Glucose turnover and recycling in colorectal carcinoma.

Abstract:

:Glucose metabolism is affected by various pathologic states including tumors. In this project, glucose turnover and recycling rates in 11 patients with colorectal carcinoma were measured using a double-labelled 3-3H and 1-14C glucose injection technique. Fasting blood glucose, lactate, pyruvate, alanine, glycerol, 3-hydroxybutyrate, acetoacetate, plasma cortisol, and plasma insulin concentrations were also measured. No patient in the study had a history of diabetes mellitus or endocrine disorders, nor any abnormal liver function tests. The findings demonstrated a significantly elevated glucose turnover rate in patients with Dukes C and D lesions in comparison to patients with Dukes B lesions. Cori recycling rates were not significantly different between Dukes B vs. Dukes C and D patients. There were no differences between Dukes B and Dukes C and D patients in any of the metabolites measured. Furthermore, there were no significant differences in glucose turnover or recycling rates as a function of pre-illness weight loss. These data suggest that, when colorectal carcinoma extends beyond the limits of the bowel wall, glucose metabolism is significantly altered.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Kokal WA,McCulloch A,Wright PD,Johnston ID

doi

10.1097/00000658-198311000-00007

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

601-4

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

198

pub_type

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