Surgery, trauma and immune suppression. Evolving the mechanism.

Abstract:

:A major surgical procedure can impair the delayed hypersensitivity response. This impairment is associated with suppressor cell activity that can alter either afferent or efferent responses. Using the third party mixed leukocyte culture to define cell types involved, major immune impairment was seen with the combination of both nonadherent and plastic adherent cells, suggesting that a T cell-macrophage interaction is required. A serum factor(s) is present in operated mice that can impair mixed leukocyte culture reactivity. A serum factor(s) in an adoptive transfer experiment is also capable of enhancing primary tumor growth. A unifying hypothesis, based predominantly on data from the current literature, is presented in an attempt to elucidate the mechanism by which all forms of major trauma are associated in some patients with "paradoxical" immune suppression.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Lundy J,Ford CM

doi

10.1097/00000658-198304000-00010

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

434-8

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

197

pub_type

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