Clinical effect of allopurinol on preserved kidneys: a randomized double-blind study.

Abstract:

:We investigated the clinical posttransplant effect of allopurinol on preserved kidneys. Thirty-four paired kidneys from brain-dead cadavers were preserved by hypothermic pulsatile perfusion with silica gel fraction in separate cassettes. Allopurinol was added to one perfusate and omitted from the other in a randomized, double-blind, prospective plan. There was no difference in the short-term or long-term function of either group of kidneys. Allopurinol does not appear to have as consistent a beneficial effect on non-ischemically damaged human kidneys as that observed experimentally on ischemically damaged canine organs.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Toledo-Pereyra LH,Simmons RL,Olson LC,Najarian JS

doi

10.1097/00000658-197701000-00021

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

128-31

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

185

pub_type

临床试验,杂志文章,随机对照试验
  • Pancreatic Cancer Surgery: The New R-status Counts.

    abstract:OBJECTIVE:To assess the relevance of resection margin status for survival outcome after resection and adjuvant therapy for pancreatic cancer. BACKGROUND:The definitions for R0 and R1 margin status after resection for pancreatic cancer are controversial. The strict definition of R0 requiring a 1 mm tumor-free margin is...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001731

    authors: Strobel O,Hank T,Hinz U,Bergmann F,Schneider L,Springfeld C,Jäger D,Schirmacher P,Hackert T,Büchler MW

    更新日期:2017-03-01 00:00:00

  • Alterations in gut hormones after laparoscopic sleeve gastrectomy: a prospective clinical and laboratory investigational study.

    abstract:OBJECTIVE:To evaluate the effect of laparoscopic sleeve gastrectomy (LSG) on fasting and meal-stimulated release of the gut hormones ghrelin, pancreatic polypeptide (PP), peptide-YY (PYY), glucagon-like peptide-1 (GLP-1), and amylin and of the adipocytokine leptin. BACKGROUND:Mounting evidence suggests that the mechan...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31826e1846

    authors: Dimitriadis E,Daskalakis M,Kampa M,Peppe A,Papadakis JA,Melissas J

    更新日期:2013-04-01 00:00:00

  • The impact of gastric distension on the lower esophageal sphincter and its exposure to acid gastric juice.

    abstract:BACKGROUND AND AIMS:The lower esophageal sphincter (LES) in patients with gastroesophageal reflux disease often has a low resting pressure and a short abdominal length. The mechanism by which this occurs is unknown. We hypothesize that gastric distension causes progressive effacement of the abdominal portion of the LES...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e3e411

    authors: Ayazi S,Tamhankar A,DeMeester SR,Zehetner J,Wu C,Lipham JC,Hagen JA,DeMeester TR

    更新日期:2010-07-01 00:00:00

  • Caloric restriction increases the expression of heat shock protein in the gut.

    abstract:OBJECTIVE:The authors determined whether caloric restriction (CR) either acutely or chronically, alters heat shock protein 70 (hsp70) gene expression in the gut. SUMMARY BACKGROUND DATA:Caloric restriction prolongs the life span and delays age-related disease (e.g., cancer) in mammals; the mechanisms responsible for t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199605000-00015

    authors: Ehrenfried JA,Evers BM,Chu KU,Townsend CM Jr,Thompson JC

    更新日期:1996-05-01 00:00:00

  • Systemic cytokine response after laparoscopic-assisted resection of rectosigmoid carcinoma: A prospective randomized trial.

    abstract:OBJECTIVE:To compare the systemic cytokine response in patients after laparoscopic-assisted resection with those after open resection of rectosigmoid carcinoma. SUMMARY BACKGROUND DATA:Laparoscopic resection of colorectal carcinoma is technically feasible, but objective evidence of its benefit is scarce. Systemic cyto...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-200004000-00008

    authors: Leung KL,Lai PB,Ho RL,Meng WC,Yiu RY,Lee JF,Lau WY

    更新日期:2000-04-01 00:00:00

  • Irrigation versus suction alone during laparoscopic appendectomy for perforated appendicitis: a prospective randomized trial.

    abstract:BACKGROUND:The efficacy of irrigating the peritoneal cavity during appendectomy for perforated appendicitis has been debated extensively. To date, prospective comparative data are lacking. Therefore, we conducted a prospective, randomized trial comparing peritoneal irrigation to suction alone during laparoscopic append...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e31826a91e5

    authors: St Peter SD,Adibe OO,Iqbal CW,Fike FB,Sharp SW,Juang D,Lanning D,Murphy JP,Andrews WS,Sharp RJ,Snyder CL,Holcomb GW,Ostlie DJ

    更新日期:2012-10-01 00:00:00

  • The LeVeen shunt in the elective treatment of intractable ascites in cirrhosis. A prospective study on 140 patients.

    abstract::One hundred and forty patients with an intractable ascites complicating a chronic liver disease received a peritoneovenous shunt (PVS) using the LeVeen valve. Operative mortality was ten per cent but was 25% in patients with severe liver failure. Intraoperative drainage of ascites sharply decreased postoperative compl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198504000-00014

    authors: Smadja C,Franco D

    更新日期:1985-04-01 00:00:00

  • Routine electroencephalographic (EEG) monitoring during carotid endarterectomy.

    abstract::Controversy continues concerning the advisability of routine shunting, no shunting, or selective shunting during carotid endarterectomy. Because of its reflection of the physiologic state of the end organ, the authors chose routine 18 lead EEG monitoring as a guide to selective shunting and as an indication of adequat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198306000-00009

    authors: Whittemore AD,Kauffman JL,Kohler TR,Mannick JA

    更新日期:1983-06-01 00:00:00

  • Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria.

    abstract:INTRODUCTION:For patients with hepatocellular carcinoma (HCC) in particular, living donor liver transplant (LDLT) improves access to transplant. We report our results in 36 patients with HCC who underwent LDLT with a median follow-up >1 year. METHODS Underlying diagnoses included: hepatitis C (24), hepatitis B (9), cry...

    journal_title:Annals of surgery

    pub_type: 评论,杂志文章

    doi:10.1097/01.sla.0000109022.32391.eb

    authors: Gondolesi GE,Roayaie S,Muñoz L,Kim-Schluger L,Schiano T,Fishbein TM,Emre S,Miller CM,Schwartz ME

    更新日期:2004-02-01 00:00:00

  • The impact of long term estrogen support after hysterectomy. A report of 1016 cases.

    abstract::1016 Women were placed on estrogen support following hysterectomy and have been followed for a total of 14,318 patient/years. Support was principally conjugated estrogen with the customary dose 1.5 mg/day. The follow-up studies in this group of women shows a marked drop in deaths from all causes over those which might...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197705000-00010

    authors: Byrd BF Jr,Burch JC,Vaughn WK

    更新日期:1977-05-01 00:00:00

  • Phospholipase A2 isoforms are altered in chronic pancreatitis.

    abstract:OBJECTIVE:To determine if phospholipase A2 (PLA2) type II and type IV mRNA expression and protein are altered in chronic pancreatitis. SUMMARY BACKGROUND DATA:PLA2s have an important regulatory function in several signaling pathways, especially in inflammation. In this study, we examined the expression of three PLA2 i...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199802000-00011

    authors: Kashiwagi M,Friess H,Uhl W,Graber H,Duarte R,Zimmermann A,Büchler MW

    更新日期:1998-02-01 00:00:00

  • Patterns of failure in patients with resected stage I and II non-small-cell carcinoma of the lung. The Ludwig Lung Cancer Study Group.

    abstract::The pattern of failure was studied in 1012 patients with resected Stage I or II non-small-cell carcinoma of the lung. Initial intrathoracic failure (41%) was more common than initial extrathoracic failure (34%) even though a complete resection was the intent in all patients. The most frequent sites of initial failure ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198701000-00012

    authors:

    更新日期:1987-01-01 00:00:00

  • Assessment of the amylase--creatinine clearance ratio in postoperative patients.

    abstract::The value of the amylase--creatinine clearance ratio (ACCR) in the diagnosis of postoperative pancreatitis was prospectively assessed. In 77 patients undergoing operations known to have a significant incidence of postoperative pancreatitis (gastric, biliary or pancreatic) i.e. "high risk" group, the ACCR was abnormall...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198008000-00011

    authors: Leckie PA,Ferreira P,Debas HT

    更新日期:1980-08-01 00:00:00

  • Medullary thyroid carcinoma: relationship of method of diagnosis to pathologic staging.

    abstract::Medullary thyroid carcinoma (MTC) develops in virtually all patients affected with multiple endocrine neoplasia type II (MEN II), a disease inherited as an autosomal dominant trait. The thyroid tumor cells secrete calcitonin (CT) and the detection of elevated plasma levels (>300 pg/ml) of this hormone in MEN II kindre...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197809000-00013

    authors: Wells SA Jr,Baylin SB,Gann DS,Farrell RE,Dilley WG,Preissig SH,Linehan WM,Cooper CW

    更新日期:1978-09-01 00:00:00

  • Resection for pancreatitis in patients with pancreas divisum.

    abstract::Pancreas divisum is an anatomic duct variant, which may predispose to pancreatitis. Most patients are managed conservatively, but some patients justify attempts to improve drainage. The correct surgical approach is not yet established, and there has been no series published concerning pancreatic resection in this cont...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198411000-00006

    authors: Blair AJ 3rd,Russell CG,Cotton PB

    更新日期:1984-11-01 00:00:00

  • Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach.

    abstract:OBJECTIVE:Comparison of minimal access retroperitoneal pancreatic necrosectomy (MARPN) versus open necrosectomy in the treatment of infected or nonresolving pancreatic necrosis. SUMMARY OF BACKGROUND DATA:Infected pancreatic necrosis may lead to progressive organ failure and death. Minimal access techniques have been ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181d96c53

    authors: Raraty MG,Halloran CM,Dodd S,Ghaneh P,Connor S,Evans J,Sutton R,Neoptolemos JP

    更新日期:2010-05-01 00:00:00

  • Steroids in the treatment of clinical septic shock.

    abstract::A prospective (Part I) and a retrospective (Part II) study were used to determine the safety and efficacy of corticosteroids in the treatment of septic shock. In Part I, 172 consecutive patients in septic shock admitted over an 8-year period were treated with either steroid or saline: 43 received dexamethasone (DMP), ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197609000-00011

    authors: Schumer W

    更新日期:1976-09-01 00:00:00

  • Relapse-free survival in patients with nonmetastatic, surgically resected pancreatic neuroendocrine tumors: an analysis of the AJCC and ENETS staging classifications.

    abstract:BACKGROUND:The risk of metastatic spread among patients with early-stage pancreatic neuroendocrine tumors has not been well established. The authors sought to evaluate whether the new TNM staging systems proposed by the American Joint Committee on Cancer (AJCC) and European Neuroendocrine Tumor Society (ENETS) are prog...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31824e6108

    authors: Strosberg JR,Cheema A,Weber JM,Ghayouri M,Han G,Hodul PJ,Kvols LK

    更新日期:2012-08-01 00:00:00

  • Repeat hepatic surgery for colorectal cancer metastasis to the liver.

    abstract:OBJECTIVE:The authors addressed whether a repeat hepatic operation is warranted in patients with recurrent isolated hepatic metastases. Are the results as good after second operation as after first hepatic operation? SUMMARY BACKGROUND DATA:Five-year survival after initial hepatic operation for colorectal metastases i...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199606000-00015

    authors: Pinson CW,Wright JK,Chapman WC,Garrard CL,Blair TK,Sawyers JL

    更新日期:1996-06-01 00:00:00

  • Post-traumatic changes in, and effect of colloid osmotic pressure on the distribution of body water.

    abstract::The aim of this study was to define the post-traumatic changes in body fluid compartments and to evaluate the effect of plasma colloid osmotic pressure (COP) on the partitioning of body fluid between these compartments. Forty-two measurements of plasma volume (green dye), extracellular volume (bromine), and total body...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198909000-00015

    authors: Böck JC,Barker BC,Clinton AG,Wilson MB,Lewis FR

    更新日期:1989-09-01 00:00:00

  • The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection: Long-Term Follow-Up Analysis.

    abstract:OBJECTIVE:This study aimed to identify risk factors for recurrence after pancreatic resection for intraductal papillary mucinous neoplasm (IPMN). SUMMARY BACKGROUND DATA:Long-term follow-up data on recurrence after surgical resection for IPMN are currently lacking. Previous studies have presented mixed results on the ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004427

    authors: Pflüger MJ,Griffin JF,Hackeng WM,Kawamoto S,Yu J,Chianchiano P,Shin E,Lionheart G,Tsai HL,Wang H,Rezaee N,Burkhart RA,Cameron JL,Thompson ED,Wolfgang CL,He J,Brosens LAA,Wood LD

    更新日期:2020-11-17 00:00:00

  • Multicenter Stratified Comparison of Hospital Costs Between Laparoscopic and Open Colorectal Cancer Resections: Influence of Tumor Location and Operative Risk.

    abstract:OBJECTIVE:To compare actual 90-day hospital costs between elective open and laparoscopic colon and rectal cancer resection in a daily practice multicenter setting stratified for operative risk. BACKGROUND:Laparoscopic resection has developed as a commonly accepted surgical procedure for colorectal cancer. There are co...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002000

    authors: Govaert JA,Fiocco M,van Dijk WA,Kolfschoten NE,Prins HA,Dekker JWT,Tollenaar RAEM,Tanis PJ,Wouters MWJM,Dutch Value Based Healthcare Study Group.

    更新日期:2017-12-01 00:00:00

  • Conversion for Unfavorable Intraoperative Events Results in Significantly Worse Outcomes During Laparoscopic Liver Resection: Lessons Learned From a Multicenter Review of 2861 Cases.

    abstract:OBJECTIVE:To investigate the risk factors for conversion during laparoscopic liver resection and its effect on patient outcome in a large cohort of patients. Additional analysis of outcomes in patients who required conversion for unfavorable intraoperative findings and conversion for unfavorable intraoperative events w...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000002332

    authors: Halls MC,Cipriani F,Berardi G,Barkhatov L,Lainas P,Alzoubi M,D'Hondt M,Rotellar F,Dagher I,Aldrighetti L,Troisi RI,Edwin B,Abu Hilal M

    更新日期:2018-12-01 00:00:00

  • The cost of not wearing seat belts. A comparison of outcome in 3396 patients.

    abstract::Data from the North Carolina Trauma Registry were analyzed to determine the effect of seat belt usage on outcome in motor vehicle accidents. Of 6237 persons involved in motor vehicle accidents, data on seat belt usage were available for 3396. Of these, 1916 were not and 1480 were wearing seat belts. The mean hospital ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199302000-00005

    authors: Rutledge R,Lalor A,Oller D,Hansen A,Thomason M,Meredith W,Foil MB,Baker C

    更新日期:1993-02-01 00:00:00

  • Perforated stress ulcer in infants: a silent threat.

    abstract::Stress ulcer has become an important clinical entity and its two major complications--bleeding and perforation--are among the most baffling problems, in terms of management, in clinical practice. Perforation, though the less common of the two, is perhaps the most formidable particularly when this occurs in a very sick...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197912000-00006

    authors: Adeyemi SD,Ein SH,Simpson JS

    更新日期:1979-12-01 00:00:00

  • Increased 18F-FDG uptake is predictive of rupture in a novel rat abdominal aortic aneurysm rupture model.

    abstract:OBJECTIVE:To determine whether F-fluorodeoxyglucose (F-FDG) micro-positron emission tomography (micro-PET) can predict abdominal aortic aneurysm (AAA) rupture. BACKGROUND:An infrarenal AAA model is needed to study inflammatory mechanisms that drive rupture. F-FDG PET can detect vascular inflammation in animal models a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000602

    authors: English SJ,Piert MR,Diaz JA,Gordon D,Ghosh A,DʼAlecy LG,Whitesall SE,Sharma AK,DeRoo EP,Watt T,Su G,Henke PK,Eliason JL,Ailawadi G,Upchurch GR Jr

    更新日期:2015-02-01 00:00:00

  • Arginine transport in human liver. Characterization and effects of nitric oxide synthase inhibitors.

    abstract:OBJECTIVE:Arginine transport was characterized and studied in human liver. SUMMARY BACKGROUND DATA:Plasma arginine uptake may regulate hepatocyte intracellular availability and the subsequent biosynthesis of nitric oxide (NO), but little is known about arginine transport across the human hepatocyte plasma membrane. M...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199309000-00014

    authors: Inoue Y,Bode BP,Beck DJ,Li AP,Bland KI,Souba WW

    更新日期:1993-09-01 00:00:00

  • Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock.

    abstract:OBJECTIVE:To determine the early effects of therapy of endotoxin (ET) shock with epinephrine, norepinephrine, or dopexamine on splanchnic circulation, oxygen metabolism, sigmoid mucosal pHi, bacterial translocation, and morphologic integrity of the ileal, colonic, and sigmoid mucosa. SUMMARY BACKGROUND DATA:Conflictin...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199808000-00014

    authors: Sautner T,Wessely C,Riegler M,Sedivy R,Götzinger P,Losert U,Roth E,Jakesz R,Függer R

    更新日期:1998-08-01 00:00:00

  • Frailty, Length of Stay, and Mortality in Kidney Transplant Recipients: A National Registry and Prospective Cohort Study.

    abstract:OBJECTIVE:To test whether frailty, a novel measure of physiologic reserve, is associated with longer kidney transplant (KT) length of stay (LOS), and modifies the association between LOS and mortality. BACKGROUND:Better understanding of LOS is necessary for informed consent and discharge planning. Mortality resulting ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002025

    authors: McAdams-DeMarco MA,King EA,Luo X,Haugen C,DiBrito S,Shaffer A,Kucirka LM,Desai NM,Dagher NN,Lonze BE,Montgomery RA,Walston J,Segev DL

    更新日期:2017-12-01 00:00:00

  • Association Between Intraoperative Platelet Transfusion and Early Graft Regeneration in Living Donor Liver Transplantation.

    abstract:OBJECTIVE:To evaluate the association between anesthetic management before and after graft reperfusion and early graft regeneration in living donor liver transplantation (LDLT). BACKGROUND:Sufficient graft regeneration is essential for the success of LDLT. Diverse signals start to trigger liver regeneration immediatel...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001526

    authors: Han S,Park HW,Song JH,Gwak MS,Lee WJ,Kim G,Lee SK,Ko JS

    更新日期:2016-12-01 00:00:00