Expression of the neurotensin gene in fetal human liver and fibrolamellar carcinoma.

Abstract:

OBJECTIVE:This study determined whether the neurotensin gene (NT/N) is expressed in the normal adult liver and focal nodular hyperplasia (FNH) and confirmed NT/N expression in fibrolamellar carcinoma; whether NT/N or the neurotensin receptor is expressed in the fetal liver; and whether hepatic resection leads to expression of NT/N. SUMMARY BACKGROUND DATA:Neurotensin (NT), a gut tridecapeptide localized in the gastrointestinal tract of the adult to the small bowel, is an important hormone-regulating gut motility, secretion, and mucosal growth. Expression of the NT/N gene has been identified in fibrolamellar carcinomas, but NT/N is not known to be expressed in the normal liver. METHODS:Sensitive ribonuclease (RNase) protection assays were used to determine whether NT/N is expressed in fibrolamellar carcinoma, FNH, or healthy fetal and adult livers. The authors also determined whether the receptor for NT was present in the fetal liver and whether liver resection and subsequent regeneration could lead to re-expression of NT/N in the rat. RESULTS:Neurotensin is expressed in fibrolamellar carcinoma and in the fetal human liver, but not in the adult liver or the samples of FNH. In addition, the authors were not able to detect expression of the NT receptor in the fetal liver and did not identify NT/N gene activation in the regenerating liver of the rat. CONCLUSIONS:The NT/N gene will be a useful molecular marker to differentiate fibrolamellar carcinoma from other liver tumors. The finding of NT/N expression in the fetal liver suggests a stem cell descendant that is common to both the liver and gut. The absence of NT/N expression in the regenerating liver suggests that NT does not play a role in this rapid growth process.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Ehrenfried JA,Zhou Z,Thompson JC,Evers BM

doi

10.1097/00000658-199410000-00007

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

484-9; discussion 489-91

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

220

pub_type

杂志文章
  • Tissue plasminogen activator reverses the deleterious effect of infection on colonic wound healing.

    abstract::Fibrin deposition in response to bacterial peritonitis appears to predispose to residual infection in the peritoneal cavity. Our previous studies have demonstrated that intraperitoneal fibrinolysis using human recombinant tissue plasminogen activator (t-PA) prevented abscess formation in a rat intra-abdominal sepsis m...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199002000-00003

    authors: Houston KA,McRitchie DI,Rotstein OD

    更新日期:1990-02-01 00:00:00

  • Sentinel node staging of resectable colon cancer: results of a multicenter study.

    abstract:OBJECTIVE AND SUMMARY BACKGROUND DATA:Sentinel lymph node (LN) sampling, a technique widely used to manage breast cancer and melanoma, seeks to select LNs that accurately predict regional node status and can be extensively examined to identify nodal metastatic disease not detected by standard histopathological staging....

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/01.sla.0000140753.41357.20

    authors: Bertagnolli M,Miedema B,Redston M,Dowell J,Niedzwiecki D,Fleshman J,Bem J,Mayer R,Zinner M,Compton C

    更新日期:2004-10-01 00:00:00

  • Factors influencing late survival after coronary bypass surgery.

    abstract::In order to determine which factors most influence late survival after the coronary bypass procedure, a review was made of the initial experience of one surgeon who performed 792 operations between 1968 and 1972. The initial 250 patients were compared with the subsequent 542 patients. The two groups were of similar ag...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197806000-00013

    authors: Lawrie GM,Morris GC Jr

    更新日期:1978-06-01 00:00:00

  • Surgical simulation: a systematic review.

    abstract:OBJECTIVE:To evaluate the effectiveness of surgical simulation compared with other methods of surgical training. SUMMARY BACKGROUND DATA:Surgical simulation (with or without computers) is attractive because it avoids the use of patients for skills practice and provides relevant technical training for trainees before t...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.sla.0000200839.93965.26

    authors: Sutherland LM,Middleton PF,Anthony A,Hamdorf J,Cregan P,Scott D,Maddern GJ

    更新日期:2006-03-01 00:00:00

  • Preventing Parastomal Hernia Using a Modified Sugarbaker Technique With Composite Mesh During Laparoscopic Abdominoperineal Resection: A Randomized Controlled Trial.

    abstract:OBJECTIVE:The aim of this study was to assess the reduction in the incidence of parastomal hernia (PH) after placement of prophylactic synthetic mesh using a modified Sugarbaker technique when a permanent end-colostomy is needed. SUMMARY OF BACKGROUND DATA:Prevention of PH formation is crucial given the high prevalenc...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000001684

    authors: López-Cano M,Serra-Aracil X,Mora L,Sánchez-García JL,Jiménez-Gómez LM,Martí M,Vallribera F,Fraccalvieri D,Serracant A,Kreisler E,Biondo S,Espín E,Navarro-Soto S,Armengol-Carrasco M

    更新日期:2016-12-01 00:00:00

  • Carcinoma of the ampulla of Vater: Review of 38 cases with emphasis on treatment and prognostic factors.

    abstract::Thirty-eight cases of carcinoma of the ampulla of Vater are presented. The diagnosis has been confirmed at laparatomy in all patients. Three operations were done, a pancreaticoduodenal resection in 23 patients, a biliary-enteric bypass in 7 patients and a biliary-enteric bypass plus excision of tumor in 8 patients. Th...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197604000-00002

    authors: Makipour H,Cooperman A,Danzi JT,Farmer RG

    更新日期:1976-04-01 00:00:00

  • The influence of a brief preoperative illness on postoperative healing.

    abstract::In a study of wound healing at high altitude, subcutaneously implanted PTFE tubes were used to stimulate and measure accumulation of wound hydroxyproline (an index of collagen) in 26 patients who had appendectomy and in 38 patients who had cholecystectomy. Patient age, length of surgery, and postoperative recovery see...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198703000-00006

    authors: Goodson WH 3rd,Lopez-Sarmiento A,Jensen JA,West J,Granja-Mena L,Chavez-Estrella J

    更新日期:1987-03-01 00:00:00

  • Demography of penetrating cardiac trauma.

    abstract::All cases of penetrating cardiac trauma in 1985 and 1986 in Jefferson County, Alabama, where patients dying of penetrating trauma received autopsies, were retrospectively reviewed. All hospitals in the county plus the single coroner's office provided the records of the 72 patients comprising this study. Incidents occu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198906000-00004

    authors: Naughton MJ,Brissie RM,Bessey PQ,McEachern MM,Donald JM Jr,Laws HL

    更新日期:1989-06-01 00:00:00

  • Anti-TNF Therapy Is Associated With an Increased Risk of Postoperative Morbidity After Surgery for Ileocolonic Crohn Disease: Results of a Prospective Nationwide Cohort.

    abstract:OBJECTIVE:To determine the risk factors of morbidity after surgery for ileocolonic Crohn disease (CD). SUMMARY BACKGROUND DATA:The risk factors of morbidity after surgery for CD, particularly the role of anti-TNF therapy, remain controversial and have not been evaluated in a large prospective cohort study. METHODS:Fr...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002017

    authors: Brouquet A,Maggiori L,Zerbib P,Lefevre JH,Denost Q,Germain A,Cotte E,Beyer-Berjot L,Munoz-Bongrand N,Desfourneaux V,Rahili A,Duffas JP,Pautrat K,Denet C,Bridoux V,Meurette G,Faucheron JL,Loriau J,Guillon F,Vicaut E

    更新日期:2018-02-01 00:00:00

  • Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone.

    abstract:OBJECTIVE:To investigate the pattern of nodal metastasis, morbidity, recurrence rates of papillary thyroid carcinoma (PTC), and parathyroid hormone (PTH) responses following neck dissection (ND) plus total thyroidectomy (TT). SUMMARY BACKGROUND DATA:While hypoparathyroidism develops after TT plus ND, little is known o...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000250451.59685.67

    authors: Roh JL,Park JY,Park CI

    更新日期:2007-04-01 00:00:00

  • The reservoir ileostomy: early experience with 54 patients.

    abstract::Reservoir and ileostomies were performed in 54 patients between 1972 and 1975. Primary colonic pathology included chronic ulcerative colitis in 47 patients, Crohn's colitis in one, familial polyposes in 5 and Gardner's Syndrome in one. Followup is complete and varies from 6 months to three years. All but three patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197702000-00008

    authors: Gelernt IM,Bauer JJ,Kreel I

    更新日期:1977-02-01 00:00:00

  • Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation.

    abstract:OBJECTIVE:To evaluate the effects of artesunate on organ injury and dysfunction associated with hemorrhagic shock (HS) in the rat. BACKGROUND:HS is still a common cause of death in severely injured patients and is characterized by impairment of organ perfusion, systemic inflammatory response, and multiple organ failur...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001664

    authors: Sordi R,Nandra KK,Chiazza F,Johnson FL,Cabrera CP,Torrance HD,Yamada N,Patel NS,Barnes MR,Brohi K,Collino M,Thiemermann C

    更新日期:2017-02-01 00:00:00

  • Myocardial revascularization: a rebuttal of the cooperative study.

    abstract::From January 1972 through December 1974, at Saint Louis University Medical Center (SLU), 345 patients similar to those of the VA Cooperative Coronary Artery Study received CABG. Operative mortality was SLU 2.3%, VA 5.6% (p < 0.05). Perioperative myocardial infarction rate was SLU 8.4%, VA 18% (p < 0.005). One year gra...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197809000-00008

    authors: Kaiser GC,Barner HB,Tyras DH,Codd JE,Mudd JG,Willman VL

    更新日期:1978-09-01 00:00:00

  • Physiologic sufficiency of regenerated lung lymphatics.

    abstract::The physiologic sufficiency of regenerated lung lymphatics after surgical transection of the lung hilum was studied experimentally. Dogs were prepared by surgical interruption of all left lung hilar tissues and structures except the skeletonized pulmonary artery and the pulmonary veins; continuity of the bronchus was ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198008000-00005

    authors: Thomas PA Jr

    更新日期:1980-08-01 00:00:00

  • Quantitative Assessment of Blood Flow in the Gastric Conduit With Thermal Imaging for Esophageal Reconstruction.

    abstract:OBJECTIVE:The study's primary aim was to evaluate the effectiveness of thermal imaging (TI) and its secondary aim was to compare TI and indocyanine green (ICG) fluorescence angiography, with respect to the evaluation of the viability of the gastric conduit. SUMMARY BACKGROUND DATA:The optimal method for evaluating per...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003169

    authors: Nishikawa K,Fujita T,Yuda M,Tanaka Y,Matsumoto A,Tanishima Y,Hanyu N,Yanaga K

    更新日期:2020-06-01 00:00:00

  • Endoscopic harvesting device type and outcomes in patients undergoing coronary artery bypass surgery.

    abstract:OBJECTIVE:To evaluate angiographic and clinical outcomes associated with open and closed dissection tunnel endoscopic vein harvesting (EVH) devices. BACKGROUND:A previous PREVENT-IV (PRoject of Ex-vivo Vein graft ENgineering via Transfection IV) analysis reported that EVH for coronary artery bypass graft surgery was a...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000000377

    authors: van Diepen S,Brennan JM,Hafley GE,Reyes EM,Allen KB,Ferguson TB,Peterson ED,Williams JB,Gibson CM,Mack MJ,Kouchoukos NT,Alexander JH,Lopes RD

    更新日期:2014-08-01 00:00:00

  • The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study.

    abstract:BACKGROUND:The advice to individuals with identified CDH1 mutations is generally to undertake prophylactic total gastrectomy (PTG). This study evaluated the effect of PTG on health-related quality of life (HRQL) in asymptomatic individuals with identified CDH1 mutations at high risk for gastric cancer. METHODS:Individ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000446

    authors: Worster E,Liu X,Richardson S,Hardwick RH,Dwerryhouse S,Caldas C,Fitzgerald RC

    更新日期:2014-07-01 00:00:00

  • Recurrent inguinal hernia.

    abstract::An analysis of 584 operations for recurrent inguinal hernia was made in an attempt to determine the cause of the recurrence based on the anatomic findings. The recurrence was indirect in 300, direct in 241, and various other in 43 operations. The causes of the indirect recurrences appeared to be an unrecognized hernia...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198512000-00019

    authors: Postlethwait RW

    更新日期:1985-12-01 00:00:00

  • The anatomy of the fasciae of the face and neck with particular reference to the spread and treatment of intraoral infections (Ludwig's) that have progressed into adjacent fascial spaces.

    abstract::Descriptions of the fasciae of the lower half of the face and of the adjacent cervical fasciae have long been puzzling and descriptively much too complex. For this reason, medical students, young medical and dental practitioners, and at times even senior surgeons frequently do not understand the anatomy of the cervico...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198612000-00015

    authors: Lindner HH

    更新日期:1986-12-01 00:00:00

  • Carotid endarterectomy: neurologic complications as related to surgical techniques.

    abstract::Three hundred seventeen carotid endarterectomies performed on 240 consecutive patients in four Charleston hospitals were reviewed. The overall incidence of stroke was 10.7% and the mortality 3.2%. From these 317 operations a standardized series of 253 operations performed on neurologically stable patients was analyzed...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197706000-00010

    authors: Prioleau WH Jr,Alken AF,Hairston P

    更新日期:1977-06-01 00:00:00

  • Axillary lymph node status, but not tumor size, predicts locoregional recurrence and overall survival after mastectomy for breast cancer.

    abstract:OBJECTIVE:To assess the significance of axillary lymph node status and tumor size for predicting locoregional recurrence (LRR) and overall survival after mastectomy for breast cancer and to discuss the utility of postmastectomy radiation therapy. SUMMARY BACKGROUND DATA:Patients with locally advanced breast cancer req...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000065289.06765.71

    authors: Beenken SW,Urist MM,Zhang Y,Desmond R,Krontiras H,Medina H,Bland KI

    更新日期:2003-05-01 00:00:00

  • An evaluation of information transfer through the continuum of surgical care: a feasibility study.

    abstract:OBJECTIVE:To evaluate information transfer and communication (ITC) across the surgical care pathway with the use of Information Transfer and Communication Assessment Tool for Surgery (ITCAS). BACKGROUND:Communication failures are the leading cause of surgical errors and adverse events. It is vital to assess the ITC ac...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e986df

    authors: Nagpal K,Vats A,Ahmed K,Vincent C,Moorthy K

    更新日期:2010-08-01 00:00:00

  • The effect of jejunoileal bypass on bile composition and the formation of billiary calculi.

    abstract::In our series of 101 patients with small bowel bypass for morbid obesity, nine developed biliary calculi postoperatively during a mean follow-up of 29.6 months. The development of gallstones depends in part on biliary cholesterol saturation and on the zeta potential of bile. In eight consecutive patients, the lithogen...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197801000-00011

    authors: Wise L,Stein T

    更新日期:1978-01-01 00:00:00

  • Unique Tracheal Fluid MicroRNA Signature Predicts Response to FETO in Patients With Congenital Diaphragmatic Hernia.

    abstract:OBJECTIVE AND BACKGROUND:Our objective was to determine the fetal in vivo microRNA signature in hypoplastic lungs of human fetuses with severe isolated congenital diaphragmatic hernia (CDH) and changes in tracheal and amniotic fluid of fetuses undergoing fetoscopic endoluminal tracheal occlusion (FETO) to reverse sever...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001054

    authors: Pereira-Terra P,Deprest JA,Kholdebarin R,Khoshgoo N,DeKoninck P,Munck AA,Wang J,Zhu F,Rottier RJ,Iwasiow BM,Correia-Pinto J,Tibboel D,Post M,Keijzer R

    更新日期:2015-12-01 00:00:00

  • Endovascular stent graft repair of abdominal and thoracic aortic aneurysms: a ten-year experience with 817 patients.

    abstract:OBJECTIVE:On November 23, 1992, the first endovascular stent graft (ESG) repair of an aortic aneurysm was performed in North America. Following the treatment of this patient, we have continued to evaluate ESG over the past 10 years in the treatment of 817 patients. SUMMARY AND BACKGROUND DATA:Abdominal (AAA) or thorac...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.sla.0000090473.63393.e9

    authors: Marin ML,Hollier LH,Ellozy SH,Spielvogel D,Mitty H,Griepp R,Lookstein RA,Carroccio A,Morrissey NJ,Teodorescu VJ,Jacobs TS,Minor ME,Sheahan CM,Chae K,Oak J,Cha A

    更新日期:2003-10-01 00:00:00

  • Registration rates, adequacy of registration, and a comparison of registered and published primary outcomes in randomized controlled trials published in surgery journals.

    abstract:OBJECTIVE:To determine the proportion of registered trials published in the surgical literature, to compare, in registered trials, the primary outcomes registered with those published and to determine whether outcome-reporting bias favored significant primary outcomes. BACKGROUND:Trial protocol registration before pat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318299d00b

    authors: Killeen S,Sourallous P,Hunter IA,Hartley JE,Grady HL

    更新日期:2014-01-01 00:00:00

  • Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte.

    abstract:OBJECTIVE:To assess the association of 0.9% saline use versus a calcium-free physiologically balanced crystalloid solution with major morbidity and clinical resource use after abdominal surgery. BACKGROUND:0.9% saline, which results in a hyperchloremic acidosis after infusion, is frequently used to replace volume loss...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31825074f5

    authors: Shaw AD,Bagshaw SM,Goldstein SL,Scherer LA,Duan M,Schermer CR,Kellum JA

    更新日期:2012-05-01 00:00:00

  • An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American Center.

    abstract:OBJECTIVE:To determine if an aggressive surgical approach, with an increase in R0 resections, has resulted in improved survival for patients with gallbladder cancer. SUMMARY BACKGROUND DATA:Many physicians express a relatively nihilistic approach to the treatment of gallbladder cancer; consensus among surgeons regardi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000154118.07704.ef

    authors: Dixon E,Vollmer CM Jr,Sahajpal A,Cattral M,Grant D,Doig C,Hemming A,Taylor B,Langer B,Greig P,Gallinger S

    更新日期:2005-03-01 00:00:00

  • Repeat hepatic surgery for colorectal cancer metastasis to the liver.

    abstract:OBJECTIVE:The authors addressed whether a repeat hepatic operation is warranted in patients with recurrent isolated hepatic metastases. Are the results as good after second operation as after first hepatic operation? SUMMARY BACKGROUND DATA:Five-year survival after initial hepatic operation for colorectal metastases i...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199606000-00015

    authors: Pinson CW,Wright JK,Chapman WC,Garrard CL,Blair TK,Sawyers JL

    更新日期:1996-06-01 00:00:00

  • Survival and Scoliosis Following Resection of Chest Wall Tumors in Children and Adolescents: A Single-center Retrospective Analysis.

    abstract:OBJECTIVE:We reviewed our experience with pediatric chest wall tumors (CWTs) to identify variables associated with survival, scoliosis development, and need for corrective scoliosis surgery. BACKGROUND:Chest wall neoplasms in children or adolescents are rare. Consequently, there are few large series that detail surviv...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003495

    authors: Saltsman JA,Danzer E,Hammond WJ,Rhee D,Berhe S,Monteagudo J,Price AP,Heaton TE,Jones DR,LaQuaglia MP

    更新日期:2019-07-25 00:00:00