Gastrointestinal adaptation following small bowel bypass for obesity.

Abstract:

:Small intestinal morphologic and biochemical changes were studied following jejuno-ileal bypass for obesity after body weight stabilization had occurred. Four patients underwent biopsy of in-continuity and bypassed jejunal and ileal segments of the small intestine 11 to 22 months after the bypass operation. Microscopically, marked mucosal villus hypertrophy of the in-continuity bowel was observed, especially in the ileum. Bypassed jejunal mucosa underwent atrophy compared with pre-bypass jejunum, whereas bypassed ileum appeared similar microscopically to pre-bypass ileum. The specific activities of mucosal disaccharidase enzymes (maltase, sucrase, lactase and trehalase) in units per mg protein remained similar to pre-bypass levels in segments of the in-continuity jejunum and the bypassed jejunum and ileum. On the other hand, elevated mucosal disaccharidase levels were measured in biopsy specimens of the in-continuity ileum. Total enzyme activity per unit length of intestine, however, was estimated to be elevated in both in-continuity jejunum and ileum secondary to mucosal villus hypertrophy. These data indicate that following small bowel bypass: (1) the in-continuity ileum undergoes greater biochemical and morphologic adaptation than the jejunum; and (2) intraluminal nutrients and chyme appear to be essential to maximal intestinal adaptation.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Dudrick SJ,Daly JM,Castro G,Akhtar M

doi

10.1097/00000658-197706000-00005

subject

Has Abstract

pub_date

1977-06-01 00:00:00

pages

642-8

issue

6

eissn

0003-4932

issn

1528-1140

journal_volume

185

pub_type

杂志文章
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    更新日期:2014-03-01 00:00:00

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    更新日期:2018-03-01 00:00:00

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    更新日期:1990-08-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究

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    pub_type: 杂志文章

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    pub_type: 杂志文章,随机对照试验

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    authors: Stewardson RH,Bombeck CT,Nyhus LM

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