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The impact of long term estrogen support after hysterectomy. A report of 1016 cases.

Abstract：

:1016 Women were placed on estrogen support following hysterectomy and have been followed for a total of 14,318 patient/years. Support was principally conjugated estrogen with the customary dose 1.5 mg/day. The follow-up studies in this group of women shows a marked drop in deaths from all causes over those which might have been expected. This improvement in mortality is principally the result of diminished number of deaths from heart attack and from cancer. Those causes of death which would not be expected to be related to hormonal therapy show the anticipated number of mortalities. There is also a marked improvement in the clinical evidence of osteoporosis. In this group there is an increase in the number of breast cancers over those which might have been expected, but there is a lower mortality from breast cancer than the anticipated mortality. The general impact of long-term estrogen therapy following hysterectomy is favorable over those figures for the expected incidence of cancer and heart disease. :The impact of long-term estrogen support following hysterectomy was studied in 1016 women (22-78 years of age) who were followed for a total of 14,318 patient/years. Patients received conjugated estrogen, 1.25 mg/day. A marked drop in deaths from all causes was seen in this group of patients. This was primarily due to a decrease in the number of deaths due to heart attack or cancer. Those causes of deaths unrelated to hormone therapy showed the expected number of mortalities. Nulliparous women seem to be at a higher risk of cancer during the first 10 years of estrogen therapy. There is a marked improvement in the clinical evidence of osteoporosis. In this group there is an increased incidence of breast cancer over the expected but a lower mortality from this cancer than the anticipated mortality. A discussion focuses on further research into this area of study but implies that estrogen therapy has favorable results over figures for the expected incidence of cancer and heart disease.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Byrd BF Jr,Burch JC,Vaughn WK

doi

10.1097/00000658-197705000-00010

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

574-80

issue

eissn

0003-4932

issn

1528-1140

journal_volume

185

pub_type

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The impact of long term estrogen support after hysterectomy. A report of 1016 cases.