Phospholipase A2 isoforms are altered in chronic pancreatitis.

Abstract:

OBJECTIVE:To determine if phospholipase A2 (PLA2) type II and type IV mRNA expression and protein are altered in chronic pancreatitis. SUMMARY BACKGROUND DATA:PLA2s have an important regulatory function in several signaling pathways, especially in inflammation. In this study, we examined the expression of three PLA2 isoforms (type I, type II, and type IV) in chronic pancreatitis. METHODS:The distribution of PLA2 was studied in 15 pancreas samples obtained from patients with chronic pancreatitis using immunohistochemical, Northern blot, and in situ hybridization techniques. Normal pancreas obtained from healthy organ donors served as control. RESULTS:Northern blot analysis revealed enhanced mRNA levels of PLA2 type II (5.7-fold) and type IV (5.1-fold) in chronic pancreatitis (p < 0.01) versus normal pancreas. In normal pancreas, intense PLA2 type I immunostaining was present in acinar cells, whereas PLA2 type II immunostaining was visible only in some acinar cells. In chronic pancreatitis, PLA2 type II immunostaining was present more frequently and with higher intensity in acinar cells. Furthermore, PLA2 type II immunoreactivity was more abundant in metaplastic ductal cells in the chronic pancreatitis samples. By in situ hybridization, areas with ductal metaplasia in chronic pancreatitis exhibited intense PLA2 type IV mRNA signals. All chronic pancreatitis tissues with concomitantly increased mRNA expression for PLA2 type II and type IV exhibited a higher degree of degeneration, ductal metaplasia, and fibrosis. CONCLUSIONS:Upregulation of PLA2 types II and IV in areas with more histologic damage suggests that these PLA2 isoforms might contribute to the morphologic changes that occur in chronic pancreatitis.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Kashiwagi M,Friess H,Uhl W,Graber H,Duarte R,Zimmermann A,Büchler MW

doi

10.1097/00000658-199802000-00011

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

220-8

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

227

pub_type

杂志文章
  • Simulation improves resident performance in catheter-based intervention: results of a randomized, controlled study.

    abstract:OBJECTIVES:Surgical simulation has been shown to enhance the training of general surgery residents. Since catheter-based techniques have become an important part of the vascular surgeon's armamentarium, we explored whether simulation might impact the acquisition of catheter skills by surgical residents. METHODS:Twenty...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000234932.88487.75

    authors: Chaer RA,Derubertis BG,Lin SC,Bush HL,Karwowski JK,Birk D,Morrissey NJ,Faries PL,McKinsey JF,Kent KC

    更新日期:2006-09-01 00:00:00

  • Open Versus Fenestrated Endovascular Repair of Complex Abdominal Aortic Aneurysms.

    abstract:OBJECTIVE:To compare outcomes of fenestrated (FEVAR) and open repairs of complex abdominal aortic aneurysms (cAAA). BACKGROUND:FEVAR has emerged as an alternative to open surgery for treating cAAA, but direct comparisons are limited. METHODS:We studied all repairs of intact or symptomatic cAAA in the Vascular Quality...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000003094

    authors: O'Donnell TFX,Boitano LT,Deery SE,Schermerhorn ML,Schanzer A,Beck AW,Green RM,Takayama H,Patel VI

    更新日期:2020-05-01 00:00:00

  • Laparoscopic Heller myotomy versus endoscopic balloon dilatation for the treatment of achalasia: a network meta-analysis.

    abstract:OBJECTIVE:Comparison of short- and long-term effects after laparoscopic Heller myotomy (LHM) and endoscopic balloon dilation (EBD) considering the need for retreatment. BACKGROUND:Previously published studies have indicated that LHM is the most effective treatment for Achalasia. In contrast to that a recent randomized...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/SLA.0000000000000212

    authors: Schoenberg MB,Marx S,Kersten JF,Rösch T,Belle S,Kähler G,Vassiliou MC,Lüth S,von Renteln D

    更新日期:2013-12-01 00:00:00

  • Variability in length of stay after colorectal surgery: assessment of 182 hospitals in the national surgical quality improvement program.

    abstract:BACKGROUND:Length of postoperative stay (LOS) has gained increasing attention as a potential indicator of surgical efficiency. Our objective was to examine the feasibility of assessing LOS at 182 hospitals to identify institutions with outlying performance. METHODS:Patients were identified who underwent colorectal sur...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/sla.0b013e3181b2a948

    authors: Cohen ME,Bilimoria KY,Ko CY,Richards K,Hall BL

    更新日期:2009-12-01 00:00:00

  • Reduction in alternative complement pathway mediated C3 conversion following burn injury.

    abstract::Studies were performed to further investigate an abnormality of the alternative complement pathway associated with burn injury. C3 conversion by inulin and cobra venom factor was measured in serial serum samples from 18 burned patients and in the sera from 25 normal controls. C3 conversion by both activating substance...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198108000-00018

    authors: Bjornson AB,Bjornson HS,Altemeier WA

    更新日期:1981-08-01 00:00:00

  • Predictive index for long-term survival after retransplantation of the liver in adult recipients: analysis of a 26-year experience in a single center.

    abstract:OBJECTIVE:To develop a prognostic scoring system for risk stratification of patients with hepatic graft failure (GF) undergoing retransplants of the liver (ReLT) and improve patient selection. SUMMARY OF BACKGROUND DATA:Retransplantation of the liver remains controversial because of inferior outcomes compared with the...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31822c5878

    authors: Hong JC,Kaldas FM,Kositamongkol P,Petrowsky H,Farmer DG,Markovic D,Hiatt JR,Busuttil RW

    更新日期:2011-09-01 00:00:00

  • Indications and outcome of pelvic exenteration for locally advanced primary and recurrent rectal cancer.

    abstract:OBJECTIVE:The outcome of pelvic exenteration was compared in patients with locally advanced primary (LAP) cancer and recurrent rectal cancer (RRC). BACKGROUND:There are few reports comparing the results of pelvic exenteration for primary advanced rectal cancer and RRC. METHODS:Consecutive patients undergoing pelvic e...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31828a0d22

    authors: Bhangu A,Ali SM,Brown G,Nicholls RJ,Tekkis P

    更新日期:2014-02-01 00:00:00

  • Glutathione protects the rat liver against reperfusion injury after prolonged warm ischemia.

    abstract:OBJECTIVE:To evaluate the potential of postischemic intravenous infusion of the endogenous antioxidant glutathione (GSH) to protect the liver from reperfusion injury following prolonged warm ischemia. BACKGROUND DATA:The release of reactive oxygen species (ROS) by activated Kupffer cells (KC) and leukocytes causes rep...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000110321.64275.95

    authors: Schauer RJ,Gerbes AL,Vonier D,Meissner H,Michl P,Leiderer R,Schildberg FW,Messmer K,Bilzer M

    更新日期:2004-02-01 00:00:00

  • Management of nonpalpable breast abnormalities.

    abstract::From January 1982 to June 1986, 444 patients had localization of 500 nonpalpable mammographically suspicious lesions using the Kopans hook wire technique. Four hundred ninety-nine biopsies were performed in 443 patients. Cancer was identified in 12% of the biopsies performed for a suspicious mass or density and in 20%...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198705000-00010

    authors: Symmonds RE Jr,Roberts JW

    更新日期:1987-05-01 00:00:00

  • Natural History and Management of Blunt Traumatic Pseudoaneurysms of the Internal Carotid Artery: The Harborview Algorithm Based Off a 10-Year Experience.

    abstract:OBJECTIVE:To define the natural history of, and treatment strategy for, blunt traumatic internal carotid artery (ICA) pseudoaneurysms. BACKGROUND:The natural history and management of traumatic ICA pseudoaneurysms is controversial. METHODS:We retrospectively identified all traumatic ICA pseudoaneurysms diagnosed on h...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001158

    authors: Morton RP,Levitt MR,Emerson S,Ghodke BV,Hallam DK,Sekhar LN,Kim LJ,Chesnut RM

    更新日期:2016-04-01 00:00:00

  • Surgical versus medical treatment of type 2 diabetes mellitus in nonseverely obese patients: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To compare surgical versus medical treatment of type 2 diabetes mellitus (T2DM) remission and comorbidities in patients with a body mass index (BMI) less than 35 kg/m2. BACKGROUND:Obesity surgery can achieve remission of T2DM and its comorbidities. Metabolic surgery has been proposed as a treatment option fo...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/SLA.0000000000001014

    authors: Müller-Stich BP,Senft JD,Warschkow R,Kenngott HG,Billeter AT,Vit G,Helfert S,Diener MK,Fischer L,Büchler MW,Nawroth PP

    更新日期:2015-03-01 00:00:00

  • Randomized Trial of Laparoscopic Nissen vs. Anterior 180 Degree Partial Fundoplication - Late Clinical Outcomes at 15-20 years.

    abstract:OBJECTIVE:To determine very late clinical outcomes at up to 20 years follow-up from a randomized controlled trial of Nissen vs. anterior 180-degree partial fundoplication. SUMMARY BACKGROUND DATA:Nissen fundoplication for gastroesophageal reflux can be followed by troublesome side effects. To address this, partial fun...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004643

    authors: Rudolph-Stringer V,Bright T,Irvine T,Thompson SK,Devitt PG,Game PA,Jamieson GG,Watson DI

    更新日期:2020-11-18 00:00:00

  • Changes in the costs of elective cholecystectomies, 1955-1965-1975.

    abstract::The costs for elective cholecystectomies were measured 1955, 1965 and 1975. The average length of stay decreased by 25% between 1955 and 1965 and with the same amount between 1965 and 1975. In spite of these marked reductions in the average length of stay there was only a significant decrease in costs between 1955 and...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Lindgren B,Petersson BG,Sörbris R,Bengmark S

    更新日期:1979-04-01 00:00:00

  • A prospective randomized trial comparing R1 subtotal gastrectomy with R3 total gastrectomy for antral cancer.

    abstract:OBJECTIVE:The authors determined if more radical surgery with extended lymphadenectomy improves the results of gastrectomy in patients with adenocarcinoma of the gastric antrum. SUMMARY BACKGROUND DATA:The overall survival in patients with gastric cancer is disappointing. Improved survival has been reported by Japanes...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-199408000-00009

    authors: Robertson CS,Chung SC,Woods SD,Griffin SM,Raimes SA,Lau JT,Li AK

    更新日期:1994-08-01 00:00:00

  • Cholecystokinin/Cholecystokinin-1 receptor-mediated peripheral activation of the afferent vagus by enteral nutrients attenuates inflammation in rats.

    abstract:OBJECTIVE:The current study investigates activation of the nutritional anti-inflammatory pathway by lipid-rich nutrition. BACKGROUND:Enteral nutrition activates humoral and neural pathways to regulate food intake and sustain energy balance. Recently, we demonstrated that enteral nutrition and in particular lipid-rich ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181dae411

    authors: Lubbers T,de Haan JJ,Luyer MD,Verbaeys I,Hadfoune M,Dejong CH,Buurman WA,Greve JW

    更新日期:2010-08-01 00:00:00

  • Vocal cord paralysis and reoperative parathyroidectomy. A prospective study.

    abstract::One hundred sixty-three patients undergoing reoperative parathyroidectomy were evaluated before and after operation to determine the incidence of, risk factors for, and morbidity of vocal cord paralysis. These patients were compared to 77 patients undergoing initial parathyroid operation, only one of whom had vocal co...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198603000-00011

    authors: Patow CA,Norton JA,Brennan MF

    更新日期:1986-03-01 00:00:00

  • Clinicopathological aspects of high bile duct cancer. Experience with resection and bypass surgical treatments.

    abstract::This report reviews the experience of the Hepatobiliary Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London with 16 patients having proximal extrahepatic bile duct malignancy who underwent resection and a comparable group of 15 patients who had surgical bypass. The purposes of the review were to eval...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198406000-00001

    authors: Beazley RM,Hadjis N,Benjamin IS,Blumgart LH

    更新日期:1984-06-01 00:00:00

  • A New Scoring System to Predict Recurrent Disease in Grade 1 and 2 Nonfunctional Pancreatic Neuroendocrine Tumors.

    abstract:OBJECTIVE:The aim of this study was to predict recurrence in patients with grade 1 or 2 nonfunctioning pancreatic neuroendocrine tumors (NF-pNET) after curative resection. BACKGROUND:Surgical resection is the preferred treatment for NF-pNET; however, recurrence occurs frequently after curative surgery, worsening progn...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002123

    authors: Genç CG,Jilesen AP,Partelli S,Falconi M,Muffatti F,van Kemenade FJ,van Eeden S,Verheij J,van Dieren S,van Eijck CHJ,Nieveen van Dijkum EJM

    更新日期:2018-06-01 00:00:00

  • Management of external gastrointestinal fistulas.

    abstract::We analyzed the course of 186 patients with external gastrointestinal fistulas treated at the University of California Medical Center, San Francisco from 1968 to 1977. There were 82 patients in the earlier group (1968-1971) and 104 patients in the later group (1972-1977). The groups differed in that 35% of patients in...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197810000-00003

    authors: Reber HA,Roberts C,Way LW,Dunphy JE

    更新日期:1978-10-01 00:00:00

  • Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression.

    abstract::The induction of donor-specific tolerance could prevent the side effects of immunosuppression while improving allograft survival. Male adult Buffalo (RT1b) rats underwent an intrathymic (IT), portal venous (PV), intrasplenic (IS), or subcutaneous (SQ) injection of 25 x 10(6) major histocompatibility complex (MHC) mism...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199210000-00003

    authors: Goss JA,Nakafusa Y,Flye MW

    更新日期:1992-10-01 00:00:00

  • Is competency assessment at the specialist level achievable? A study for the national training programme in laparoscopic colorectal surgery in England.

    abstract:OBJECTIVES:To develop, validate, and implement a competency assessment tool (CAT) for technical surgical performance in the context of a summative assessment process for the National Training Programme in Laparoscopic Colorectal Surgery (NTP). BACKGROUND:The NTP is an educational initiative by the National Cancer Acti...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318275b72a

    authors: Miskovic D,Ni M,Wyles SM,Kennedy RH,Francis NK,Parvaiz A,Cunningham C,Rockall TA,Gudgeon AM,Coleman MG,Hanna GB,National Training Programme in Laparoscopic Colorectal Surgery in England.

    更新日期:2013-03-01 00:00:00

  • Visceral blood flow following thermal injury.

    abstract::To determine if visceral blood flow was altered by thermal injury, effective renal blood flow (ERBF) was measured by para-aminohippurate clearance in five control subjects and 13 nonbacteremic burn patients (mean burn size: 50% total body surface, range: 24.5-83.5) 6-25 days after burn injury. Splanchnic blood flow (S...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198101000-00018

    authors: Aulick LH,Goodwin CW Jr,Becker RA,Wilmore DW

    更新日期:1981-01-01 00:00:00

  • Laparoscopic repair of very large hiatus hernia with sutures versus absorbable mesh versus nonabsorbable mesh: a randomized controlled trial.

    abstract:OBJECTIVE:Determine whether absorbable or nonabsorbable mesh in repair of large hiatus hernias reduces the risk of recurrence, compared with suture repair. BACKGROUND:Repair of large hiatus hernia is associated with radiological recurrence rates of up to 30%, and to improve outcomes mesh repair has been recommended. P...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000000842

    authors: Watson DI,Thompson SK,Devitt PG,Smith L,Woods SD,Aly A,Gan S,Game PA,Jamieson GG

    更新日期:2015-02-01 00:00:00

  • APC and PIK3CA Mutational Cooperativity Predicts Pathologic Response and Survival in Patients Undergoing Resection for Colorectal Liver Metastases.

    abstract:OBJECTIVE:The aim of the study was to determine the prognostic impact of co-existence of APC and PIK3CA mutations in patients undergoing preoperative chemotherapy and resection for colorectal liver metastases (CLM). BACKGROUND:Co-occurring genetic events have been shown to drive carcinogenesis in multiple malignancies...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002245

    authors: Yamashita S,Chun YS,Kopetz SE,Maru D,Conrad C,Aloia TA,Vauthey JN

    更新日期:2020-12-01 00:00:00

  • Cost-effectiveness of Enhanced Recovery Versus Conventional Perioperative Management for Colorectal Surgery.

    abstract:OBJECTIVE:To determine the cost-effectiveness of enhanced recovery pathways (ERPs) versus conventional care for patients undergoing elective colorectal surgery. BACKGROUND:ERPs for colorectal surgery are clinically effective, but their cost-effectiveness is unknown. METHODS:A multi-institutional prospective cohort co...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001019

    authors: Lee L,Mata J,Ghitulescu GA,Boutros M,Charlebois P,Stein B,Liberman AS,Fried GM,Morin N,Carli F,Latimer E,Feldman LS

    更新日期:2015-12-01 00:00:00

  • Experimental gastric sympathectomy: an effective prophylaxis of gastric stress lesions.

    abstract::Fifteen mini-pigs were bled to a mean aortic blood pressure of 40 mm Hg and maintained at that level for three hours. The control group consisted of eight animals with shock for three hours, while the test group was comprised of seven animals with a similar shock period but which had undergone splanchnicectomy 14 days...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197712000-00019

    authors: Hottenrott C,Seufert RM,Kühne FW,Büsing M

    更新日期:1977-12-01 00:00:00

  • Antiviral Therapy Reduces Hepatocellular Carcinoma Recurrence in Patients With Low HBV-DNA Levels: A Randomized Controlled Trial.

    abstract:BACKGROUND:Despite antiviral treatment has been shown to reduce hepatocellular carcinoma (HCC) recurrence after curative treatment for hepatitis B virus (HBV)-related HCC in patients with high preoperative HBV-DNA levels, it is still unclear whether antiviral therapy is useful in reducing recurrence in patients with lo...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000002727

    authors: Huang G,Li PP,Lau WY,Pan ZY,Zhao LH,Wang ZG,Wang MC,Zhou WP

    更新日期:2018-12-01 00:00:00

  • Plasma cholecystokinin and pancreatic polypeptide response after radical pancreatoduodenectomy with Billroth I and Billroth II type of reconstruction.

    abstract::This study was conducted to elucidate plasma cholecystokinin (CCK) and pancreatic polypeptide (PP) response after pancreatoduodenectomy and to compare response of CCK and PP in patients who had pancreatoduodenectomy with Billroth I and Billroth II type of reconstruction. Basal levels of plasma CCK were significantly l...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198708000-00006

    authors: Inoue K,Tobe T,Suzuki T,Hosotani R,Kogire M,Fuchigami A,Miyashita T,Tsuda K,Seino Y

    更新日期:1987-08-01 00:00:00

  • Pigment gallstones form as a composite of bacterial microcolonies and pigment solids.

    abstract::Although previous studies have suggested that bacteria may contribute to pigment gallstone formation, the current experiments provide evidence that bacteria have a central role in this process. The studies included scanning electron microscopy (SEM) of gallstones, measurements of bacterial adherence to gallstones in v...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198709000-00002

    authors: Stewart L,Smith AL,Pellegrini CA,Motson RW,Way LW

    更新日期:1987-09-01 00:00:00

  • The impact of long term estrogen support after hysterectomy. A report of 1016 cases.

    abstract::1016 Women were placed on estrogen support following hysterectomy and have been followed for a total of 14,318 patient/years. Support was principally conjugated estrogen with the customary dose 1.5 mg/day. The follow-up studies in this group of women shows a marked drop in deaths from all causes over those which might...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197705000-00010

    authors: Byrd BF Jr,Burch JC,Vaughn WK

    更新日期:1977-05-01 00:00:00