Transplantation of pediatric donor kidneys to adult recipients. Is there a critical donor age?

Abstract:

:Cadaver kidneys remain a scarce resource, yet single pediatric donor kidneys are underutilized at some centers. Between 1967 and 1984, 133 single pediatric and 318 adult donor cadaver transplants were performed. Patient and graft survival, renal function, and complications in adult recipients grouped by donor age were compared. Recipient age for all groups was similar (34-36 years). Life table analysis revealed no difference in graft survival in recipients of kidneys from donors aged 2, 3, 4, 5-10, and 11-15 when compared with adult donors. Graft survival in these groups improved over time with current 1-year survival over 75%. Recipients from donors less than 24 months of age demonstrated significantly poorer results, with no kidney surviving greater than 2 months. Serum creatinine of grafts functioning greater than 6 months was similar in all groups. It is concluded that single pediatric kidneys from donors greater than 2 years of age can be successfully transplanted to adults with good long-term results.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Wengerter K,Matas AJ,Tellis VA,Quinn T,Soberman R,Veith FJ

doi

10.1097/00000658-198608000-00011

subject

Has Abstract

pub_date

1986-08-01 00:00:00

pages

172-5

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

204

pub_type

杂志文章
  • Gastric surgery for morbid obesity. The Adelaide Study.

    abstract::The efficacy of three gastric restriction operations were compared in a prospective randomized study of 310 morbidly obese subjects. The median patient age was 34 years (range, 18 to 62 years). They were predominantly female (13:1) and had a median pre-operative weight that was 198% of their ideal weight (range, 160% ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199004000-00007

    authors: Hall JC,Watts JM,O'Brien PE,Dunstan RE,Walsh JF,Slavotinek AH,Elmslie RG

    更新日期:1990-04-01 00:00:00

  • Impact of neoadjuvant chemoradiation on lymph node status in esophageal cancer: post hoc analysis of a randomized controlled trial.

    abstract:OBJECTIVE:The study objectives were to analyze the impact of the number of lymph nodes (LNs) reported as resected (NLNr) and the number of LNs invaded (NLNi) on the prognosis of esophageal cancer (EC) after neoadjuvant chemoradiotherapy. BACKGROUND:Pathological LN status is a major disease prognostic factor and marker...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000000991

    authors: Robb WB,Dahan L,Mornex F,Maillard E,Thomas PA,Meunier B,Boige V,Pezet D,Le Brun-Ly V,Bosset JF,Mabrut JY,Triboulet JP,Bedenne L,Seitz JF,Mariette C,Fédération Française de Cancérologie Digestive, Société Française de Radiot

    更新日期:2015-05-01 00:00:00

  • Use of transcutaneous oxygen sensors to titrate PEEP.

    abstract::The relationship of transcutaneous oxygen tension (PtcO2) to arterial oxygen tension (PaO2), pulmonary shunt (Qsp/Qt), mixed venous oxygen tension (PVO2), and O2 delivery was determined in patients with respiratory failure in order to explore the possible usefulness of PtcO2 to titrate the level of positive end expira...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198102000-00014

    authors: Tremper KK,Waxman K,Shoemaker WC

    更新日期:1981-02-01 00:00:00

  • Primary hyperparathyroidism in the 1990s. Choice of surgical procedures for this disease.

    abstract::Many advances have occurred in recent years in the diagnosis, localization, and treatment of primary hyperparathyroidism. Several different operative choices for primary hyperparathyroidism also have been proposed--a unilateral approach versus the standard bilateral parathyroid exploration. The unilateral approach is ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199204000-00002

    authors: Kaplan EL,Yashiro T,Salti G

    更新日期:1992-04-01 00:00:00

  • Decreased surgical risks of pancreas transplantation in the modern era.

    abstract:OBJECTIVE:To document the decreased incidence of surgical complications after pancreas transplantation in recent times. SUMMARY BACKGROUND DATA:Compared with other abdominal transplants, pancreas transplants have historically had the highest incidence of surgical complications. However, over the past few years, the au...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200002000-00017

    authors: Humar A,Kandaswamy R,Granger D,Gruessner RW,Gruessner AC,Sutherland DE

    更新日期:2000-02-01 00:00:00

  • Complications of vagotomy in the treatment of hiatal hernia.

    abstract::Inclusion of vagotomy and pyloroplasty in the surgical treatment of gastroesophageal reflux associated with hiatal hernia has long been controversial. To evaluate the morbidity of vagotomy in the treatment of reflux esophagitis, a retrospective study of 311 patients treated by the Hill posterior gastropexy technique o...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197606000-00003

    authors: Vansant JH,Baker JW Jr

    更新日期:1976-06-01 00:00:00

  • Personal experience with 411 hepatic resections.

    abstract::Over a 24-year period, 411 partial hepatic resections were performed: 142 right or left trisegmentectomies, 158 lobectomies, 25 segmentectomies, and 86 local excisions. The operations were performed for benign lesions in 182 patients, for primary hepatic malignancies in 106, and for hepatic metastases in 123, includin...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198810000-00004

    authors: Iwatsuki S,Starzl TE

    更新日期:1988-10-01 00:00:00

  • Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To evaluate whether intraoperative subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI) in elective laparotomies compared to saline. BACKGROUND:SSI is a common complication after gastrointestinal surgery. To date, there is a lack of evidence whether subcutaneous woun...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000003645

    authors: Strobel RM,Leonhardt M,Krochmann A,Neumann K,Speichinger F,Hartmann L,Lee LD,Beyer K,Daum S,Kreis ME,Lauscher JC

    更新日期:2020-07-01 00:00:00

  • Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach.

    abstract:OBJECTIVE:Comparison of minimal access retroperitoneal pancreatic necrosectomy (MARPN) versus open necrosectomy in the treatment of infected or nonresolving pancreatic necrosis. SUMMARY OF BACKGROUND DATA:Infected pancreatic necrosis may lead to progressive organ failure and death. Minimal access techniques have been ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181d96c53

    authors: Raraty MG,Halloran CM,Dodd S,Ghaneh P,Connor S,Evans J,Sutton R,Neoptolemos JP

    更新日期:2010-05-01 00:00:00

  • Management Considerations for the Surgical Treatment of Colorectal Cancer During the Global Covid-19 Pandemic.

    abstract:OBJECTIVE:The COVID-19 pandemic requires to conscientiously weigh "timely surgical intervention" for colorectal cancer against efforts to conserve hospital resources and protect patients and health care providers. SUMMARY BACKGROUND DATA:Professional societies provided ad-hoc guidance at the outset of the COVID-19 pan...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004029

    authors: O'Leary MP,Choong KC,Thornblade LW,Fakih MG,Fong Y,Kaiser AM

    更新日期:2020-08-01 00:00:00

  • Comparison of four provocative tests for the diagnosis of gastrinoma.

    abstract::In an attempt to determine the best provocative test for the diagnosis of gastrinoma, ten normal subjects, 13 patients with known gastrinoma, and one patient with presumed gastrinoma were administered four regimens: (1) rapid calcium infusion (2 mg Ca++/kg/min), (2) secretin (2 clinical units (CU)/kg/bolus), (3) long ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198305000-00015

    authors: Romanus ME,Neal JA,Dilley WG,Leight GS,Linehan WM,Santen RJ,Farndon JR,Jones RS,Wells SA Jr

    更新日期:1983-05-01 00:00:00

  • A clinicopathologic study of sex cases.

    abstract::Six patients with surgically treated Menetrier's disease are presented. Diffuse or focal cystic hyperplasia of mucous secreting epithelium of the fundus with antral sparing characterized the stomachs in all of these cases. In most instances the disorder was found during evaluation of non-specific complaints of pain, n...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197704000-00015

    authors: Davis JM,Gray GF,Thorbjarnarson B

    更新日期:1977-04-01 00:00:00

  • Surgical correction of posttransplant renovascular hypertension.

    abstract::The incidence of renovascular hypertension in the transplanted kidney is reported to range between 5 and 15%. A review of 391 consecutive renal transplant patients revealed 16 patients (5.4%) with hypertension secondary to partial obstruction of renal arterial blood flow. The clinical course of this group of patients ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198011000-00010

    authors: Dickerman RM,Peters PC,Hull AR,Curry TS,Atkins C,Fry WJ

    更新日期:1980-11-01 00:00:00

  • Regional therapy in the management of intrahepatic recurrence after surgery for hepatoma.

    abstract::The significance of regional therapy against the intrahepatic recurrence for hepatocellular carcinoma (HCC) was evaluated. During the past 6 years, 101 patients who had radical operations for HCC (liver cirrhosis, 75%; chronic hepatitis, 22%) were followed. Forty-seven patients (47%) had recurrences; the liver was the...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198707000-00006

    authors: Sasaki Y,Imaoka S,Fujita M,Miyoshi Y,Ohigashi H,Ishikawa O,Furukawa H,Koyama H,Iwanaga T,Kasugai H

    更新日期:1987-07-01 00:00:00

  • HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients.

    abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDA) is a devastating disease that killed nearly 38,000 people in the United States this past year. OBJECTIVE:Treatment of PDA typically includes surgery and/or chemotherapy with gemcitabine. No reliable biomarker exists for prognosis or response to chemotherapy. Two previo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181f1fd44

    authors: Richards NG,Rittenhouse DW,Freydin B,Cozzitorto JA,Grenda D,Rui H,Gonye G,Kennedy EP,Yeo CJ,Brody JR,Witkiewicz AK

    更新日期:2010-09-01 00:00:00

  • The impact of Clostridium difficile on a surgical service: a prospective study of 374 patients.

    abstract:OBJECTIVE:To evaluate the epidemiology of Clostridium difficile colitis (CDC) in a subset of patients admitted specifically to a surgical service. SUMMARY BACKGROUND DATA:CDC is an increasingly prevalent nosocomial infection that can prolong hospitalization and adversely affect patient outcome. Although this disease h...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199802000-00021

    authors: Kent KC,Rubin MS,Wroblewski L,Hanff PA,Silen W

    更新日期:1998-02-01 00:00:00

  • Abdominal aortic aneurysm in high-risk patients. Outcome of selective management based on size and expansion rate.

    abstract::Low mortality rates for elective surgical treatment of abdominal aortic aneurysms justify an aggressive approach in most patients. However, in high-risk patients with small aneurysms and no symptoms, the decision to operate remains a delicate balance of risk and benefit. Our observations include 99 high-risk patients ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198409000-00003

    authors: Bernstein EF,Chan EL

    更新日期:1984-09-01 00:00:00

  • Identifying patients at high risk for venous thromboembolism requiring treatment after outpatient surgery.

    abstract:OBJECTIVE:To identify independent predictors of 30-day venous thromboembolism (VTE) events requiring treatment after outpatient surgery. BACKGROUND:An increasing proportion of surgical procedures are performed in the outpatient setting. The incidence of VTE requiring treatment after outpatient surgery is unknown. MET...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3182519ccf

    authors: Pannucci CJ,Shanks A,Moote MJ,Bahl V,Cederna PS,Naughton NN,Wakefield TW,Henke PK,Campbell DA,Kheterpal S

    更新日期:2012-06-01 00:00:00

  • Racial/Ethnic Disparities in Perioperative Outcomes of Major Procedures: Results From the National Surgical Quality Improvement Program.

    abstract:OBJECTIVE:To determine the association between race/ethnicity and perioperative outcomes in individuals undergoing major oncologic and nononcologic surgical procedures in the United States. BACKGROUND:Prior work has shown that there are significant racial/ethnic disparities in perioperative outcomes after several type...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001078

    authors: Ravi P,Sood A,Schmid M,Abdollah F,Sammon JD,Sun M,Klett DE,Varda B,Peabody JO,Menon M,Kibel AS,Nguyen PL,Trinh QD

    更新日期:2015-12-01 00:00:00

  • Interleukin 12 secretion enhances antitumor efficacy of oncolytic herpes simplex viral therapy for colorectal cancer.

    abstract:OBJECTIVE:To assess the strategy of combining oncolytic herpes simplex virus (HSV) therapy with immunomodulatory therapy as treatment for experimental colon cancer. The oncolytic HSV recombinant NV1023 and the interleukin 12 (IL-12)-secreting oncolytic NV1042 virus were evaluated in vitro and in vivo with respect to an...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200106000-00012

    authors: Bennett JJ,Malhotra S,Wong RJ,Delman K,Zager J,St-Louis M,Johnson P,Fong Y

    更新日期:2001-06-01 00:00:00

  • Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.

    abstract:OBJECTIVE:To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy. SUMMARY BACKGROUND DATA:Genetic polymorphisms for immunoregulatory cytokines may explain individual variation in response to trauma. Esophagectomy is as...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.sla.0000259389.09161.49

    authors: Azim K,McManus R,Brophy K,Ryan A,Kelleher D,Reynolds JV

    更新日期:2007-07-01 00:00:00

  • Metabolic consequences of (regional) total pancreatectomy.

    abstract::Little information has been reported on the metabolic characteristics of the totally pancreatectomized patient or the efficacy of medical management after radical pancreatic surgery. The prospective evaluation of 49 such patients, with 31% followed for 48 or more months, forms the basis of this report. The major immed...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199108000-00007

    authors: Dresler CM,Fortner JG,McDermott K,Bajorunas DR

    更新日期:1991-08-01 00:00:00

  • Human tissue reaction to sutures.

    abstract::Tissue reaction to sutures was studied in 666 specimens obtained from patients from one day to 23 years after operation. Reaction to catgut depends on the stage of absorption and is mainly histocytic in type. Nonabsorbable sutures are encapsulated by a rim of connective tissue, while near the suture histocytes, giant ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197502000-00003

    authors: Postlethwait RW,Willigan DA,Ulin AW

    更新日期:1975-02-01 00:00:00

  • Operative treatment of Crohn's ileocolitis complicated by ileosigmoid and ileovesical fistulae.

    abstract::Ileovesical and ileosigmoid fistulae were found to coexist in 22 patients with Crohn's ileocolitis. Persistent or recurrent urinary tract infection was a complaint in all cases, and 11 patients reported pneumaturia and/or fecaluria. Thus, bladder involvement was either suspected or clinically apparent in each patient....

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198801000-00010

    authors: Schraut WH,Chapman C,Abraham VS

    更新日期:1988-01-01 00:00:00

  • A simple test to identify coarctation of the aorta.

    abstract::Despite the widespread recognition of coartation of the aorta there are still many patients in whome the diagnosis is not made. A simple clinical test which is useful in making the diagnosis in infants and adults, is described. It depends upon the differential color changes between fingers and toes after releasing a m...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197611000-00014

    authors: Gerbode F

    更新日期:1976-11-01 00:00:00

  • Current Surgical Management of Pediatric Idiopathic Constipation: A Systematic Review of Published Studies.

    abstract:OBJECTIVE:Surgery for pediatric idiopathic constipation (IC) is undertaken after failure of bowel management programs. Decisions are influenced by rectal biopsy, transit studies, megacolon/megarectum, degree of soiling/incontinence, and anorectal manometry profile(s). A systematic review of ALL published studies critic...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000001191

    authors: Siminas S,Losty PD

    更新日期:2015-12-01 00:00:00

  • Antiviral Therapy Reduces Hepatocellular Carcinoma Recurrence in Patients With Low HBV-DNA Levels: A Randomized Controlled Trial.

    abstract:BACKGROUND:Despite antiviral treatment has been shown to reduce hepatocellular carcinoma (HCC) recurrence after curative treatment for hepatitis B virus (HBV)-related HCC in patients with high preoperative HBV-DNA levels, it is still unclear whether antiviral therapy is useful in reducing recurrence in patients with lo...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000002727

    authors: Huang G,Li PP,Lau WY,Pan ZY,Zhao LH,Wang ZG,Wang MC,Zhou WP

    更新日期:2018-12-01 00:00:00

  • Infected aortic aneurysms. A changing entity.

    abstract::Infected (mycotic) aortic aneurysms are infrequent and, without surgical intervention, usually lead to uncontrolled sepsis or catastrophic hemorrhage. Symptoms are frequently absent or non-specific during the early stages, and a high index of suspicion is essential to make the diagnosis. Surgery performed after ruptur...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199205000-00005

    authors: Gomes MN,Choyke PL,Wallace RB

    更新日期:1992-05-01 00:00:00

  • Prophylactic and preventive antibiotic therapy: timing, duration and economics.

    abstract::Previous studies have demonstrated that administered antibiotics must be active against major anticipated pathogens and must have reached sufficient concentrations in the tissue or body fluid at risk by the time of bacterial challenge if prophylactic therapy is to be maximally effective in reducing the infection rate ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197906000-00004

    authors: Stone HH,Haney BB,Kolb LD,Geheber CE,Hooper CA

    更新日期:1979-06-01 00:00:00

  • Long-term survival after resection for bronchogenic carcinoma.

    abstract::Of 915 resections for bronchogenic carcinoma over a 25-year period (1945-1969), 249 patients survived over 5 years; 127 of the patients eligible survived over 10 years, 61 over 15 years, and 22 over 20 years. The case material was divided into three time periods: 1945-49, 1950-59 and 1960-69, as well as by extent of r...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197609000-00010

    authors: Paulson DL,Reisch JS

    更新日期:1976-09-01 00:00:00