pregnant women. Trauma casualty outcome improves after implementation of gui...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Sela HY,Weiniger CF,Hersch M,Smueloff A,Laufer N,Einav S

    更新日期:2011-08-01 00:00:00

  • Ileal pouch-anal anastomosis: comparison of results in familial adenomatous polyposis and chronic ulcerative colitis.

    abstract::The aim of this study was to compare the immediate postoperative results and the long-term outcome of ileal pouch-anal anastomosis in 94 patients with familial adenomatous polyposis to those in 758 patients with ulcerative colitis. Two colitis patients died after operation (0.3%), but no polyposis patients died. Overa...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Dozois RR,Kelly KA,Welling DR,Gordon H,Beart RW Jr,Wolff BG,Pemberton JH,Ilstrup DM

    更新日期:1989-09-01 00:00:00

  • Prophylactic revascularization of the gut.

    abstract::Reconstitution of the mesenteric vascular circulation, in our experience, is advisable when advanced occlusive disease is noted on the preoperative arteriogram of patients selected for aortoiliofemoral, renal artery, or aortic aneurysm surgery. A lateral aortogram is mandatory, and the presence of an anastomotic meand...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Connolly JE,Kwaan JH

    更新日期:1979-10-01 00:00:00

  • Experimental gastric sympathectomy: an effective prophylaxis of gastric stress lesions.

    abstract::Fifteen mini-pigs were bled to a mean aortic blood pressure of 40 mm Hg and maintained at that level for three hours. The control group consisted of eight animals with shock for three hours, while the test group was comprised of seven animals with a similar shock period but which had undergone splanchnicectomy 14 days...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Hottenrott C,Seufert RM,Kühne FW,Büsing M

    更新日期:1977-12-01 00:00:00

  • Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases.

    abstract:OBJECTIVE:To determine overall survival and disease-free survival in selected patients with nonresectable liver-only colorectal cancer receiving liver transplantation. BACKGROUND:Patients with nonresectable colorectal cancer receiving palliative chemotherapy has a 5-year overall survival of about 10%. Liver transplant...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章


    authors: Dueland S,Syversveen T,Solheim JM,Solberg S,Grut H,Bjørnbeth BA,Hagness M,Line PD

    更新日期:2020-02-01 00:00:00

  • Carcinoembryonic antigen (CEA) as a prognostic and monitoring test in clinically complete resection of colorectal carcinoma.

    abstract::The prognostic and postoperative monitoring capabilities of the CEA assay were compared to pathological staging of the operative specimens, clinical followup including endoscopy, radiology and scanning techniques, as well as DNCB skin testing and laboratory enzyme determinations (alkaline phosphatase and transaminase)...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Herrera MA,Chu TM,Holyoke ED

    更新日期:1976-01-01 00:00:00

  • Medullary thyroid carcinoma: relationship of method of diagnosis to pathologic staging.

    abstract::Medullary thyroid carcinoma (MTC) develops in virtually all patients affected with multiple endocrine neoplasia type II (MEN II), a disease inherited as an autosomal dominant trait. The thyroid tumor cells secrete calcitonin (CT) and the detection of elevated plasma levels (>300 pg/ml) of this hormone in MEN II kindre...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Wells SA Jr,Baylin SB,Gann DS,Farrell RE,Dilley WG,Preissig SH,Linehan WM,Cooper CW

    更新日期:1978-09-01 00:00:00

  • Sentinel lymph node biopsy in patients with thin primary cutaneous melanoma.

    abstract:OBJECTIVES:To determine the rate and clinicopathologic factors predictive of sentinel lymph node (SLN) positivity, regional lymph node recurrence, and survival in a large series of patients with thin primary cutaneous melanoma who underwent SLN biopsy (SLNB). METHODS:Patients with thin (≤1 mm) melanomas who underwent ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Murali R,Haydu LE,Quinn MJ,Saw RP,Shannon K,Spillane AJ,Stretch JR,Thompson JF,Scolyer RA

    更新日期:2012-01-01 00:00:00

  • Sampling procedures in estrogen receptor determinations.

    abstract::To determine the significance of proteolysis and delayed freezing of tumor samples on estrogen receptor levels, values from 19 of 31 biopsy specimens were compared with that in remaining tumor at the completion of mastectomy. There was a 15-100% decrease in receptor content. Time-decay studies on selected postmastecto...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Newsome JF,Avis FP,Hammond JE,Sherwood S

    更新日期:1981-05-01 00:00:00

  • A manometric study of anal fissure treated by subcutaneous lateral internal sphincterotomy.

    abstract::A prospective, manometric trial of anal fissure treated by subcutaneous lateral internal sphincterotomy (SLIS) was designed to elucidate the pathophysiology of this condition. Anorectal manometry with a closed, precalibrated, water-filled microballoon using the station pull-through technique was performed on 13 patien...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: McNamara MJ,Percy JP,Fielding IR

    更新日期:1990-02-01 00:00:00

  • Defining "the elderly" undergoing major gastrointestinal resections: receiver operating characteristic analysis of a large ACS-NSQIP cohort.

    abstract:OBJECTIVE:"The elderly" is an often used but poorly defined descriptor of surgical patients. Investigators have used varying subjectively determined age cutoffs to report outcomes in the elderly. We set out to use objective outcomes data to determine the "at-risk" elderly population. METHODS: PATIENTS:129,331 patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Kurian AA,Wang L,Grunkemeier G,Bhayani NH,Swanström LL

    更新日期:2013-09-01 00:00:00

  • Carotid endarterectomy: neurologic complications as related to surgical techniques.

    abstract::Three hundred seventeen carotid endarterectomies performed on 240 consecutive patients in four Charleston hospitals were reviewed. The overall incidence of stroke was 10.7% and the mortality 3.2%. From these 317 operations a standardized series of 253 operations performed on neurologically stable patients was analyzed...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Prioleau WH Jr,Alken AF,Hairston P

    更新日期:1977-06-01 00:00:00

  • Lethal "thin" malignant melanoma. Identifying patients at risk.

    abstract::Thin melanomas can metastasize and be lethal. The purpose of this review was to identify negative risk factors in patients with melanomas less than 0.76 mm thick. Six hundred and eighty-one (681) such patients are reviewed in this study. Of those referred without metastatic disease (583 patients), metastases developed...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Slingluff CL Jr,Vollmer RT,Reintgen DS,Seigler HF

    更新日期:1988-08-01 00:00:00

  • Infected aortic aneurysms. A changing entity.

    abstract::Infected (mycotic) aortic aneurysms are infrequent and, without surgical intervention, usually lead to uncontrolled sepsis or catastrophic hemorrhage. Symptoms are frequently absent or non-specific during the early stages, and a high index of suspicion is essential to make the diagnosis. Surgery performed after ruptur...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Gomes MN,Choyke PL,Wallace RB

    更新日期:1992-05-01 00:00:00

  • Percutaneous transhepatic bile drainage.

    abstract::Percutaneous transhepatic bile drainage was performed in 13 patients with obstructive jaundice, using a combination of the PTC technique and a Seldinger angiography catheter. In 11 cases, the outflow of bile through the catheter was satisfactory and complications were few. Since the risk of the procedure is low and it...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Mori K,Misumi A,Sugiyama M,Okabe M,Matsuoka T

    更新日期:1977-01-01 00:00:00

  • Optimizing Surveillance and Re-intervention Strategy Following Elective Endovascular Repair of Abdominal Aortic Aneurysms.

    abstract:BACKGROUND:EVAR for abdominal aortic aneurysm has an initial survival advantage over OR, but more frequent complications increase costs and long-term aneurysm-related mortality. Randomized controlled trials of EVAR versus OR have shown EVAR is not cost-effective over a patient's lifetime. However, in the EVAR-1 trial, ...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Kim LG,Sweeting MJ,Epstein D,Venermo M,Rohlffs FEV,Greenhalgh RM

    更新日期:2019-10-07 00:00:00

  • Prospective Creation and Validation of the PREVENTT (Prediction and Enaction of Prevention Treatments Trigger) Scale for Surgical Site Infections (SSIs) in Patients With Diverticulitis.

    abstract:OBJECTIVE:Create and validate diverticulitis surgical site infection prediction scale. BACKGROUND:Surgical site infections cause significant morbidity after colorectal surgery. An infection prediction scale could target infection prevention bundles to high-risk patients. METHODS:Prospectively collected National Surgi...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Bordeianou L,Cauley CE,Patel R,Bleday R,Mahmood S,Kennedy K,Ahmed KF,Yokoe D,Hooper D,Rubin M,Partners Colorectal Collaborative.

    更新日期:2019-12-01 00:00:00

  • Open Versus Fenestrated Endovascular Repair of Complex Abdominal Aortic Aneurysms.

    abstract:OBJECTIVE:To compare outcomes of fenestrated (FEVAR) and open repairs of complex abdominal aortic aneurysms (cAAA). BACKGROUND:FEVAR has emerged as an alternative to open surgery for treating cAAA, but direct comparisons are limited. METHODS:We studied all repairs of intact or symptomatic cAAA in the Vascular Quality...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究


    authors: O'Donnell TFX,Boitano LT,Deery SE,Schermerhorn ML,Schanzer A,Beck AW,Green RM,Takayama H,Patel VI

    更新日期:2020-05-01 00:00:00

  • Surgical management of acute cholecystitis in patients 65 years of age and older.

    abstract::The proportion of the population of the U.S. 65 years of age and over is increasing. Biliary tract disease is estimated to involve 15% of the adult population. A review of 12,200 patients treated surgically at one medical center reveals that 2401 (20%) had acute cholecystitis. There were 93 deaths, for a mortality rat...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Glenn F

    更新日期:1981-01-01 00:00:00

  • Blood transfusions and prognosis in colorectal cancer: long-term results of a randomized controlled trial.

    abstract:OBJECTIVE:Perioperative blood transfusions may adversely affect survival in patients with colorectal malignancy, although definite proof of a causal relationship has never been reported. BACKGROUND:We report the long-term outcomes of a randomized controlled trial performed between 1986 and 1991 to compare the effects ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Harlaar JJ,Gosselink MP,Hop WC,Lange JF,Busch OR,Jeekel H

    更新日期:2012-11-01 00:00:00

  • A model for predicting the risk of carotid artery disease.

    abstract:OBJECTIVE:To develop a model for the identification of individuals at risk for carotid stenosis (CS) that could be useful in a clinical setting when trying to decide whether screening is worthwhile. BACKGROUND:Evidence that aggressive medical therapy and life style changes reduce the risk of stroke in individuals with...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Greco G,Egorova NN,Moskowitz AJ,Gelijns AC,Kent KC,Manganaro AJ,Zwolak RM,Riles TS

    更新日期:2013-06-01 00:00:00

  • Microbial colonization of tumors in relation to the upper gastrointestinal tract in patients with gastric carcinoma.

    abstract::The microbial colonization of the oropharynx, the esophagus, the stomach, and the duodenum was studied in relation to the microbial flora found on tumor and gastric mucosal biopsies in 23 patients with gastric carcinoma. The tumor was colonized in all patients, and the stomach, the esophagus, the duodenum, and the gas...

    journal_title:Annals of surgery

    pub_type: 杂志文章


    authors: Sjöstedt S,Kager L,Heimdahl A,Nord CE

    更新日期:1988-03-01 00:00:00