Prophylactic and preventive antibiotic therapy: timing, duration and economics.

Abstract:

:Previous studies have demonstrated that administered antibiotics must be active against major anticipated pathogens and must have reached sufficient concentrations in the tissue or body fluid at risk by the time of bacterial challenge if prophylactic therapy is to be maximally effective in reducing the infection rate of potentially contaminated surgery. The need for continuing antibiotic prophylaxis beyond the day of operation, however, has been uncertain. In a prospective, randomized, double-blind study of 220 patients undergoing elective gastric, biliary or colonic surgery, perioperative administration of cefamandole plus five days of placebo was compared to perioperative plus five days of postoperative antibiotic therapy; no significant difference was found between the groups in the rate of infection of wound (6 and 5%, respectively), peritoneum (2% each) and elsewhere (6% and 5%). In another prospective, randomized, nonblind study of 451 determinant cases of 1,624 patients undergoing emergency laparotomy, cephalothin was instituted preoperatively but after peritoneal contamination had occurred (i.e., abdominal trauma, etc.); continued postoperative antibiotic again failed to reduce further the wound and peritoneal infection rates, as noted on comparing perioperative therapy alone (infection rates 8 and 4%, respectively) with perioperative plus 5-7 days of postoperative treatment (10% and 5%, respectively). Analysis of these data, as well as of the extra expenses incurred by 463 patients because of infection in a previous prophylactic antibiotic study, revealed an average additional expenditure of $2,686.00 for each instance of postoperative infection of the wound and/or peritoneum; whereas savings of $300.00 per patient at risk were obtained whenever appropriate prophylactic antibiotic had been given.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Stone HH,Haney BB,Kolb LD,Geheber CE,Hooper CA

doi

10.1097/00000658-197906000-00004

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

691-9

issue

6

eissn

0003-4932

issn

1528-1140

journal_volume

189

pub_type

临床试验,杂志文章,随机对照试验
  • Prognostic Value of a Four-miRNA Signature in Patients with Lymph Node Positive Locoregional Esophageal Squamous Cell Carcinoma Undergoing Complete Surgical Resection.

    abstract:OBJECTIVE:This study was intended to identify prognostic biomarkers for lymph node (LN)-positive locoregional esophageal squamous cell carcinoma (ESCC) patients. SUMMARY OF BACKGROUND DATA:Surgery is a major treatment for LN-positive locoregional ESCC patients in China. However, patient outcomes are poor and heterogen...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003369

    authors: Wen J,Wang G,Xie X,Lin G,Yang H,Luo K,Liu Q,Ling Y,Xie X,Lin P,Chen Y,Zhang H,Rong T,Fu J

    更新日期:2019-04-30 00:00:00

  • Small amount of low-residue diet with parenteral nutrition can prevent decreases in intestinal mucosal integrity.

    abstract:OBJECTIVE:To investigate the suitable combination ratio of low-residue diet (LRD) and parenteral nutrition (PN) for nutritional support of surgical patients. SUMMARY BACKGROUND DATA:Bacterial translocation (BT) is a severe complication of total parenteral nutrition (TPN). However, it is sometimes impossible to supply ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200001000-00016

    authors: Omura K,Hirano K,Kanehira E,Kaito K,Tamura M,Nishida S,Kawakami K,Watanabe Y

    更新日期:2000-01-01 00:00:00

  • Predictive index for long-term survival after retransplantation of the liver in adult recipients: analysis of a 26-year experience in a single center.

    abstract:OBJECTIVE:To develop a prognostic scoring system for risk stratification of patients with hepatic graft failure (GF) undergoing retransplants of the liver (ReLT) and improve patient selection. SUMMARY OF BACKGROUND DATA:Retransplantation of the liver remains controversial because of inferior outcomes compared with the...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31822c5878

    authors: Hong JC,Kaldas FM,Kositamongkol P,Petrowsky H,Farmer DG,Markovic D,Hiatt JR,Busuttil RW

    更新日期:2011-09-01 00:00:00

  • Lethal "thin" malignant melanoma. Identifying patients at risk.

    abstract::Thin melanomas can metastasize and be lethal. The purpose of this review was to identify negative risk factors in patients with melanomas less than 0.76 mm thick. Six hundred and eighty-one (681) such patients are reviewed in this study. Of those referred without metastatic disease (583 patients), metastases developed...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198808000-00004

    authors: Slingluff CL Jr,Vollmer RT,Reintgen DS,Seigler HF

    更新日期:1988-08-01 00:00:00

  • Strategies in the surgical treatment of malignant ventricular arrhythmias. An 8-year experience.

    abstract::Introduction of the automatic implantable cardioverter defibrillator (AICD) has dramatically affected the surgical treatment of malignant ventricular tachyarrhythmias. The authors continue to perform electrophysiologically directed subendocardial resection (SER) of left ventricular (LV) scars in selected patients, and...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199209000-00010

    authors: Geha AS,Elefteriades JA,Hsu J,Biblo LA,Hoch DH,Batsford WP,Rosenfeld LE,Carlson MD,Johnson NJ,Waldo AL

    更新日期:1992-09-01 00:00:00

  • Wait times for cancer surgery in the United States: trends and predictors of delays.

    abstract:BACKGROUND:Patients frequently voice concerns regarding wait times for cancer treatment; however, little is known about the length of wait times from diagnosis to surgery in the United States. Our objectives were (1) to assess changes in wait times over the past decade and (2) to identify patient, tumor, and hospital f...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318211cc0f

    authors: Bilimoria KY,Ko CY,Tomlinson JS,Stewart AK,Talamonti MS,Hynes DL,Winchester DP,Bentrem DJ

    更新日期:2011-04-01 00:00:00

  • Factors Associated With Recurrence and Survival in Lymph Node-negative Gastric Adenocarcinoma: A 7-Institution Study of the US Gastric Cancer Collaborative.

    abstract:OBJECTIVES:To determine pathologic features associated with recurrence and survival in patients with lymph node-negative gastric adenocarcinoma. STUDY DESIGN:Multi-institutional retrospective analysis. BACKGROUND:Lymph node status is among the most important predictors of recurrence after gastrectomy for gastric aden...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001084

    authors: Jin LX,Moses LE,Squires MH 3rd,Poultsides GA,Votanopoulos K,Weber SM,Bloomston M,Pawlik TM,Hawkins WG,Linehan DC,Strasberg SM,Schmidt C,Worhunsky DJ,Acher AW,Cardona K,Cho CS,Kooby DA,Levine E,Winslow ER,Saunders ND

    更新日期:2015-12-01 00:00:00

  • Colon cancer cells that are not growth inhibited by TGF-beta lack functional type I and type II TGF-beta receptors.

    abstract:OBJECTIVE:The authors determined the molecular mechanisms for the failure of transforming growth factor-beta (TGF-beta) to inhibit the growth of SW1116 and SW48 colon cancer cell lines. BACKGROUND:Transforming growth factor-beta is a bifunctional regulator of cell growth that typically stimulates proliferation of mese...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199506000-00015

    authors: MacKay SL,Yaswen LR,Tarnuzzer RW,Moldawer LL,Bland KI,Copeland EM 3rd,Schultz GS

    更新日期:1995-06-01 00:00:00

  • Impaired mobility, ASA status and administration of tramadol are risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery.

    abstract:OBJECTIVE:The aim of this prospective study was to determine incidence, duration, and risk factors for postoperative delirium (PD) in elderly patients undergoing major abdominal surgery. SUMMARY BACKGROUND DATA:The incidence and risk factors of PD after major abdominal surgery in elderly patients are not well document...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181c1cfc9

    authors: Brouquet A,Cudennec T,Benoist S,Moulias S,Beauchet A,Penna C,Teillet L,Nordlinger B

    更新日期:2010-04-01 00:00:00

  • Visceral blood flow following thermal injury.

    abstract::To determine if visceral blood flow was altered by thermal injury, effective renal blood flow (ERBF) was measured by para-aminohippurate clearance in five control subjects and 13 nonbacteremic burn patients (mean burn size: 50% total body surface, range: 24.5-83.5) 6-25 days after burn injury. Splanchnic blood flow (S...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198101000-00018

    authors: Aulick LH,Goodwin CW Jr,Becker RA,Wilmore DW

    更新日期:1981-01-01 00:00:00

  • The Objective Structured Clinical Examination. The new gold standard for evaluating postgraduate clinical performance.

    abstract:OBJECTIVE:The authors determine the reliability, validity, and usefulness of the Objective Structured Clinical Examination (OSCE) in the evaluation of surgical residents. SUMMARY BACKGROUND DATA:Interest is increasing in using the OSCE as a measurement of clinical competence and as a certification tool. However, conce...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199512000-00007

    authors: Sloan DA,Donnelly MB,Schwartz RW,Strodel WE

    更新日期:1995-12-01 00:00:00

  • Chemical debridement of burns.

    abstract::The development of effective, non-toxic (local and systemic) methods for the rapid chemical (enzymatic and non-enzymatic) debridement of third degree burns would dramatically reduce the morbidity and mortality of severely burned patients. Sepsis is still the major cause of death of patients with extensive deep burns. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197410000-00032

    authors: Levenson SM,Kan D,Gruber C,Crowley LV,Lent R,Watford A,Seifter E

    更新日期:1974-10-01 00:00:00

  • Role of Serum Carcinoma Embryonic Antigen (CEA) Level in Localized Pancreatic Adenocarcinoma: CEA Level Before Operation is a Significant Prognostic Indicator in Patients With Locally Advanced Pancreatic Cancer Treated With Neoadjuvant Therapy Followed by

    abstract:OBJECTIVE:The aim of the study was to identify the prognostic factors before neoadjuvant chemoradiotherapy (NCRT) in the patients with localized PDAC. Furthermore, to identify the post-surgical survival predictors of patients with LAPC. SUMMARY OF BACKGROUND DATA:Surgical resection may occupy an important position in ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004148

    authors: Kato H,Kishiwada M,Hayasaki A,Chipaila J,Maeda K,Noguchi D,Gyoten K,Fujii T,Iizawa Y,Tanemura A,Murata Y,Kuriyama N,Usui M,Sakurai H,Isaji S,Mizuno S

    更新日期:2020-07-24 00:00:00

  • Appendectomy: a contemporary appraisal.

    abstract:OBJECTIVE:The authors present an accurate and comprehensive snapshot of appendicitis and the practice of appendectomy in the 1990s. METHODS:Appendectomies were performed on 4950 patients in 147 Department of Defense hospitals worldwide over a 12-month period ending January 31, 1993. RESULTS:The median age was 23 year...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199703000-00003

    authors: Hale DA,Molloy M,Pearl RH,Schutt DC,Jaques DP

    更新日期:1997-03-01 00:00:00

  • The impact of long term estrogen support after hysterectomy. A report of 1016 cases.

    abstract::1016 Women were placed on estrogen support following hysterectomy and have been followed for a total of 14,318 patient/years. Support was principally conjugated estrogen with the customary dose 1.5 mg/day. The follow-up studies in this group of women shows a marked drop in deaths from all causes over those which might...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197705000-00010

    authors: Byrd BF Jr,Burch JC,Vaughn WK

    更新日期:1977-05-01 00:00:00

  • Optimization of staging of the neck with prophylactic central and lateral neck dissection for papillary thyroid carcinoma.

    abstract:OBJECTIVE:To analyze the yield and rate of node metastases (pN1) for prophylactic central (CND) and lateral neck dissection (LND) for papillary thyroid carcinoma, the risk factors for pN1, and outcomes. BACKGROUND:Prophylactic CND and LND are not routinely employed. Adjuvant radioiodine treatment may be modulated, how...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31824b7b68

    authors: Hartl DM,Leboulleux S,Al Ghuzlan A,Baudin E,Chami L,Schlumberger M,Travagli JP

    更新日期:2012-04-01 00:00:00

  • Gastrointestinal adaptation following small bowel bypass for obesity.

    abstract::Small intestinal morphologic and biochemical changes were studied following jejuno-ileal bypass for obesity after body weight stabilization had occurred. Four patients underwent biopsy of in-continuity and bypassed jejunal and ileal segments of the small intestine 11 to 22 months after the bypass operation. Microscopi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197706000-00005

    authors: Dudrick SJ,Daly JM,Castro G,Akhtar M

    更新日期:1977-06-01 00:00:00

  • Risk and location of cancer in patients with preoperative colitis-associated dysplasia undergoing proctocolectomy.

    abstract:OBJECTIVE:To evaluate the influence of preoperative dysplasia grade, appearance, and site on risk and location of cancer in patients with colitis. BACKGROUND:The ability to predict the presence and location of cancer in colitis patients with dysplasia is essential to facilitate recommendations regarding the necessity ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31828e7417

    authors: Kiran RP,Ahmed Ali U,Nisar PJ,Khoury W,Gu J,Shen B,Remzi FH,Hammel JP,Lavery IC,Fazio VW,Goldblum JR

    更新日期:2014-02-01 00:00:00

  • Hepatic resection.

    abstract::The current performance and applicability of elective hepatic resection represents an impressive evolution. From removal of tumor-bearing, ill-defined portions of the liver, which is always threatened by the inability to control bleeding, surgery of the liver has progressed to hemostatically controlled dissection of a...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199001000-00001

    authors: Schwartz SI

    更新日期:1990-01-01 00:00:00

  • General surgery in patients on maintenance hemodialysis.

    abstract::A review of the experience with 66 patients on chronic hemodialysis who underwent 67 major surgical procedures is presented. There were 58 general surgical procedures, and nine major cardiovascular procedures including four emergency cardiac valve replacements. The preoperative, intraoperative and postoperative manage...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197406000-00008

    authors: Haimov M,Glabman S,Schupak E,Neff M,Burrows L

    更新日期:1974-06-01 00:00:00

  • Impact of pancreatic head resection on direct medical costs in patients with chronic pancreatitis.

    abstract:OBJECTIVE:To quantitate disease-specific hospital-based medical costs in 34 patients with chronic pancreatitis before and after treatment by either duodenal-preserving pancreatic head resection (DPPHR) or pylorus-preserving pancreaticoduodenectomy (PPPD). SUMMARY BACKGROUND DATA:Pancreatic head resection in selected p...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200111000-00012

    authors: Howard TJ,Jones JW,Sherman S,Fogel E,Lehman GA

    更新日期:2001-11-01 00:00:00

  • Is Less More? A Microsimulation Model Comparing Cost-effectiveness of the Revised American Thyroid Association's 2015 to 2009 Guidelines for the Management of Patients With Thyroid Nodules and Differentiated Thyroid Cancer.

    abstract:OBJECTIVE:To assess relative clinical and economic performance of the revised American Thyroid Association (ATA) thyroid cancer guidelines compared to current standard of care. BACKGROUND:Diagnosis of thyroid cancer in the United States has tripled whereas mortality has only marginally increased. Most patients present...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003074

    authors: White C,Weinstein MC,Fingeret AL,Randolph GW,Miyauchi A,Ito Y,Zhan T,Ali A,Gazelle GS,Lubitz CC

    更新日期:2020-04-01 00:00:00

  • Stimulation of wound healing by epidermal growth factor. A dose-dependent effect.

    abstract::This work was undertaken to study the effects of various doses of locally applied epidermal growth factor (EGF) on developing granulation tissue in rats. Cylindrical hollow sponge implants were used as an inductive matrix for the growth of granulation tissue. In the test groups, the implants were injected daily with a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198604000-00007

    authors: Laato M,Niinikoski J,Lebel L,Gerdin B

    更新日期:1986-04-01 00:00:00

  • Computed tomography as a screening exam in patients with suspected blunt aortic injury.

    abstract:BACKGROUND:Chest computed tomography (CT) screening of patients with blunt trauma for thoracic aortic injury is controversial. This study was undertaken to determine whether CT could exclude aortic injury and be used to select patients for aortography. METHODS:Computed tomography and aortography were used to evaluate ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-199411000-00015

    authors: Durham RM,Zuckerman D,Wolverson M,Heiberg E,Luchtefeld WB,Herr DJ,Shapiro MJ,Mazuski JE,Salimi Z,Sundaram M

    更新日期:1994-11-01 00:00:00

  • Reporting of short-term clinical outcomes after esophagectomy: a systematic review.

    abstract:OBJECTIVE:This review summarizes reporting of complications of esophageal cancer surgery. BACKGROUND:Accurate assessment of morbidity and mortality after surgery for cancer is essential to compare centers, allow data synthesis, and inform clinical decision-making. A lack of defined standards may distort clinically rel...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0b013e3182480a6a

    authors: Blencowe NS,Strong S,McNair AG,Brookes ST,Crosby T,Griffin SM,Blazeby JM

    更新日期:2012-04-01 00:00:00

  • Laparoscopic adjustable silicone gastric banding versus vertical banded gastroplasty in morbidly obese patients: a prospective randomized controlled clinical trial.

    abstract:OBJECTIVE:To compare, in a prospective, randomized, single-institution trial laparoscopic adjustable silicone gastric banding (LASGB) with laparoscopic vertical banded gastroplasty (LVBG) in morbidly obese patients. SUMMARY BACKGROUND DATA:LASGB is a simple and safe procedure, but some reports have suggested disappoin...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.sla.0000098627.18574.72

    authors: Morino M,Toppino M,Bonnet G,del Genio G

    更新日期:2003-12-01 00:00:00

  • Surgical significance of popliteal arterial variants. A unified angiographic classification.

    abstract::Distal popliteal arterial variations may influence the success of femorodistal popliteal and tibial arterial reconstructions. Two patients whose bypass procedures were initially unsatisfactory because of a poor choice for anastomosis stimulated a review of variations in the distal popliteal artery in 1000 femoral arte...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198912000-00014

    authors: Kim D,Orron DE,Skillman JJ

    更新日期:1989-12-01 00:00:00

  • Prevalence, Management and Outcomes Related to Preoperative Medical Orders for life Sustaining Treatment (MOLST) in an Adult Surgical Population.

    abstract:OBJECTIVE:To determine prevalence of documented preoperative code status discussions and post-operative outcomes (specifically mortality, readmission and discharge disposition) of patients with completed Medical Orders for Life-Sustaining Treatments (MOLST) forms before surgery. SUMMARY OF BACKGROUND DATA:A MOLST form...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004675

    authors: Tanious M,Lindvall C,Cooper Z,Tukan N,Peters S,Streid J,Fields K,Bader A

    更新日期:2020-12-18 00:00:00

  • Risk factors for ileoanal J pouch-related septic complications in ulcerative colitis and familial adenomatous polyposis.

    abstract:OBJECTIVE:To analyze the association between pre- and perioperative factors and pouch-related septic complications (PRSC) in ulcerative colitis (UC) and in familial adenomatous polyposis (FAP) after ileal pouch-anal anastomosis (IPAA). SUMMARY BACKGROUND DATA:For patients with UC and FAP, IPAA is the surgical therapy ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200202000-00008

    authors: Heuschen UA,Hinz U,Allemeyer EH,Autschbach F,Stern J,Lucas M,Herfarth C,Heuschen G

    更新日期:2002-02-01 00:00:00

  • Validation of the simulated ward environment for assessment of ward-based surgical care.

    abstract:OBJECTIVE:To assess the feasibility of developing a simulated ward environment in which to assess the ward-based care of surgical patients by clinicians of varying levels of experience (construct validation). BACKGROUND:Increasing evidence points to the importance of the postoperative or ward-based phase of surgical c...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318288e1d4

    authors: Pucher PH,Aggarwal R,Srisatkunam T,Darzi A

    更新日期:2014-02-01 00:00:00